중독한 추체로 증상을 보인 cyclosporine에 의한 뇌증 1예

강정현,곽승근,신현영,김성은,이정호,이정찬,곽상혁,윤환중,조덕연,김삼용,김제,송창준 충남대학교 의과대학 지역사회의학연구소 2000 충남의대잡지 Vol.27 No.1

The use of cyclosporine(CsA), a potent immunosuppressive agent, is associated with numerous side effects. Neurotoxicity was earlier less well known, but with growing experience central nervous system side effects are now reported up to 40% of patients. Among various CsA-induced neurotoxicities, tremor is most common and posterior leukoencephalopathy is well characterized. An encephalopathy presenting with pyramidal weakness, however, seems to be rare and poorly documented. We report here a case of encephalopathy presenting with multiple generalized seizures followed by fluctuating quadriparesis developed a few days after starting CsA and resolved spontaneously after withdrawal of the drug . A 48-year-old woman with aplastic anemia was placed upon immmunosuppressive treatment consisting of antithymocyte globulin(ATG), CsA, and methylprednisolone. Two days after starting the therapy, she developed a generalized seizure. The next day she developed 2 more episodes of seizure and the therapy was stopped. Computed tomogram of the brain was normal. Six days after starting therapy, she developed mild motor weakness and paresthesia of both lower extremities, which progressed to a definite quariparesis confining her to a bed in 3 days. Magnetic resonance imaging(MRI) of the brain revealed asymmetric, bilateral high-signal abnormalites in the subcortical white matter of fronto-temporal areas. After reaching to a maximum with some fluactuation(14 days after starting the therapy) the motor weakness started to be resolved. She was discharged with a almost complete resolution of the weakness 45 days after starting the therapy. Five months later she did well and brain MRI was negative.

비만증 환자에서 한약제에 의한 체중 감소효과

Oh, Seung-Joon,Jeong, In-Kyung,Kim, Young-Seol,Choi, Young-Kil,Paeng, Jeong-Ryung,Bae, Jung-Hwan,Shin, Hyun-Dae 경희대학교 동서의학연구소 1999 INTERNATIONAL SYMPOSIUM ON EAST-WEST MEDICINE Vol.1999 No.1

Seung-Joon Oh, In-Kyung Jeong, Young-Seol Kim, Young-Kil Choi, Jeong-Ryung Paeng¹, Jung-Hwan Bae and Hyun-Dae Shin²Department of internal Medicine, College Medicine, Endocrine Research Institute¹. Department of Rehabilitation, College of Oriental Medicine², Seoul, korea. Bady Fat Reduction Effects of Red Ginseng Compound Preparation on the Patients with Obesity. Proceedings of International Symposium on East-West Medicine, Seoul. 244-254, 1999.-Obesity can be defined as a metabolic disease due to an increased state of fat tissues caused by an imbalance of calorie intake and use. Recently, in Korea by improvement and westernization of food intake, along with decrease in exercise activities, the prevalence of obesity has increased greatly. Our objectives were to study stability and effects of decrease in body fat by administering red ginseng compound preparation (known to have body fat decreasing effects in laboratory animals) to obesity patients on low calorie diets. Changes in weight and body fat were measured while carrying out calorie-restricted diets on patients for 4 weeks, then administering red ginseng compound preparation for another 4 weeks. The patients were 20 people whose BMI were 25kg/㎡ or over and whose percent body fat was also 30% or over when tested by bioelectrical conductivity. 1. Changes in weight were from 70.04kg(base line) to 67.43kg(after taking red ginseng compound preparation). 2. In similar sense, BMI decreased from 27.12kg/㎡(base line) to 26.56kg/㎡(after dieting), and further to 26.01kg/㎡ (after taking red ginseng compound preparation). The BMI seemed to decrease significantly compared to the baseline after the use of red ginseng compound. 3. Waist hip ratio was changed from 0.8858(base line) to 0.8728, but it was statistically insignificant. 4. The percent body fat was 35,16%(base line), 33.87%(after dieting), and 31.68%(after taking red ginseng compound preparation). 5. Complete blood cell count and blood chemisrty remained unaffected by the administration. 6. In concern to endocrinologic studies, T3 decreased from 118.7 to 98.2ng/dL, and T4 increased from 8.8 to 9.2㎕/ dL. Epinephrine showed a tendency to decreased from 0.27 to 0.25 ng/mL, and norepinephrine increased from 0.39 to 0.44ng/mL. 7. Leptin was not changed. 8. Some patients complained adverse effects; constipation(5 patients, may be due to diet therapy), fatigue (2 patients), pruritus(2 patients), flushing(s patients), dizziness(3 patients) and epigastric discomfort(2 patients). However their symptoms were mild, so medication did not stopped. In conclusion, loss of weight without significant side effects was observed during low calorie diet and red ginseng compound preparation administration. This is thought to be in relation to sympathetic nerve system rather than adrenal gland. Also, further long0term studies should be required, since the observed results were based on short-term changes in weight.

