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송성훈,박진영,이행자,조홍식,장상목 동아대학교 환경문제연구소 1999 硏究報告 Vol.22 No.2
The phase transition phenomena and the phase separation phenomena of surfactants(SPES) are analyzed using QCA with resonant frequency and resonant resistance. The phase transition phenomena of SPES at 30℃ can be determined by measuring the resonant frequency and resonant resistance by lecithin coated on quartz crystal. The surfactants capacity of SPES can be analyzed by measuring the resonant frequency and resonant resistance of surfactants using QCA.
Hong, Sang‐,Mo,Park, Cheol‐,Young,Hwang, Dong‐,Min,Han, Kyung Ah,Lee, Chang Beom,Chung, Choon Hee,Yoon, Kun‐,Ho,Mok, Ji‐,Oh,Park, Kyong Soo,Park, Sung‐,Woo Blackwell Publishing Ltd 2017 Diabetes, obesity & metabolism Vol.19 No.5
<P><B>Aims</B></P><P>This trial consisted of a 24‐week multicentre, randomized, double‐blind, double‐dummy, active‐controlled study and a 52‐week open label extension study to assess the efficacy and safety of evogliptin, a novel dipeptidyl peptidase‐4 inhibitor, compared to sitagliptin in patients with type 2 diabetes who have inadequate glycaemic control with metformin alone.</P><P><B>Methods</B></P><P>Adult patients with type 2 diabetes mellitus (N = 222) with HbA1c 6.5% to 11% who were receiving stable doses of metformin (≥1000 mg/d) were randomized 1:1 to add‐on evogliptin 5 mg (N = 112) or sitagliptin 100 mg (N = 110) once daily for 24 weeks. The primary efficacy analysis consisted of a comparison of the change from baseline HbA1c at week 24. Non‐inferiority was concluded if the upper limit of the 2‐sided 95% confidence interval for the HbA1c difference between treatments was <0.35%.</P><P><B>Results</B></P><P>Mean changes in HbA1c following addition of evogliptin or sitagliptin were −0.59% and −0.65%, respectively. The between‐group difference was 0.06% (2‐sided 95% confidence interval, −0.10 to 0.22), demonstrating non‐inferiority. After the 52‐week treatment, evogliptin caused a persistently decreased level of HbA1c (−0.44% ± 0.65%, P < .0001). In general, both treatments were well tolerated, with incidences and types of adverse events comparable between the two groups. Hypoglycaemic events, mostly mild, were reported in 0.9% of patients treated with evogliptin and in 2.8% of patients treated with sitagliptin for 24 weeks.</P><P><B>Conclusions</B></P><P>Evogliptin 5 mg added to metformin therapy effectively improved glycaemic control and was non‐inferior to sitagliptin and well tolerated in patients with type 2 diabetes mellitus that was inadequately controlled by metformin alone.</P>
Presence of glioma stroma mesenchymal stem cells in a murine orthotopic glioma model.
Kim, Sang-Mok,Kang, Seok-Gu,Park, Na-Ri,Mok, Hyun-Su,Huh, Yong-Min,Lee, Su-Jae,Jeun, Sin-Soo,Hong, Yong-Kil,Park, Chun-Kun,Lang, Frederick F Springer Verlag 2011 Child's nervous system Vol.27 No.6
<P>High-grade gliomas are closely related to the mesenchymal phenotype which might be explained by unorthodox differentiation of glioma cancer stem cells (gCSCs). We reasoned that other non-neural stem cells, especially mesenchymal stem cells (MSCs), might play a role in expressing mesenchymal phenotype of high-grade gliomas. Thus we hypothesized that cells resembling MSCs exist in glioma specimens.</P>
각종 조혈모세포 근원별 CD34+ 양성세포율 및 혈구 집락배양의 비교
목지오,변재호,김숙자,전진우,원종호,백승호,서원석,홍대식,박희숙 대한조혈모세포이식학회 1996 대한조혈모세포이식학회지 Vol.1 No.1
