Bayesian Prediction Model Based on Attribute Weighting and Kernel Density Estimations

Xiang, Zhong-Liang,Yu, Xiang-Ru,Kang, Dae-Ki Hindawi Limited 2015 Mathematical problems in engineering Vol.2015 No.-

<P>Although naïve Bayes learner has been proven to show reasonable performance in machine learning, it often suffers from a few problems with handling real world data. First problem is conditional independence; the second problem is the usage of frequency estimator. Therefore, we have proposed methods to solve these two problems revolving around naïve Bayes algorithms. By using an attribute weighting method, we have been able to handle conditional independence assumption issue, whereas, for the case of the frequency estimators, we have found a way to weaken the negative effects through our proposed smooth kernel method. In this paper, we have proposed a compact Bayes model, in which a smooth kernel augments weights on likelihood estimation. We have also chosen an attribute weighting method which employs mutual information metric to cooperate with the framework. Experiments have been conducted on UCI benchmark datasets and the accuracy of our proposed learner has been compared with that of standard naïve Bayes. The experimental results have demonstrated the effectiveness and efficiency of our proposed learning algorithm.</P>

Adiponectin Receptor 1 (ADIPOR1) rs1342387 Polymorphism and Risk of Cancer: a Meta-analysis

Yu, Li-Xiang,Zhou, Nan-Nan,Liu, Li-Yuan,Wang, Fei,Ma, Zhong-Bing,Li, Jie,Yu, Zhi-Gang Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.18

Many studies have indicated possible associations between a polymorphism of adiponectin receptor 1 (ADIPOR1) rs1342387 and risk of cancer, but contradictory results have been reported. The main aim of this study was to draw a reliable conclusion about the relationship between the rs1342387 polymorphism and cancer incidence, by conducting a literature search of Pubmed, Embase, Wanfang and Cochrane libraries. Eleven studies including 3, 738 cases and 4, 748 controls were identified in this meta-analysis. The ADIPOR1 rs1342387 polymorphism was associated with risk of colorectal cancer for all genetic comparison models (GG vs AA, OR: 1.44, 95%CI: 1.21-1.70; G carriers vs A carriers, OR: 1.23, 95%CI: 1.11-1.36; dominant model, OR: 1.28, 95%CI: 1.10-1.49 and recessive model, OR: 1.31, 95%CI: 1.12-1.55). Stratified by ethnicity, the rs1342387 polymorphism was significantly associated with risk of colorectal cancer in Asian ancestry for all genetic comparison models (GG vs AA, OR: 1.56, 95%CI: 1.26-1.92; G carriers vs. A carriers OR: 1.30, 95%CI: 1.18-1.43; dominant model OR: 1.31, 95%CI: 1.08-1.60 and recessive model OR: 1.44, 95%CI: 1.26-1.64), but not in Caucasian or mixed (Caucasian mainly) groups. In summary, the ADIPOR1 rs1342387 polymorphism is significantly associated with risk of colorectal cancer among individuals of Asian ancestry.

Screening of the Antigen Epitopes of Basic Fibroblast Growth Factor by Phage Display

Jun Jian Xiang,Zhen Yu Zhong,Ning Deng,Zhen Dong Zhong,Hong Yu Yang 한국생활환경학회 2005 BMB Reports Vol.38 No.3

Optical Properties of Zinc-oxide Films Determined Using Spectroscopic Ellipsometry with Various Dispersion Models

Zhong-Hong Dai,Jie Shao,Yi-Ming Chen,Yu-Xiang Zheng,Jia-Da Wu,Liang-Yao Chen,Rong-Jun Zhang 한국물리학회 2009 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.55 No.3

In this work, we have studied the optical properties of wurtizite zinc-oxide films grown on silicon (100) substrates by means of pulsed laser deposition (PLD). Spectroscopic ellipsometry and three dispersion models, namely, the Sellmeier, Cauchy, and Forouhi-Bloomer models, were applied for determining the optical constants of the ZnO thin films. A comparison was made between two samples that were deposited for 30 minutes (sample I) and 60 minutes (sample II), respectively. X-ray diffraction analysis indicates that there are two types of preferred-orientation, i.e., (101) and (100) orientations for sample I and II, respectively. Results show that the Cauchy model gives the best fit for the samples with least root mean square error (RMSE) whereas the Forouhi-Bloomer model is most suitable for the data analysis in both the transparent and the absorption regions. The optical properties extracted from different dispersion models have been compared with the data reported in the literature. The results given in this work show that different dispersion models should be applied to obtain the optical constants In this work, we have studied the optical properties of wurtizite zinc-oxide films grown on silicon (100) substrates by means of pulsed laser deposition (PLD). Spectroscopic ellipsometry and three dispersion models, namely, the Sellmeier, Cauchy, and Forouhi-Bloomer models, were applied for determining the optical constants of the ZnO thin films. A comparison was made between two samples that were deposited for 30 minutes (sample I) and 60 minutes (sample II), respectively. X-ray diffraction analysis indicates that there are two types of preferred-orientation, i.e., (101) and (100) orientations for sample I and II, respectively. Results show that the Cauchy model gives the best fit for the samples with least root mean square error (RMSE) whereas the Forouhi-Bloomer model is most suitable for the data analysis in both the transparent and the absorption regions. The optical properties extracted from different dispersion models have been compared with the data reported in the literature. The results given in this work show that different dispersion models should be applied to obtain the optical constants

