기어의 자동설계와 검증에 관한 연구

한민식,김승현,송호봉,전언찬 한국공작기계학회 2009 한국공작기계학회 춘계학술대회논문집 Vol.2009 No.-

Gear is main machine element which is used for the power transmit device when it si short in the gear. We use a standard goods in the case of the gear. But in case of special purpose, we need to manufacture the gear that have different angles. In this paper, we manufactured standard gears using W-EDM and Hobbing machine. We got a 3D shape doing reverse engineering manufactured gears. And then compared CAD data and measured data. Finally we verified ADS through comparing ADS data and KISSsoft data.

두개저 골절 환자의 임상적 고찰

김한식,목진호,이규춘,이영배 동국대학교 경주대학 1997 東國論集 Vol.16 No.2

저자들은 최근 2년간 본원 신경외과에 입원 치료 받았던 두부외상 환자 중 자료 분석이 가능했던 119례의 두 개저부 골절 환자를 대상으로 임상 분석하여 다음과 같은 결론을 얻었다. 두부외상후 두개저 골절의 발생 빈도는 34%로 남녀 발생비는 5 : 1이었고, 활동기 연령인 20∼59세가 70.6%를 차지 하였다. 원인으로는 교통사고가 56.3%로 가장 많고 추락, 산재, 낙상, 구타 순이었으며, 내원당시 환자상태는 경증뇌손상(GCS 13-15)이 64.7%, 중증 뇌손상(3∼8) 21.8%, 중등도 뇌손상(9∼12) 13.5% 순이었고 예후도 GCS가 높을수록 양호하였다. 임상소견은 뇌척수액 비루(43.7%)가 가장 흔하고 비루(31.9%), 안와부 반상출혈(31.1%), 기뇌증(26.1%), 청각소실(18.5%)등이었다. 뇌척수액루의 지속 기간은 87.7%가 7일 이내였고 보존적 치료로 93.9%가 해결되었다. 2∼4주 지속된 경우는 요추천자 배액술, 4주 이상된 경우는 수술을 시행하였다. 뇌신경 손상은 안면신경마비가 31.7%로 가장 높았고 발현 시기는 지연성 마비가 69.2%, 조기마비가 30.8%였다. 뇌막염의 발생 빈도는 5.9%로 모두 뇌척수액루가 1주 이상 지속된 경우였고, 항생제 투여군과 비투여군의 뇌막염 발생율은 각각 6.1%와 4.8%로 항생제가 감염율을 낮추지는 못했다. 119 consecutive cases with basal skull fractures out of 343 head injuried patients who were treated in Pohang Hospital from July 1995 to July 1997 were analysed. The authors reviewed the clinical features, radiologic findings, complications and outcomes. Most of the patients(70.6%) were between 20 and 59 years old. The basal skull fractures were more common in men than women-the ratio being 5 : 1. The cause of BSF were traffic accident(56.3%), fall down, work related, silp down, and assults in decreasing order of frequency. The outcome of treatment wee related to initial GCS(Glasgow coma scale) of patients. The severity of head injury were mild(GCS13-15)-64.7%, Moderate(GCS9-12)-13.5%, and severe(GCS3-8)-21.8%, The most common feature of BSF were rhinorrhea(43.7%), otorrhea(31.3%), raccoon's eye(31.1%), pneumocephalus(26.1%), hearing disturbance(18.5%). Most of CSF leakage(86.7%) were noted within 24hours after injury and most of leakage(93.9%) were ceased by conservative management within 2 weeks, but one case that did not respond to conservative and lumbar drainage required operative repair. The facial nerve(31.7%) was the most frequently involved cranial nerve followed by vestibulocochlear and optic nerve. The onset of facial palsies were immediate in 30.8% and delayed 69.2%. The incidence of meningitis was 5.9% and the prophylactic antibiotics had no beneficial effect in reducing the infection rate.