폐렴구균 감염증에서 항생제 내성의 임상적 의미 : Asian Network for Surveillance of Resistant Pathogens(ANSORP) Study

정숙인,기현균,손준성,고관수,김나영,장현하,오원섭,백경란,이남용,김신우,이혁,--,송재훈 대한감염학회 2003 감염과 화학요법 Vol.35 No.5

목적 : 전 세계적으로 폐렴구균의 페니실린을 포함한 β-lactam과 마크로라이드 및 퀴놀론 계열의 항생제에 대한 내성이 급격히 증가하여 임상적으로 문제가 되고 있으나, 시험관내 내성이 실제 임상적 예후에 미치는 영향에 대해서는 아직까지 논란이 되고 있다. 본 연구는 폐렴구균의 항생제 내성률이 높은 아시아 지역에서 항생제 내성이 폐렴구균 감염증의 임상경과에 미치는 영향을 평가하기 위하여 시행되었다. 방법 : ANSORP에서 주관한 전향적 임상 연구로서 1999년 11월부터 2001년 8월까지 아시아 지역 11개국의 14개 기관에서 진단된 침습성 폐럼구균 감염증 환자를 대상으로 내성 균주 감염의 위험요인, 임상양상, 예후 등의 임상적 분석을 시행하였다. 결과 : 총 646명 환자의 평균연령은 30.1세(6일-89세)였고, 이전 3개월 내에 항생제 사용력이 있는 환자는 159명(32.4%)이었다. 질환별로는 폐렴이 377예(58.4%)로 가장 많았고, 중이염 67예, 뇌수막염 66예(10.2%), 일차성 균혈증 65예(10.1%)였다. 총 646균주 중 347균주(53.7%)가 페니실린 비감수성(중등도 내성 23.1%, 고도 내성 23.1%)이었고, 페니실린에 대한 MIC_(90)은 0.03㎍/mL에서 4㎍/mL까지의 분포를 보였다. 페니실린 비감수성 균주에 의한 감염증과 차이가 없었다. 페니실린 내성 폐렴구균 폐렴에 의한 사망률은 페니실린 감수성 폐렴구균 폐렴에 의한 사망률과 차이가 없었다(p=0.846). Erythromycin에 대한 고도 내성을 보이는 균주의 비율이 매우 높았으나, 실제 임상상이나 치사율에는 영향을 미치지 않았다(p=0.092). 페니실린 비감수성 폐렴구균에 의한 뇌수막염의 치사률도 감수성 균주에 의한 사망률과 차이가 없었다(p=0.059). 결론 : 본 연구의 결과 페니실린 및 베타 락탐 제제에 대한 시험관 내성은 폐렴구균 폐렴이나 뇌수막염의 임상상이나 치사율에 영향을 미치지 않는 것으로 확인되었다. 이는 내성의 정도와 연관될 것으로 생각되므로, 향후 고도 내성 균주가 증가할 때 추가 검증을 요한다. 아울러 macrolide 및 퀴놀론계 항생제 내성의 임상적 의미에 대한 후속 연구가 필요할 것으로 사료된다. Background : Despite the widespread emergence of antimicrobial resistance among pneumococcal strains worldwide, clinical implications of in vitro resistance still remain an open question. To evaluate the clinical impact of pneumococcal resistance in Asian countries where the prevalence of pneumococcal resistance was reported to be highest in the world, ANSORP has performed a prospective, multinational surveillance study with cases with invasive pneumococcal diseases in Asian countries. Methods : In vitro susceptibility of pneumococcal isolates was determined by broth microdilution tests with 16 antimicrobial agents. All enrolled cases of pneumococcal infections were analyzed with regard to demographic data, clinical features, risk factors and mortality. Results : A total of 646 patients with pneumococcal infections were enrolled from 14 centers in 12 countries between the period from November 1999 to August 2001. Pneumonia (58.4%) was the most common clinical disease followed by bacteremia (33.4%), otitis media (10.4%), and meningitis (10.2%). Among 646 isolates, 347 (53.7%) were penicillin non-susceptible (intermediate 23.1%, resistant 30.7%). MIG_(90)s for penicillin ranged from 0.03 (India) to 4.0 ㎍/mL (Korea, Taiwan, Vietnam, and Hong Kong). Overall mortality from pneumococcal diseases by penicillin non-susceptible strains was not different from that by susceptible strains. Pneumococcal pneumonia caused by penicillin- or erythromycin-resistant strains showed similar mortality, severity of illness, or complications to that by susceptible strains. Mortality from pneumococcal meningitis caused by penicillin non-susceptible strains was also similar to that by susceptible strains. Conclusion : Data suggest that current situation of in vitro resistance to penicillin or macrolides may not affect the mortality from pneumococal pneumonia or meningitis caused by antibiotic-resistant strains.

