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      • SSCISCOPUSKCI등재
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        Does the Cage Position in Transforaminal Lumbar Interbody Fusion Determine Unilateral versus Bilateral Screw Placement?: A Review of the Literature

        Haley M. McKissack,Howard Benjamin Levene 대한척추외과학회 2019 Asian Spine Journal Vol.13 No.2

        This literature review examines the relative placement of the interbody cage with respect to the unilateral screw construct to address the need for bilateral screw placement versus unilateral screw placement. Transforaminal lumbar interbody fusion (TLIF) has become a widely used technique for correcting lumbar intervertebral pathologies. This review addresses the necessity for further study on the effects of the relative position of intervertebral cage placement on the outcome of lumbar spine surgery after TLIF with unilateral pedicle screw fixation. Previous studies have addressed various factors, including posterior screw fixation, cage size, cage shape, and number of levels fused, that impact the biomechanics of the lumbar spine following TLIF. A simple survey of the literature was conducted. A search of the English literature was conducted using the keywords ‘TLIF,’ ‘transforaminal lumbar interbody fusion,’ ‘graft placement,’ ‘graft position,’ ‘cage position,’ ‘cage placement,’ ‘unilateral pedicle screw,’ ‘unilateral TLIF cage placement,’ ‘lumbar biomechanics,’ ‘lumbar stability,’ ‘lumbar fusion,’ and ‘lumbar intervertebral cage’ with various combinations of the operators ‘AND’ and ‘OR’ and no date restrictions. Seventeen articles in the English literature that were most relevant to this research question were identified. To the best of our knowledge, there are no published data addressing the effects of cage placement relative to the unilateral screw on lumbar stability in TLIF with unilateral pedicle screw fixation. Investigation of the effects of cage placement is, thus, warranted to achieve optimal clinical outcomes in patients undergoing TLIF with unilateral pedicle screw fixation.

      • 교사와 학생과의 연결을 위한 코어반성

        Haley Moore 한국홀리스틱융합교육학회 2019 한국홀리스틱융합교육학회 학술발표대회논문집 Vol.2019 No.10

        Educators are constantly looking for new and inspired methods of connecting with their students, colleagues, and administrators. So often, teaching becomes weighed down with testing, ranking, meeting deadlines, and passing evaluations. However, education should be more than that, it should be a connection between one soul and qualities. Educational research in the United States has begun to move in the direction of mindfulness, both for teachers and students, and you can see evidence of schools using techniques of engaging with In this series of studies, educators and students were introduced to a method of self-reflection called core reflection. The participants learned how to implement aspects of core reflection with themselves in times of conflict, and with those around them (whether students or teachers). The result of these studies was largely positive, with students and teachers inspired to continue using core reflection as a mindfulness exercise and as a way to engage with self-feelings and regulate their reactions to outside events and influences. This study was presented at the 2017 APNHE Annual Meeting in Bangkok, Thailand. The focus of the presentation was to introduce the studies, and to provide the attendees with skills and ideas that they could implement immediately into their teaching lives.

      • SCIESCOPUSKCI등재

        CONSIDERATIONS IN THE DEVELOPMENT OF FUTURE PIG BREEDING PROGRAM - REVIEW -

        Haley, C.S. Asian Australasian Association of Animal Productio 1991 Animal Bioscience Vol.4 No.4

