Discovery of Gene Sources for Economic Traits in Hanwoo by Whole-genome Resequencing

Shin, Younhee,Jung, Ho-jin,Jung, Myunghee,Yoo, Seungil,Subramaniyam, Sathiyamoorthy,Markkandan, Kesavan,Kang, Jun-Mo,Rai, Rajani,Park, Junhyung,Kim, Jong-Joo Asian Australasian Association of Animal Productio 2016 Animal Bioscience Vol.29 No.9

Hanwoo, a Korean native cattle (Bos taurus coreana), has great economic value due to high meat quality. Also, the breed has genetic variations that are associated with production traits such as health, disease resistance, reproduction, growth as well as carcass quality. In this study, next generation sequencing technologies and the availability of an appropriate reference genome were applied to discover a large amount of single nucleotide polymorphisms (SNPs) in ten Hanwoo bulls. Analysis of whole-genome resequencing generated a total of 26.5 Gb data, of which 594,716,859 and 592,990,750 reads covered 98.73% and 93.79% of the bovine reference genomes of UMD 3.1 and Btau 4.6.1, respectively. In total, 2,473,884 and 2,402,997 putative SNPs were discovered, of which 1,095,922 (44.3%) and 982,674 (40.9%) novel SNPs were discovered against UMD3.1 and Btau 4.6.1, respectively. Among the SNPs, the 46,301 (UMD 3.1) and 28,613 SNPs (Btau 4.6.1) that were identified as Hanwoo-specific SNPs were included in the functional genes that may be involved in the mechanisms of milk production, tenderness, juiciness, marbling of Hanwoo beef and yellow hair. Most of the Hanwoo-specific SNPs were identified in the promoter region, suggesting that the SNPs influence differential expression of the regulated genes relative to the relevant traits. In particular, the non-synonymous (ns) SNPs found in CORIN, which is a negative regulator of Agouti, might be a causal variant to determine yellow hair of Hanwoo. Our results will provide abundant genetic sources of variation to characterize Hanwoo genetics and for subsequent breeding.

남성 노인의 전립선 증상, 수면의 질, 삶의 질에 관한 연구

신경림(Kyung-Rim Shin),강윤희(Younhee, Kang),신미경(Mee-Kyung, Shin) 한국노년학회 2008 한국노년학 Vol.28 No.4

본 연구의 목적은 노인의 전립선 증상 정도와 그 유형에 대해 알아보고 전립선 증상과 삶의 질, 수면의 질과의 관계를 파악하기 위함이다. 연구 대상자는 2단계 BK(Brain Korea)21 핵심 사업팀에 의해 구축된 노인 건강 통합 DB의 65세 이상 남ㆍ여 노인 230명 중 남성 노인 100명을 대상으로 하였다. 연구도구는 남성 전립선 증상 측정도구(IPPS), 수면 질 측정 도구(PSQI)와 삶의 질 측정 도구(SF-36-K)이었다. 각 도구의 해석은 점수가 높을수록 전립선 증상이 심한 것을 의미하며, 점수가 높을수록 수면의 질 정도가 낮고, 5점 이상은 수면이 방해받고 있음을 의미한다. 또한, 삶의 질 측정 도구에서는 각 건강 상태 관련 삶의 질 점수가 높을수록 삶의 질이 높음을 의미한다. 자료분석은 빈도와 백분율, 평균과 표준편차로 일반적 특성, 대상자의 전립선 증상, 유형, 수면의 질과 삶의 질 정도를 산출하였다. 대상자의 전립선 증상과 수면의 질, 삶의 질과의 관계 파악은 Pearson's correlation coefficient을 실시하였다. 대상자의 평균 연령은 71.44세였으며 대상자의 전립선 증상은 35점 만점에 평균 8.01(±7.91)점이었고, 중등도 이상의 대상자가 연구 대상자의 44%를 차지하였다. 대상자의 수면의 질은 21점 만점에 평균 4.20(±2.25)점으로 나타났으며 수면 하부 영역별로는 주관적 수면의 질, 수면 잠재기, 수면 기간, 수면방해, 낮 동안 기능장애, 수면제사용, 수면 효율성 순으로 영역별 수면의 질이 낮은 수준을 보였다. 전립선 증상과 수면의 질(r=.272, p=.006)은 전립선 증상이 심할수록 수면이 질이 낮아지는 것을 의미하는 양의 상관관계를 보였고, 전립선 증상과 양의 상관관계를 보이는 수면 하부 영역인 주관적 수면의 질(r=.237, p=.017)과 수면 방해 영역(r=.269, p=.007)별 관계있는 세부 전립선 증상으로는 각각, 긴급뇨, 세뇨, 야뇨; 잔뇨, 간헐적 뇨, 긴급뇨, 야뇨이었다. 전립선 증상과 신체적 건강 관련 삶의 질(r=-.197, p=.049)은 전립선 증상이 심할수록 신체적 건강 관련 삶의 질이 낮아지는 것을 의미하는 음의 상관관계를 보였으며, 신체 건강 관련 삶의 질에 상관관계가 있는 세부 전립선 증상은 잔뇨감 증상이었다. 이상으로 본 연구결과에서 다수의 남성들이 전립선 증상을 호소하고 있으며 이로 인한 수면의 질과 건강 관련 삶의 질정도가 낮아짐을 알 수가 있다. 따라서 전립선 증상 관리법에 대한 간호 중재 교육이 시급함을 알 수가 있다. This study aimed to identify the severity and types of prostate symptom, to identify the relationship of prostate symptom, sleep quality and quality of life of the elderly in korea, so to provide basic data for developing nursing interventions for the elderly's prostate symptom management. This study used a descriptive correlational research design. The subjects of this study were 100 elderly men over 65yr in an urban city. Data were collected through personal interviews using questionnaires from September 2006 to March 2007. The IPPS, PSQI and SF-36-K were administered. The collected data were analyzed by descriptive statistics and Pearson's correlation. The major findings of this study were as follows: 1) 44% of the participants have moderate to severe Prostate symptom(IPSS>7). 2) Prostate symptom has positive relationship with sleep quality(r=.272, p=.006) and negative relationship with health related quality of life(r=-.197, p=.049). The results of this study indicate that prostate symptom is related to sleep quality and quality of life. So it is necessary to give information to the elderly about the effective coping method of prostate symptom and about the life style which have positive effect to prostate symptom.

