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( Kyong Hwan Lee ),( Youn Woo Lee ),( Jae Duck Kim ),( Kwang Su Jeon ),( Baik Hyon Ha ) 한국화학공학회 1997 Korean Journal of Chemical Engineering Vol.14 No.6
Catalytic cracking of vacuum gas oil has been investigated at 500℃ over mixed catalysts in a micro-activity tester. The catalyst consists of mordenite treated by either HCI/steam or HF and alumina prepared at pH of 9.5 or 7.8. The catalysts retaining mordenite in which SiO₂/Al₂O₃weight ratio ranged from 15 to 20 show the maximum activity and selectivity for gasoline. Both the activity and selectivity for gasoline seem to depend strongly on both acid strength of mixed catalysts and mesopore volume of the mordenite. It is found, however, that the selectivity of kerosene+diesel in liquid product as well as the yield of aromatics in gasoline are influenced more by mesopore volume of mordenite than by acid properties of mordenite in the catalyst of mordenite/alumina.
Jaegeun Lee(이재근),Seung Woo Yang(양승우),Seunghee Lee(이승희),Yun Kyong Hyon(현윤경),Jinbum Kim(김진범),Long Jin(김용),Ji Yong Lee(이지용),Jong Mok Park(박종목),Taeyoung Ha(하태영),Ju Hyun Shin(신주현),Jae Sung Lim(임재성),Yong Gi 대한비뇨기종양학회 2019 대한비뇨기종양학회지 Vol.17 No.2
Purpose: The aim of this study was to evaluate the applicability of machine learning methods that combine data on age and prostate-specific antigen (PSA) levels for predicting prostate cancer. Materials and Methods: We analyzed 943 patients who underwent transrectal ultrasonography (TRUS)-guided prostate biopsy at Chungnam National University Hospital between 2014 and 2018 because of elevated PSA levels and/or abnormal digital rectal examination and/or TRUS findings. We retrospectively reviewed the patients’ medical records, analyzed the prediction rate of prostate cancer, and identified 20 feature importances that could be compared with biopsy results using 5 different algorithms, viz., logistic regression (LR), support vector machine, random forest (RF), extreme gradient boosting, and light gradient boosting machine. Results: Overall, the cancer detection rate was 41.8%. In patients younger than 75 years and with a PSA level less than 20 ng/mL, the best prediction model for prostate cancer detection was RF among the machine learning methods based on LR analysis. The PSA density was the highest scored feature importances in the same patient group. Conclusions: These results suggest that the prediction rate of prostate cancer using machine learning methods not inferior to that using LR and that these methods may increase the detection rate for prostate cancer and reduce unnecessary prostate biopsy, as they take into consideration feature importances affecting the prediction rate for prostate cancer.
Recent progress in development and applications of second near? infrared (NIR-II) nanoprobes
Jongyoon Shinn,Sunyoung Lee,Hyon Kyong Lee,Jaeeun Ahn,Seon Ah Lee,Seonju Lee,이용현 대한약학회 2021 Archives of Pharmacal Research Vol.44 No.2
Optical probes for near-infrared (NIR) lighthave clear advantages over UV/VIS-based optical probes,such as their low levels of interfering auto-fl uorescenceand high tissue penetration. The second NIR (NIR-II) window(1000−1350 nm) off ers better light penetration, lowerbackground signal, higher safety limit, and higher maximumpermitted exposure than the fi rst NIR (NIR-I) window(650−950 nm). Therefore, NIR-II laser–based photoacoustic(PA) and fl uorescence (FL) imaging can off er higher sensitivityand penetration depth than was previously available,and deeper lesions can be treated in vivo by photothermaltherapy (PTT) and photodynamic therapy (PDT) with anNIR-II laser than with an NIR-I laser. Advances in creationof novel nanomaterials have increased options for improvinglight-induced bioimaging and treatment. Nanotechnologycan provide advantages such as good disease targetingability and relatively long circulation times to supplementthe advantages of optical technologies. In this review, wepresent recent progress in development and applications ofNIR-II light–based nanoplatforms for FL, PA, image-guidedsurgery, PDT, and PTT. We also discuss recent advances insmart NIR-II nanoprobes that can respond to stimuli in thetumor microenvironment and infl amed sites. Finally, we considerthe challenges involved in using NIR-II nanomedicinefor eff ective diagnosis and treatment.
