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Geometric Optimization of a Mathematical Model of Radiofrequency Ablation in Hepatic Carcinoma
Wang, Kai-Feng,Pan, Wei,Wang, Fei,Wang, Gao-Feng,Madhava, Pai,Pan, Hong-Ming,Kong, De-Xing,Liu, Xiang-Guan Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.10
Radio frequency ablation (RFA) is an effective means of achieving local control of liver cancer. It is a particularly suitable mode of therapy for small and favorably located tumors. However, local progression rates are substantially higher for large tumors (>3.0 cm). In the current study, we report on a mathematical model based on geometric optimization to treat large liver tumors. A database of mathematical models relevant to the configuration of liver cancer was also established. The specific placement of electrodes and the frequency of ablation were also optimized. In addition, three types of liver cancer lesion were simulated by computer guidance incorporating mathematical models. This approach can be expected to provide a more effective and rationale mechanism for employing RFA in the therapy of hepatic carcinoma.
Wang, Tao,Liu, Chang,Xiong, Yuan-Zhu,Deng, Chang-Yan,Zuo, Bo,Xie, Hong-Tao,Xu, De-Quan Asian Australasian Association of Animal Productio 2007 Animal Bioscience Vol.20 No.8
The protein encoded by SLC27A2 gene is an isozyme of long-chain fatty-acid-coenzyme A ligase family, and it converts free long-chain fatty acids into fatty acyl-CoA esters, and thereby plays a key role in lipid biosynthesis and fatty acid degradation. In the present study, SLC27A2 located on human chromosome 15 was selected as candidate gene and we isolated and cloned partial fragments of mRNA sequence and genomic fragments of porcine SLC27A2 gene. The coding region of the gene as determined by alignments shared 90% and 82% identity with human and mouse cDNAs, respectively. Detection in LargeWhite and Meishan breeds showed that a single nucleotide polymorphism (SNP) ($A{\rightarrow}G$) existed in exon 7, which caused corresponding amino acid changed for encoding. In LargeWhite pigs it encoded for Val while in Meishan pigs it encoded for Ile, so we developed the PCR-RFLP genotype method for detection of this polymorphism. Association study in 135 $F_2$ reference family indicated that significant correlation existed between the polymorphism and growth and carcass traits.
De Peng Yuan,Xiao Feng Xu,Hong Woo-Jong,Si Ting Wang,Xin Tong Jia,Yang Liu,Shuang Li,Zhi Min Li,Qian Sun,Qiong Mei,Shuai Li,정기홍,Song Hong Wei,Yuan Hu Xuan 한국식물생명공학회 2020 Plant biotechnology reports Vol.14 No.5
Sheath blight disease (ShB) severely afects rice production; however, the details of defense against ShB remain unclear. To understand the rice defense mechanism against ShB, an RNA sequencing analysis was performed using Rhizoctonia solani inoculated rice leaves after 48 h of inoculation. Among them, 3417 genes were upregulated and 2532 were downregulated when compared with the control group (>twofold or<1/2). In addition, the diferentially expressed genes were classifed via Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and MapMan analyses. Fifty-nine GO terms and seven KEGG pathways were signifcantly enriched. A MapMan analysis demonstrated that the phytohormone and metabolic pathways were signifcantly altered. Interestingly, the expression levels of 359 transcription factors, including WRKY, MYB, and NAC family members, as well as 239 transporter genes, including ABC, MFS, and SWEET, were signifcantly changed in response to R. solani AG1-IA inoculation. Additionally, OsWRKY53 and OsAKT1 negatively regulate the defense response in rice against R. solani via gain of function study for OsWRKY53 and loss of function study for OsAKT1, respectively. Furthermore, several diferentially expressed genes contain R. solani-responsive cis acting regulatory elements in their promoter regions. Taken together, our analyses provide valuable information for the additional study of the defense mechanisms against ShB, and the candidate genes identifed in this study will be useful resource for future breeding to enhance resistance against ShB.
Research on the Automatic Assessment System for the Ship Handling Simulator
De-Long Wang,Hong-Xiang Ren,Jin-Gang Yin 국제이네비해양경제학회 2023 International Journal of e-Navigation and Maritime Vol.20 No.-
At present, the assessment for the crew training using the ship handling simulator is completed by the assessor, which is subjective and difficult to unify the assessment criteria. Under this assessment mode, the assessor will have a great work intensity. So it is necessary to design and develop the automatic assessment system for the ship handling simulator. This paper introduces the automatic assessment system developed by Dalian Maritime University (shorted for DMU), which includes the assessment method, system architecture and implementation. A selected example of applications is described.
