Multicentric Castleman 병 : 1예 보고 A Case Report

정선관,이성아 圓光大學校 醫科學硏究所 1995 圓光醫科學 Vol.11 No.2

Castleman disease is a rare disease entity of unknown etiology. Although the mediastinum is its most common location, it also occurs in other areas of the body, usually where lymph nodes are normally found. The multicentric form of the disease has been recognized only recently as a disease with an aggressive, often malignant course. The authors present the radiologic findings of a case of multicentric Castleman disease.

‘천안함 침몰’ 사건의 보도 경향과 이데올로기적 의미

백선기(Seon-Gi Baek),이금아(Keum-Ah Lee) 부산울산경남언론학회 2011 지역과 커뮤니케이션 Vol.15 No.1

본 연구는 미디어 보도가 지니는 담론 형성과 그에 따른 이데올로기적 의미를 파악하고자 하였다. 미디어 보도는 수용자가 사회적 현실을 인식하는 데 중요한 역할을 하며, 특정 담론과 이데올로기적 의미를 생성한다. 이는 대부분의 수용자들이 미디어 보도를 통해 사안을 인식함을 의미한다. 특히 남북관계나 안보와 관련한 사안은 직접적으로 얻을 수 있는 정보의 양이 매우 적기 때문에, 수용자들은 미디어를 통한 간접적인 정보에 따라 사안을 인식하게 된다. 바로 이러한 점에서 남북관련 사안에 대한 미디어 보도는 중요한 역할과 기능을 수행한다. 이에 본 연구자들은 2010년 3월 발생한 ‘천안함’ 침몰 사건에 대한 우리 언론의 보도경향과 그에 따라 생성되는 담론 형성에 주목하였고, 그에 따른 이데올로기적 의미에 대해 숙고하였다. 분석대상으로 조선일보와 경향신문을 선정하였고, ‘천안함’ 침몰이 발생한 3월 26일부터 최종보고서가 발간된 9월 13일까지의 이들 신문들의 기사들을 수집하였다. 이들 기사들에 대해 백선기가 최근에 창안한 기호네트워크분석(Semiotic Network Analysis)과 담론구조분석(Discourse Structure Analysis)을 적용하였다. 연구결과, 각 언론사는 자사의 이념적 스펙트럼에 따라 우호적인 기호들을 사용하였고, 이들의 특정 네트워크를 구성하였음이 발견되었다. 그리고 이들 기호네트워크 구조들을 근간으로 각기 서로 다른 담론들이 생성되었음도 발견되었다. 이는 ‘천안함 침몰’ 사건에 대해 신문별로 서로 다른 성격의 사건으로 규정하였고, 서로 다른 해석과 해결 방안들을 제시하였음을 의미한다. 이로 인해 우리 사회는 천안함 침몰에 대해 전혀 다른 대립적 시각들이 존재하게 되었고, 이로 인해 사회는 이데올로기적으로 명료하게 분리되었다. The purpose of this study was to investigate media coverage patterns on the sinking of “Cheonan warship” and their ideological implications. On March 26, 2010 the warship was sunk suddenly by unidentified causes so that 46 crew members should be dead. in Korean society, it happened to occur many discourses about this incident through media coverage. Various rumors and suspicious arguments about its causes and means were suggested without any kinds of clarifications. The most controversial issue was whether it was caused by sea-missile assaults of North Korean forces’ or not. The society was severely divided into two groups on the basis of belief or doubt on it. The authors were interested in why this kind of split could happen to occur in Korean society, how much such kind of social phenomenon would be connected to media coverage, and what it would imply in Korean society. In order to solve these interests as well as research questions, they collected news items of two high circulative newspapers from March 26, 2010 to September 13, 2010. As one newspaper was conservative and anti-North Korea oriented, the other was progressive and pro-North Korea oriented. Each of news items was analyzed with a Semiotic Network Analysis (SNA) and a Discursive Structure Analysis (DSA) which were recently created by Seon-Gi Baek. As results of this study, it was firstly found that each of media tended to select specific signs and narratives to define the incident from its basic ideology and North Korea policy. The conservative newspaper tended to define it as ‘incident of North Korean attack’ and ask for ‘official sorry of North Korean leaders’, while the progressive newpaper defined it ‘unfortune accident’ and ask for ‘South Korean governmental responsibility’. Secondly, the former described such dead crew members as ‘war heroes’ because it assumed that they would be dead in the middle of battle, as the latter represented them as just ‘victims’ because they would be dead by uncertain causes. Thirdly, the former produced many discourses about ‘critic against the North Korean leaders’, ‘revenge against the North Korea’, ‘counter attack against the North Korea’, ‘reinforcement for the national security’, etc. On the other hand, the latter took initiatives to suggest another discourses about ‘critic against irresponsibility of South Korean government’, ‘doubt against the final report on the incident’, ‘warning against the reinforcement of national security’, etc. In conclusion, it could be argued that such kind of dividence in Korean society would happened to occur by the dichotomous coverage pattern between the conservative media and the progressive ones.

