원자력 발전소용 이종재(Cu 합금/STS316L) 마찰용접의 최적화와 AE에 의한 실시간 평가에 관한 연구

유인종(IN-JONG YOO),권상우(SANG-WOO KWON),황성필(SUNG-PHIL HWANG),공유식(YU-SIK KONG),오세규(SAE-KYOO OH) 한국해양공학회 2001 韓國海洋工學會誌 Vol.15 No.2

In this paper, joints of Cu-1Cr-0.1Zr alloy to S1S316L were performed by friction welding method. Particularly, Cu-1Cr-0.1Zr alloy is attractive candidate as nuclear power plant material and exibit the best combination of high strength and good electrical and thermal conductivity of any copper alloy examined. The stainless steel is a structural material while copper alloy acts as a heat sink material for the surface heat flux in the first Wall. So, in this paper, not only the development of optimizing of friction welding with more reliability and more applicabililty but also the development of in-process real-time weld quality (such as strength and toughness) evaluation technique by acoustic emission for friction welding of such nuclear reactor component of Cu-1Cr-0.1Zr alloy to STS316L steel were performed.

학습부진아의 학습기술이 진로장애요인에 미치는 영향

공인규,정흥식,안창규 釜山大學校 敎育硏究所 2006 敎育硏究 Vol.16 No.1

KASINICS 광학계의 고스트 분석

이성호,육인수,진호,박수종,한정열,이대희,공경남,조승현,박영식,박장현,한원용,Lee, Sung-Ho,Yuk, In-Soo,Jin, Ho,Pak, Soo-Jong,Han, Jeong-Yeol,Lee, Dae-Hee,Kong, Kyung-Nam,Cho, Seung-Hyun,Park, Young-Sik,Park, Jang-Hyun,Han, Won-Yong 한국천문학회 2005 天文學論叢 Vol.20 No.1

The reimaging optics of the KASINICS (KASI Near Infrared Camera System) includes many transparent components like an entrance window, band-pass filters, and blocking filters. As observational targets or in-field background objects, bright stars may cause optical ghosts that can significantly degrade the system performance of the KASINICS. We estimated analytically the relative brightness of ghost components with respect to a point source and examined the effects of tilting optical components as a method of suppressing ghosts. We also performed numerical ray tracings including all the optical components and found the results are consistent with those of the analytic estimations. We conclude that the KASINICS will not suffer from significant ghost effects with appropriate anti-reflection coatings and fittings for the optical components.

Effect of Temperature Shock on Cultured Olive Flounder(Paralichthys olivaceus) and Black Rockfish(Sebastes schlegeli)

KONG, IN SOO,LEE, SANG JUN,Lee, Jeong Ho,Kim, Yoon,Lee, Jong Hee,Min, Kwang Sik,Kang, Jeong Ha,Myung, Jeong In 한국수산학회 2001 Fisheries and Aquatic Sciences Vol.4 No.3

Aim of this research is to investigate the effect of temperature shocks on the physiological responses of cultured olive flounder (Paralichthys olivaceus) and black rockfish (Sebastes schlegeli). Olive flounder and black rockfish were suffered with high and low temperature shocks for 4 and 8 h, respectively, in laboratory conditions and then the changes in glucose, lactate, total protein, uric acid, and triglycerides-glycerol in blood plasma were analyzed. We observed that lactate and uric acid increased for up to 4 h and then decreased for up to 8 h by the high and low temperature shocks, and total protein decreased for up to 4 h and then recovered for up to 8 h by the high temperature shock in both fishes. Glucose by the high and low temperature shocks and triglycerides-glycerol by the low temperature shock increased for up to 4 h, and then decreased in olive flounder, but increased for up to 8 h in black rockfish. From the result, we speculated that the two fishes have an interspecific variation in the regulatory systems of glucose and triglycerides-glycerol. Glucose would play important role as an energy source during the temperature shocks and for an intermediate substance for low temperature tolerance, and glycerol of triglycerides-glycerol would play an important role for low temperature tolerance. In olive flounder, the turnover of chemical change by temperature shock took more than 4 h, all chemicals returned almost to the initial level for up to 8 h, but fish death followed only in 8 h with the high temperature shocked group within two days. Therefore, we suggested that fish would be damaged severely by the longer time exposure of high temperature and mortality would occur after a certain time later than the shocked time as a post-effect.

