Definitive extended field intensity-modulated radiotherapy and concurrent cisplatin chemosensitization in the treatment of IB2-IIIB cervical cancer

Guangyu Zhang,Fangfang He,Chunli Fu,Youzhong Zhang,Qiuan Yang,Jianbo Wang,Yufeng Cheng 대한부인종양학회 2014 Journal of Gynecologic Oncology Vol.25 No.1

Objective: To assess the toxicity of delivering extended field intensity-modulated radiotherapy (EF-IMRT) and concurrent cisplatin chemotherapy for locally advanced cervical carcinoma. Methods: Forty-five patients who underwent EF-IMRT and concurrent cisplatin chemotherapy for the treatment of stage IB2 to IIIB cervical cancer were retrospectively reviewed. The clinical target volume included all areas of gross and potentially microscopic disease and regional lymph node regions. All patients underwent high-dose-rate brachytherapy. The acute and late toxicity were scored using the Common Terminology Criteria for Adverse Events and the Radiation Therapy Oncology Group late radiation morbidity scoring criteria, respectively. Results: The median follow-up was 28 months (range, 5 to 62 months). Forty-two patients had a complete response, and three had a persistent disease. Of those 42 patients, 15 patients (35.7%) had recurrence. The regions of recurrence were in-field in 2 patients and out-field in 13 patients. Acute grade ≥3 gastrointestinal, genitourinary and hematologic toxicity occurred in 3, 1, and 9 patients, respectively. Three patients (6.7%) suffered from late grade 3 toxicities. Seven patients experienced ovarian transposition, 5 of those patients (71%) maintained ovarian function. Thirty-eight patients (84.4%) were alive at the last follow-up. Conclusion: Concurrent cisplatin chemotherapy with EF-IMRT was safe. The acute and late toxicities are acceptable. EF-IMRT provides an opportunity to preserve endocrine function for patients with ovarian transposition.

港口水工布局對海灣環境的影響

장광옥(Zhang Guangyu) 한국항만경제학회 1994 韓國港灣經濟學會誌 Vol.10 No.-

Many ecological indices in sea water are influenced by the flow pattern. so the natural purification mechanism in the bay. such as, water exchange. distribution in time and space of the ecological system indices etc, will change with the flow pattern of the water. the natural dynamic topography wilt change for the water engineering, and the flow pattern will be influenced, so the bay ecological environment will be influenced. This effect is more evident for the bay which has absorption function of pollution. Assessment of the environment for every harbor layout schemes is one of the important contents for the stage of layout and design.<br/> The effects to the flow pattern are studied in this paper caused by the habour water engineering, and changes of the ecological environment in bay is also studied, A method and thinking way is given to the optimization of water engineering layout schemes. It is a benefical test to combine modern environment science with traditional ways of harbour layout and design. Besides the environment assessment and optimization of general layout scheme of YanTian harbour is concluded from the results of this article.

Comparison of Monoexponential, Biexponential, Stretched-Exponential, and Kurtosis Models of Diffusion-Weighted Imaging in Differentiation of Renal Solid Masses

Jianjian Zhang,Shiteng Suo,Guiqin Liu,Shan Zhang,Zizhou Zhao,Jianrong Xu,Guangyu Wu 대한영상의학회 2019 Korean Journal of Radiology Vol.20 No.5

Objective: To compare various models of diffusion-weighted imaging including monoexponential apparent diffusion coefficient (ADC), biexponential (fast diffusion coefficient [Df], slow diffusion coefficient [Ds], and fraction of fast diffusion), stretched-exponential (distributed diffusion coefficient and anomalous exponent term [α]), and kurtosis (mean diffusivity and mean kurtosis [MK]) models in the differentiation of renal solid masses. Materials and Methods: A total of 81 patients (56 men and 25 women; mean age, 57 years; age range, 30–69 years) with 18 benign and 63 malignant lesions were imaged using 3T diffusion-weighted MRI. Diffusion model selection was investigated in each lesion using the Akaike information criteria. Mann–Whitney U test and receiver operating characteristic (ROC) analysis were used for statistical evaluations. Results: Goodness-of-fit analysis showed that the stretched-exponential model had the highest voxel percentages in benign and malignant lesions (90.7% and 51.4%, respectively). ADC, Ds, and MK showed significant differences between benign and malignant lesions (p < 0.05) and between low- and high-grade clear cell renal cell carcinoma (ccRCC) (p < 0.05). α was significantly lower in the benign group than in the malignant group (p < 0.05). All diffusion measures showed significant differences between ccRCC and non-ccRCC (p < 0.05) except Df and α (p = 0.143 and 0.112, respectively). α showed the highest diagnostic accuracy in differentiating benign and malignant lesions with an area under the ROC curve of 0.923, but none of the parameters from these advanced models revealed significantly better performance over ADC in discriminating subtypes or grades of renal cell carcinoma (RCC) (p > 0.05). Conclusion: Compared with conventional diffusion parameters, α may provide additional information for differentiating benign and malignant renal masses, while ADC remains the most valuable parameter for differentiation of RCC subtypes and for ccRCC grading.

