Metabolic Regulation of Gene Expression by Histone Lysine β-Hydroxybutyrylation

Xie, Zhongyu,Zhang, Di,Chung, Dongjun,Tang, Zhanyun,Huang, He,Dai, Lunzhi,Qi, Shankang,Li, Jingya,Colak, Gozde,Chen, Yue,Xia, Chunmei,Peng, Chao,Ruan, Haibin,Kirkey, Matt,Wang, Danli,Jensen, Lindy M. Elsevier 2016 Molecular cell Vol.62 No.2

<P><B>Summary</B></P> <P>Here we report the identification and verification of a β-hydroxybutyrate-derived protein modification, lysine β-hydroxybutyrylation (Kbhb), as a new type of histone mark. Histone Kbhb marks are dramatically induced in response to elevated β-hydroxybutyrate levels in cultured cells and in livers from mice subjected to prolonged fasting or streptozotocin-induced diabetic ketoacidosis. In total, we identified 44 histone Kbhb sites, a figure comparable to the known number of histone acetylation sites. By ChIP-seq and RNA-seq analysis, we demonstrate that histone Kbhb is a mark enriched in active gene promoters and that the increased H3K9bhb levels that occur during starvation are associated with genes upregulated in starvation-responsive metabolic pathways. Histone β-hydroxybutyrylation thus represents a new epigenetic regulatory mark that couples metabolism to gene expression, offering a new avenue to study chromatin regulation and diverse functions of β-hydroxybutyrate in the context of important human pathophysiological states, including diabetes, epilepsy, and neoplasia.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Lysine β-hydroxybutyrylation (Kbhb) is a new type of histone mark </LI> <LI> 44 non-redundant histone Kbhb sites are identified in human and mouse cells </LI> <LI> Histone Kbhb increases under starvation and STZ-induced ketoacidosis </LI> <LI> Starvation-induced H3K9bhb is associated with active gene expression </LI> </UL> </P> <P><B>Graphical Abstract</B></P> <P>[DISPLAY OMISSION]</P>

A Theoretical Solution of Deformation and Stress Calculation of the Underlying Tunnel Caused by Foundation Pit Excavation

Haibin Li,Bo Liu,Li Li,Qian Zhang,Chengwei Huang 대한토목학회 2024 KSCE Journal of Civil Engineering Vol.28 No.6

In the methods for mitigating the effect of foundation pit excavation on underlying tunnel, the conventional analytical calculation method adopted the elastic foundation beam to derive the tunnel deformation and internal forces. However, this traditional approach assumes that the released stress is loaded on the excavation face and subsequently affects the tunnel stress, which can be obtained by Mindlin’s solution. The limitations of this method are analyzed, and the soil deformation caused by excavation is introduced as an external load in the model. A differential equation of the elastic foundation beam is established and used to derive the analytic solution of the deformation and internal force of the tunnel by analysis of the empirical formula of soil deformation under foundation pit. Additionally, the weighted residual solution is introduced due to the difficulty in calculation of analytic solution. Considering that the project in this study is a three-dimensional problem?the torque is derived for a complete elastic foundation beam solution.

Analysis of Multi-Agent-Based Adaptive Droop-Controlled AC Microgrids with PSCAD: Modeling and Simulation

Li, Zhongwen,Zang, Chuanzhi,Zeng, Peng,Yu, Haibin,Li, Hepeng,Li, Shuhui The Korean Institute of Power Electronics 2015 JOURNAL OF POWER ELECTRONICS Vol.15 No.2

A microgrid (MG) with integrated renewable energy resources can benefit both utility companies and customers. As a result, they are attracting a great deal of attention. The control of a MG is very important for the stable operation of a MG. The droop-control method is popular since it avoids circulating currents among the converters without using any critical communication between them. Traditional droop control methods have the drawback of an inherent trade-off between power sharing and voltage and frequency regulation. An adaptive droop control method is proposed, which can operate in both the island mode and the grid-connected mode. It can also ensure smooth switching between these two modes. Furthermore, the voltage and frequency of a MG can be restored by using the proposed droop controller. Meanwhile, the active power can be dispatched appropriately in both operating modes based on the capacity or running cost of the Distributed Generators (DGs). The global information (such as the average voltage and output active power of the MG and so on) required by the proposed droop control method to restore the voltage and frequency deviations can be acquired distributedly based on the Multi Agent System (MAS). Simulation studies in PSCAD demonstrate the effectiveness of the proposed control method.