Vertebrobasilar Dolichoectasia 4례 : 증례보고 A Case Report

목진호,김한식,이규춘,이영배 동국대학교 경주대학 1998 東國論集 Vol.17 No.1

Dolichoectasia란 혈관이 연장되고 방추상으로 팽창된 것을 말하며 두경부 혈관에서는 추골-기저동맥과 내경동맥에 주로 발생하며 중대뇌동맥이나 전대뇌동맥에는 드물게 발생한다 Vertebrobasilar dolichoectasia는 대부분 무증상이지만, 일분 환자에서는 뇌간이나 뇌신경들을 압박하거나 뇌허혈을 유발하여 증상을 나타낼 수 있고 임상증상에 따라 1) ischemic symptom 2) cranial nerve compression symptom 3) pseudotumor symptom 으로 구분할 수 있다. 그러나 임상경과중 반복적인 뇌 허혈증상 또는 뇌간 경색증을 유발하여 심각한 임상경과와 불량한 예후를 나타낼 수도 있다. 따라서 Vertebrobasilar dolichoectasia로 진단된 환자에서는 적극적으로 고혈압을 치료하며, 임상증상이 없더라도 항응고 제제나 항혈소판 제제를 투약하며 주의 깊게 관찰하여야 할 것이다. 자들은 일과성 허혈성 발작이나 뇌신경기능 장애를 보이는 Vertebrobasilar dolichoectasia 4례를 경험하였기에 문헌고찰과 함께 보고하는 바이다. The dolichoectasia of cerebral arteries is an uncommon entity and the term dolichoectasia (elongation-distention) has been used to describe these vessels, which are characterized by elongation and fusiform dilatation. The vertebrobasilar system and intracranial internal caroted arteries are more frequently involved and the diagnosis can be made by cerebral angiography, brain CT or brain MRI. It is generally asymptomatic, but may present with a variety of symptoms. Headache, cranial nerve paresis and cerebral ischemia are the most common clinical presentations. Cerebral ischemia, especially brain stem infarction, due to vertebrobasilar dolichoectasia is rare, but its development may be fatal. When the dolichoectasia is diagnosed by CT findings, even if it is clinically asymptomatic, it may be better to treat patients with medical therapy used to prevent ischemic stroke. We report four cases with vertebrobasilar dolichoectasia, all of them had ischemic symptoms and were treated with medical therapy.

신경망을 이용한 회전 역진자 시스템의 제어

탁한호,이주원,신춘식 진주산업대학교 1997 論文集 Vol.36 No.-

Today, the complexity and nonlinearity in system have increased. For example, an inverted pendulum of nonlinear system is widely used as a substitute of nonlinear control system. But it is difficult to establish mathemathical equation and model control system. This paper aims to propose a method to control desired position and desired pole angle of the rotary inverted pendulum using multilayer neural networks. In the begining of learning, we controller the system using PD controller to avoid unstability of system. After learning of neural networks we controlled the system using neural networks. In this paper we compare the result of PD controller with result of neural networks, and point out some good points of neural networks for nonlinear system control.

두부외상후 생존기간에 영향을 주는 요인분석

목직호,김한식,이규춘,이영배 동국대학교 경주대학 1997 東國論集 Vol.16 No.2

1995년 7월부터 1997년 7월까지 최근 2년간 본원 신경외과에 입원한 343례의 두부손상 환자중 사망한 25례를 조기사망군(7일이내)과 후기사망군(7일후)으로 분류하여 분석해본 결과 7.3%의 사망률을 보였으며 남자 사망자는 여자에 비해 3.2배였으며, 연령 별로는 조기사망군은 40대이상에서 많았고 후기 사망군은 60대 이상의 고령에서 다소 많았다. 조기사망군에서는 낮은 GCS, 비정상적인 동공반사 반응, 타장기 손상, 저혈압, 저산소증, 고혈당, 심한 정중전이, 뇌실압박, 두개골 골절, 개두술의 빈도가 높게 조사되었다. 이송시간은 조기사망군에서 1시간 이내에 도착한 경우가 많아 신속한 후송이 이루어졌다. 한편 후기사망군에서는 저이산화탄소혈증, 빈혈, 고나트륨혈증등이 높게 조사되었다. 사인은 조기사망군에서 1차성두개강내 병변 및 저혈량 등이 많았고 후기사망례는 폐렴, 성인성 호흡곤란 증후군, 외상후성 뇌경색증 등이 주요 사망 원인이었다. 따라서 생존기간별로 위험도가 높은 요소를 찾아 그에 대한 적극적인 치료를 하는 것이 두부 손상으로 인한 사망률을 개선하는데 바람직한 것으로 생각된다. We present a study the variable factor in the early(within one week) and late death(after one week) after head injury. The multiple factors were analysed on the clinical, imaging, and laboratory characteristics of 25 patients who were dead among 343 head injured persons during recent 2 years form July, 1995 to July, 1997. The mortality rate was 7.3% and the ratio of male to female was 3.2 to 1. The early death were younger than late death(5th decade vs 7th decade). Mechanism of injury were motor vehicle accident(64%), followed by work-related, slip and fall, and unknown. The early death had a higher percentage of low GCS score, abnormal pupil reflex, other associated injury, hypotension, hypoxemia, hyperglycemia, midline shift, ventricle compression, skull fracture, and craniotomy compared with the late death. On the other hand, the late death had a higher incidence of hypocarbia, anemia, and hypernatremia than the early death. The main causes of death were primary intracranial lesions and hypovolemia in the early death and pneumonia, ARDS, and posttraumatic cerebral infarction in the late death.