An experimental study on positioning conformance control of starch gelant in the heterogeneous porous media by using CT technology

Lei Zhang,Hongming Xu,Chunsheng Pu,Guangyu Yuan,Guangyao Leng,Chunlei Zhang 한국공업화학회 2017 Journal of Industrial and Engineering Chemistry Vol.54 No.-

In order to increase the economic efficiency of conformance control in the time of low oil price, a gelant should be injected into the specified location (positioning conformance control) to improve the swept volume in the maximum extent in the heterogeneous oil reservoir. For this purpose, an in-situ crosslinking polymer gelant (it is consisting of modified starch, acrylamide, N, N'- methylene diacrylamide, and potassium persulfate) is taken as the object of study by CT scan. Based on the dynamic and visible images of fluids distribution in the porous media, the gelant can be used to achieve the positioning conformance control because it can almost maintain a whole slug during transportation in porous media. According to the relationship of transportation distance and injection volume of the gelant in porous media, the gelant can be displaced to the specified location in porous media. In addition, the characteristics of water flooding of heterogeneous porous media before and after positioning conformance control are studied by CT scan, which can investigate the function of positioning conformance control and the extent of improving the swept volume in the heterogeneous reservoirs. The experimental results in this paper can provide theoretical guidance for the practical application of positioning conformance control in the heterogeneous oil reservoirs.

Combined effect of Fe2O3 and Cr2O3 on the structure and properties of glass-ceramics prepared from Baotou steel blast furnace slag

Guangyu Wang,Yongsheng Du,Jie Ma,Hongxia Zhang,Shunli Ouyang,Leibo Deng,Hua Chen,Ming Zhao 한양대학교 세라믹연구소 2021 Journal of Ceramic Processing Research Vol.22 No.6

CaO-MgO-Al2O3-SiO2 glass-ceramics were successfully prepared using Baotou Steel BFS as the raw materials, choosing Fe2O3and Cr2O3 as nucleating agents. This paper focused on analyzing the combined effect of Fe2O3 and Cr2O3 on the structure andproperties of the glass-ceramics. Experimental results showed that the crystallization mechanism of glass-ceramics convertedsurface crystallization into bulk crystallization and the main crystalline phase of glass-ceramics changed gradually from augiteto diopside with the decrease of Fe2O3/Cr2O3 ratios. Therefore, an appropriate ratio of Fe2O3/Cr2O3 can act as nuclei forcrystallization of augite with integrated interlocking crystal structure and the physicochemical properties of glass-ceramic canbe improved. Consequently, the fracture mode of glass-ceramic was changed from intercrystalline to mixed transcrystalline/intercrystalline and therefore the average crack length can be shortened. Glass-ceramic with Fe2O3/Cr2O3 ratio of 1 had a highbending strength of 138.93 MPa, Vickers hardness of 7.51 GPa and acid resistance of 97.75%.

Efficacy of Different Number of XELOX or SOX Chemotherapy Cycles After D₂ Resection for Stage III Gastric Cancer

Yu, Yuanyuan,Zhang, Zicheng,Meng, Qianhao,Wang, Ke,Li, Qingwei,Ma, Yue,Yao, Yuanfei,Sun, Jie,Wang, Guangyu The Korean Gastric Cancer Association 2022 Journal of gastric cancer Vol.22 No.2

