CXCL-13 Regulates Resistance to 5-Fluorouracil in Colorectal Cancer

Guolin Zhang,Xin Luo,Wei Zhang,Engeng Chen,Jianbin Xu,Fei Wang,Gaoyang Cao,Zhenyu Ju,Dongai Jin,Xuefeng Huang,Wei Zhou,Zhangfa Song 대한암학회 2020 Cancer Research and Treatment Vol.52 No.2

Purpose 5-Fluorouracil (5-Fu) is used as a conventional chemotherapy drug in chemotherapy for patients with advanced colorectal cancer, but many patients still suffer from treatment failure due to 5-Fu resistance. Emerging observations revealed the important role of chemokine (C-X-C motif) ligand 13 (CXCL-13) in tumor microenvironment and its relationship with prognosis in patients with colorectal cancer. This study is designed to reveal the important role of CXCL-13 in causing colorectal cancer resistance to 5-Fu. Materials and Methods CXCL-13 levels of patient's serum or cell culture supernatants were measured separately by enzyme-linked immunosorbent assay. In cell assays, cell viability is detected by Cell Counting Kit-8. Therefore, the recombinant human CXCL-13 was used to simulate its high expression in cells while its antibody and siRNA were used to reduce CXCL-13 expression in cells. Results In this study, we demonstrated that CXCL-13 is associated with 5-Fu resistance by culture medium exchange experiments and cytokine arrays of colorectal cancer resistant and nonresistant cells. Clinical studies showed that CXCL-13 is highly expressed in the serum of 5-Fu–resistant patients. High levels of serum CXCL-13 also predict a worse clinical outcome. The addition of recombinant CXCL-13 cytokine resulted in 5-Fu resistance, while its antibody overcame 5-Fu resistance, and knockdown of CXCL-13 expression by siRNA also reduced 5-Fu resistance, which can be saved by added recombination CXCL-13. Conclusion These results not only identify a CXCL-13 mediated 5-Fu resistance mechanism but also provide a novel target for 5-Fu–resistant colorectal cancer in prevention and treatment strategies.

Chinese Society of Allergy Guidelines for Diagnosis and Treatment of Allergic Rhinitis

Lei Cheng,Jianjun Chen,Qingling Fu,Shaoheng He,Huabin Li,Zheng Liu,Guolin Tan,Zezhang Tao,Dehui Wang,Weiping Wen,Rui Xu,Yu Xu,Qintai Yang,Chonghua Zhang,Gehua Zhang,Ruxin Zhang,Yuan Zhang,Bing Zhou,Do 대한천식알레르기학회 2018 Allergy, Asthma & Immunology Research Vol.10 No.4

Allergic rhinitis (AR) is a global health problem that causes major illnesses and disabilities worldwide. Epidemiologic studies have demonstrated that the prevalence of AR has increased progressively over the last few decades in more developed countries and currently affects up to 40% of the population worldwide. Likewise, a rising trend of AR has also been observed over the last 2-3 decades in developing countries including China, with the prevalence of AR varying widely in these countries. A survey of self-reported AR over a 6-year period in the general Chinese adult population reported that the standardized prevalence of adult AR increased from 11.1% in 2005 to 17.6% in 2011. An increasing number of original articles and imporclinical trials on the epidemiology, pathophysiologic mechanisms, diagnosis, management and comorbidities of AR in Chinese subjects have been published in international peer-reviewed journals over the past 2 decades, and substantially added to our understanding of this disease as a global problem. Although guidelines for the diagnosis and treatment of AR in Chinese subjects have also been published, they have not been translated into English and therefore not generally accessible for reference to non-Chinese speaking international medical communities. Moreover, methods for the diagnosis and treatment of AR in China have not been standardized entirely and some patients are still treated according to regional preferences. Thus, the present guidelines have been developed by the Chinese Society of Allergy to be accessible to both national and international medical communities involved in the management of AR patients. These guidelines have been prepared in line with existing international guidelines to provide evidence-based recommendations for the diagnosis and management of AR in China.

