정상 한국인에서 연령증가에 따른 혈장 Dehydroepiandrosteronesulfate ( DHEA-S ) 농도 및 DHEA - S / cortisol 비의 변화

박성우,유형준,임성희,최문기,유재명,박민숙,이권엽,박철수,김철홍,김현규,김두만,박규용 대한내분비학회 1997 Endocrinology and metabolism Vol.12 No.2

Backgroud: DHEA-S is the most abundant steroid hormone in circulation, and primarily secreted from the adrenal cortex, but its physiological role is little known. One of the characteristic features of DHEA-S is progressive decrement of plasma DHEA-S level with advancing age, in contrast, plasma levels of other adrenal hormones are not chaging or littie decreasing. To grasp the trends of plasma DHEA-S level and DHEA-S/cortisol ratio by age in healthy Korean, we measured the plasma DHEA-S levels and DHEA-S/cortisol ratios in healthy Korean. Methods: Healthy Korean(men: 99, women: 102, age range: 15-97 year old)were studied. Subjects were not taking drugs(such as glucocorticoid or androgenic medication) or cigarettes known to modify the plasma level of DHEA-S and cortisol, and had no evidence of hepatic, renal disease or hyperlipidemia as determined by serum lipid, bilirubin, SGOT, SGPT, BUN, creatinine. Data were analyzed by 10-year age group for men and women: i.e, 10-19, 20-29, 30-39, 40- 49, 50-59, 60-69, 70-79, 80-89 and 90 year or more. Plasma DHEA-S levels were measured by using a commercially available RIA kit with 125I labeled-DHEA-SO4(Coat-A Count DHEA-SO4), and for the measurement of plasma cortisol levels, commercial Gamma Coat TM[125I] Cortisol Radioimmunassay Kit was used. Results:. 1) In both men and women, plasma DHEA-S level showed high interindividual variation within the same age group. 2) There were individual sex differences in plasma levels of DHEA-S, in all age groups, plasma DHEA-S levels were significantly higher values for men than for women. 3) Maximum plasma DHEA-S levels(men; 237+-3.35 ug/dL, women; 108+-17.5 ug/dL) were at third decade in both men and women. 4) Both men and women showed the continuous decline in plasma DHEA-S level with age. These age-related decline was more prominent in men than in women(men; y= -3.152 * +292.6, r2= 0.8459, P$lt;0.05, women; y= -1.417 * +143.3, r2 = 0.7278, P$lt; 0.05). 5) As an index of aging, there was no stastical difference between DHEA-S and DHEA- S/cortisol ratio. Conclusion: In healthy Korean, there were high interindividual variation of plasrna DHEA-S levels. In both men and women plasma DHEA-S level was peak at third decade, and from when it declined progressively with age. These results suggest that although the reliability of single plasma DHEA-S measurement are limited, the decline of DHEA-S with advancing age might be a specific marker of endocrinologic hormonal milieu(aging index). Also, concerning to individual adrenal secreting capacity, we measured DHEA-S/cortisol ratio. But we did not found that plasma DHEA-S/cortisol ratio is superior to the plasma DHEA-S level as an aging index. (J Kor Soc Endocrinol 12:245-254, 1997)

한국인 폐확산능 정상예측식의 임상적 유용성과 정확성

나승원 ( Seung Won Ra ),박태선 ( Tai Sun Park ),홍윤기 ( Yoon Ki Hong ),홍상범 ( Sang Bum Hong ),심태선 ( Tae Sun Shim ),임채만 ( Chae Man Lim ),이상도 ( Sang Do Lee ),고윤석 ( Youn Suck Koh ),김우성 ( Woo Sung Kim ),김동순 ( Dong 대한결핵 및 호흡기학회 2008 Tuberculosis and Respiratory Diseases Vol.64 No.2