후두와 병변 수술의 발생한 경막하 긴장성 기두증

목진호,김한식,이규춘,박용석,이영배 東國大學校醫學硏究所 1999 東國醫學 Vol.6 No.-

긴장성 기두증은 신경외과영역에서 개두수술 후에 발생할 수 있는 드문 합병증으로 특히 만성 뇌경막하 혈종 제거수술이나 좌위에서 후두와 수술을 시행한 경우에 발생할 수 있다. 따라서 개두수술 후에 신경학적 증상의 악화가 있거나 수술 후 예상경과를 취하지 않는 경우에는 긴장성 기두증의 발생 가증성을 항상 고려하여야 한다. 긴장성 기두증의 발생기전은 물병을 거꾸로 세운 것과 같은 기전(Inverted pop-bottle mechanism)으로 뇌척수액이 누수된 만큼 공기방울이 경막하강으로 올라가 빈 공간을 메우는 것이다. 이와 같은 기전으로 두개강내로 들어간 공기가 일정한 압력을 가지게 되어 주변 뇌조직을 압박하여 신경학적 장애를 초래하게 된다. 뇌전산화 단층촬영을 이용하여 쉽게 진단이 가능하며 치료는 두개골 천공을 시행하여 두개강내 공기를 배기시켜 줌으로서 가능하다. 저자들은 복와위에서 후두와 병변 수술 후에 발생한 긴장성 기두증을 뇌전산화 단층촬영을 이용하여 진단하고 전두골을 천공하여 두개강내 공기를 배기시켜 치험하였기에 문헌고찰과 함께 증례를 보고하는 바이다. 중심단어:긴장성 기두증, 후두와 수술, 경막하강, 복와위 Tension pneumocephalus is a rare complication in neurosurgical operation and should be considered whenever a patient fails to recover as expected following surgery. The possible mechanism for the entry of air into the subdural space is analogous to the entry of air into an inverted soda-pop bottle. As the fluid pours out. air bubbles reach the top of the container, Computed tomography permitted rapid diagnosis including localization of the air, thus facilitating prompt treatment. Peaking of frontal lobe. mountain appearance of frontal lobe. and air densities at the cisterns are characteristic findings of' tension pneumocephalus on brain CT scan. This condition is easily diagnosed and treated using twist-drill aspiration. The authors describe a case of subdural tension pneumocephalus complicating the early postoperative course after posterior fossa surgery in the prone position.

