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Ban, Jung Ok,Kim, Dae Hwan,Lee, Hee Pom,Hwang, Chul Ju,Shim, Jung-Hyun,Kim, Dae Joong,Kim, Tae Myoung,Jeong, Heon-Sang,Nah, Seong Su,Chen, Hanyong,Dong, Zigang,Ham, Young Wan,Kim, Youngsoo,Han, Sang-B Wiley (Blackwell Publishing) 2014 British journal of pharmacology Vol.171 No.11
<P>Products of Maillard reactions between aminoacids and reducing sugars are known to have anti-inflammatory properties. Here we have assessed the anti-arthritis effects of (E)-2,4-bis(p-hydroxyphenyl)-2-butenal and its possible mechanisms of action.</P>
21-Cr 페라이트계 스테인리스강의 기계적 물성 모델링과 적용
정한용(Hanyong Jung),정양진(Yangjin Chung),박기철(Keecheol Park),남재복(Jaebok Nam) 대한기계학회 2013 대한기계학회 춘추학술대회 Vol.2013 No.12
In this paper, phenomenological material models describing anisotropic plastic behavior of 21-Cr ferritic stainless steel were investigated using three yield functions of Hill(1948), Barlat and Lian(1989) and Barlat et al.(2003, referred to as Yld2000-2d) criteria. Uniaxial tension and equi-biaxial bulge test were conducted for mechanical properties. Three yield functions calculated from experiments were used for comparing to the one element simulation using LS-DYNA. The results presented that the three directional tensile properties by Yld2000-2d criterion were in good agreement with tensile test Thinning distribution calculated by Yld2000 2d model was compared to those of the real part of door in
유입부하 변동에 따른 Bio-Sac 생물반응조의 최적 송풍량 결정에 관한 연구
정호종(Jung, Hojong),정민재(Jung, Minjae),최한영(Choi, Hanyong) 한국방재학회 2017 한국방재학회논문집 Vol.17 No.4
설계인구보다 증가된 인구에 따라서 하수처리장에서는 설계수질과 유입수질간에는 많은 차이가 있으며, 설계 유입수 농도보다 초과로 유입이 된 하수처리장은 적정운전에 많은 곤란함을 겪고 있다. 그런데 Bio-Sac공법은 설계대비 초과된 유입 BOD, SS, T-N에 의해 하수처리장에 대해서는 국⋅내외 선행 연구가 많이 부족하고, 미흡한 실정이다. 본 연구의 목적은 성남판교수질복원센터를 대상으로 설계초과되는 유입 BOD, SS, T-N 변동에 따른 생물반응조의 송풍량 조절을 통해 질산화, 탈질화 반응의 의한 최적의 송풍량을 선정하기 위한 연구이다. 생물반응조 호기조 송풍량 40, 50 및 60 Nm3/min으로 변경하여 실험한 결과50 Nm3/min일 때 질소제거율 92.8% 질산화율 96.9% 탈질화율 94.3%로 나타났다. 질소제거율과, 탈질율을 고려할 때 최적의 송풍량은 50 Nm3/min일 때 처리효율이 효과적이라는 결과를 얻었다. There are many differences between the design water quality and the influent water quality at the sewage treatment plant, depending on the population that is larger than the design population, and the sewage treatment plant which has flowed in excess of the design influent concentration suffers from the problem of proper operation. However, in the Bio-Sac construction method, there are insufficient prior researches on the sewage treatment plant due to excess BOD, SS, and T-N compared to the design. The purpose of this study is to select the optimal amount of ventilation by nitrification and denitrification through controlling the amount of blowing of bioreactor according to fluctuating influent BOD, SS, and T-N exceeding the design for Seongnam Pangyo water quality restoration center. Experiments were conducted at 40, 50 and 60 Nm3 / min ventilation rate of the bioreactor. The nitrogen removal rate was 92.8%, the nitrification rate was 96.9%, and the denitrification rate was 94.3% at 50 Nm3 / min. Considering the nitrogen removal rate and denitrification rate, the optimum treatment efficiency was 50 Nm3 / min.