연구배경: 폐확산능을 해석하는 데 필요한 정상예측식으로는 한국인을 대상으로 하여 박 등이 개발한 식(박 식)이 있으나 아직 외국 정상예측식을 많이 사용하고 있다. 이에 국내에서 많이 사용하는 외국 정상예측식인 Burrows 식과 박 식의 임상적 유용성과 정확성을 비교하고자 하였다. 방법: 1. 임상적 유용성 연구; 2006년 7월부터 12월까지 6개월간 폐확산능검사를 시행한 환자 중 두 식을 각각 정상예측식으로 적용하였을 때 폐확산능 해석이 다른 276명(대상군 A)을 대상으로 하였다. 대상군 A에게 두 식을 각각 적용하였을 때 폐확산능 해석과 임상적 판단과의 일치도를 비교하여 임상적 유용성을 평가하였다. 2. 간질성폐질환 진단의 정확성 비교; 2001년부터 2006년까지 폐조직검사를 시행하여 확진된 간질성폐질환군과 서울아산병원에서 모집한 정상군을 대상으로 하여 정상예측식으로 두 식을 각각 적용하였을 때 폐확산능 해석의 정확도를 비교하였고, 두 식이 차이가 나는지 맥니머의 카이스퀘어 검정을 하였다. 결과: 1. 임상적 판단과의 일치도 비교; 276명을 임상정보를 토대로 폐확산능을 예측하여 분류한 결과 정상 54명, 감소 220명, 불분명이 2명이었다. 예측식으로 박 식과 Burrows 식을 적용하였을 때 임상적 판단과 일치하는 환자는 각각 78%와 22%이었다(p<0.001). 2. 간질성폐질환 진단의 정확성 비교; 박 식은 민감도 90.1%, 특이도 100%이었고 Burrows 식은 민감도 64.2%, 특이도 100%로 민감도가 통계학적으로 유의하게 박 식이 높았다(p<0.001). 결론: 우리나라 정상예측식인 박 식이 외국 정상예측식인 Burrows 식을 정상예측식으로 적용하는 것보다 임상적 유용성이나 간질성폐질환 진단의 민감도에서 더 우월하였다. 향후 폐확산능검사의 정상예측식으로 박 식을 사용해야 할 것으로 사료된다. Background: Park et al. developed the Korean reference equation for the measurement of diffusing capacity in 1985. However, the equation has not been widely used in Korea and foreign reference equations have been popularly used. We intended to compare the clinical usefulness and the accuracy of the the Korean reference equation (Park`s equation) with that of the foreign equation (Burrows` equation) that is commonly used in Korea. Methods: 1. Evaluation of clinical usefulness; Among 1,584 patients who underwent diffusing capacity (DLCO) at the Asan Medical Center from July to December 2006, group A subjects included 276 patients who had different interpretations of DLCO in trials employing Burrows` equation and Park`s equation. Clinical assessment was decided by consensus of two respiratory physicians. In order to evaluate the clinical usefulness of Burrows` equation and Park`s equation, agreement of clinical assessment and DLCO interpretation were measured. 2. Evaluation of accuracy; Group B subjects were 81 patients with interstitial lung disease (ILD) and 39 normal subjects. The 81 ILD patients were diagnosed following a surgical lung biopsy. The accuracy of diagnosing ILD as well as sensitivity and specificity were evaluated according to the use of the reference equations (Burrows` equation and Park`s equation) for DLCO. Results: Agreement between clinical assessment and interpretation of DLCO was 22% for the use of Burrows` equation and 78% for the use of Park`s equation. The sensitivity and specificity of the Burrows` equation for diagnosing ILD were 64.2% and 100%. The sensitivity and specificity of the Park`s equation for diagnosing ILD were 90.1% and 100%. The sensitivity of the Park`s equation for diagnosing ILD was significantly higher than that of Burrows` equation (p<0.001). Conclusion: The Korean reference equation (Park`s equation) was more clinically useful and had higher sensitivity for diagnosing ILD than the foreign reference equation (Burrows` equation). (Tuberc Respir Dis 2008;64:80-86)

정신과 병실의 치료환경에 대한 평가 : (Ⅱ)3개 병실환경에 대한 특성간의 비교연구 (Ⅱ)A Comparison Study Among The Characteristics of 3 Different Therapeutic Milieus.

