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Liu, Jia,Ge, Yang-Yang,Zhu, Hong-Cheng,Yang, Xi,Cai, Jing,Zhang, Chi,Lu, Jing,Zhan, Liang-Liang,Qin, Qin,Yang, Yan,Yang, Yue-Hua,Zhang, Hao,Chen, Xiao-Chen,Liu, Zhe-Ming,Ma, Jian-Xin,Cheng, Hong-Yan,S Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.16
Radiation therapy is an important treatment for head and neck squamous cell carcinoma (HNSCC). However, how to promote radiation sensitivity in HNSCC remains a challenge. This study aimed to investigate the radiosensitizing effects of fenofibrate on HNSCC and explore the underlying mechanisms. HNSCC cell lines CNE-2 and KB were subjected to ionizing radiation (IR), in the presence or absence of fenofibrate treatment. Cell growth and survival, apoptosis and cell cycle were evaluated. In addition, CNE-2 cells were xenografted into nude mice and subjected to IR and/or fenofibrate treatment. The expression of cyclinB and CDK1 was detected by Western blotting. Our results showed that fenofibrate efficiently radiosensitized HNSCC cells and xenografts in mice, and induced apoptosis and G2/M arrest via reducing the activity of the CDK1/cyclinB1 kinase complex. These data suggest that fenofibrate could be a promising radiosensitizer for HNSCC radiotherapy.
Maltol Inhibits Apoptosis of Human Neuroblastoma Cells Induced by Hydrogen Peroxide
Yang, Yang,Wang, Jian,Xu, Caimin,Pan, Huazhen,Zhang, Zinan Korean Society for Biochemistry and Molecular Biol 2006 Journal of biochemistry and molecular biology Vol.39 No.2
To analyze the effect of Maltol on the apoptosis of Human Neuroblastoma Cells (SH-SY5Y) treated by free radical which was generated from Hydrogen Peroxide ($H_2O_2$), flow cytometry analysis on Phosphatidylserine (PS) inverting percentage was applied to determine the apoptosis. MTT (3-(4,5-dimethythiazol-2-yl)-2,5-diphenyl-tetrazolium bromide) assay was employed to analyze the cell viability. DNA electrophoresis was used to detect DNA fragmentation. Moreover intracellular calcium of concentration ($[Ca^{2+}]_i$) was measured by fluorescence emission. Flow cytometry analysis on the function of mitochondria and Western blto analysis of NF-${\kappa}B$. The results showed that the pretreatment with maltol for 2 hours could prevent the $H_2O_2$-induced apoptosis. Maltol could reduce the inverting percentage of PS, DNA fragmentation and $[Ca^{2+}]_i$, and enhance the cellular function of mitochondria. NF-${\kappa}B$ activated by $H_2O_2$ is reduced. The experiments suggest that maltol could effectively inhibit the apoptosis induced by $H_2O_2$. As a novel anti-oxidant, maltol is a new promising drug in protecting the neurological cells from the damage by free radical.
Jian-yang Xue,Liangjie Qi,Kun Yang,Zhanjing Wu 국제구조공학회 2017 Structural Engineering and Mechanics, An Int'l Jou Vol.63 No.5
In order to study the failure mode and seismic behavior of the interior-joint in steel traditional-style buildings, a single beam-column joint and a double beam-column joint were produced according to the relevant building criterion of ancient architectural buildings and the engineering instances, and the dynamic horizontal loading test was conducted by controlling the displacement of the column top and the peak acceleration of the actuator. The failure process of the specimens was observed, the bearing capacity, ductility, energy dissipation capacity, strength and stiffness degradation of the specimens were analyzed by the load-displacement hysteresis curve and backbone curve. The results show that the beam end plastic hinge area deformed obviously during the loading process, and tearing fracture of the base metal at top and bottom flange of beam occurred. The hysteresis curves of the specimens are both spindle-shaped and plump. The ultimate loads of the single beam-column joint and double beam-column joint are 48.65 kN and 70.60 kN respectively, and the equivalent viscous damping coefficients are more than 0.2 when destroyed, which shows the two specimens have great energy dissipation capacity. In addition, the stiffness, bearing capacity and energy dissipation capacity of the double beam-column joint are significantly better than that of the single beam-column joint. The ductility coefficients of the single beam-column joint and double beam-column joint are 1.81 and 1.92, respectively. The cracks grow fast when subjected to dynamic loading, and the strength and stiffness degradation is also degenerated quickly.