        Pig breeding programs have been very successful in the improvement of animals by the simple expedient of focusing on a few traits of economic importance, particularly growth efficiency and leanness. Further reductions in leanness may become more difficult to achieve, due to reduced genetic variation, and less desirable, due to adverse correlated effects on meat and eating quality. Best linear unbiased prediction (BLUP) of breeding values makes possible the incorporation of data from many sources and increases the value of including traits such as sow performance in the breeding objective. Advances in technology, such as electronic animal identification, electronic feeders, improved ultrasonic scanners and automated data capture at slaughter houses, increase the number of sources of information that can be included in breeding value predictions. Breeding program structures will evolve to reflect these changes and a common structure is likely to be several or many breeding farms genetically linked by A.i., with data collected on a number of traits from many sources and integrated into a single breeding value prediction using BLUP. Future developments will include the production of a porcine gene map which may make it possible to identify genes controlling economically valuable traits, such as those for litter size in the Meishan, and introgress them into nucleus populations. Genes identified from the gene map or from other sources will provide insight into the genetic basis of performance and may provide the raw material from which transgenic programs will channel additional genetic variance into nucleus populations undergoing selection.

      • Uncommon Therapy

        Haley, Jay 圓光大學校 醫科大學 神經精神科學敎室 1997 圓光精神醫學 Vol.13 No.2

        사람이 한 증상을 갖고 있을 때, 정의에 의하면 그는 그가 자기 자신을 도울 수 없다는 것을 가르키고 있다. 그의 행동은 비자발적이다. 공포증 환자 혹은 강박증 환자 혹은 알코올 환자 혹은 혼란된 가족은, 그들은 자신들이 하는 대로 행동을 하지 않을 수 없다는 것을 주장하지만, 고통을 가져오는 방식 속에 계속 머무른다. 같은 방식으로 최면술에 지원한 대상자가 자주 지시를 따르지 않는다. 그는 거부 하지는 않는다. 그는 단지 자신이 할 수 없다는 것을 가르킨다. 또는 그가 이것이 일어나게 하지 않는다는 것을 가르키지만 그는 반대 방식으로 반응할 것이다. 예를 들어 만약 대상자가 의자의 팔걸이에 손을 두기를 요청받고 그 뒤 손이 점점 가벼워져 들어 올려질 것이라고 듣는다면, 그는 손이 들어 올려지게 하지 못할 수가 있거나, 혹은 "점점 무거워진다"고 말할지 모른다. 최면술의 기술은 이같은 저항을 다루는 것이고 그리고 변화를 일으키는 것이고, 그리고 치료의 기술은 또한 이같은 종류의 문제에 대한 효과적인 해결인 것이다.

      • SCIESCOPUSKCI등재

        Bisphosphonate Use Does Not Impact Survival in Patients with Pancreatic Cancer: A Propensity Score Matching Analysis

        ( Haley M. Zylberberg ),( Sheila D. Rustgi ),( Anthony Yang ),( Anne Aronson ),( Elizabeth Kessel ),( Sunil Amin ),( Aimee L. Lucas ) 대한간학회 2021 Gut and Liver Vol.15 No.5

        Background/Aims: Bisphosphonates are increasingly recognized for their anti-neoplastic properties, which are the result of their action on the mevalonate pathway. Our primary aim was to investigate the association between bisphosphonate use and survival in patients with pancreatic cancer. Since statins also act on the mevalonate pathway, we also investigated the effect of the combined use of bisphosphonates and statins on survival. Methods: The Surveillance, Epidemiology, and End Results registry (SEER)-Medicare linked database was used to identify patients with pancreatic ductal adenocarcinoma (PDAC) between 2007 and 2015. Kaplan-Meier models were used to examine the association between survival with bisphosphonate use alone and in combination with statins within 1 year prior to the diagnosis of PDAC. Propensity score matching analysis and Cox-proportional hazard models were used to determine the association between overall survival with bisphosphonate use alone and combined with statins, after adjusting for relevant confounders, such as the Charlson comorbidity index score, stage, treatment, sociodemographic characteristics, and propensity score. Results: In total, 13,639 patients with PDAC were identified, and 1,203 (8.82%) used bisphosphonates. There was no difference in the mean survival duration between bisphosphonate users (7.27 months) and nonusers (7.25 months, p=0.61). After adjustment for confounders, bisphosphonate use was still not associated with improved survival (hazard ratio, 1.00; 95% confidence interval, 0.93 to 1.08; p=0.96). Combined bisphosphonate and statin use was also not associated with improved survival (hazard ratio, 0.97; 95% confidence interval, 0.87 to 1.07; p=0.48) after adjustment for confounders. Conclusions: Our findings suggest that the use of bisphosphonates, whether alone or in combination with statins, does not confer a survival advantage in patients with PDAC. (Gut Liver 2021;15:782-790)