박정주,이만홍,신동범 大韓神經精神醫學會 1985 신경정신의학 Vol.24 No.3

The importance of milieu characteristics of psy-chiatric inpatient treatment programs has been widely recognized and a number of instruments hare been developed to measure these milieu char-acteristics. Amog these instruments, the Ward Atmosphere Scale (WAS), which was developed by Dr. Moos and his colleagues in the Social Ecology Laboratory at the Stanford University, is one of the most widely used and the most reliable test. In previous study of this series by the authers, the WAS proved to be applicable with the subs-tantial reliability in Korea and useful in system-atic comparisons among the different therapeutic milieus of Korea and possibly between the char-acteristics of American and Korean Programs. So for the next step, the authers administered the WAS to 291 subjects sampled from 3 different psychiatric inpatient wards: Custodial ward(CUW), Medically oriented ward (MOW) and the authers’ Therapeutic community ward(TCW) to assess the characteristics of social atmospheres of several different therapeutic milieus. The authers com-pared these 3 different psychiatric wards: CUW, MOW and TCW and compared the subgroups according to subject’s status in each therapeutic milieu: staff, student and patient and finally compared a Korean TCW to American Normative Sample. The results were as follows: 1. The subscale means of WAS were highest in TCW, and MOW, CUW in order. 2. According to the characteristics of Dimension of WAS, TCW was analogous to Therapeutic community program, MOW to Relationship-oriented program and CUW to Control-oriented program of Price and Moos. 3. Patients perceived their therapeutic milieus as more restricted by staffs and more difficult to express anger and aggression openly than staffs perceived in all three psychiatric wards. And staffs saw their therapeutic milieus more positively and optimistically in TCW and more negatively and pessimistically in CUW. 4. The subscale means of WAS were higher in a Korean TCW than American Normative Sample but anger and aggression was lower in a Korean TCW than American Normative Sample significantly.

칼라모니터의 색특성 평가

朴勝玉,朴正萬,金洪錫 대진대학교 1993 大眞論叢 Vol.1 No.-

To Evaluate the colorimetric properties of color monitor, a set of assumptions about the monitor's performance are described. These are the assumption of phosphor constancy, phosphor independece, spatial uniformity, and temporal stability. The results of measurements that test the validity of these assumptions for a multisync color monitor are presented.

무지개 松魚의 遺傳 育種學的 硏究 : Ⅳ.血淸成分 水準의 年中 變化 Ⅳ.Annual Changes of Serum Components Levels

