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고 Mn-Cr 강의 조사손상에 미치는 전자선 조사 온도의 영향
배동수,정호신,강창용,남승훈,이해무 대한금속재료학회 2004 대한금속·재료학회지 Vol.42 No.3
The effect of electron-beam irradiation temperature on irradiation damage of 12%Cr-15%Mn austenitic steel for structural material of nuclear and/or fusion reactors from the point of view of the reduced activation was investigated by using the 1,250 keV HVEM and an energy dispersed X-ray analyzer(EDX) in a 200 keV FE-TEM with beam diameter of about 0.5 nm. Void formation was not observed in irradiated specimen. The dislocation loop growth was observed and the density and size of dislocation loop were increased with irradiation dose. Irradiation-induced segregations of Cr and Mn at grain boundary were also observed by electron-beam irradiation condition. The amount of Mn segregation was increased with irradiation temperature, however, segregation phenomenon was disappeared in the case of Cr.
이재영,윤성호,서유진,최정희,서창희,남동호,김윤근,민경업,박해심 대한천식 및 알레르기학회 2004 천식 및 알레르기 Vol.24 No.1
Background : The common whelk (Buccinum undatum) is one of the largest and most common snails in the North Atlantic. In Korea and Japan, common whelk is a popular eatable shellfish. Although shellfish has been known as the one of the most common causes of food allergy, there has been no published report on allergenecity and clinical significance of this sea snail. In this study, we determined the sensitization rate to common whelk and its relationship with other food allergens in allergy patients. Method : We carried out the skin prick test (SPT) with commonly consumed food stuffs in Korea including common whelk in 1700 patients over 1 year. The specific IgE to common whelk were detected by enzyme-linked immunosorbent assay (ELISA). ELISA inhibition test using sensitized sera was conducted. Results : SPT to common whelk was positive (≥2+) in 83 (4.9%) patients studied. Twenty-four (38.7%) of 62 SPT-positive patients had high serum specific IgE to common whelk. ELISA inhibition test showed significant inhibitions by abalone as well as by common whelk and, minimal inhibition were noted by shrimp. Significant correlation was also noted in specific IgE levels between common whelk and abalone (r=0.58, F<.05). Conclusion : IgE-sensitization rate to common whelk was 4.9% in allergy patients. Further stuides are needed to evaluate the clinical significance of sensitized patients to common whelk, and to confirm a cross reactivity with abalone. (J Asthma Allergy Immunol 24 : 77-84, 2004)
운동유발성 아나필락시스 환자에서 혈 중 tryptase 측정 1례
예영민,임선교,서유진,최정희,서창희,남동호,박해심 대한천식 및 알레르기학회 2004 천식 및 알레르기 Vol.24 No.1
Exercise-induced anaphylaxis(EIA) is a medical emergency in that it derives from a physical allergy. We reported a case of food-independent EIA based on history and laboratory data. A 40-year-old male patient was presented with generalized urticaria, angioedema, and syncope after jogging. He had suffered from allergic rhinitis for 25 years. Increased level of serum tryptase was noted. Mast cell activation might be suggested in the pathophysiologic mechanism of EIA. (J Asthma Allergy Clin Immunol 24 : 152-5, 2004)
IgA and IgG Antibodies to Streptococcus Pneumoniae in Induced Sputum from Asthmatic Patients
Nahm, Dong-Ho,Park, Hae-Sim 아주대학교 1997 아주의학 Vol.2 No.1
Eosinophils are known to be main effector cells in airway inflammation of bronchial asthma and contribute to epithelial damage by degranulation of cytotoxic granular proteins. The mechanism of eosinophil degranulation in asthmatic airway is still poorly understood. There have been some in vitro data suggesting immunoglobulins as a stimulus for eosinophil degranulation. In order to evaluate a possible role of specific antibodies to bacterial organism on eosinophil degranulation within airway secretion from atopic asthmatic patients, we measured IgA and IgG antibodies to Streptococcus pneumoniae polysaccharide antigen in the induced sputum from 16 atopic asthmatic patients and 12 non-atopic non-asthmatic controls by enzyme-linked immunosorbent assay (ELISA). Eosinophil cationic protein (ECP) levels were measured in induced sputum from 16 atopic asthmatic patients. Levels of specific igA antibodies to S. pneumoniae in the induced sputum from mite-sensitive asthmatic patients were significantly higher than those from controls (p< 0.005). No significant difference was found in the levels of IgG antibodies to S. pneumoniae in induced sputum between asthmatics and controls. ECP levels in induced sputum from mite-sensitive asthmatics correlated significantly with the levels of specific igA antibodies to S. pneumoniae (r=0.56, p< 0.05), but not with lgG antibodies to S. pneumoniae. These results suggest that IgA antibodies to bacterial antigen could participate in eosinophil degranulation in the airway secretion from atopic asthmatics patients.
Personalized Immunomodulatory Therapy for Atopic Dermatitis: An Allergist`s View
( Dong Ho Nahm ) 대한피부과학회 2015 Annals of Dermatology Vol.27 No.4
The current standard medical therapy for atopic dermatitis (AD) mainly focuses on symptomatic relief by controlling skin inflammation with topical corticosteroids and/or topical calcineurin inhibitors. However, the clinical efficacy of pharmacological therapy is often disappointing to both patients and physicians. The terminology of AD contains a historical meaning of eczematous dermatitis caused by hypersensitivity reaction to environmental inhalant or food allergen. Complex interrelationships among genetic abnormalities, environmental triggers, skin barrier defects, and immune dysfunction resulting in a vicious domino-circle seem to be involved in the development and maintenance of AD. In the viewpoint of AD as an allergic disease, complete avoidance of clinically relevant allergen or induction of specific immune tolerance through administrations of allergen (allergen immunotherapy) can provide clinical remission by breaking the vicious domino-circle maintaining a chronic disease state. In recent clinical studies, monoclonal antibodies including the anti-interleukin-4 receptor antibody and anti-B cell antibody induced significant clinical improvements in patients with AD. The detailed characteristics of immune dysfunction are heterogeneous among patients with AD. Therefore, a personalized combination of immunomodulatory therapies to reduce hypersensitivity (allergen immunotherapy) and correct immune dysfunction (monoclonal antibody therapy) could be a reasonable therapeutic approach for patients with AD. Future immunomodulatory therapies for AD should be developed to achieve long-term treatment-free clinical remission by induction of immune tolerance. (Ann Dermatol 27(4) 355∼363, 2015)