Jian-yang Xue,Linlin Ma,Zhanjing Wu 한국강구조학회 2018 International Journal of Steel Structures Vol.18 No.2
This paper presents experimental study and fi nite-element analysis (FEA) on seismic performance of steel joints between double beams and column (DBC) in Chinese traditional style buildings. Eight 1/2-scaled DBC joints were designed according to the principle of “strong-member and weak-joint” and tested under low cyclic reversed loading. The failure modes, hysteresis loops, skeleton curves, ductility and energy-dissipation capacity of the joints were analyzed. It is shown that the failure modes of the joints were shear buckling at lower panel zone, bending failure at middle panel zone, and welds fracturing at the panel zone of the joints. The section types of beams, axial compression ratio, and joint forms between double beams and column had signifi cant impacts on the bearing capacity of the joints. The bearing capacity of the joints decreased as the axial compression ratio increased. Moreover, the bearing capacity of the joints with box beams was larger than that of the joints with H-section beams. Elaborate FEA models of the joints were presented, and a preliminary FEA was fi rst performed to predict the mechanical properties and hysteretic behaviors of the joints. The results of FEA were correlated well with those of test, and the eff ect of the panel zone thickness on mechanical behaviors of the joints was analyzed, which indicated that the simplifi ed FEA model could provide a powerful tool for future research in design methods of DBC joints in Chinese traditional style buildings.
Yang, Nian-Qin,Zhang, Jian,Tang, Qun-Ye,Guo, Jian-Ming,Wang, Guo-Min Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.15
To investigate the role of miR-1297 and the tumor suppressor gene PTEN in cell proliferation of testicular germ cell tumors (TGCT). MTT assays were used to test the effect of miR-1297 on proliferation of the NCCIT testicular germ cell tumor cell line. In NCCIT cells, the expression of PTEN was assessed by Western blotting further. In order to confirm target association between miR-1297 and 3'-UTR of PTEN, a luciferase reporter activity assay was employed. Moreover, roles of PTEN in proliferation of NCCIT cells were evaluated by transfection of PTEN siRNA. Proliferation of NCCIT cells was promoted by miR-1297 in a concentration-dependent manner. In addition, miR-1297 could bind to the 3'-UTR of PTEN based on luciferase reporter activity assay, and reduced expression of PTEN at protein level was found. Proliferation of NCCIT cells was significantly enhanced after knockdown of PTEN by siRNA. miR-1297 as a potential oncogene could induce cell proliferation by targeting PTEN in NCCIT cells.
Power–Delay Tradeoff in Wireless Powered Communication Networks
Yang, Jian,Yang, Qinghai,Kwak, Kyung Sup,Rao, Ramesh R. IEEE 2017 IEEE Transactions on Vehicular Technology VT Vol.66 No.4
<P>In this paper, we investigate the power-delay tradeoff for the newly emerging wireless powered communication networks, in which wireless powered devices (WPDs) harvest energy from a power station via wireless energy transfer in the downlink and then communicate with an information receiving station in the uplink. Each WPD is equipped with an energy buffer and a data buffer to store the random harvested energy and the bursty data arrivals, respectively. To minimize the time-averaged power consumption, a stochastic optimization problem is formulated subject to both constraints of data queue stability and harvested energy availability. By employing Lyapunov optimization theory, we transform the stochastic optimization problem into a series of deterministic problems, where each is further proved to become the standard convex optimization problem and, hence, can be effectively and optimally solved by standard convex optimization techniques. Correspondingly, we propose an Online Power and TIMe Allocation (Optima) algorithm, which requires no a priori distribution knowledge of channel states and data arrivals. Most importantly, the proposed algorithm achieves the power-delay tradeoff as [O(1/V), O(V)], with V being a system control parameter, and provides a significant method to control the power-delay performance on demand in system design. Simulation results verify the theoretical analysis and validate the effectiveness of the proposed algorithm.</P>
Analysis on the Increasing Marginal Revenue of the Network Economy
YANG JIAN 국제융합경영학회 2018 융합경영연구 Vol.6 No.3
On the basis of discussing the network economy concept and the commentary of the marginal revenue decreasing of traditional economic theory, The concept of network economy has just been put forward in recent years. The reason why such a concept appears is that the information technology, marked by computer network, plays an increasingly important role in economic activities. Some people define network economy as an economic form based on network technology and human capital. this paper points out network economy existing the marginal revenue increasing and analyzes the reasons that influencing the marginal revenue increasing.