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Dajeong Shin,Byoungok Cho,Jaeyoung Shin,Jihyeon Park,Feng Wang,Suping Hao,Eunseo Kang,Seonil Jang 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
Oxidative stress in neurons causes DNA breakdown, cell membrane damage, and neuronal cell death, and can cause neurodegenerative changes. Recently, research interest in discovering herbal medicine materials that can protect cells from oxidative stress is increasing. Humulus japonicus, Diospyros lotus, Zingiber officinale and Red Ginseng are oriental medicine materials that have been used in traditional medicine in Korea and China. In the present study we evaluated the ameliorative effects of H. japonicus, D. lotus, Z. officinale and Red Ginseng extracts mixture (HDZR) against 6-OHDA-induced oxidative stress in microglia. As a result, HDZR restored cells damaged by 6-OHDA in microglia. HDZR pretreatment protected the microglia against oxidative stress by reducing cell death, apoptosis and reactive oxygen species generation. HDZR pretreatment also increased superoxide dismutase and catalase enzyme activity. Moreover, HDZR activated the Nrf2/HO-1 pathway. Taken together, these results showed that HDZR treatment has potential as a therapeutic agent against neuron injury through the suppression of oxidative stress.
Jihyeon Park,Eunseo Kang,Jaeyoung Shin,Byoungok Cho,Feng Wang,Suping Hao,Dajeong Shin,Seonil Jang 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
A normal inflammatory response is essential to protect the body from foreign substances. However, excessive inflammation contributes to diseases such as oxidative stress, heart disease and cancer. In this study, we investigated the anti-inflammatory effects of red ginseng marc, Artemisia scoparia, Paeonia japonica, and Angelica gigas (RAPA) extract mixture in LPS-stimulated RAW 264.7 cell. As a result, RAPA suppressed the expression of inflammatory factors such as iNOS and COX-2 and decreased the production of nitric oxide. In addition, RAPA decreased the expression of inflammatory cytokines TNF-α and IL-6. Furthermore, RAPA inhibited the phosphorylation of MAPKs and NF-κB. In conclusion, RAPA inhibited nitric oxide production by inhibiting iNOS expression and inhibited inflammatory cytokine production by down-regulating MAPK and Nf-κB signaling pathways in LPS-Stimulated RAW 264.7 cells. The results of this study suggest that RAPA can be used as a material to control excessive inflammatory responses.
바이오매스로부터 생산한 바이오차에 의한 수질오염물질 흡착 : Adsorption of Water Pollution by Biochar Produced from Biomass
박윤,정수연,정은서,신윤정,이은주,이재원 전남대학교 농업과학기술연구소 2022 농업생명과학연구동향 Vol.60 No.-
Biochar is produced from lignocellulosic biomass (wood, agricultural and forestry waste, etc.) through thermal decomposition at high temperature. Water pollution (pesticides, dyes, heavy metals, and volatile organic compounds [VOCs]) can be efficiently removed by biochar. In particular, waste biomass is typically used as fuel or thrown away; thus, it is necessary to determine a valuable utilization for it. The process of biochar production is simple and suitable for the production of porous structures. In this paper, 1) biochar production and its characteristics based on biomass types, 2) research trends on the adsorption of water pollution (pesticides, dyes, heavy metals, VOCs) on biochar, and 3) expected effects are discussed.