Analysis of Multi-Agent-Based Adaptive Droop-Controlled AC Microgrids with PSCAD

Zhongwen Li,Chuanzhi Zang,Peng Zeng,Haibin Yu,Hepeng Li,Shuhui Li 전력전자학회 2015 JOURNAL OF POWER ELECTRONICS Vol.15 No.2

A microgrid (MG) with integrated renewable energy resources can benefit both utility companies and customers. As a result, they are attracting a great deal of attention. The control of a MG is very important for the stable operation of a MG. The droop-control method is popular since it avoids circulating currents among the converters without using any critical communication between them. Traditional droop control methods have the drawback of an inherent trade-off between power sharing and voltage and frequency regulation. An adaptive droop control method is proposed, which can operate in both the island mode and the grid-connected mode. It can also ensure smooth switching between these two modes. Furthermore, the voltage and frequency of a MG can be restored by using the proposed droop controller. Meanwhile, the active power can be dispatched appropriately in both operating modes based on the capacity or running cost of the Distributed Generators (DGs). The global information (such as the average voltage and output active power of the MG and so on) required by the proposed droop control method to restore the voltage and frequency deviations can be acquired distributedly based on the Multi Agent System (MAS). Simulation studies in PSCAD demonstrate the effectiveness of the proposed control method.

Failure correlation reliability analysis of solid rocket motor grain based on polynomial chaos expansion

Yangtian Li,Haibin Li,Guangmei Wei 대한기계학회 2020 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.34 No.8

Polynomial chaos expansion (PCE) method has better fitting capacity and rate of convergence than other traditional reliability analysis methods. This paper presents the failure correlation reliability analysis based on PCE for improving calculation precision and reducing computational cost. An example of solid rocket motor grain solidification and cooling is analyzed, and the failure correlation reliability between inner surface crack and insulation layer debonding is studied. Results show that an accurate failure correlation reliability analysis result can be obtained by proposed method, and the precision and efficiency of the proposed method are verified by comparing it with traditional methods.

Differential evolution algorithm with improved crossover operation for combined heat and power economic dynamic dispatch problem with wind power

Li Mengdi,Zou Dexuan,Ouyang Haibin 한국CDE학회 2023 Journal of computational design and engineering Vol.10 No.4

This paper proposes a differential evolution algorithm with improved crossover operation (ICRDE) to deal with combined heat and power dynamic economic dispatch (CHPDED) problems with wind power. First, the improved crossover operation is used to maintain the population diversity by using original individuals, first mutated individuals, and second mutated individuals. Second, the scaling factor and weighted factor are incorporated into the mutation operation to improve the convergence efficiency of the algorithm. Third, adaptive control parameters are introduced to balance local exploitation and global exploration. Moreover, after being updated by the mutation and crossover operation of ICRDE at each generation, the solutions of ICRDE will be further amended using a constraint handling method, which improves the chance of acquiring feasible solutions. Experimental results demonstrate that ICRDE has strong global optimization ability and surpasses the compared algorithms for the CEC2017 benchmark functions, the combined heat and power economic dispatch problems, and the CHPDED problem with and without wind power.

Tuning the physicochemical properties of axitinib by crystallization: Preparation, calculation and Structure-property relationship

Haibin Qu,Zhonghua Li,Guimin Zhang,Zongyi Zhou,Songgu Wu 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.124 No.-

Crystal engineering is a radical method to modulate the physicochemical properties of the drugs to meetthe needs of the pharmaceutical industry. Examined herein are six axitinib solid-state forms, includinganhydrous forms (Ⅳand XLI), solvates (acetic acid, nitromethane and n-propanol), and cocrystal (nicotinamide). Comprehensive characterization containing morphology, hygroscopicity, solubility, fluorescenceand powder tabletability were performed. Calculations of lattice energy, packing coefficient andenergy framework rationalized the structure–property relationship of these six forms from the packinglandscape. This system illustrates that form IV and cocrystal improve the solubility of axitinib, but thehumidity stability is also decreased. Six crystal forms show polychromatic solid-state luminescence rangingfrom violet to indigo to green. Form IV and cocrystal with slip plane structures exhibited superior tensilestrength and compactibility than isotropic form XLI. Elusive form VI can be obtained by controllingthe humidity levels during desolvation of the solvate. This work not only realizes the regulation of betterphysicochemical properties of axtinnib for industrial manufacturing, but also provides a detailed understandingof the structure–property relationship of drugs in complex polymorphic systems.