朴弘陽,尹鐘萬,金桂雄 건국대학교 동물자원연구센터 1991 動物資源硏究誌 Vol.16 No.-

본 연구는 무지개 松魚 암컷 3년생 120마리에 대하여 1989년 3월부터 1990년 2월까지 계절 및 人工産卵前後에 따른 血淸成分 含量 水準을 측정하였고, 각 血淸 成分間의 상관관계를 조사하였다. 장차 무지개 松魚의 繁殖效率 增進에 필요한 遺傳育種學的 基礎 資料를 얻기 위하여 실시되었다. 본 연구에서 얻어진 결과를 요약하면 다음과 같다. 1) 血淸中 albumin, calcium, glucose, total protein, alkalin phosphatase, SGOT 및 phosphorus의 함량은 産卵期中에 높은 수준이었으나, cholesterol, creatinine 및 triglycerides의 含量은 卵黃形成期中에 비교적 높은 수준을 유지 하였다. 2) 人工産卵展, 産卵後 및 過熟時期에 따른 血淸中 albumin, calcium, cholesterol, creatinine, total protein, triglycerides, alkaline phosphatase 및 phosphorus의 含量은 人工産卵前에 비교적 높은 수준을 유지한 반면에, BUN, glucose, SGOT 및 SGPT의 含量은 過熟時期에 높은 수준이었다. 그리고 A/G 比率은 非産卵期인 6월, 7월 및 8월에 最高水準을 유지하다가 産卵時期直前부터 감소하여 산란시기 동안에 낮은 수준으로 계속 유지되었다. 3) 産卵期中 albumin수준과 calcium(r=-0.793)간에는 부(-)의 상관이었으나, 그 밖의 다른 성분간에는 有意性이 인정되는 정(+)의 상관이 존재하였다. BUN 含量水準과 alkaline phosphatase(r=0.790), SGOT(r=0.881) 및 SGPT(r=0.902)와는 正(+)의 高度相關이 존재하였다. Glucose수준과 모든 다른 성분간에는 負(-)의 相關關係였으마, cholesterol수준과 그 밖의 다른 성분간에는 正(+)의 相關이 존재하였다. Glucose수준과 total protein(r=0.856), triglycerides(r=0.973), alkaline phosphatase(r=0.738), SGOT(r=0.711) 및 SGPT(r=0.738), 및 SGPT(r=0.657)間에는 正(+)의 高度相關을 보였으며, creatinine 수준과 total protein(r=0.672)에도 正(+)의 상관관계가 존재하였다. Total protein과 triglycerides(r=0.911)와는 正(+)의 高度相關이었으며, alkaline phosphatase 水準과 SGOT(r=0.936) 및 SGPT(r=0.926)間은 正(+)의 高度相關關係가 있다. 또한 SGOT와 SGPT(r=0.995)와는 매우 높은 정(+)의 상관관계가 존재하였다. 4) 産卵期中 호르몬과 血淸成分間의 상관관계에 있어서 血淸中 LH 濃度와 BUN(r=0.747)과는 유의한 負(-)의 相關이었으나, creatinine(r=0.887) 및 total protein(r=0.688)과는 正(+)의 高度相關이 존재하였다. FSH濃度와 creatinine(r=0.831) 및 total protein(r=0.709)간에는 正(+)의 상관관계가 있었다. Estradion-17β와 creatinine(r=0.899), total protein(r=0.899), total protein(r=0.859) 및 trigpycerides(r=0.673)간에 비교적 높은 正(+)의 상관이었으나, progesterone 濃度과 BUN(r=-0.606)간에는 負(-)의 상관관계가 존재하였다. This study was carried out to investigate serum components levels(12 components) obtained from 120 of 3-year-old female rainbow trout(Oncorhynchus mykiss). All data were collected and analysed monthly from March in 1989 to February in 1990. Serum protein components were assayed by blood analyzer. The results obtained in this study were as follows; 1. The contents of serum albumin ,calcium, glucose, total protein, alkalkine phosphatase, SGOT, and phosphorus increased during spawning period, but those of serum cholesterol, creatinine, and triglycerides maintained relatively high levels during vitellogenetic period. 2. The contents of serum albumin, calcium, cholesterol, creatinine, total protein, triglycerides, alkaline phosphatase and phosphorus prior to handstripping were relatively high, while those of serum BUN, glucose, SGOT and SGPT were high in over-ripe stage. 3. The correlation between serum albumin and calcium during correlations of albumin and other contents were significantly positive. Those of serum BUN with alkaline phosphatase(r=0.790), SGOT(r=0.881) and SGPT(r=0.902) were highly positive. The content of calcium was highly correlated with various serum contents, and that of cholesterol was a signigicantly correlated with other serum contents. The correlations of serum glucose with total protein(r=0.856), triglycerides(r=0.973), alkaline phosphatase(r=0.738), SGOT(r=0.711) and SGPT(r=0.657) were significantly high. The correlation coefficients between creatinine and total protein, between total protein and triglycerides, and between SGOT and SGPT were significantly high. In addition, those of serum alkaline phosphatase with SGOT and SGPT were also significantly high. 4. The correlation of serum LH with BUN during spawning period was highly negative(r=-0.793), while the correlations of LH with creatinie and total protein were high(r=0.887 and 0.688, respectively). Similarly, the relationships of serum FSH with creatinine(r=0.831) and total protein(r=0.709) were significantly highly positive. The concentration of estradiol-17βwas highly correlated with creatinie, total protein, and triglycerides. But the relation of serum progesterone with BUM was significantly negative(r=-0.606).