De Juan Zhi,Na Feng,Dong Ling Liu,Rong Li Hou,Mei Zu Wang,Xiao Xia Ding,Hong Yu Li 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.3
Although realgar bioleaching solution (RBS) hasbeen proved to be a potential candidate for cancer therapy, themechanisms of RBS anticancer are still far from beingcompletely understood. Dosed with RBS in C. elegans, themultivulva phenotype resulting from oncogenic ras gain-offunctionwasinhibited in a dose dependentmanner. It could beabrogated by concurrent treatment C. elegans with RBS andthe radical scavengerDMSO. However, RBS could not induceDAF-16 nuclear translocation in TJ356 or the increase of HSP16.2 expression in CL2070, which both could be arousedvisible GFP fluorescent variation to represent for oxidativestress generation. Treatment C. elegans with superoxide aniongenerator paraquat, similar results were also obtained. Ourresults indicated that RBS suppress excessive activated ras byincreasing reactive oxygen species (ROS) in C. elegans. Secondly, ROS induced by RBS significantly accumulated ona higher level inC. elegans with amutational ras than that withwild ras, thus leading to oxidative stress on ras gain-of-functionbackground rather than on normal ras context. Our resultsfirstly demonstrated that using C. elegans as amodel organismfor evaluating prooxidant drug candidates for cancer therapy.
Zhi, De Juan,Feng, Na,Liu, Dong Ling,Hou, Rong Li,Wang, Mei Zu,Ding, Xiao Xia,Li, Hong Yu 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.3
Although realgar bioleaching solution (RBS) has been proved to be a potential candidate for cancer therapy, the mechanisms of RBS anticancer are still far from being completely understood. Dosed with RBS in C. elegans, the multivulva phenotype resulting from oncogenic ras gain-of-function was inhibited in a dose dependent manner. It could be abrogated by concurrent treatment C. elegans with RBS and the radical scavenger DMSO. However, RBS could not induce DAF-16 nuclear translocation in TJ356 or the increase of HSP 16.2 expression in CL2070, which both could be aroused visible GFP fluorescent variation to represent for oxidative stress generation. Treatment C. elegans with superoxide anion generator paraquat, similar results were also obtained. Our results indicated that RBS suppress excessive activated ras by increasing reactive oxygen species (ROS) in C. elegans. Secondly, ROS induced by RBS significantly accumulated on a higher level inC. elegans with amutational ras than that with wild ras, thus leading to oxidative stress on ras gain-of-function background rather than on normal ras context. Our results firstly demonstrated that using C. elegans as amodel organism for evaluating prooxidant drug candidates for cancer therapy.
Characteristics of Carbohydrate Assimilation and Distribution in Walnut (Juglans regia L.)
Shi-Wei Wang,Cun-De Pan,Cui-Fang Zhang,Hong Chen 한국원예학회 2021 원예과학기술지 Vol.39 No.2
Based on <SUP>13</SUP>C isotope tracer technology, we investigated the <SUP>13</SUP>C abundance (δ<SUP>13</SUP>C), <SUP>13</SUP>C content(<SUP>13</SUP>Camount), and new fixed <SUP>13</SUP>C percentage (<SUP>13</SUP>CPCT) in different organs and different metabolic components in girdled fruit-bearing shoots at different stages of fruit growth and development in walnut. Our aim was to analyze the dynamic characteristics of carbohydrate assimilation, transportation, and utilization in different stages of walnut fruit growth and development. The results showed that (1) at 0 h after the feeding, δ<SUP>13</SUP>C, <SUP>13</SUP>Camount, and <SUP>13</SUP>CPCT in sucrose from the leaves were the highest and positively correlated with net photosynthetic rate of leaves (p < 0.05); (2) at 24 h after the feeding, δ13C, <SUP>13</SUP>Camount, and <SUP>13</SUP>CPCT in sucrose from the carpopodium reached their peak values; (3) δ<SUP>13</SUP>C,<SUP>13</SUP>Camount, and <SUP>13</SUP>CPCT in sucrose from the peel were lower than those of hexose at 48 h after feeding in the fast-growing stage, but they all reached maximum levels in peel sucrose at 48 h after feeding in the oil conversion stage; and (4) the highest δ<SUP>13</SUP>C, <SUP>13</SUP>Camount, and <SUP>13</SUP>CPCT were recorded in all carbohydrates from the seed kernel 48 h after feeding, among which the highest δ<SUP>13</SUP>C, <SUP>13</SUP>Camount, and <SUP>13</SUP>CPCT were recorded in sucrose. These results suggested that sucrose was the main form of carbohydrate assimilation and transportation in walnut fruit, and large amounts of sucrose are accumulated in the peel and in the kernel, where it is also the base for the transformation of oil.