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Flexible Composites: Carbon Nanotube Fiber Based Stretchable Conductor (Adv. Funct. Mater. 7/2013)
Zu, Mei,Li, Qingwen,Wang, Guojian,Byun, Joon‐,Hyung,Chou, Tsu‐,Wei WILEY‐VCH Verlag 2013 Advanced Functional Materials Vol.23 No.7
<P>Stretchable conductors based on buckled carbon nanotube (CNT) fibers are fabricated using a simple prestraining‐then‐buckling approach. The primary deformation mode of the CNT fibers is lateral kinking. This buckling shape is quite different from the sinusoidal shape observed previously in systems that are otherwise similar. As reported by Tsu‐Wei Chou and co‐workers on page 789, the prepared CNT fiber/poly(dimethylsiloxane) (PDMS) composite film shows excellent stability and repeatability in performance as a stretchable conductor. </P>
Wang, Chang-Dong,Yuan, Cheng-Fu,Bu, You-Quan,Wu, Xiang-Mei,Wan, Jin-Yuan,Zhang, Li,Hu, Ning,Liu, Xian-Jun,Zu, Yong,Liu, Ge-Li,Song, Fang-Zhou Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.2
Fangchinoline (Fan) inhibits cell proliferation and induces apoptosis in several cancer cell lines. The effects of Fan on cell growth and proliferation in breast cancer cells remain to be elucidated. Here, we show that Fan inhibited cell proliferation in the MDA-MB-231 breast cancer cell line through suppression of the AKT/Gsk-3beta/cyclin D1 signaling pathway. Furthermore, Fan induced apoptosis by increasing the expression of Bax (relative to Bcl-2), active caspase 3 and cytochrome-c. Fan significantly inhibited cell proliferation of MDA-MB-231 cells in a concentration and time dependent manner as determined by MTT assay. Flow cytometry analysis demonstrated that Fan treatment of MDA-MB-231 cells resulted in cell cycle arrest at the G1 phase, which correlated with apparent downregulation of both mRNA and protein levels of both PCNA and cyclin D1. Further analysis demonstrated that Fan decreased the phosphorylation of AKT and GSK-3beta. In addition, Fan up-regulated active caspase3, cytochrome-c protein levels and the ratio of Bax/Bcl-2, accompanied by apoptosis. Taken together, these results suggest that Fan is a potential natural product for the treatment of breast cancer.
Gui Mei Yu,Shu Long Zu,Wei Wei Zhou,Xi Jun Wang,Lei Shuai,Xue Lian Wang,Jin Ying Ge,Zhi Gao Bu 대한수의학회 2017 Journal of Veterinary Science Vol.18 No.-
Rabies remains an important worldwide health problem. Newcastle disease virus (NDV) was developed as a vaccine vector in animals by using a reverse genetics approach. Previously, our group generated a recombinant NDV (LaSota strain) expressing the complete rabies virus G protein (RVG), named rL-RVG. In this study, we constructed the variant rL-RVGTM, which expresses a chimeric rabies virus G protein (RVGTM) containing the ectodomain of RVG and the transmembrane domain (TM) and a cytoplasmic tail (CT) from the NDV fusion glycoprotein to study the function of RVG’s TM and CT. The RVGTM did not detectably incorporate into NDV virions, though it was abundantly expressed at the surface of infected BHK-21 cells. Both rL-RVG and rL-RVGTM induced similar levels of NDV virus-neutralizing antibody (VNA) after initial and secondary vaccination in mice, whereas rabies VNA induction by rL-RVGTM was markedly lower than that induced by rL-RVG. Though rL-RVG could spread from cell to cell like that in rabies virus, rL-RVGTM lost this ability and spread in a manner similar to the parental NDV. Our data suggest that the TM and CT of RVG are essential for its incorporation into NDV virions and for spreading of the recombinant virus from the initially infected cells to surrounding cells.