Isolation and Characterization of Parthenogenetic Embryonic Stem (pES) Cells Containing Genetic Background of the Kunming Mouse Strain

Yu, Shu-Min,Yan, Xing-Rong,Chen, Dong-Mei,Cheng, Xiang,Dou, Zhong-Ying Asian Australasian Association of Animal Productio 2011 Animal Bioscience Vol.24 No.1

Parthenogenetic embryonic stem (pES) cells could provide a valuable model for research into genomic imprinting and X-linked diseases. In this study, pES cell lines were established from oocytes of hybrid offspring of Kunming and 129/Sv mice, and pluripotency of pES cells was evaluated. The pES cells maintained in the undifferentiated state for more than 50 passages had normal karyotypes with XX sex chromosomes and exhibited high activities of alkaline phosphatase (AKP) and telomerase. Meanwhile, these cells expressed ES cell molecular markers SSEA-1, Oct-4, Nanog, and GDF3 but not SSEA-3 detected by immunohistochemistry and RT-PCR. The pES cells could be differentiated into various types of cells from three germ layers in vitro by analysis of embryoid bodies (EBs) with immunohistochemistry and RT-PCR, and in vivo by observation of pES cell-derived teratoma sections. Therefore, the established pES cell lines contained all features of mouse ES cells. This work provides a new strategy for isolating pES cells from Kunming mice, and the pES cell lines could be applied as the cell model in research into genomic imprinting and epigenetic regulation of Kunming mice.

Selection signature reveals genes associated with susceptibility loci affecting respiratory disease due to pleiotropic and hitchhiking effect in Chinese indigenous pigs

Xu, Zhong,Sun, Hao,Zhang, Zhe,Zhang, Cheng-Yue,Zhao, Qing-bo,Xiao, Qian,Olasege, Babatunde Shittu,Ma, Pei-Pei,Zhang, Xiang-Zhe,Wang, Qi-Shan,Pan, Yu-Chun Asian Australasian Association of Animal Productio 2020 Animal Bioscience Vol.33 No.2

Objective: Porcine respiratory disease is one of the most important health problems causing significant economic losses. To understand the genetic basis for susceptibility to swine enzootic pneumonia (EP) in pigs, we detected 102,809 single nucleotide polymorphisms in a total of 249 individuals based on genome-wide sequencing data. Methods: Genome comparison of susceptibility to swine EP in three pig breeds (Jinhua, Erhualian, and Meishan) with two western lines that are considered more resistant (Duroc and Landrace) using cross-population extended haplotype homozygosity and F-statistic (F_ST) statistical approaches identified 691 positively selected genes. Based on quantitative trait loci, gene ontology terms and literature search, we selected 14 candidate genes that have convincible biological functions associated with swine EP or human asthma. Results: Most of these genes were tested by several methods including transcription analysis and candidate genes association study. Among these genes: cytochrome P450 1A1 and catenin beta 1 (CTNNB1) are involved in fertility; transforming growth factor beta receptor 3 plays a role in meat quality traits; Wnt family member 2, CTNNB1 and transcription factor 7 take part in adipogenesis and fat deposition simultaneously; plasminogen activator, urokinase receptor (completely linked to AXL receptor tyrosine kinase, r² = 1) plays an essential role in the successful ovulation of matured oocytes in pigs; colipase like 2 (strongly linked to SAM pointed domain containing ETS transcription factor, r² = 0.848) is involved in male fertility. Conclusion: These adverse genes susceptible to swine EP may be selected while selecting for economic traits (especially reproduction traits) due to pleiotropic and hitchhiking effect of linked genes. Our study provided a completely new point of view to understand the genetic basis for susceptibility or resistance to swine EP in pigs thereby, provides insight for designing sustainable breed selection programs. Finally, the candidate genes are crucial due to their potential roles in respiratory diseases in a large number of species, including human.