CIM환경을 위한 공정품질정보시스템 개발

정원,신현명,이경호 한국경영과학회 1998 한국경영과학회지 Vol.23 No.3

A Process Quality Information System (PQIS) for the CIM environment is presented. The system includes three subsystems which are quality control, statistical analysis, and information management. As part of CIM, the PQIS was designed by using the ICAM Definition(IDEF) methodology. The Oracle-CDE was utilized as a graphic development tool which made the system more user friendly. PQIS operates on IBM or compatible PCs under MS-Windows and Oracle DBMS. The methodology developed in this research provides a foundation for the application of CIM subsystems.

대학생들의 손잡이(Handedness)평가

신현정,최성진 심리과학연구소 2001 심리과학연구 Vol.2 No.-

The present study was conducted to find an appropriate measurement norm and classification system of handedness in college students. Oldfield test was administered to 643 college students. There were lower percentage left-handers among college students(3.6%) than Americans(10.4%) and Koreans(4.8%). This results provide that expression of handedness can be modified by cultural influences. 본 연구는 손잡이 평가기준과 분류체계를 마련하는 기초 자료로 사용할 목적으로 실시되었다. 643명의 대학생들에게 Oldfield 손잡이검사를 실시하였다. 연구 결과는 대학생들의 왼손잡이 분포에서 이전 연구(미국 : 10.4%, 한국 : 4.8%)보다 낮은 비율(3.6%)을 보였다. 본 연구의 결과는 문화적 차이에 따라 손잡이 분류체계와 기준이 다르다는 것을 나타낸다.

자동차 프레스공정의 자동검사/계측시스템

정원,신현명,박종락 한국경영과학회 1999 經營 科學 Vol.16 No.2

This paper presents an automated visual inspection/measuring system for the door inner panel manufacturing process The main objective of this research is to develop inspection applications with a machine vision system related to the determination or quantification of parameters such as dimension, shape, quality of surfaces, number of holes in a panel, and presence or absence of specific features For quality measurements, we showed a subpixel image processing technology that will improve the consistency of results and level of precision Also presented is a data analysis method to detect process shifts so that corrective action can be undertaken before more defective units are manufactured

치아 맹출전 시행한 기관 삽관이 유치열기에 미치는 영향에 대한 증례보고

신윤경,Hyun, Hong-Keun,김영재,김정욱,장기택,이상훈,김종철,한세현 大韓小兒齒科學會 2008 大韓小兒齒科學會誌 Vol.35 No.3

유치 맹출전에 치조융기에 가해진 외상은 유치의 맹출 지연 및 형태이상,치배의 변위 등을 일으킬 수 있으며 심한 경우 구개의 흠 형성,절치의 결함 및 후천성 구개열 등을 야기할 수 있다. 본 증례는 치아가 맹출하기 전에 수차례의 기관 삽관을 시행한 병력이 있는 심한 저체중아에서 맹출지연,형태이상,법랑질 저형성,영구치 치배 등의 변위가 관찰되어 이를 보고하는 바이다. Delayed eruption and abnormal morphology of the primary incisors following intubation may be due to follicular displacement and localized trauma caused by the process of intubation. Result of such damage included palatal groove formation, defective incisors and acquired clefts. This clinical report presents effect of intubation on the primary dentition of premature low-birth-weight children prior to tooth eruption.