Three-Dimensional Z-Plasty(Yoon's Method)를 이용한 내안각 췌피 성형술

박흥식,김우신,윤진호,나민화,김한중 대한미용성형외과학회 1997 Archives of Aesthetic Plastic Surgery Vol.3 No.1

The presence of epicanthal folds in Asian eyelids is one of their unique features, in combination with the lack of supratarsal folds. Western culture has influenced many people to prefer to eliminate the prominent epicanthal fold. A number of surgical techniques have been suggested for their correction. However, difficulty with design, excessive and prominent scarring of medial canthal and nasal area, recurrence, and rigidity of application are potential problems associated with many procedures. This paper describes a epicanthoplasty with three-dimensional Z-plasty. Through epicanthal fold incision, the medial canthal tendon is medially advanced and sutured to the periosteum of nasal bone. After the transposition of the flaps, trimming of the flap is usually required. Three-dimensional Z-plasty creates the attractive eyes. From March, 1995 to March, 1997, the technique was applied to 37 patients with epicanthal fold and was performed with or without double-fold operation. There were 34 females and 3 males with ages ranging from 17 to 30 years. Through 2 years follow-up, this technique has delivered esthetically good results with minimal postoperative scar and could made the reduction of ICD from 40 ± 2.13 mm to 34 ± 1.98 mm. The advantages of epicanthoplasty procedure using three-dimensional Z-plasty(Yoon's method) are as follows; 1) simple in design 2)minimal postoperative scar in the medial canthal area 3) versatile in its application 4) no recurrence 5) no hypertrophic scar 6) preserving ethnic identity.

Malachite Green유도체의 합성과 그 항균성에 관한 연구

金浩植,金鍾大,金在根,韓文洙 嶺南大學校附設 基礎科學硏究所 1986 基礎科學硏究 Vol.6 No.-

Malachite Green derivative bearing butyl group was prepared in the form of Leuco base, 4-butyl-4'. 4"-bis(dimethylamino) triphenylmethane, by the condensation reaction of N,N-dimethylaniline with the formyl derivative of butylbenzene, which had been obtained from butylbenzene by chlormethylation followed by oxidation. The butylbenzene was prepared by the alkylation reaction of benzene with n-butyl choride which had been obtained from n-butyl alcohol and zinc chloride. The antimicrobial and antifungal activity of buty-Malachite Green was evaluated in terms of minimum inhibitory concentration by the dilution method. The butyl-Malachite Green showed considerably increasing activity. This activity was stronger than that of hexyl-Malachite Green. This phenomenon suggested that the activities of the alkyl derivatives increase with decrease in the number of carbon in the alkyl group.

日本 自然科學分野 學術硏究 動向 調査硏究

金漢洙,洪翰植,金完鎬,金源,李永吉,徐英淑 경북대학교 1981 새마을 硏究論叢 Vol.1 No.-

Vascular Protective Role of Samul-Tang in HUVECs: Involvement of Nrf2/HO-1 and NO

Choi, Eun Sik,Lee, Yun Jung,Seo, Chang Seob,Yoon, Jung Joo,Han, Byung Hyuk,Park, Min Cheol,Kang, Dae Gill,Lee, Ho Sub Hindawi Publishing Corporation 2016 Evidence-based Complementary and Alternative Medic Vol.2016 No.-

<P>Samul-Tang (Si-Wu-Tang, SMT), composed of four medicinal herbs, is a well-known herbal formula treating hematological disorder or gynecologic disease. However, vascular protective effects of SMT and its molecular mechanisms on the vascular endothelium, known as the central spot of vascular inflammatory process, are not reported. The aim of this study was to investigate vascular protective effects of SMT water extract in human umbilical vein endothelial cells (HUVECs). Water extract of SMT was prepared and identified by HPLC-PDA analysis. Expression of cell adhesion molecules (CAMs) and heme oxygenase-1 (HO-1) and translocation of nuclear factor-kappa B (NF-<I>κ</I>B) and nuclear factor-erythroid 2-related factor 2 (Nrf2) were determined by western blot. Nuclear localization of NF-<I>κ</I>B and Nrf2 was visualized by immunofluorescence and DNA binding activity of NF-<I>κ</I>B was measured. ROS production, HL-60 monocyte adhesion, and intracellular nitric oxide (NO) were also measured using a fluorescent indicator. SMT suppressed NF-<I>κ</I>B translocation and activation as well as expression of CAMs, monocyte adhesion, and ROS production induced by TNF-<I>α</I> in HUVECs. SMT treated HUVECs showed upregulation of HO-1 and NO which are responsible for vascular protective action. Our study suggests that SMT, a traditionally used herbal formula, protects the vascular endothelium from inflammation and might be used as a promising vascular protective drug.</P>