Facile Fabrication of Non-fluorinated Durable Superhydrophobic Cotton Fabric

Guolin Zheng,Yuhe Wu,Dan Zhang,Shuai Liu,Zhu Long,Rong Li 한국섬유공학회 2020 Fibers and polymers Vol.21 No.11

The superhydrophobic surface is easy to lose the superhydrophobicity in the practical applications, due to the factthat the micro- and nanoscale rough structure is easily damaged. Therefore, it is one of the challenges to endow solid surfacewith durable superhydrophobic property. In this work, the environment-friendly superhydrophobic cotton fabric was preparedby dip-coating methodology. Meanwhile, the cotton fabric was endowed with durable superhydrophobicity. Herein, theoctadecylamine was utilized to reduce the surface free energy of cotton fabric. However, octadecylamine was only adsorbedon the fabric surface. Therefore, the hydrophobic resin was employed to supply enough adhesion force. As a result, thelimitation that traditional methods frequently utilize additional nanoparticles to construct hierarchical rough surfaces wasbroken. The water contact angles of the coated cotton fabric at room temperature and 70 oC reached 154.4±0.6 o and120±1.1 o, respectively. Moreover, the coated cotton fabric still reserved superhydrophobic property after 30th cycle’sabrasion and exhibited excellent hydrophobicity after 500th cycle’s abrasion. In addition, the surface free energy of originalcotton fabric reduced by 54.7 % so that the coated cotton fabric had outstanding repellency to hydrochloric acid, sodiumhydroxide solution, coffee and sodium chloride solution, respectively.

User Bandwidth Demand Centric Soft-Association Control in Wi-Fi Networks

( Guolin Sun ),( Sebakara Samuel Rene Adolphe ),( Hangming Zhang ),( Guisong Liu ),( Wei Jiang ) 한국인터넷정보학회 2017 KSII Transactions on Internet and Information Syst Vol.11 No.2

To address the challenge of unprecedented growth in mobile data traffic, ultra-dense network deployment is a cost efficient solution to offload the traffic over some small cells. The overlapped coverage areas of small cells create more than one candidate access points for one mobile user. Signal strength based user association in IEEE 802.11 results in a significantly unbalanced load distribution among access points. However, the effective bandwidth demand of each user actually differs vastly due to their different preferences for mobile applications. In this paper, we formulate a set of non-linear integer programming models for joint user association control and user demand guarantee problem. In this model, we are trying to maximize the system capacity and guarantee the effective bandwidth demand for each user by soft-association control with a software defined network controller. With the fact of NP-hard complexity of non-linear integer programming solver, we propose a Kernighan Lin Algorithm based graph-partitioning method for a large-scale network. Finally, we evaluated the performance of the proposed algorithm for the edge users with heterogeneous bandwidth demands and mobility scenarios. Simulation results show that the proposed adaptive soft-association control can achieve a better performance than the other two and improves the individual quality of user experience with a little price on system throughput.

Ultra-lightweight Poly(Sodium Acrylate) Modified TEMPO-oxidized Cellulose Nanofibril Aerogel Spheres and Their Superabsorbent Properties

Fang Zhang,Hao Ren,Guolin Tong 한국펄프·종이공학회 2016 한국펄프·종이공학회 학술발표논문집 Vol.2016 No.10

Synthesis of core–shell structure UiO-66-NH2@Ni-MOF composite for the effective removal of uranium (VI)

Qin Zhang,Lijiao Fan,Wenbin Liu,Yuming Xie,Jiangang Li,Guolin Huang 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.124 No.-

The core–shell structure UiO-66-NH2@Ni-MOF was prepared by in-diffusion growth of 2D Ni-MOF onUiO-66-NH2 using PVP (polyvinylpyrrolidone) as a structural guide. It was applied to the adsorption ofU(VI) in aqueous solution. The materials were characterized by powder X-ray diffraction (PXRD),Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), transmission electronmicroscopy (TEM), and energy dispersive spectrometer (EDS). The UiO-66-NH2@Ni-MOF adsorptionto U(VI) was investigated experimentally. The study showed that the adsorption of U(VI) onto UiO-66-NH2@Ni-MOF was endothermic and spontaneous. At pH 5.00 and 308 K, the adsorption capacity was581.40 mg/g according to Langmuir model. In addition, the adsorption process can be described by thepseudo-second-order kinetic model. The adsorption capacity was kept at 83.83% of its original one afterfive sorption–desorption cycles, a promising indication for repetitive usage.