Hepatocellular Carcinoma in Korea Between 2008 and 2011: an Analysis of Korean Nationwide Cancer Registry

( Jun Sik Yoon ),( Han Ah Lee ),( Jun Yong Park ),( Bo Hyun Kim ),( In Joon Lee ),( Young Eun Chon ),( Suk Kyun Hong ),( Dong Hyeon Lee ),( Hyun-joo Kong ),( Young-joo Won ),( Eunyang Kim ),( Jeong-ho 대한간암학회 2020 대한간암학회지 Vol.20 No.1

Backgrounds/Aims: Backgrounds/Aims: In Korea, hepatocellular carcinoma (HCC) is the sixth most common cancer and results in the second-highest cancer death rate among all cancers. We aimed to describe the characteristics of patients who were newly diagnosed with HCC in Korea between 2008 and 2011. Methods: The Korean Primary Liver Cancer Registry (KPLCR) is a random sample consisting of approximately 15% of patients with newly diagnosed primary liver cancer registered in the Korean Central Cancer Registry. We investigated the baseline characteristics, treatment modalities, and overall survival (OS) of patients with HCC registered in the KPLCR between 2008 and 2011. Results: A total of 6,083 patients were histologically or radiologically diagnosed with HCC. The hepatitis B virus was the predominant HCC etiology (72.0%). According to the Barcelona Clinic Liver Cancer (BCLC) staging system, stages 0, A, B, C, and D accounted for 8.6%, 39.7%, 11.5%, 33.8%, and 6.9%, respectively. Transarterial therapy (41.7%) was the most commonly performed initial treatment, followed by best supportive care (21.7%), surgical resection (16.7%), and local ablation therapies (10.6%). The overall rate of adherence to the BCLC treatment guideline was only 37.7%. The 1-, 3-, and 5-year OS rates were 65.6%, 46.2%, and 36.8%, respectively. Conclusions: Between 2008 and 2011, approximately half of patients with HCC (48.3%) were candidates for curative treatment (BCLC stage 0 or A), but one-third of patients (33.8%) had advanced HCC (BCLC stage C). Transarterial therapy was the most commonly conducted initial treatment and the 5-year OS rate was 36.8% in this period. (J Liver Cancer 2020;20:41-52)

우리나라 암환자의 의료기관 접근성의 지역간 불균형

문연옥(Yeon Ok Moon),박은철(Eun Cheol Park),신해림(Hai Rim Shin),원영주(Young Joo Won),정규원(Kyu Won Jung),황순영(Soon Young Hwang),이진희(Jin Hee Lee),공현주(Hyun Joo Kong),황승식(Seung Sik Hwang),이종구(Jong Koo Lee),공인식(In Sik 한국역학회 2006 Epidemiology and Health Vol.28 No.2

  Objectives: To investigate the differences in accessing regional hospitals and the utilization rate of hospitals located in other regions for cancer patients by regions.   Methods: Data for the utilization of regional hospitals for cancer patients were obtained from the Korean National Cancer Incidence Databases in 1999 and 2002. We divided the regions into 16 provinces by administrative districts. We using the SAS 9.1.3 to analyze difference of regional self-sufficiency and the Arcview 3.2 to show in a schematize for regional variation of the regional self-sufficiency.   Results: There were regional variations in the regional self-sufficiency of cancer patients. Especially, Jeollanamdo(1999 13.6%, 2002 12.8%), Gyeongsangbuk-do(1999 22.0%, 2002 20.7%), and Chungcheongnam-do(1999 27.8%, 2002 27.1%) had low regional self-sufficiency. The regional self-sufficiency in Gyeonggi-do and utilization rate of cancer patients who lived in other regions were increased between 1999 and 2002(regional self-sufficiency: 1999 37.2%, 2002 48.2%).   Conclusion: The results of this study showed that there were regional variation in utilization of regional hospitals for cancer patients. Accessibility of cancer patients in metropolitan areas was higher than in small size cities, medium size cities, and rural county areas. These results suggested that it should be considered support medical facilities for cancer patients in rural areas where have lower relevance rate.

