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InHae Choi,Chun Gun Park,Kyeong Eun Lee 한국데이터정보과학회 2018 한국데이터정보과학회지 Vol.29 No.3
This paper studies an efficient procedure for the outlier detection and variable selection problem in linear regression. The effect of outliers is added in linear regression as a mean shift parameter, nonzero or zero constant. To t this mean shift model, most penalized regressions have used some adaptive penalties on the parameters to shrink most of the parameters to zero. Such penalized models do select the true variables well, but do not detect the outliers correctly. To overcome this problem, we first determine a group of possibly suspected outliers using difference-based regression model (DBRM) and add the group to the linear model as the parameters of the effect of each suspected outlier. Then, we perform outlier detection and variable selection simultaneously using Lasso regression or Elastic net regression for the linear regression with the effect term of each suspected outlier added. The proposed method is more efficient than the previous penalized regression. We compare the proposed procedure with other methods using a simulation study and apply this procedure to the real data.
드론의 캘리브레이션을 위한 기준점 배치에 따른 시뮬레이션
최인하(Inha Choi),김의명(Euimyoung Kim) 대한공간정보학회 2021 한국지형공간정보학회 학술대회 Vol.2021 No.11
본 연구에서는 드론의 캘리브레이션을 위한 시뮬레이션을 수행하기 위해 촬영 계획을 기반으로 지상기준점과 드론의 위치/자세 및 카메라의 위치/자세 데이터를 자동으로 생성하였다. 생성한 시뮬레이션 데이터를 기반으로 지상기준점(GCP: Ground Control Point) 배치에 따른 시스템 캘리브레이션 시뮬레이션을 수행한 결과 카메라와 GPS 센서 간 기선 차이가 각 -0.12m, -0.04m로 나타나 기준점의 배치가 캘리브레이션 결과에 미치는 영향을 확인할 수 있었다.
A case of generalized argyria presenting with muscle weakness
Inha Jung,Eun-Jeong Joo,Byung seong Suh,Cheol-Bae Ham,Ji-Min Han,You-Gyung Kim,Joon-Sup Yeom,Ju-Yeon Choi,Ji-Hye Park 대한직업환경의학회 2017 대한직업환경의학회지 Vol.29 No.-
Background: Argyria is a rare irreversible cutaneous pigmentation disorder caused by prolonged exposure to silver. Herein, we report a case of generalized argyria that developed after chronic ingestion of soluble silver-nano particles and presented with muscle weakness. Case presentation: A 74-year-old woman visited our emergency room, complaining of fever and mental deterioration. She was diagnosed with acute pyelonephritis and recovered after antibiotic therapy. At presentation, diffuse slate graybluish pigmented patches were noticed on her face and nails. Two months prior to visiting our hospital, she was diagnosed with inflammatory myopathy and given steroid therapy at another hospital. We performed a nerve conduction study that revealed polyneuropathy. In skin biopsies from pigmented areas of the forehead and nose, the histopathologic results showed brown-black granules in basement membranes of sweat gland epithelia, which are diagnostic findings of argyria. We reviewed pathology slides obtained from the left thigh muscles and found markedly degenerated myofibers with disorganization of myofibrils without inflammatory reactions, consistent with unspecified myopathy, rather than inflammatory myopathy. The patient was diagnosed with generalized argyria with polyneuropathy and myopathy and transferred to a rehabilitation institution after being tapered off of steroids. Conclusions: Clinicians should be aware of clinical manifestations of argyria and consider it in differential diagnosis when they examine patients who present with skin pigmentation and muscle weakness.
( Inha Lee ),( Young Bin Won ),( Heeyon Kim ),( Jae Hoon Lee ),( Bo Hyon Yun ),( Seok Kyo Seo ),( Sihyun Cho ),( Byung Seok Lee ),( Young Sik Choi ) 대한산부인과학회 2019 대한산부인과학회 학술대회 Vol.105 No.-
Objective: Emerging evidence suggests that several cytokines support embryonic development, protecting blastomeres from cell stress and apoptosis, promoting implantation. Therefore, possible correlations between embryo quality and the concentrations of specific cytokines in the culture medium of human embryos have been explored for many years. The aim of this study was to assess the levels of variety of cytokines in culture medium of preimplantation embryos and to investigate their relationship with embryo quality and in vitro fertilization (IVF) outcomes. Methods: A total of 75 samples were obtained from 31 infertile couples undergoing either IVF or ICSI treatment between August 2018 and May 2019. Each embryo was cultured separately, and embryo culture media was collected 72 hours after fertilization. The cytokine concentrations of each culture media were analyzed for 23 selected cytokines using Multiplex cytokine/chemokine panel II (Merck Millipore®). Prior to day 3 embryo transfer, morphological evaluation of each embryo was performed and categorized into two groups (top quality and non-top). Results: The median age of 31 patients was 34 years old (range:25-39). Thirteen cytokines resulted in out of range data due to small sample volume; therefore, 10 out of 23 cytokines were quantified and compared between top quality embryo group and non-top quality embryo group. Among 10 cytokines, Chemokine ligand (CCL)-8, CCL-13, CCL-15, CCL-27, and CXCL-12 were significantly elevated in top embryo group. Conclusion: Our results suggest that specific cytokines that are measured from human embryo culture medium can serve as a potential tool for predicting embryo quality and IVF outcomes.