Application of Archimedean Copulas to the Analysis of Drought Decadal Variation in China

Dongdong Zuo,Guolin Feng,Zengping Zhang,Wei Hou 한국기상학회 2018 Asia-Pacific Journal of Atmospheric Sciences Vol.54 No.2

The joint probability and return period were calculated to analyze the drought characteristics and decadal variation. According to the fit analysis, the Gumbel-Hougaard copula provided the best fit to the observed data. Based on four drought duration classifications and four severity classifications, the drought events were divided into 16 drought types according to the different combinations of duration and severity classifications, and the probability and return period were analyzed for different drought types. The results showed that the occurring probability of six common drought types (0 < D ≤ 1 and 0.5 < S ≤ 1, 1 < D ≤ 3 and 0.5 < S ≤ 1, 1 < D ≤ 3 and 1 < S ≤ 1.5, 1 < D ≤ 3 and 1.5 < S ≤ 2, 1 < D ≤ 3 and 2 < S, and 3 < D ≤ 6 and 2 < S) accounted for 76% of the total probability of all types.

INFLUENCE OF TIRE BELT LAYER PRESSURE SHARE RATIO ON TIRE CONTOUR AND PERFORMANCE BASED ON NEW NON-NATURAL EQUILIBRIUM CONTOUR THEORY

Liang Chen,Li Han,Yang Jian,Wang Guolin,Zhang Lingxin 한국자동차공학회 2023 International journal of automotive technology Vol.24 No.2

Tire contour design theory has always been studied because of its significant effect on tire performance. Based on the new non-natural equilibrium contour theory, the influence of belt pressure share ratio on the carcass contour is studied. The type of 385 / 65R22.5 all-steel radial tire was chosen as the research object and the finite element analysis technique was adopted to calculate the belt pressure share ratio. The results show that with the increase of the belt pressure share ratio, the clamping effect of belt layer on the carcass is strengthened, the curvature of tire crown in carcass contour increases and the crown curve tends to be rounded. The influence of belt pressure share ratio on wear, footprint, rolling resistance and grip performance was also explored with the finite element technology. It turned out that with the increase of the belt pressure share ratio, the tire wear increased, rolling resistance reduced, grip performance enhanced.

Two new triterpenoid saponins derived from the leaves of Panax ginseng and their antiinflammatory activity

Li, Fu,Cao, Yufeng,Luo, Yanyan,Liu, Tingwu,Yan, Guilong,Chen, Liang,Ji, Lilian,Wang, Lun,Chen, Bin,Yaseen, Aftab,Khan, Ashfaq A.,Zhang, Guolin,Jiang, Yunyao,Liu, Jianxun,Wang, Gongcheng,Wang, Ming-Kui The Korean Society of Ginseng 2019 Journal of Ginseng Research Vol.43 No.4

Background: The leaves and roots of Panax ginseng are rich in ginsenosides. However, the chemical compositions of the leaves and roots of P. ginseng differ, resulting in different medicinal functions. In recent years, the aerial parts of members of the Panax genus have received great attention from natural product chemists as producers of bioactive ginsenosides. The aim of this study was the isolation and structural elucidation of novel, minor ginsenosides in the leaves of P. ginseng and evaluation of their antiinflammatory activity in vitro. Methods: Various chromatographic techniques were applied to obtain pure individual compounds, and their structures were determined by nuclear magnetic resonance and high-resolution mass spectrometry, as well as chemical methods. The antiinflammatory effect of the new compounds was evaluated on lipopolysaccharide-stimulated RAW 264.7 cells. Results and conclusions: Two novel, minor triterpenoid saponins, ginsenoside $LS_1$ (1) and 5,6-didehydroginsenoside $Rg_3$ (2), were isolated from the leaves of P. ginseng. The isolated compounds 1 and 2 were assayed for their inhibitory effect on nitric oxide production in LPS-stimulated RAW 264.7 cells, and Compound 2 showed a significant inhibitory effect with $IC_{50}$ of $37.38{\mu}M$ compared with that of NG-monomethyl-L-arginine ($IC_{50}=90.76{\mu}M$). Moreover, Compound 2 significantly decreased secretion of cytokines such as prostaglandin $E_2$ and tumor necrosis factor-${\alpha}$. In addition, Compound 2 significantly suppressed protein expression of inducible nitric oxide synthase and cyclooxygenase-2. These results suggested that Compound 2 could be used as a valuable candidate for medicinal use or functional food, and the mechanism is warranted for further exploration.