The Primary Process and Key Concepts of Economic Evaluation in Healthcare

Younhee Kim,Yunjung Kim,Hyeon-Jeong Lee,Seulki Lee,Sun-Young Park,오성희,Suhyun Jang,Tae-Jin Lee,Jeonghoon Ahn,Sangjin Shin 대한예방의학회 2022 예방의학회지 Vol.55 No.5

Economic evaluations in the healthcare are used to assess economic efficiency of pharmaceuticals and medical interventions such as diagnoses and medical procedures. This study introduces the main concepts of economic evaluation across its key steps: planning, outcome and cost calculation, modeling, cost-effectiveness results, uncertainty analysis, and decision-making. When planning an economic evaluation, we determine the study population, intervention, comparators, perspectives, time horizon, discount rates, and type of economic evaluation. In healthcare economic evaluations, outcomes include changes in mortality, the survival rate, life years, and quality-adjusted life years, while costs include medical, non-medical, and productivity costs. Model-based economic evaluations, including decision tree and Markov models, are mainly used to calculate the total costs and total effects. In cost-effectiveness or cost-utility analyses, cost-effectiveness is evaluated using the incremental cost-effectiveness ratio, which is the additional cost per one additional unit of effectiveness gained by an intervention compared with a comparator. All outcomes have uncertainties owing to limited evidence, diverse methodologies, and unexplained variation. Thus, researchers should review these uncertainties and confirm their robustness. We hope to contribute to the establishment and dissemination of economic evaluation methodologies that reflect Korean clinical and research environment and ultimately improve the rationality of healthcare policies.

Impact of depression and activities of daily living on the fear of falling in Korean community‐dwelling elderly

Shin, Kyung Rim,Kang, Younhee,Kim, Mi Young,Jung, Dukyoo,Kim, Jeong Soo,Hong, Chong Min,Yun, Eun Suk,Ma, Rye Won Blackwell Publishing Asia 2010 NURSING AND HEALTH SCIENCES Vol.12 No.4