      • SCISCIESCOPUS

        First-principles assessment of CO<sub>2</sub> capture mechanisms in aqueous piperazine solution

        Stowe, Haley M.,Paek, Eunsu,Hwang, Gyeong S. The Royal Society of Chemistry 2016 Physical chemistry chemical physics Vol.18 No.36

        <P>Piperazine (PZ) and its blends have emerged as attractive solvents for CO<SUB>2</SUB> capture, but the underlying reaction mechanisms still remain uncertain. Our study particularly focuses on assessing the relative roles of PZCOO<SUP>−</SUP> and PZH<SUP>+</SUP> produced from the PZ + CO<SUB>2</SUB> reaction. PZCOO<SUP>−</SUP> is found to directly react with CO<SUB>2</SUB> forming COO<SUP>−</SUP>PZCOO<SUP>−</SUP>, whereas PZH<SUP>+</SUP> will not. However, COO<SUP>−</SUP>PZCOO<SUP>−</SUP> appears very unlikely to be produced in thermodynamic equilibrium with monocarbamates, suggesting that its existence would predominantly originate from the surface reaction that likely occurs. We also find production of H<SUP>+</SUP>PZCOO<SUP>−</SUP> to be more probable with increasing CO<SUB>2</SUB> loading, due partly to the thermodynamic favorability of the PZH<SUP>+</SUP> + PZCOO<SUP>−</SUP>→ H<SUP>+</SUP>PZCOO<SUP>−</SUP> + PZ reaction; the facile PZ liberation may contribute to its relatively high CO<SUB>2</SUB> absorption rate. This study highlights an accurate description of surface reaction and the solvent composition effect is critical in thermodynamic and kinetic models for predicting the CO<SUB>2</SUB> capture processes.</P> <P>Graphic Abstract</P><P>In this theoretical study, we elucidate molecular mechanisms underlying CO<SUB>2</SUB> absorption in aqueous piperazine (PZ) solution. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c6cp03584a'> </P>

      • Fundamental Understanding of CO<sub>2</sub> Capture and Regeneration in Aqueous Amines from First-Principles Studies: Recent Progress and Remaining Challenges

        Stowe, Haley M.,Hwang, Gyeong S. American Chemical Society 2017 INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH - Vol.56 No.24

        <P>Aqueous amine-based chemical scrubbing has been considered the most promising near-term solution for CO<SUB>2</SUB> capture from flue gas. However, its widespread implementation is hindered by the high cost associated with the parasitic energy consumption during solvent regeneration, along with degradation and corrosion problems. Computer simulations have been widely used to improve our fundamental understanding of CO<SUB>2</SUB> absorption materials and processes in efforts to design and develop high-performance, cost-effective solvents. Here, we review recent progress in first-principles studies on molecular mechanisms underlying CO<SUB>2</SUB> absorption into aqueous amines and solvent regeneration. We also briefly discuss aspects that remain unclear, such as degradation and corrosion mechanisms, and the reaction-diffusion behavior of CO<SUB>2</SUB> at the solvent/gas interface. This review highlights the increasingly significant role of first-principles-based atomistic modeling in exploring the function and properties of candidate materials, as well as the complex physicochemical phenomena underlying CO<SUB>2</SUB> capture, solvent degradation, and corrosion, especially when direct experimental characterization at the atomic level may be difficult.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/iecred/2017/iecred.2017.56.issue-24/acs.iecr.7b00213/production/images/medium/ie-2017-00213t_0012.gif'></P>

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