Stability of phenolic acids and the effect on weed control activity

Li, Jiayu,Zhang, Qi,Hu, Wenwen,Yang, Xiaoyan,He, Haibin 한국응용생명화학회 2015 Applied Biological Chemistry (Appl Biol Chem) Vol.58 No.6

Phenolic acid is a very important class of allelochemicals with allelopathic weed control activity. In this study, three benzoic acid derivatives (syringic, 4-hydroxybenzoic, and vanillic acids), three cinnamic acid derivatives (cinnamic, 4-hydroxycinnamic, and ferulic acids) were tested, and high-performance liquid chromatography was used to conduct a dynamic analysis on the changes in the concentration of phenolic acids in a bioassay based on the initial concentration and test time. The results showed that the concentration of individual phenolic acids and a solution of mixed phenolic acids decreased to a certain extent irrespective of environment, i.e., bioassay (4-7 days) or a ricegrowing environment, and a significant decrease in concentration was measured after 48 h. Based on the above results, the laboratory bioassay was conducted using a fresh solution of phenolic acids every 48 h. The results showed that the instability of phenolic acid could affect its weed control activity, and this effect was more significant for high concentrations of phenolic acids. On the other hand, changing the solution did not have a significant impact on the weed control activity of phenolic acids in the natural environment (pH 6.50), in which allelopathic rice release phenolic acids. These results reveal the instability of phenolic acids could significantly reduce the inhibition rate on the growth index for receptor plants in an indoor bioassay.

Stability of phenolic acids and the effect on weed control activity

Jiayu Li,Qi Zhang,Wenwen Hu,Xiaoyan Yang,Haibin He 한국응용생명화학회 2015 Applied Biological Chemistry (Appl Biol Chem) Vol.58 No.6

Phenolic acid is a very important class of allelochemicals with allelopathic weed control activity. In this study, three benzoic acid derivatives (syringic, 4-hydroxybenzoic, and vanillic acids), three cinnamic acid derivatives (cinnamic, 4-hydroxycinnamic, and ferulic acids) were tested, and high-performance liquid chromatography was used to conduct a dynamic analysis on the changes in the concentration of phenolic acids in a bioassay based on the initial concentration and test time. The results showed that the concentration of individual phenolic acids and a solution of mixed phenolic acids decreased to a certain extent irrespective of environment, i.e., bioassay (4–7 days) or a ricegrowing environment, and a significant decrease in concentration was measured after 48 h. Based on the above results, the laboratory bioassay was conducted using a fresh solution of phenolic acids every 48 h. The results showed that the instability of phenolic acid could affect its weed control activity, and this effect was more significant for high concentrations of phenolic acids. On the other hand, changing the solution did not have a significant impact on the weed control activity of phenolic acids in the natural environment (pH 6.50), in which allelopathic rice release phenolic acids. These results reveal the instability of phenolic acids could significantly reduce the inhibition rate on the growth index for receptor plants in an indoor bioassay.

Visit-to-Visit Variability of Lipids Measurements and the Risk of Stroke and Stroke Types: A Prospective Cohort Study

Anxin Wang,Haibin Li,Jinhuan Yuan,Yingting Zuo,Yijun Zhang,Shouhua Chen,Shouling Wu,Yongjun Wang 대한뇌졸중학회 2020 Journal of stroke Vol.22 No.1

Background and Purpose Previous studies suggested increased visit-to-visit variability of total cholesterol (TC) is associated with stroke. This study aimed to investigate the associations of various lipids measurements variability and the risk of stroke and stroke type (ischemic and hemorrhagic stroke). Methods Fifty-one thousand six hundred twenty participants in the Kailuan Study without history of myocardial infarction, stroke, and cancer who underwent three health examinations during 2006 to 2010 were followed for incident stroke. Variability in TC, triglycerides, high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) measurements were measured using the coefficient of variation (CV), standard deviation (SD), variability independent of the mean (VIM), and average real variability (ARV). Results During a median of 6.04 years of follow-up, 1,189 incident stroke (1,036 ischemic and 160 hemorrhagic stroke) occurred. In the multivariable-adjusted model, the hazard ratio (HR) comparing participants in the highest versus lowest quartile of CV of HDL-C were 1.21 (95% confidence interval [CI], 1.02 to 1.45; P for trend=0.013) for ischemic stroke. The highest quartile of CV of LDL-C was associated with 2.17-fold risk of hemorrhagic stroke (HR, 2.17; 95% CI, 1.25 to 3.75; P for trend=0.002) compared with the lowest quartile. We did not observe any significant association between TC and triglycerides variability with any of stroke. Consistent results were obtained when calculating variability index using SD, VIM, or ARV. Conclusions These findings suggest the high visit-to-visit HDL-C and LDL-C variability were associated with an increased incidence of ischemic and hemorrhagic stroke, respectively.