Zhi, De Juan,Feng, Na,Liu, Dong Ling,Hou, Rong Li,Wang, Mei Zu,Ding, Xiao Xia,Li, Hong Yu 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.3
Although realgar bioleaching solution (RBS) has been proved to be a potential candidate for cancer therapy, the mechanisms of RBS anticancer are still far from being completely understood. Dosed with RBS in C. elegans, the multivulva phenotype resulting from oncogenic ras gain-of-function was inhibited in a dose dependent manner. It could be abrogated by concurrent treatment C. elegans with RBS and the radical scavenger DMSO. However, RBS could not induce DAF-16 nuclear translocation in TJ356 or the increase of HSP 16.2 expression in CL2070, which both could be aroused visible GFP fluorescent variation to represent for oxidative stress generation. Treatment C. elegans with superoxide anion generator paraquat, similar results were also obtained. Our results indicated that RBS suppress excessive activated ras by increasing reactive oxygen species (ROS) in C. elegans. Secondly, ROS induced by RBS significantly accumulated on a higher level inC. elegans with amutational ras than that with wild ras, thus leading to oxidative stress on ras gain-of-function background rather than on normal ras context. Our results firstly demonstrated that using C. elegans as amodel organism for evaluating prooxidant drug candidates for cancer therapy.
De Juan Zhi,Na Feng,Dong Ling Liu,Rong Li Hou,Mei Zu Wang,Xiao Xia Ding,Hong Yu Li 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.3
Although realgar bioleaching solution (RBS) hasbeen proved to be a potential candidate for cancer therapy, themechanisms of RBS anticancer are still far from beingcompletely understood. Dosed with RBS in C. elegans, themultivulva phenotype resulting from oncogenic ras gain-offunctionwasinhibited in a dose dependentmanner. It could beabrogated by concurrent treatment C. elegans with RBS andthe radical scavengerDMSO. However, RBS could not induceDAF-16 nuclear translocation in TJ356 or the increase of HSP16.2 expression in CL2070, which both could be arousedvisible GFP fluorescent variation to represent for oxidativestress generation. Treatment C. elegans with superoxide aniongenerator paraquat, similar results were also obtained. Ourresults indicated that RBS suppress excessive activated ras byincreasing reactive oxygen species (ROS) in C. elegans. Secondly, ROS induced by RBS significantly accumulated ona higher level inC. elegans with amutational ras than that withwild ras, thus leading to oxidative stress on ras gain-of-functionbackground rather than on normal ras context. Our resultsfirstly demonstrated that using C. elegans as amodel organismfor evaluating prooxidant drug candidates for cancer therapy.
Zhang, Hong-Yun,Tiggelaar, Sarah M.,Sahasrabuddhe, Vikrant V.,Smith, Jennifer S.,Jiang, Cheng-Qin,Mei, Run-Bo,Wang, Xian-Guo,Li, Zu-An,Qiao, You-Lin Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.1
Objectives: To determine the prevalence of HPV and cervical neoplasia among HIV-infected women in southwestern China. Methods: Cervical cytology, HPV detection by Hybrid Capture-$2^{TM}$ assay, and diagnostic colposcopy were followed by cervical biopsy if indicated. Logistic regression analysis was used to analyze associations between HPV co-infection and cervical intraepithelial neoplasia (CIN), and HIV-related clinical and laboratory parameters. Results: Colposcopic-histopathologically proven CIN2+ lesions were present in 7/83 (8.4%) HIV-infected women. Nearly half (41/83, 43%) were co-infected with carcinogenic HPV genotypes. HPV co-infection was higher in women with colposcopic-histopathologically proven CIN2+ lesions than women with <CIN1 after adjusting for age (OR: 8.3, 95% CI: 0.9, 73.4). Women with CD4+ cell counts less than 350 $cells/{\mu}L$ had higher CIN2+ prevalence after adjusting for current ART status and age (adjusted OR: 6.3, 95% CI: 1.1, 36.5). Conclusions: HIV/AIDS care and treatment programs should integrate effective cervical cancer prevention services to mitigate the risk of invasive cervical cancer among HIV-infected women in China.