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Je‑Oh Lim,Je‑Won Ko,Tae‑Yang Jung,Woong‑Il Kim,So‑Won Pak,In‑Sik Shin,Won‑Kee Yun,Hyoung‑Chin Kim,Jeong‑Doo Heo,Jong‑Choon Kim 대한독성 유전단백체 학회 2020 Molecular & cellular toxicology Vol.16 No.3
Background Silica dioxide nanoparticles (SiONPs) have been used for various medical applications, including therapeutics and imaging, and the use of SiONPs has increased gradually over the years. However, despite an increase in the use of SiONPs, not much is known about mechanism of action of SiONPs and their pulmonary toxicity. Objective The present study investigated the pulmonary toxicity of SiONPs and explored the underlying mechanism of action, primarily focusing on thioredoxin-interacting protein (TXNIP)/NOD-like receptor pyrin domain-containing 3 (NLRP3) in SiONPs-treated mice. We investigated the toxic effects of SiONPs in the lung of BALB/c mice administered 5, 10, and 20 mg/kg SiONPs for 3 days. Results Exposure to SiONPs markedly increased inflammatory cell counts, including those of neutrophils and macrophages, and levels of inflammatory mediators, such as interleukin (IL)-1β, IL-6, and tumor necrosis factor-α in a dose-dependent manner in the bronchoalveolar lavage fluid. Moreover, the inflammation was verified upon histopathological analysis. In addition, exposure to SiONPs increased the expression of TXNIP in a dose-dependent manner and, in turn, upregulated NLRP3 inflammasome proteins, which subsequently induced IL-1β production. Conclusion Collectively, exposure to SiONPs induced inflammation in the lungs of mice, which resulted in the activation of IL-1β production via the TXNIP-NLRP3 axis. Our results provide useful information on the pulmonary toxicity induced by SiONPs and provide insights into the underlying mechanism of action.
포름알데하이드에 폭로된 해부학 실습 학생들의 임파구 자매염색분체교환
백두진,주수자,김기영,이수진,심상효,손정일,심성한,송재철,조율희 大韓産業醫學會 1998 대한직업환경의학회지 Vol.10 No.2
Sister-chromatid exchanges measured in the peripheral lymphocytes of 15 non-smoking medical students after exposure to formaldehyde during 24-week anatomy class showed a small but significant (p=0.0468) increase when compared with samples obtained from the same individuals immediately before exposure. Mean frequencies of sister-chromatid exchange of cultured peripheral lymphocytes were 5.40±0.24 from the samples before exposure and 5.87±0.22 from the same samples after exposure. Breathing-zone air samples collected by formaldehyde monitoring kit with digital colorimeter(SKC) showed a mean concentration of 0.72±0.02 ppm formaldehyde.
흥미로운 구조를 가진 Dipyrrolylbenzene들의 합성에 관한 연구
정대일,김인식,정두희,박철우,김윤영 東亞大學校 大學院 1996 大學院論文集 Vol.21 No.-
1-(2-Aminophenyl)pyrrole 20a and 1,2-dipyrrolylbenzene 17a were synthesized by using 1,2-phenylenediamine 16a with 2,5-dimethoxytetrahydrofuran 12 in glacial acid. 1-(3-Aminophenyl)pyrrole 20b and 1,3-dipyrrolylbenzene 17b were obtained by using 1,3-phenylenediamine 16b with 2,5-dimethoxytetrahydrofuran 12 in glacial acetic acid. 1,4-Dipyrrolybenzene 17c was synthesized by using 1,4-phenylenediamine 16c with 2,5-dimethoxytetrahydrofuran 12 in glacial acetic acid. Aminophenylpyrroles 20 and dipyrrolylbenzenes 17 were respectively synthesized by the treatment of 1,2-phenylenediamine 16a, 13-phenylenediamine 16b, 1,4-phenylenediamine 16c and 2,5-dimethoxytetrahydrofuran 12 in no solvent, acrylic acid, silica-gel, acrylic acid + silica-gel + acetic acid instead of glacial acetic acid. In case of silica-gel + acetic acid among various methods reactivity about synthesis of dipyrrolylbenzene 17 was best. 9-Phenylcarbazole 15 was synthesized by treatment of 1-phenylpyrrole 13 with 2,5-dimethoxytetrahydrofuran 12 in glacial acetic acid.
Jeong Il Yu,Doo Ho Choi,Seung Jae Huh,Won Park,Dongryul Oh,Duk Soo Bae 대한방사선종양학회 2013 Radiation Oncology Journal Vol.31 No.2
Purpose: We designed this study to identify and suggest the reasonable timing of adjuvant radiotherapy in the treatment of uterine carcinosarcoma according to the surgical intent and patterns of progression. Materials and Methods: We retrospectively analyzed a total of 50 carcinosarcoma patients diagnosed between 1995 and 2010. Among these 50 patients, 32 underwent curative surgery and 13 underwent maximal tumor debulking surgery. The remaining five patients underwent biopsy only. Twenty-six patients received chemotherapy, and 15 patients received adjuvant radiotherapy. Results: The median follow-up period was 17.3 months. Curative resection (p < 0.001) and stage (p < 0.001) were statistically significant factors affecting survival. During follow-up, 30 patients showed progression. Among these, eight patients (16.0%) had loco-regional progression only. The patients who had received adjuvant radiotherapy did not show loco-regional progression, and radiotherapy was a significant negative risk factor for loco-regional progression (p = 0.01). The time to loco-regional progression was much earlier for non-curative than curative resection (range, 0.7 to 7.6 months vs. 7.5 to 39.0 months). Conclusion: Adjuvant radiotherapy in the treatment of carcinosarcoma might be related to a low loco-regional progression rate. Radiotherapy should be considered in non-curatively resected patients as soon as possible.