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An Improved Estimation of Outgoing Longwave Radiation Based on Geostationary Satellite
Hyunji Kim,Minji Seo,Noh-hun Seong,Kyeong-sang Lee,Sungwon Choi,Dong-Hyun Jin,Morang Huh,한경수 대한원격탐사학회 2019 大韓遠隔探査學會誌 Vol.35 No.1
The Outgoing Longwave Radiation (OLR) is an important satellite-driven variable for understanding the Earth’s energy budget balance. The geostationary OLR retrievals require angular and spectral integration using an empirical equation for irradiance flux-to-OLR from a regression analysis, which determines the accuracy of the narrowband satellite-based OLR. We selected homogeneous pixels which is satisfied less temporal-spatial variability of cloud, on three infrared channels (6.7, 10.8, 12.0 μm) of the first multipurpose geostationary satellite in Korea, namely the Communication, Ocean and Meteorological Satellite/Meteorological Imager (COMS/MI). Multiple regression analysis was performed to retrieve OLR with improved accuracy using selected parameters based on theoretical and physical significance. This algorithm yielded retrieval with higher accuracy than broadband-based OLR retrieval: RMSE of 10.54 to 3.81 W m-2, and bias of -8.49 to -0.07 W m-2.
Bioconcentration of methylmercury in microzooplankton in a temperate river
Kim, Hyunji,Noh, Seam,Kim, Eunhee,Poopal, Rama Krishnan,Lee, Hak Young,Han, Seunghee Wiley (John WileySons) 2011 Environmental toxicology and chemistry Vol.30 No.12
<P>To understand the bioconcentration of methylmercury (MeHg) at the base of the riverine food chain, we determined levels of dissolved organic carbon, microseston, Hg, and MeHg in surface water in relation to the microzooplankton MeHg from Yeongsan River. The spatial distribution of unfiltered Hg (0.29-3.1 ng/L) and dissolved Hg (0.15-0.74 ng/L) closely followed the microseston distribution. The spatial distribution of unfiltered MeHg (0.0078-0.077 ng/L) and dissolved MeHg (0.0069-0.018 ng/L) increased with increasing distance from the river mouth and appeared to arise from the shallow wetlands surrounding the upper riverbanks and then to be transported downstream. The logarithm of the MeHg bioconcentration factor for microzooplankton ranged from 5.3 to 6.0 (5.7 0.18), and for microseston ranged from 4.0 to 5.4 (4.9 0.35). Linear correlation statistics comparing microzooplankton MeHg and river water characteristics revealed that microzooplankton MeHg concentration was most significantly correlated with unfiltered MeHg (r = 0.83) and particulate MeHg (r = 0.80) levels. This result suggests that MeHg in unfiltered river water, which is relatively easy to determine, can be used as a surrogate for MeHg in microzooplankton that may influence MeHg levels in higher-trophic-level organisms.</P>
Methylmercury Mass Budgets and Distribution Characteristics in the Western Pacific Ocean
Kim, Hyunji,Soerensen, Anne L.,Hur, Jin,Heimbü,rger, Lars-Eric,Hahm, Doshik,Rhee, Tae Siek,Noh, Seam,Han, Seunghee American Chemical Society 2017 Environmental science & technology Vol.51 No.3
<P>Methylmercury (MeHg) accumulation in marine organisms poses serious ecosystem and human health risk, yet the sources of MeHg in the surface and subsurface ocean remain uncertain. Here, we report the first MeHg mass budgets for the Western Pacific Ocean estimated based on cruise observations. We found the major net source of MeHg in surface water to be vertical diffusion from the subsurface layer (1.8-12 nmol m(-2) yr(-1)). A higher upward diffusion in the North Pacific (12 nmol m(-2) yr(-1)) than in the Equatorial Pacific (1.8-5.7 nmol m(-2) yr(-1)) caused elevated surface MeHg concentrations observed in the North Pacific. We furthermore found that the slope of the linear regression line for MeHg versus apparent oxygen utilization in the Equatorial Pacific was about 2-fold higher than that in the North Pacific. We suggest this could be explained by redistribution of surface water in the tropical convergence-divergence zone, supporting active organic carbon decomposition in the Equatorial Pacific Ocean. On the basis of this study, we predict oceanic regions with high organic carbon remineralization to have enhanced MeHg concentrations in both surface and subsurface waters.</P>
An Improved Estimation of Outgoing Longwave Radiation Based on Geostationary Satellite
Kim, Hyunji,Seo, Minji,Seong, Noh-hun,Lee, Kyeong-sang,Choi, Sungwon,Jin, Donghyun,Huh, Morang,Han, Kyung-Soo The Korean Society of Remote Sensing 2019 大韓遠隔探査學會誌 Vol.35 No.1
The Outgoing Longwave Radiation (OLR) is an important satellite-driven variable for understanding the Earth's energy budget balance. The geostationary OLR retrievals require angular and spectral integration using an empirical equation for irradiance flux-to-OLR from a regression analysis, which determines the accuracy of the narrowband satellite-based OLR. We selected homogeneous pixels which is satisfied less temporal-spatial variability of cloud, on three infrared channels (6.7, 10.8, $12.0{\mu}m$) of the first multipurpose geostationary satellite in Korea, namely the Communication, Ocean and Meteorological Satellite/Meteorological Imager (COMS/MI). Multiple regression analysis was performed to retrieve OLR with improved accuracy using selected parameters based on theoretical and physical significance. This algorithm yielded retrieval with higher accuracy than broadband-based OLR retrieval: RMSE of 10.54 to $3.81W\;m^{-2}$, and bias of -8.49 to $-0.07W\;m^{-2}$.