應力波 放出信號의 周波數 스펙트럼 特性分析

朴正萬,朴勝玉,金洪錫 대진대학교 1993 大眞論叢 Vol.1 No.-

The effects of source, specimen and transducer frequency characteristics on the spectral content of acoustic emission signals were investigated. A substantial difference in the ball impact was detected. The fine structures of the signal spectra depended strongly on specimen resonances as well as transducer resonances. The frequancy spectra of the piezoelectric transducer, glass and PMMA plates were determined by a calibration system consisting of a breaking pencil lead and an optical probe. These transfer functions were used to calculate the source wave spectra due to dropping steel balls. The experimental source spectra were compared with theoretical predictions. The agreement between experiment and theory was good, although certainly not perfect.

칼라영상시스템의 칼라보정 연구

朴勝玉,朴正萬,金洪錫,辛鉉德,林在權 대진대학교 1994 大眞論叢 Vol.2 No.-

We proposed a color calibration algorithm by considering spectral characteristic of the chosen color reproduction system which can be applied to device independent using characteristic vectors of surface reflectance. To evaluate color reproducing characteristics we applied the proposed color calibration algorithm by choosing the color of Macbeth ColorChecker's twenty four as a test color set.

칼라영상시스템에 의한 물체색 측정연구

朴勝玉,朴正萬,金洪錫,林在權 대진대학교 1993 大眞論叢 Vol.1 No.-

To simulate accurate spectral reflectance from the red-green-blue output of a video digitizing system, a set of basis functions were computed. 1565 reflectance spectra of the chips in the Munsell Book of Color(Glossy) were measured with a spectrophotometer in KRISS. The autocorrelation matrix of these samples was formed and the eigenvectors and the eigenvalues of this matrix were computed by using Karhunen-Loeve transformation.

폐결핵 환자의 우울 상태

홍정표,최선희,조만종,이성주,박종,김기순,김양옥 朝鮮大學校 附設 醫學硏究所 1997 The Medical Journal of Chosun University Vol.22 No.1

The main purpose of this study is to identify and evaluate the depressive states for the patients with chronic pulmonary tuberculosis. A questionnaire(Self-rating Depression Scale, SDS) survey was performed toward 57 pulmonary tuberculosis patients with initial treatment who started chemotherapy and 53 pulmonary tuberculosis patients with retreatment, admitted to one tuberculosis-centered hospital and two general hospital. Fifty three healthy persons as control group were investigated with the same questionnaire for comparison. The survey was performed from July to August 1996. The results are as follws : 1. The patients had significantly high scores in the depression than control and the patient with retreatment showed significantly high scores in the depression than the patient with initia1treatment(P<0.01). 2. The depressive levels of the patients were associated with duration of admission and the expectancy of recovery (P<0.05). 3. The percentage of the subjects with 40 or more scores tentatively classifiable as psychologically depressed was 67.1% of the total subjects, 48.4% of the control groups, 75.0% of the patient with initial treatment and 84.1% of the patient with retreatment. Because patient with pulmonary tuberculosis with initial treatment showed higher depression scores than normal persons, and patients with retreatment due to failure of initial treatment showed higher depression scores than initial treatment, it is necessary to give attention to depression of the patients during treatment of pulmonary tuberculosis.

칼라영상시스템에 의한 색재현 연구

朴勝玉,朴正萬,金洪錫 대진대학교 1993 大眞論叢 Vol.1 No.-

The tristimulus values of an object color are dependent on both the spectral power distribution of the illuminant and the surface reflectance of the object. Furthermore the physical factors that are relevant to color image processing include camera sensor spectral response and monitor phosphor power distributions. In this paper, we measured the chromaticity coordinates of monitor reproducing colors and compared them to actual color chips. Also the similar comparisons are made under changing illuminant conditions.