Jung, Sung Keun,Lee, Mee-Hyun,Lim, Do Young,Kim, Jong Eun,Singh, Puja,Lee, Sung-Young,Jeong, Chul-Ho,Lim, Tae-Gyu,Chen, Hanyong,Chi, Young-In,Kundu, Joydeb Kumar,Lee, Nam Hyouck,Lee, Charles C.,Cho, Y American Society for Biochemistry and Molecular Bi 2014 The Journal of biological chemistry Vol.289 No.52
<P>Non-small-cell lung cancer (NSCLC) is associated with diverse genetic alterations including mutation of epidermal growth factor receptor (EGFR). Isoliquiritigenin (ILQ), a chalcone derivative, possesses anticancer activities. In the present study, we investigated the effects of ILQ on the growth of tyrosine kinase inhibitor (TKI)-sensitive and -resistant NSCLC cells and elucidated its underlying mechanisms. Treatment with ILQ inhibited growth and induced apoptosis in both TKI-sensitive and -resistant NSCLC cells. ILQ-induced apoptosis was associated with the cleavage of caspase-3 and poly-(ADP-ribose)-polymerase, increased expression of Bim, and reduced expression of Bcl-2. <I>In vitro</I> kinase assay results revealed that ILQ inhibited the catalytic activity of both wild type and double mutant (L858R/T790M) EGFR. Treatment with ILQ inhibited the anchorage-independent growth of NIH3T3 cells stably transfected with either wild type or double-mutant EGFR with or without EGF stimulation. ILQ also reduced the phosphorylation of Akt and ERK1/2 in both TKI-sensitive and -resistant NSCLC cells, and attenuated the kinase activity of Akt1 and ERK2 <I>in vitro</I>. ILQ directly interacted with both wild type and double-mutant EGFR in an ATP-competitive manner. A docking model study showed that ILQ formed two hydrogen bonds (Glu-762 and Met-793) with wild type EGFR and three hydrogen bonds (Lys-745, Met-793, and Asp-855) with mutant EGFR. ILQ attenuated the xenograft tumor growth of H1975 cells, which was associated with decreased expression of Ki-67 and diminished phosphorylation of Akt and ERK1/2. Taken together, ILQ suppresses NSCLC cell growth by directly targeting wild type or mutant EGFR.</P>
KyoungSae Na,HanYong Jung,Soyoung Irene Lee,ShinGyeom Kim 대한신경정신의학회 2004 PSYCHIATRY INVESTIGATION Vol.1 No.2
Objective-Mild traumatic brain injury (mTBI) is frequently associated with psychiatric symptoms and cognitive dysfunction, as well as with the receipt of workers’ compensation, as many mTBIs occur due to work-related accidents. We hypothesized that depression and insufficient cognitive effort mediate the relationship between sociodemographic variables and cognitive dysfunction in mTBI. Methods-A retrospective chart review study was conducted using 115 records of patients with mTBI. Cognitive effort was measured based on scores on the Rey 15-Item Test. Multivariate linear regression analysis was performed to examine factors predictive of cognitive functions. Path analysis was subsequently performed to investigate the mediating effects of depression and cognitive effort in relation to receipt of workers’ compensation and demographic variables. Results-Fifteen of the 115 participants (13.0%) received failing scores on the Rey 15-Item Test, which indicated insufficient cognitive effort. Path analysis indicated that cognitive effort mediated the effects of age and workers’ compensation on cognitive functions. Conclusion-Given the significant mediating effects of cognitive effort on cognitive performance, it is important to address patient motivation and encourage mTBI patients covered by workers’ compensation to perform tests with authentic effort.
Incidence and Course of Depression in Patients with Alzheimer’s Disease
SeungHo Ryu,HanYong Jung,KangJoon Lee,SeokWoo Moon,DongWoo Lee,Narei Hong,BaikSeok Kee,DoHoon Kim,Changsu Han,ChangUk Lee 대한신경정신의학회 2017 PSYCHIATRY INVESTIGATION Vol.14 No.3
Objective-Depressive symptoms are common in Alzheimer’s disease (AD) and they might influence the course and prognosis of AD. Depression could appear anytime in the course of the disease, and could either last considerably long or disappear easily. This study is intended to investigate the occurrence of depression in the course of AD and the risk factors of incidence. Methods-This study targeted 1,272 AD patients without depressive symptoms at the start of this study in Korea. A total of 775 subjects completed the study, and the occurrence of depression was assessed after 12 months. Demographic information of subjects was collected and cognitive functions, overall functions, and depression severity were assessed at the start of this study and after 12 months. Results-Among the 775 subjects, 103 subjects (13.29%) developed depression 12 months later. The MMSE-KC scores showed significant changes in both groups that developed depression and did not. In the univariate analysis, significant differences in the incidence of depression were found in terms of gender, the administration of the antidepressant at the baseline, the SGDS-K score, and the GDS score. The multiple logistic regression analysis showed that the increase in the incidence of depression was associated with a female, in the increase in SGDS-K score and the GDS score. Conclusion-The incidence of depression in the subjects who completed the 12-month follow-up observation was 13.29%. Moreover, in the multivariate analysis, a female gender and the severity of dementia, including the overall functions, seemed associated with the occurrence of depression.
Psychosocial Risk Factors for Suicide
Soyoung Irene Lee,HanYong Jung 대한신경정신의학회 2006 PSYCHIATRY INVESTIGATION Vol.3 No.2
Objective: There is little information as to the social or environmental correlates to human suicidal behavior. Thus, the purpose of this overview was to investigate and review the psychosocial correlates that are suggested to mediate suicidal behaviors. Method: A literature search was conducted on suicide and its risk, risk factors, population characteristics, and prediction. Thereafter, articles dealing with familial, social and environmental characteristics as risk factors for suicidal behavior are summarized in a review which is written in a narrative manner. Results: Risk factors for suicide occurring from the interaction between the individual and family context (abuse, loss, family discord) and those occurring from the interaction between the individual and his or her larger environmental context (stressful life events, social influence and support) are presented. Conclusions: This overview provides a summary of the recognized psychosocial risk factors for suicidal behavior. It is revealed that the psychosocial characteristics are a necessary component of a suicide risk assessment. Familial, social and environmental factors must be understood in a comprehensive context along with the psychiatric disorder and the biological vulnerability.