장애아통합보육에 대한 교사인식 연구

문선화,이선애 한국영유아보육학회 2003 한국영유아보육학 Vol.0 No.33

The purpose of this study was to investigate the factors that affect of integrated day care services including the efficiencies, problems and preparations to be providing this programs to both regular and exceptional children. The factors are classified with personnel related this service and day care facilities. The 112 persons out of 170 were responded for this research and their background was the day care teachers, special educators, PT/OT, and social workers who are directly or indirectly working with either regular or exceptional children at the regular day care centers, the center for the handicapped children only and the center for the integrated facilities. The results of this research findings are as follows: First, children whether they are disabilities or not helping each other. The number of children per a teacher and in a classroom were overcrowded, but guidelines or restrictions and regulations to the facilities are not adequately established. Second, the respondents' licenses vary from different resources and purposes, so it would be provided sometimes insufficient services in need of both regular and handicapped children. Third, integrated day care centers showed rather a high tendency of sufficient services than other day care programs. Fourth, teacher's age, kind of licenses and type of day care centers are influential factors affecting providing services to the children, but factors had feeble influence on the efficiencies and preparations of integrated day care.

갑상선 유두암이 병발된 가족성 대장 용종증 1예

백종현,소창배,이은영,이지숙,신은경,박은호,서정아,양재홍,송준영,박선자,박요한,최영식 고신대학교의과대학 2007 고신대학교 의과대학 학술지 Vol.22 No.2

Familial adenomatous polyposis (FAP) is an autosomal dominant syndrome, typically characterized by multiple colorectal adenomas and increased incidence of colorectal carcinomas if it is not treated. Moreover, a variety of extracolonic manifestation are seen. The prevalence of thyroid tumors developing in patients with FAP is about 1∼2%. Generally, papillary thyroid cancer indicates low mortality but ,however, as people get older, the cancer becomes more aggressive. So, the operation is required. Recently we experienced a case of FAP, presenting with papillary thyroid carcinoma, and reported with a brief review of literatures.

LPE법으로 작성한 산화물초전도체 Bi₂Sr₂-Ca₁+Cu₂ 막(films) 의 초전도특성

신재수,황선아,이종용,이권재 대전대학교 기초과학연구소 1997 自然科學 Vol.8 No.2

LPE(Liquid press epitaxy)법을 이용하여, Sr과 Ca가 서로 상호 치환된 산화물초전도체 Bi₂Sr₂??Ca₁+x??Cu₂O??(x?=0, 0.1, 0.2, 0.3, 0.4, 0.5, 0.6) 막(film)을 작성하여 상호치환 상태와 초전도특성과의 관계를 알아보았다. 작성한 막(film)의 조성비은 융액조성비(x?)와 막(film)속의 조성비(x?)가 비례함을 알 수 있었고, c-축으로 강하게 배향된전형적인 Bi2212상의 단일상(singe-phase)을 보였다. 치환량 x?의 증가에 따라, 임계온도 T??, c-축의 길이, carrier농도 등은 단조로이 감소하고 있음을 알 수 있었다. We investigated the superconductivity of Bi₂Sr₂_Ca₁+x?Cu₂O?+?x?=0, 0.1, 0.2, 0.3, 0.4, 0.5, 0.6) films by liquid phase epitaxial method. X-ray diffraction measurements revealed that films were predominantly oriented with the c-axis perpendicular to the substrate surfaces. The zero-resistance temperature and the lattice parameter c linearly decreased with the increase of x?, corresponding to the decrease of the carrier concentration.