( Inha Lee ),( Young Bin Won ),( Jisun Yun ),( Jae Hoon Lee ),( Seok Kyo Seo ),( Si Hyun Cho ),( Young Sik Choi ),( Byung Seok Lee ),( Bo-hyon Yun ) 대한산부인과학회 2018 대한산부인과학회 학술대회 Vol.104 No.-
Objective: Thioredoxin (TRX) is a redox regulating antioxidant protein that prevents cell damage from oxidative stress and TRX binding protein(TBP)-2 are regulatory protein of TRX. Altered TRX and TBP-2 expressions in endometrium are known to be associated with the development of endometriosis. The aim of the study was to identify a role of Histone deacetylase inhibitor (HDACi) in human endometrial cells, by modifying TRX and TBP-2 expression. Methods: From July, 2015 to June, 2016, eutopic and ectopic endometrium was obtained from the patients who had undergone hysterectomy and ovarian cyst enucleation due to endometriosis respectively. The cultured human endometrial stromal cells (HESCs) and ishikawa cells were treated with HDACi (suberoylanilide hydroxamic acid, SAHA). After inducing cell inflammation adding oxidative stress on the cells, SAHA treatment and following changes of cell proliferation, viability and TRX, TBP-2 expression were examined. Inflammatory cytokines including Interleukin (IL)-1, IL-6, IL-10 and Tumor necrosis factor- were measured from the supernatants of the cultured cell treated with SAHA. Results: Expression of TBP-2 was significantly increasing according to the increase of SAHA concentration in eutopic, ectopic endometrial stromal cell and ishikawa cell. Cell proliferation was shown according to the recombinant high mobility group box(rHMGB)-1 treatment in cultured ectopic, eutopic endometrial cells. Expression of TBP-2 was significantly decreased after inducing oxidative stress by rHMGB-1 on the endometrial cells, which recovery was shown by treating SAHA, resulting in TBP-2 increase and decreased TRX/TBP-2 ratio. Inflammatory cytokine secretion was decreased according to the SAHA treatment by concentration in endometrial cells. Conclusion: SAHA may affect the inflammation induced by oxidative stress in development of endometriosis, via resuming the TRX and TBP-2 expression, leading a potential treatment option in endometriosis. Acknowledgements: This study was supported by a faculty research grant of Yonsei University College of Medicine for 6-2015-0073.
Effect of particulate matter on endometriosis
( Inha Lee ),( Heeyon Kim ),( Bo Hee Won ),( Hye In Kim ),( So Hyun Ahn ),( Yun Jeong Park ),( Hae Won Baek ),( Jae Hoon Lee ),( Bo Hyon Yun ),( Seok Kyo Seo ),( Young Sik Choi ),( Sihyun Cho ),( Byun 대한산부인과학회 2020 대한산부인과학회 학술대회 Vol.106 No.-
Objective: Endometriosis is a common gynecologic disorder that is characterized by chronic pelvic pain, dysmenorrhea, and infertility. Although the adverse effects of particulate matter on the human body and many diseases are proven, studies of the effects on endometriosis and related infertility are insignificant not only in Korea but around the world. The object of this study is to evaluate the effect of the particulate matter on the endometrium of the endometriosis compared to controls. Methods: During the surgery, endometrial tissues in patients with and without endometriosis were obtained under informed consent. Benign ovarian cysts without endometriosis were served as controls. Each endometrium of the endometriosis and control cells were treated with 400ug of the urban particulate matter(SRM 1648a). Cell Counting Kit-8 (CCK-8) was used to determinate the cell viability. After protein extractions, expression levels of four cell signaling molecules related to apoptosis, caspase3, BAX, Bcl-2, and p53 were evaluated by using western blot. Results: After treating the particulate matter, cell viability was decreased in endometrium of both endometriosis and controls, with significanlty higher decrease rate in endometriosis group. Also, Expression of Caspase3, BAX, p53 was lower in eutopic endometrium of endometriosis compared to controls while Bcl-2 was higher in endometriosis. When particulate matter was applied, all protein levels in eutopic endometrium of the controls were decreased, while the decrease tendency was not definite in the endometrium of the endometriosis group. Conclusion: Particulate matter affects the cell proliferation and apoptosis of the endometrium cells by altering the cell signaling molecules. The effect of particulate matter was different in endometriosis group compared with control group and endometriosis might have reseistance in particulate matter.