Kadayat, Tara Man,Park, Seojeong,Shrestha, Aarajana,Jo, Hyunji,Hwang, Soo-Yeon,Katila, Pramila,Shrestha, Ritina,Nepal, Mahesh Raj,Noh, Keumhan,Kim, Sang Kyoon,Koh, Woo-Suk,Kim, Kil Soo,Jeon, Yong Hyun American Chemical Society 2019 Journal of medicinal chemistry Vol.62 No.17
<P>With the aim of developing new effective topoisomerase IIα-targeted anticancer agents, we synthesized a series of hydroxy- and halogenated 2,4-diphenyl indeno[1,2-<I>b</I>]pyridinols using a microwave-assisted single step synthetic method and investigated structure-activity relationships. The majority of compounds with chlorophenyl group at 2-position and phenol group at the 4-position of indeno[1,2-<I>b</I>]pyridinols exhibited potent antiproliferative activity and topoisomerase IIα-selective inhibition. Of the 172 compounds tested, <B>89</B> showed highly potent and selective topoisomerase IIα inhibition and antiproliferative activity in the nanomolar range against human T47D breast (2.6 nM) cancer cell lines. In addition, mechanistic studies revealed compound <B>89</B> is a nonintercalative topoisomerase II poison, and in vitro studies showed it had promising cytotoxic effects in diverse breast cancer cell lines and was particularly effective at inducing apoptosis in T47D cells. Furthermore, in vivo administration of compound <B>89</B> had significant antitumor effects in orthotopic mouse model of breast cancer.</P> [FIG OMISSION]</BR>
ChulHyun Cho,JiHye Choi,SeungGul Kang,HoKyoung Yoon,YoungMin Park,JoungHo Moon,KiYoung Jung,JinKyu Han,HongBum Shin,HyunJi Noh,YongSeo Koo,Leen Kim,HyunGoo Woo,HeonJeong Lee 대한신경정신의학회 2017 PSYCHIATRY INVESTIGATION Vol.14 No.6
Objective-Restless legs syndrome (RLS) is a highly heritable and common neurological sensorimotor disease disturbing sleep. The objective of study was to investigate significant gene for RLS by performing GWA and replication study in a Korean population. Methods-We performed a GWA study for RLS symptom group (n=325) and non-RLS group (n=2,603) from the Korea Genome Epidemiology Study. We subsequently performed a replication study in RLS and normal controls (227 RLS and 229 controls) to confirm the present GWA study findings as well as previous GWA study results. Results-In the initial GWA study of RLS, we observed an association of rs11645604 (OR=1.531, p=1.18×10-6) in MPHOSPH6 on chromosome 16q23.3, rs1918752 (OR=0.6582, p=1.93×10-6) and rs9390170 (OR=0.6778, p=7.67×10-6) in UTRN on chromosome 6q24. From the replication samples, we found rs9390170 in UTRN (p=0.036) and rs3923809 and rs9296249 in BTBD9 (p=0.045, p=0.046, respectively) were significantly associated with RLS. Moreover, we found the haplotype polymorphisms of rs9357271, rs3923809, and rs9296249 (overall p=5.69×10-18) in BTBD9 was associated with RLS. Conclusion-From our sequential GWA and replication study, we could hypothesize rs9390170 polymorphism in UTRN is a novel genetic marker for susceptibility to RLS. Regarding with utrophin, which is encoded by UTRN, is preferentially expressed in the neuromuscular synapse and myotendinous junctions, we speculate that utrophin is involved in RLS, particularly related to the neuromuscular aspects.