Standardized Suicide Prevention Program for Gatekeeper Intervention of North Korean Defectors in South Korea

Lee Yeon Jung,Lee Hyeon-Ah,Kim Kyong Ah,Baik Myungjae,Paik Jong-Woo,Seol Jinmi,Lee Sang Min,Lee Eun-Jin,Lee Haewoo,Lim Meerae,Jun Jin Yong,Ki Seon Wan,Jeon Hong Jin,Kwon Sun Jung,Lee Hwa-Young 대한신경정신의학회 2023 PSYCHIATRY INVESTIGATION Vol.20 No.5

Objective North Korean defectors (NKDs) have experienced substantial difficulties during the migration and settlement in South Korea. They have a high prevalence of depression, post-traumatic stress disorder, and suicidal behaviors. The high prevalence of mental disorders among NKDs can lead to a high suicide rate. However, there are no suicide prevention programs for NKDs. This study aims to customize a suicide prevention program with content suitable for NKDs’ particular circumstances.Methods A multidisciplinary research team developed this program based on domestic and international gatekeeper training programs for suicide prevention and articles related to suicide prevention.Results We developed a multi-part gatekeeper training program, “Suicide CARE for NKDs.” In the “Introduction,” trainees learn about the need for the program and its importance. In “Careful observation,” trainees learn to recognize linguistic, behavioral, and situational signals of suicide risk. In “Active listening,” trainees learn how to ask about suicidal thoughts and to listen empathetically. In “Risk evaluation and expert referral,” trainees learn to evaluate suicide risk and to connect NKDs with institutes or services.Conclusion We expect this program to become useful for training gatekeepers to prevent suicide among NKD. A future follow-up study is needed to confirm the efficacy of the program.

The prevalence of HPV infection in the semen among Korean men and the effect of HPV infection on sperm parameters

( Seon Ah Kim ),( So Yoon Kim ),( Yoo Kyung Lee ),( Ki Heon Lee ),( Kyeong A So ),( Mi Kyung Kim ),( Sung Jae Kim ),( Doo Jin Paik ),( Joong Shik Lee ),( Hyo Serk Lee ),( Ju Tae Seo ),( Mi Seon Jeong 대한산부인과학회 2015 대한산부인과학회 학술대회 Vol.101 No.-

Effects of infections with five sexually transmitted pathogens on sperm quality

Kim, Sung Jae,Paik, Doo-Jin,Lee, Joong Shik,Lee, Hyo Serk,Seo, Ju Tae,Jeong, Mi Seon,Lee, Jae-Ho,Park, Dong Wook,Han, Sangchul,Lee, Yoo Kyung,Lee, Ki Heon,Lee, In Ho,So, Kyeong A,Kim, Seon Ah,Kim, Jur The Korean Society for Reproductive Medicine 2017 Clinical and Experimental Reproductive Medicine Vol.44 No.4

Objective: This study investigated the prevalence of infections with human papillomavirus, Chlamydia trachomatis, Ureaplasma urealyticum, Mycoplasma hominis, and Mycoplasma genitalium in the semen of Korean infertile couples and their associations with sperm quality. Methods: Semen specimens were collected from 400 men who underwent a fertility evaluation. Infection with above five pathogens was assessed in each specimen. Sperm quality was compared in the pathogen-infected group and the non-infected group. Results: The infection rates of human papillomavirus, C. trachomatis, U. urealyticum, M. hominis, and M. genitalium in the study subjects were 1.57%, 0.79%, 16.80%, 4.46%, and 1.31%, respectively. The rate of morphological normality in the U. urealyticum-infected group was significantly lower than in those not infected with U. urealyticum. In a subgroup analysis of normozoospermic samples, the semen volume and the total sperm count in the pathogen-infected group were significantly lower than in the non-infected group. Conclusion: Our results suggest that infection with U. urealyticum alone and any of the five sexually transmitted infections are likely to affect sperm morphology and semen volume, respectively.