<P><B>Abstract</B></P><P>This study determined the predictors of the fear of falling (FOF) in 213 South Korean community‐dwelling elderly. The Fall Efficacy Scale, Pittsburgh Sleep Quality Index, Korean Geriatric Depression Screening Scale, and Barthel Index were used to measure the FOF, sleep quality, depression, and activities of daily living, respectively. In addition, information regarding the participants' demographic details and the number of types of medication was collected. The data were analyzed by using hierarchical regression. The general regression model, with the FOF as a dependent variable, was statistically significant. The FOF variance was partially explained. Depression and activities of daily living significantly influenced the FOF. Thus, the results indicate that the FOF in community‐dwelling elderly Koreans is affected by depression and activities of daily living. Therefore, an older adult with recognized signs of depression must be provided with more appropriate care and the allocation of specific interventional strategies in order to maintain activities of daily living should be developed to manage the FOF.</P>

낙상을 경험한 노인의 운동 프로그램 재참여 경험

신경림(Shin Kyung Rim),강윤희(Kang Younhee),정덕유(Jung Dukyoo),김미영(Kim Miyoung),이에리쟈(Lee Eliza),윤은숙(Yun Eun Suk),김윤주(Kim Yun Ju),마예원(Ma,Rye Won),오승진(Oh Seung Jin) 질적연구학회 2011 질적연구 Vol.12 No.2

Purpose: This study aimed to understand the experiences of older adults participating in community exercise programs who return to the program after experiencing a fall, and to explore how their experiences changed after falling. Methods: The subjects were 15 older adults who have experienced accidental falls and have continued to participate in the programs even after falling. Data were collected from February to March 2011 through unstructured face-to-face interviews. Data analysis was using Colaizzi's phenomenological method. Results: The experiences of older adults were divided into the following six categories: "practicing exercise in order to recover from physical impairment", "having gone through trial and error to find the exercise that is right for me", "noticing physical changes as a result of exercise", "having developed confidence through exercise", "having stronger physical functions thanks to consistent exercise", and "lingering fears about recurrent falling." The subjects stated that the best strategy for overcoming their fear of recurrent falling is "to actively participate in exercise programs." Conclusion: By gradually proceeding the exercise that was right for their physical condition and refraining from being over-hasty, they experienced positive physical and emotional changes, gained confidence about their lives in old age, and developed improved physical functionality.

경도인지장애 노인의 우울 예측 요인

신경림(Shin, Kyung Rim),강윤희(Kang, Younhee),김미영(Kim, Miyoung),정덕유(Jung, Dukyoo),이에리쟈(Lee Eliza) 한국성인간호학회 2012 성인간호학회지 Vol.24 No.2

노인의 낙상 경험

신경림(Shin Kyung Rim),강윤희(Kang Younhee),정덕유(Jung Dukyoo),박효정(Park Hyo Jung),엄지연(Eom Ji Yon),윤은숙(Yun Eun Suk),김미정(Kim Mi Jung) 질적연구학회 2010 질적연구 Vol.11 No.1

Purpose: The purpose of this study was to explore experiences among older adults who has fallen within one year. Methods: The participants in this study were 14 old adults who has fallen within one year. Among them, 3 resided in nursing home and the others were dwelled in community. Data collection was conducted using a face to face interview in nursing home and focus group interview in community center, which were recorded on audio tape. Transcribed data was analyzed through thematic analysis method. Results: The results of this study were deduced as 2 main themes and 6 other themes. Study participants reported pros and cons after they had fall experiences. They indicated pros such as vigilance, affirmative coping for preventing repeated falling, and reconfirmation toward meaning of life. Additionally, physical withdrawn, psychological withdrawn, and passive handling with regard to repeated falling. Conclusion: The results of this study supported the older adults who had an experience of falling may have both positive and negative reflects. Based on the results, effective fall intervention program should be developed.

관상동맥질환자의 건강통제위, 회복력, 사회적 지지와 건강증진행위 간의 관계

신나연(Shin, Nayeon),강윤희(Kang, Younhee) 한국성인간호학회 2015 성인간호학회지 Vol.27 No.3

경도인지장애 여성노인의 건강관리 유형

신경림(Shin, Kyung Rim),강윤희(Kang, Younhee),김미영(Kim, Miyoung),정덕유(Jung, Dukyoo),김미정(Kim, Mijung),박금주(Park, Kuemju),권유림(Kweon, Yoorim) 대한여성건강학회 2011 여성건강 Vol.12 No.1

노인의 전립샘 비대증상, 일상생활 수행능력 및 수면의 질

신경림(Shin Kyung Rim),공수자(Gong Su Ja),강윤희(Kang Younhee),옥지원(Oak Ji Won),임은주(Lim Eun Ju) 한국성인간호학회 2009 성인간호학회지 Vol.21 No.1