Silicon PIN Diode을 이용한 X, r선 검출기에 관한 연구
경광현,박기정,이인수,정진백,한상용,이해룡,권수일 식품의약품안전청 1997 식품의약품안전청 연보 Vol.1 No.-
본 연구에서는 유방촬영용 X선 장치를 이용하여 밀리암페어초는 8mAs로 고정하고 관전압(kV)를 22kV에서 28kV까지 1kV씩 변화 시키면서 silicom PIN diode를 이용한 방사선검출기의?작과 이의 특성들을 실험한 결과, 관전압변화에 따른 silicon PIN diode의 출력 차이는 BR type과 BQ type의 출력 V/mAs는 1.19~1.42배의 범위에서 증가하고 이었으며, 각각에 대한 기울기는 0.0937,0.092로 직성성은 매우 야오한 것으로 나타났다. 그리고 동일 관전압에서 X선 조사부에 따른 silicom PIN diode들의 출력은 모델과는 관계없이 diode의 좌측(left side)과 우측(right side)부분에서는 일치하였으나, 하측(lower side)에서의 출력이 상측(upper side)qhek 1.06~1.16배 큰것으로 각각 나타났다. 한편 동일 관전압에서 2개의 silicon PIN diode의 배치 방향에 따른 출력도 모델과는 관계없이 종축으로 또는 횡축으로 정렬 시키던 간에 동일한 것으로 각각 나타났고, 관전압변화에 따른 출력차이도 배치방향과 관계없이 거의비슥한 걱으로 나타났다. 그리고 표준γ선에 대한 silicom PIN diode의 성능측정 결과 BR type과 BQ type 모두 CS-137의 0.66MeV의 enerhy peak의 경우 8.3%,Co-60의 경우 1.17MeV와 1.33MeV에 대하여 각각 6.7%와 5.1%의 에너지분해능을 얻었다. This experimental study is to develop a small compact radiation detector with high quantum efficiency for X or γ ray. So, we measured and evaluated outputs of silicon PIN diodes. To perform this experiment, X-ray tube is positioned approximately 22 inch and expesure conditions are adjusted from 22 tV to 28 kV at intervals of 1 kV and B mAs with mammographic X-ray equipment. The results were summarized. as follows. With regard to outputs of silieon PIN diodes by the change of X-ray tube voltage, it revealed the linearity on eutputs of BR and BQ type was good, respectively. And it appeared that the outputs for upper & lower portion of silicon PTN diode at the same X-ray tube voltage was nearly same without regard to type of the diodes. But the outputs for left portion of the diodes was higher than right portien of it. We also found that the outputs for array directions of a couple of the diodes was nearly same from the horizontal or longitudinal array directions independent of their types. When tested with a standard Cs-137 γ-ray sources, the energy resolution of the silicon PIN diodes detector was 8.3% (0.66 MeV),6.7% (1.17 MeV) aud 5.1% (1.33 MeV) for Co-60.
X선관전압축정기 개발에 관한 연구 : 신호처리장치를 중심으로 On the Signal Process Unit
경광현,박기정,이인수,정진백,한상용,이해룡,권수일,문창호 식품의약품안전청 1998 식품의약품안전청 연보 Vol.2 No.-
유방촬영용보선장치의 성능란리 목적의 일환으로 널리 사용하고 있는 비젓속형 관전압흑정기를 개발하기 위하여 1995년부터 계속 수행하여 온 연구결과를 토대로하여 이 측정기를 금년데 개발하였다. 이 측정기의_측정할수 있는 관전압떰위는 22~60 tV, 사용하기 위한 전원은 4개의 alkaline battery(1.5 Vx4개 ), 측정치에 대한 표시치는 4 digital LCD로 하였으며 , 필터의 선택 (Al 또.는 Mo)도 할 수 있도록 하였다. 이 측정기에 대한 기술적 차양을 핌가하기 위하여 x선칸초점~측isr기간거리는 so cm로 고정하고,관전압은 234~34 tV의 범위에서 2 tV씩 변화시켰으며, 밀리암페어초는 24 mAs(80 mA, 0.3 sec)의 X선조사조건을 설정하였다. 이와 같은 X선조사조건애서 』선관초점~검출기간』리(15 cm~so cm)의 변화에 따른 관전압 측정치가 15㎝이상의 게리에서는 오차를 될 수가 업었으며, X선 중심에 파른 측정j'1의 러치변화(중심부터 상하좌우 6㎝까지)에 따른 관전압측정치의 변화는 5 tin 미만에서는 나타나지 않았다. 또한 X선관의 양극~음극측에 따른 측정기의 방향변화(중심에서 상하좌우)에 있어서도관전압측정치의 변화가나타나지 않았다. 그리고 이 측정기의 재현성은 ±0.060%이었으며,불확도는 ± 0.53 %로서 A사의 digi1 kvmer :± 0.5 tV, B사의 digiI kV meter:±(1.0kv+2 %) 및 C사의 digitalkvmeter :츠 1.5 tV와 비교할 태 매우양호한것으로나타났다. The digital kV meter and the penetrameter are commonly used non-invasive methods in determining X-ray tube voltage of mammographic X-ray equipments. This study is to develop nonivasive electronic instrument(so called, "KFDA digital kV meter") for measuring X-ray tube voltages from mammographic X-ray equipments. We measured the distance dependence for focal spot to detector distances, position dependence and for a misalignment to X-ray central beam in X-ray KFDA digi. tal kV meter and evaluated uncertainty and reproducibility to kV value measured with developed digi? tal kV meter. To perform this experiment, the KFDA digital kV meter is positioned at 50 cm from focal spot and X-ray exposure techniques are adjusted from 24 kV to 34 kV at intervals of 2 kV and 24 mA: with mammographic X-ray equipment calibrated. The results were summarized as follows. The uncer? tainty and reproducibility of the KFDA digital kV meter was ± 0.53 % and ± 0.06 % A nd it revealed the distance dependence and position dependece were negligible for forcal spot to detector distances of cm or greater and for a misalignment of 5 cm or less at a distance of 50 cm, respectively.
Lee, Youn Woo,Lee, Kyong Hwan,Kim, Jae Duck,Jeon, Kwang Su,Ha, Baik Hyon 한국화학공학회 1997 Korean Journal of Chemical Engineering Vol.14 No.6
Catalytic cracking of vacuum gas oil has been investigated at 500℃ over mixed catalysts in a micro-activity tester. The catalyst consists of mordenite treated by either HCI/steam or HF and alumina prepared at pH of 9.5 or 7.8. The catalysts retaining mordenite in which SiO₂/Al₂O₃weight ratio ranged from 15 to 20 show the maximum activity and selectivity for gasoline. Both the activity and selectivity for gasoline seem to depend strongly on both acid strength of mixed catalysts and mesopore volume of the mordenite. It is found, however, that the selectivity of kerosene+diesel in liquid product as well as the yield of aromatics in gasoline are influenced more by mesopore volume of mordenite than by acid properties of mordenite in the catalyst of mordenite/alumina.