Purpose: We aimed to explore whether the prognosis of patients treated with capecitabine and oxaliplatin (XELOX) or S-1 and oxaliplatin (SOX) regimens who received fewer cycles of chemotherapy after D2 radical resection for gastric cancer (GC) would be non-inferior to that of patients who received the standard number of cycles of chemotherapy. Materials and Methods: Data on patients who received XELOX or SOX chemotherapy after undergoing D2 radical resection at Harbin Medical University Cancer Hospital between January 2011 and May 2016 were collected. Results: In patients who received 4, 6, and 8 cycles of chemotherapy, the 5-year overall survival (OS) rates were 59.4%, 64.8%, and 62.7%, respectively. Compared to patients who received 4 cycles of chemotherapy, those who received 6 cycles (hazard ratio [HR], 0.882; 95% confidence interval [CI], 0.599-1.299; P=0.52) or 8 cycles (HR, 0.882; 95% CI, 0.533-1.458; P=0.62) of chemotherapy did not exhibit significantly prolonged OS. The 3-year disease-free survival (DFS) rate of patients who received 4, 6, and 8 cycles of chemotherapy was 62.1%, 67.2%, and 60.8%, respectively. Compared to patients who received 4 cycles of chemotherapy, those who received 6 cycles (HR, 0.835; 95% CI, 0.572-1.221; P=0.35) or 8 cycles (HR, 0.972; 95% CI, 0.606-1.558; P=0.91) of chemotherapy did not show significantly prolonged DFS. However, the 3-year DFS and 5-year OS rates of patients who received 6 cycles of chemotherapy appeared to be superior to those of patients who received 4 and 8 cycles of chemotherapy. Conclusions: For patients with stage III GC, 4 to 6 cycles of XELOX or SOX chemotherapy may be a favorable option. This study provides a rationale for further randomized clinical trials.

Preparation of Al2O3/AZ91D Mg Interpenetrating Composites Using Lost Foam Casting Combined with Layered Extrusion Forming

Wenming Jiang,Guangyu Li,Feng Guan,Junwen Zhu,Dongping Zhang,Zitian Fan 대한금속·재료학회 2022 METALS AND MATERIALS International Vol.28 No.4

A novel method named lost foam casting (LFC) process combined with layered extrusion forming (LEF) technology wasproposed to prepare the Al2O3/AZ91D Mg interpenetrating composites, and the microstructural characteristics, thermalexpansion performance and wear resistance of the Al2O3/AZ91D interpenetrating composites were investigated in this work. The results indicated that a superior bonding between AZ91D magnesium alloy and Al2O3porous ceramic was achieved. The Al2O3/AZ91D interpenetrating composites exhibited obvious improvements in the thermal expansion performance andthe wear resistance compared to the AZ91D alloy. Therefore, the LFC process combined with the LEF technology providesa promising method for the preparation of the Al2O3/AZ91D interpenetrating composites.

An Improved Affinity Propagation Clustering Algorithm Based on Entropy Weight Method and Principal Component Analysis

Wang Limin,Zhang Li,Han Xuming,Ji Qiang,Mu Guangyu,Liu Ying 보안공학연구지원센터 2016 International Journal of Database Theory and Appli Vol.9 No.6

Traditional affinity propagation algorithm has inefficient results when conducting clustering analysis of high dimensional data because "dimension effect" lead to difficult find the proper class structure .In view of this, the author proposes an improved algorithm on the basis of Entropy Weight Method and Principal Component Analysis (EWPCA-AP). EWPCA-AP algorithm empowers the sample data by Entropy Weight Method, eliminate data irrelevant attributes by Principal Component Analysis, and travel with neighbor clustering algorithm, realization of high-dimensional data clustering in low dimension space. The numerical result of simulation experiment shows that the new EWPCA-AP algorithm can effectively eliminate the redundancy and irrelevant attributes of data and improve the performance of clustering. In addition, the proposed algorithm is applied in the area of the economy in our country and the clustering result is consistent with the real one. This algorithm provides a new intelligent evaluation method for Chinese economy.

The Evolutionary Response of Alcohol Dehydrogenase and Aldehyde Dehydrogenases of Acetobacter pasteurianus CGMCC 3089 to Ethanol Adaptation

Yu Zheng,Keping Zhang,Guangyu Su,Qi Han,Yanbing Shen,Min Wang 한국식품과학회 2015 Food Science and Biotechnology Vol.24 No.1

The acetic acid bacterium Acetobacter pasteurianus is used for vinegar fermentation with ethanol as a substrate. However, growth of A. pasteurianus is inhibited by high ethanol concentrations. The ethanol resistance of A. pasteurianus CGMCC 3089 was improved using a continuous ethanol stress adaptation culture. Characterization studies of strains during evolutionary processes were performed for improved ethanol resistance by comparison of cell growth and alcohol dehydrogenase (ADH) and aldehyde dehydrogenases (ALDH) activities. Improved resistance against ethanol was an inheritable phenotype instead of a transient physiologic adaptation. The evolutionary response of ADH and ALDH to high concentrations of ethanol was responsible for the ethanol resistance of A. pasteurianus, instead of mutations in the open reading frames of ADH and ALDH, or long nucleotide sequence insertion or deletion in the genome.

Computational fluid dynamics simulation study of gas flow in dry vacuum pump

Xiangji YUE,Yingli ZHANG,Dechun BA,Yaoshuai BA,Yanjun LU,Guangyu WANG 한국진공학회 2016 한국진공학회 학술발표회초록집 Vol.2016 No.8