Genetic relationships of collected strains using simple sequence repeat (SSR) marker in Flammulina velutipes

Sung-I Woo,Kyoung-In Seo,Kab Yeul Jang,Ji-Hoon Im,Pyung-Gyun Shin,Youn-Lee Oh,Min Ji Oh,Won-Sik Kong 한국버섯학회 2017 버섯 Vol.21 No.1

Microsatellite SSR markers were developed and utilized to reveal the genetic diversity of 32 strains of Flammulina velutipes collected in Korea, China, and Japan. From SSR-enriched library, 490 white colonies were randomly selected and sequenced. In the 490 sequenced clones, 85 clones (17.35%) were redundant. Among the remaining 405 unique clones, 201 clones (49.6%) contained microsatellite sequences. As a result, 12 primer pairs produced reproducible polymorphic bands within diverse 4 strains and these selected markers were further characterized in 32 Flammulina velutipes strains. A total of 34 alleles were detected using the 12 markers, with an average of 3.42 alleles and the number of alleles ranged from two to seven per locus. The major allele frequency ranged from 0.42 (GB-FV-127) to 0.98 (GB-FV-166), and values for observed (HO) and expected (HE) heterozygosity ranged from 0.00 to 0.94 (mean = 0.18) and from 0.03 to 0.67 (mean = 0.32), respectively. SSR loci amplified with GB-FV-127 markers gave the highest polymorphism information content (PIC) of 0.61 and mean allele number of five, while for loci amplified with GB-FV-166 markers these values were the lowest, namely 0.03 and two. The mean PIC value (0.29) observed in the present study with average number of alleles (3.42). The genetic relationships among 32 Flammulina velutipes strains based on SSR data were generated by UPGMA cluster analysis. In conclusion, we succeeded in developing 12 polymorphic SSRs markers from SSR-enriched library of Flammulina velutipes. These SSRs are presently being used for phylogenic analysis and evaluation of genetic variations. In future, these SSR markers will be used in clarifying taxonomic relationships among the Flammulina velutipes.

Protective Effects of Silymarin against the Toxicity of Bisphenol A (BPA) on Boar Sperm Quality

Jang, Hyun-Young,Kong, Hong-Sik,Choi, Byoung-Yang,Shin, Jong-Suh,Cheong, Hee-Tae,Kim, Jong-Tack,Park, In-Chul,Park, Choon-Keun,Yang, Boo-Keun 韓國受精卵移植學會 2011 한국동물생명공학회지 Vol.26 No.4

BPA, a diphenyl compound containing groups, that make it structurally similar to synthetic estrogen and is considered as one of the major endocrine disruptors. Silymarin has extensively been used to prevent and/or alleviate some human disease, especially for the treatment of adverse liver conditions. It has an antioxidative efficacy and cancer preventive efficacy. Therefore, we examined the hypothesis that silymarin can inhibit BPA-induced toxicity in boar sperm duing in vitro storage. Sperm characteristics (motility, viability, membrane integrity and mitochondrion activity) in semen exposed to BPA (10~200 uM) were sharply lowered, while it increase in a dose and time dependent manner due to silymarin addition (50~200 uM) into semen extender in the presence of BPA (100 uM). All of the evaluated characteristics were gradually improved in the groups that were treated with silymarin (50~200 uM) in the presence of BPA (100 uM) in comparison to BPA 100 uM alone group, irrespective of incubation periods (3 and 6 h). These results demonstrate that silymarin can ameliorate the toxicity of BPA on boar sperm characteristics during in vitro storage, suggesting that silymarin indirectly act as an antioxidant.