Occurrence of Toxigenic Fusarium vorosii among Small Grain Cereals in Korea

Lee, Theresa,Paek, Ji-Seon,Lee, Kyung Ah,Lee, Soohyung,Choi, Jung-Hye,Ham, Hyeonheui,Hong, Sung Kee,Ryu, Jae-Gee The Korean Society of Plant Pathology 2016 Plant Pathology Journal Vol.32 No.5

Fusarium graminearum species complex (FGSC) causes Fusarium head blight in small grain cereals. To date, four species (F. graminearum, F. asiaticum, F. boothii, and F. meridionale ) belonging to FGSC frequently occur in Korean cereals. In addition, we first reported the occurrence of additional species (F. vorosii ) within FGSC, which was isolated from barley, corn, and rice in Korea. Phylogenetic analysis of the Fusarium isolates of this group using combined multigene sequences confirmed species identification. Moreover, the macroconidia produced by these isolates were morphologically similar to those of the F. vorosii holotype. Chemical analysis indicated that the F. vorosii isolates produced various trichothecenes such as nivalenol and deoxynivalenol with their acetyl derivatives along with zearalenone. Pathogenicity tests demonstrated that all of the F. vorosii isolates examined were pathogenic on barley, corn, and rice with variation in aggressiveness. This study is the first report of F. vorosii in Korean cereals, their pathogenicity towards barley and corn, and their ability to produce trichothecenes and zearalenone.

3-Deoxysappanchalcone Inhibits Cell Growth of Gefitinib-Resistant Lung Cancer Cells by Simultaneous Targeting of EGFR and MET Kinases

Lee Jin-Young,Lee Seung-On,Kwak Ah-Won,Chae Seon-Bin,Cho Seung-Sik,Yoon Goo,Kim Ki-Taek,Choi Yung Hyun,Lee Mee-Hyun,Joo Sang Hoon,Park Jin Woo,Shim Jung-Hyun 한국응용약물학회 2023 Biomolecules & Therapeutics(구 응용약물학회지) Vol.31 No.4

The mechanistic functions of 3-deoxysappanchalcone (3-DSC), a chalcone compound known to have many pharmacological effects on lung cancer, have not yet been elucidated. In this study, we identified the comprehensive anti-cancer mechanism of 3-DSC, which targets EGFR and MET kinase in drug-resistant lung cancer cells. 3-DSC directly targets both EGFR and MET, thereby inhibiting the growth of drug-resistant lung cancer cells. Mechanistically, 3-DSC induced cell cycle arrest by modulating cell cycle regulatory proteins, including cyclin B1, cdc2, and p27. In addition, concomitant EGFR downstream signaling proteins such as MET, AKT, and ERK were affected by 3-DSC and contributed to the inhibition of cancer cell growth. Furthermore, our results show that 3-DSC increased redox homeostasis disruption, ER stress, mitochondrial depolarization, and caspase activation in gefitinib-resistant lung cancer cells, thereby abrogating cancer cell growth. 3-DSC induced apoptotic cell death which is regulated by Mcl-1, Bax, Apaf-1, and PARP in gefitinib-resistant lung cancer cells. 3-DSC also initiated the activation of caspases, and the pan-caspase inhibitor, Z-VAD-FMK, abrogated 3-DSC induced-apoptosis in lung cancer cells. These data imply that 3-DSC mainly increased mitochondria-associated intrinsic apoptosis in lung cancer cells to reduce lung cancer cell growth. Overall, 3-DSC inhibited the growth of drug-resistant lung cancer cells by simultaneously targeting EGFR and MET, which exerted anti-cancer effects through cell cycle arrest, mitochondrial homeostasis collapse, and increased ROS generation, eventually triggering anticancer mechanisms. 3-DSC could potentially be used as an effective anti-cancer strategy to overcome EGFR and MET target drug-resistant lung cancer.