초피나무 樹皮의 脂質成分에 관한 硏究

申秀澈,徐在信,鄭賢淑 順天大學校 1983 論文集 Vol.2 No.1

초피나무 樹皮에 含有된 一般成分과 脂質成分의 構成 및 脂肪酸의 組成을 分析한 結果를 要約하면 다음과 같다. 1. 一般分析値는 水分이 61.09%, 組蛋白質이 12.18%, 組脂質이 5.89%, 조섬유가 11.66%, 회분이 9.18%였다. 2. 脂肪質의 構成은 中性脂質이 64.77%, 糖脂質이 27.2%, 燐脂質이 7.58%였고, 中性脂質成分은 hydrocarbon, esterified sterol, triglyceride, free fatty acid, free sterol diglyceride 및 monoglyceride의 成分으로 分離 同定하였다. 3. GC에 의하여 7가지 脂肪酸이 檢出되었는데 주요 脂肪酸은 palmitoleic acid, oleic acid, linoleic acid, linolenic acid의 不飽和 脂肪酸이었고, myristic acid, palmitic acid, stearic acid의 飽和脂肪酸은 소량 含有되어 있었다. The lipid components and fatty acid composition of crude lipid in bark of Xanthoxylum piperitum were determined by the methods of thin layer chromatography and gas liquid chromatography. The results were summerized as follows: 1. Proximate components of the bark were shown to be 61.09% moisture, 12.18% crude protein 5.89% crude lipid, 11.66% crude fiber, 9.18% ash. 2. Lipid components were 64.77% neutral lipid, 27.2% glycolipid and 7.58% phospholipid The neutral lipids were fractionated and identified as hydrocarbons, esterified sterols, triglycerides free fatty acid, free sterols, diglycerides and monoglycerides. 3. Lipids of the bark of X. piperitum contained 7kinds of fatly acid as constituent by gas liquid chromatography anlysis. The main fatty acides in the lipids were unsaturated fatty acids(palmitoleic acid, oleic acid, linoleic acid, linolenic acid), and saturated fatty acids(myristic acid, palmitic acid, stearic acid) were as minor components.

Sr·페라이트 본드자석의 자기 특성에 관한 연구

신용진,정병두,문현욱 明知大學校 産業技術硏究所 1996 産業技術硏究所論文集 Vol.15 No.-

In this paper, we mention the magnetic properties of Sr ferrite bonded magnet. In order to compose Sr ferrite, first, a little CaO, SiO2, Na2Si3 and A12O3 are added to SrO n·Fe203(n=5.9). Then, the composition is calcinated at 1225℃ under N2 environment for1 hour with addition of PVA 6wt% solution. The carbon coating method increase grinding effect on powder fabrication. To fabricate anisotropic Sr ferrite bonded magnet 82∼92wt% of Sr ferrite and polyamide12 are kneaded and then 0∼12kOe of magnetic field is allied. On magnet fabrication, an optimal condition of injection mold is obtained under the injection temperature 250℃, the injection pressure 120㎏/cm², the magnetic field 8kOe and magnetic field applied time 8sec. As the results of experiments, we obtain (BH)max=2.09MGoe properly on anisotropic bonded magnet which is fabricated by using injection mold method in magnetic field.

無定形 실리카(왕겨재 및 실리카 흄)를 添加한 슬래그 시멘트의 蒸氣 養生에 의한 機械的 性質

申鉉澤,鄭喜天 慶尙大學校 1991 論文集 Vol.30 No.2

슬래그 시멘트에 무정형 실리카로서 왕겨재 및 실리카홈을 혼화재로 첨가한 조합물을 양생온도 90℃, 120℃, 양생시간 6,9,12hrs.로 변화시켜 증기양생한 경화체의 압축강도 및 미세조직을 관찰한 실험 결과는 다음과 같다. 1. 슬래그 시멘트에 왕겨재 또는 실리카 홈 0,3,5,7we.% 양생 조건 120℃-6,9,12hrs. 일때 9시간 증기양생시 가장 높은 압축강도를 나타낸다. 2. 동일한 상기 조건에서 혼합재료로서 왕겨재가 실리카 홈보다 높은 압축강도를 나타낸다. 3. 왕겨재 5%첨가시 120℃-9hrs 양생조건 일때 최고 압축강도는 793kg/㎠을 나타내었다. 4. SEM 미세조직 관찰에서 최고 압축강도가 높은 왕겨재의 경우는 미세기공이 적고 조직이 치밀함을 보여주었다. The mechanical properties and SEM micrograph of portland slag cement-amorphous silica(rice husk ash and silia fume) systems were studied with various compositions. Samples were steam cured at 90 and 120℃ for 6, 9, and 12hrs., respectively. The highest compressive strength (793 kg/ ㎠) was abtained the composition in weight ratio of portland slag cement : rice husk ash = 95 : 5 at 120℃-9hr steam curing. SEM micregraphs of the specimens with 5 wt.% RHA steam curing at 120℃-9hrs were more dense than specimen with 5 wt.% SF.