목적: 각종 조혈모세포의 근원인 말초혈액(PB), 고용량 항암요법과 조혈성장인자 투여후 얻은 말초혈액(MPB), 골수(BM) 및 제대혈 (UB)의 단핵구를 이용하여 CD₃₄+ 세포양성율 및 각종 조혈전구 세포의 집락 형성능을 비교 관찰하고자 한다. 방법: flow cytometry와 anti-CD₃₄+ 단세포항체를 이용하여 각종 조혈모세포 근원의 CD₃₄+ 양성세포함유 정도를 측정하였고, 분리된 단핵구를 집락배양하여 CFU-GM, BFU-E, CFU-GEMM 및 HPP-CFC의 집락형성능을 관찰하였다. 결과: 1) 각 조혈모세포의 근원별 CD₃₄+ 양성세포의 분리 전후의 비교 CD₃₄+ 양성세포의 양성률은 고용량 항암요법과 조혈성장인자 투여후 얻은 말초혈액에서 3.46±0.72%로 가장 높았으며 골수와 제대혈에서 각각 1.78±0.86%과 1.53±0.43%으로 비슷하였으며 말초혈액에서 0.14%로 가장 낮았다. CD₃₄+ 세포를 분리하였을 때, 분리후 CD₃₄+ 양성세포는 제대혈액에서 96.99±1.95%로 가장 높았으며 고용량 항암요법과 조혈성장인자 투여후 얻은 말초혈액에서 72.54±14.06%, 골수에서 60.6±1.9%, 그리고 말초혈액에서 54%로 나타났다. 2)각 조혈모세포의 근원별 조혈전구세포의 집락형성 CFU-GM, BFU-E, CFU-GEMM 그리고 HPP-CFC를 사용한 집락배양결과 CD₃₄+ 양성세포 분리군에서 비분리군에 비해 집락수가 많았으며, CFU-GM의 경우 그 비는 말초혈액, 골수, 그리고 제대혈액에서 각각 112배, 10배, 5배, 26배 또한 CFU-GEMM은 각각 136배, 8배, 12배가 높았다. 결론: 각종 조혈모세포의 근원별 CD₃₄+ 양성세포의 양성세포율 및 조혈전구세포 집락배양비교시 CD₃₄+ 양성세포와 조혈전구세포가 말초혈액이나 골수보다 MPB나 제대혈에서 훨씬 많은 것을 관찰하였다. Background: Classically bone marrow is the major source of hemopoietic stem cells of the allo/autologous hemopoietic stem cell tansplantation. Recently, hemopoietic stem cells circulate in peripheral blood, "mobilized" with cytokines and/or cytotoxic chemotherapy and umbilical cord blood stem cells, are widly used for high dose chemotherapy with hemopoietic stem cells support. The aim of this study is to investigate the possibility of clinical applications of selected CD34+ cells with source of hemopoietic stem cells such as, peripheral blood(PB), mobilized PB(MPB), bone marrow(BM), and umbilical cord blood(UB) Methods: We evaluated the comparison of the clonogenicithy and percentage of CD₃₄+ cells according to each source of hemopoietic stem cells in before and after separation of CD₃₄+ cells through in vitro colony assay and flow cytometry with anti-CD₃₄+ monoclonal antibody. Results: 1) CD34+ cells were detected in PB, MPB, BM, and UB at incidences of 0.14%, 3.46 ±0.72%, 1.78±0.86%, and 1.53±0.43% of total mononuclear cells. And the most CD34+ cells were detected in UB after seperation of CD₃₄+ cells. 2) The colony counts revealed more in CD₃₄+ isolating group. Clonogenicity of CD₃₄+ cells in PB, MPB, BM, and UB was 112-fold, 10-fold, 5-fold, and 26-fold in colony forming unit-granulocyte and macrophage(CFU-GM), and 136-fold, 8-fold, 3-fold, and 12-fold in colony of forming unit-granulocyte, erythrocyte, monocyte, megakaryocyte(CFU-GEMM). The colony counts of UB and MPB were large numbers more than PB and BM. Conclusion: Clonogenicity and percentage of CD₃₄+ cells are superior MPB and UB than in PB and BM.
Dwarf Galaxy Discoveries from the KMTNet Supernova Program. I. The NGC 2784 Galaxy Group
Park, Hong Soo,Moon, Dae-Sik,Zaritsky, Dennis,Pak, Mina,Lee, Jae-Joon,Kim, Sang Chul,Kim, Dong-Jin,Cha, Sang-Mok American Astronomical Society 2017 The Astrophysical journal Vol.848 No.1
<P>We present BVI surface photometry of 31 dwarf galaxy candidates discovered in a deep image stack from the KMTNet Supernova Program of similar to 30 square degrees centered on the nearby NGC 2784 galaxy group. Our final images have a 3 sigma surface brightness detection limit of mu(V) approximate to 28.5 mag arcsec(-2). The faintest central surface brightness that we measure is mu(0,V) = 26.1 mag arcsec(-2). If these candidates are at the distance of NGC 2784, then they have absolute magnitudes greater than M-V = -9.5 mag and effective radii larger than 170 pc. Their radial number density decreases exponentially with distance from the center of NGC 2784 until it flattens beyond a radius of 0.5 Mpc. We interpret the baseline density level to represent the background contamination and estimate that 22 of the 31 new candidates are dwarf members of the group. The candidate's average color, <(B - V)(0)> approximate to 0.7, and Sersic structural parameters are consistent with those parameters for the dwarf populations of other groups. We find that the central population of dwarfs is redder and brighter than the rest of the population. The measured faint-end slope of the luminosity function, alpha approximate to -1.33, is steeper than that of the Local Group, but consistent with published results for other groups. Such comparisons are complicated by systematic differences among different studies, but will be simpler when the KMTNet survey, which will provide homogenous data for 15-20 groups, is completed.</P>