Integrative radiogenomic analysis for genomic signatures in glioblastomas presenting leptomeningeal dissemination

You, Hye Jin,Park, Ho-Young,Kim, Jinkuk,Lee, In-Hee,Seol, Ho Jun,Lee, Jung-Il,Kim, Sung Tae,Kong, Doo-Sik,Nam, Do-Hyun Williams & Wilkins Co 2016 Medicine Vol.95 No.27

<▼1><P>Supplemental Digital Content is available in the text</P></▼1><▼2><P><B>Abstract</B></P><P>Despite therapeutic advances, the prognosis for glioblastoma (GBM) remains poor. In particular, leptomeningeal dissemination (LMD) has a dismal prognosis. The aim of this study was to identify tumor molecular phenotype, which has a great propensity to develop LMD. Between May 2004 and December 2012, a total of 145 GBM tumor samples were obtained from data registry. A total of 20 of the 145 patients with GBM were found to develop LMD. A specialized radiologist confirmed the diagnosis of LMD on magnetic resonance imaging. To clarify the genomic signatures in GBM with LMD, we performed integrative analysis of whole transcriptome sequencing and copy number alteration in the radiological features indicating LMD phenotypes in GBM. Eleven newly diagnosed patients with GBM with LMD had worse prognosis than those without LMD (median 5.55 vs. 12.94 months, <I>P</I> < 0.0001). Integrating analysis using gene expression based on the change of copy number revealed that SPOCK1, EHD2, SLC2A3, and ANXA11 were highly expressed with the gain of copy number, compared with the gene expression in the non-LMD group. In addition, it was demonstrated that NME2, TMEM100, and SIVA1 were downregulated with the loss of copy number. We also found that mesenchymal subtype accounted for 50% in LMD group, whereas mesenchymal subtype consisted of 29% in non-LMD group, even though there was no statistical significance (<I>P</I> = 0.06). Through this radiogenomic analysis, we suggested the possibility of finding candidate genes associated with LMD and highlighted the significance of integrating approach to clarify the molecular characteristics in LMD.</P></▼2>

Possible Application of Artificial Insemination Buffer for Increasing Production Efficiency of Female Cow Offspring

Bang, Jae-Il,Ha, A-Na,Lee, Kyeong-Lim,Jin, Jong-In,Jung, Kyung-Il,Lee, Jin-Gean,Ryu, Yeong-Sil,Min, Chan-Sik,Deb, Gautam Kumar,Kong, Il-Keun 韓國受精卵移植學會 2011 한국동물생명공학회지 Vol.26 No.4

The present research was carried out to evaluate the possibility of increasing female offspring production ratios using artificial insemination buffer (AIB) before artificial insemination (AI). In this experiment, we optimized AIB composition, made an AIB gun and analyze factors affecting AI non-return rate after AIB treatment. The AIB was made with the base of Tris-buffer supplemented with L-arginine and several other chemicals that might reduce the motility of male sperm compared to the female counterpart, therefore, increasing the possibility of fertilization by female sperm. AIB must be deposited into to cervix by AIB gun. After 15 min of AIB deposition, frozen semen was deposited into the same place. A total of 348 cattle were inseminated with AIB insemination, and there were no significant differences between AIB and traditional AI non-return rates (56.8% vs. 55.7%). The AI non-return rate in AIB group, however, differed significantly among 7 Hanwoo farms. The parturition numbers ( to ) of cows did not affect AIB AI rate. The proportion of AIB AI success rates was significantly higher in Hanwoo cows than in dairy cows (61.0% vs. 48.7%), but the average AI success rate did not differ significantly between AIB and conventional AI (56.8% vs. 55.7%). The female offspring production rate in to cervix deposition place was significantly higher than that in the uterus body (77.7% vs. 59.6%, p<0.05). The injection volume of AIB in 5 and 10 ml was significantly higher than that in 2 ml (77.7%, 78.7% vs. 51.8%, p<0.05), but there were no differences in AIB injection volume between 5 and 10 ml. The best exposure time of AIB in the cervix was 10 to 15 min rather than 5 min (79.2%, 77.2% vs. 52.6%, p<0.05). AIB therefore needs to have an exposure time of at least over 10 min for a higher production rate of female offspring. In conclusion, AIB could be used in AI industry to increase the female offspring ratio and AIB AI can increase the AI success rate.