Performances of the Effervescent Atomizer for Water Mist Fire Extinguishing

( Jin Xiang Wu ),( Qiang Liang ),( Lian Sheng Liu ),( Yun Zhong Yan ),( En Yu Wang ),( Qing Miao ) 한국액체미립화학회 2005 한국액체미립화학회 학술강연회 논문집 Vol.2005 No.-

Based on the mechanism of effervescent atomization, a new effervescent atomization system of water mist was designed. In this system, the gas medium is carbon dioxide, which is soluble and can be used in fire suppression. High pressure saturated carbon dioxide-water solution flowed through the throttle orifice, carbon dioxide was bubbled, and the two-phase flow was formed in the mixing chamber of nozzle. At last, the water mist was formed downstream of the exit orifice of nozzle. In order to examine the feasibility of this system, data were collected, processed and analyzed with DUAL PDA. The velocity profile and drop-size distribution (D10, D32, Dv0.9) downstream of the effervescent atomizer were gained. The efficiency of fire suppression of this system were experimentally investigated by putting out the fire of industry alcohol and diesel oil. The experimental results showed that this water mist system is feasible for fire suppression.

Genotypic analysis of degenerative Cordyceps militaris cultured in the pupa of Bombyx mori

Juan Yin,Xiang-Dong XIN,Yu-JieWENG,Shao-Hui Li,Jun-Qiang JIA,Zhong Zheng Gui 한국곤충학회 2018 Entomological Research Vol.48 No.3

The chemical composition and pharmacological effects of Cordyceps militaris are similar to those of Cordyceps sinensis, with the former undergoing greater development and utilization. Strain degeneration is a common phenomenon that occurs with high frequency during the subculturing of C. militaris, however, and the mechanism underlying strain degeneration remains unclear. In this study, we used touch‐down PCR to compare the ITS1 + 5.8S + ITS2, 18S, 28S and mating‐type (MAT) regions sequence of wild‐type and degenerated strains of C. militaris. We also used quantitative real‐time PCR to analyze expression levels of the CmMAT gene. Sequence analysis showed that the ITS1 + 5.8S + ITS2 and 28S regions of degenerated and wild‐type strains were completely identical, the 18S region of the degenerated strain contained seven single‐base mutations, including six base substitutions and one single‐base insertion. Compared with the wild‐type strain, the degenerated strain contained a deletion of the MAT1–2‐1 region, three base substitutions in the MAT1–1‐1 region, and a base substitution in the MAT1–1‐2 region that causes a glycine‐to‐valine amino acid substitution. Quantitative real‐time PCR analysis detected no CmMAT1–2‐1 gene expression in the degenerated strain, confirming the deletion of the CmMAT1–2‐1 gene. Expression levels of the CmMAT1–1‐1 and CmMAT1–1‐2 genes were significantly down‐regulated to only 7.5 % and 4.4 %, respectively, that of the wild‐type strain. These results indicate that 18S and MAT region mutations, as well as down‐regulated of CmMAT gene expression levels, may play important roles in C. militaris degeneration. This study provides a theoretical basis for further elucidation of the molecular mechanisms of C. militaris degeneration.

A novel conversion for blast furnace slag (BFS) to the synthesis of hydroxyapatite-zeolite material and its evaluation of adsorption properties

Changxin Li,Xiang Li,Yuan Yu,Qingwu Zhang,Li Li,Hong Zhong,Shuai Wang 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.105 No.-

Blast furnace slag (BFS), as a byproduct from manufacturing iron, served as a cost-effective raw materialfor preparation of hydroxyapatite-zeolite composite material (HAP-ZE); this research introduces a way ofsynthesizing hydroxyapatite-zeolite composite material (HAP-ZE) using BFS with alkaline fusion andhydrothermal treatment. According to analysis with XRD, FT-IR, BET, ICP, FE-SEM, EDX and elementalmapping, the major phases in the HAP-ZE composite material synthesized under the most desirable conditions(at aging time of 6 h and at Ca/P ratio (starting gel) = 1.67) were identified to be zeolite and HAPwith molar ratio of Ca/P = 1.61, Si/Al = 1.31, Na/Al = 1.75 and with a mean surface area of 44.22 m2.g 1. Moreover, the research found that the minor metals (Mg, Fe, K, etc.) generated from BFS have little influenceon the synthesis of HAP-ZE. The thus obtained HAP-ZE material has a great adsorption performancein removing Mn2+, NH4 + and phosphate ions mixed in water, on grounds of the higher ion-exchange capacitiesand abundantly existing Ca2+ ions in HAP-ZE structure. This novel process makes synthesizing HAPZEcomposite material from BFS possible and lays a great foundation for effective application of BFS.

Structure and Properties of Polyimide (BTDA-TDI/MDI co-polyimide) Fibers Obtained by Wet-Spinning

Hong Bing Xiang,Zhong Huang,Li Qi Liu,Lei Chen,Jing Zhu,Zu Ming Hu,Jun Rong Yu 한국고분자학회 2011 Macromolecular Research Vol.19 No.7

BTDA-TDI/MDI (P84, synthesized by the condensation of 2,4-diisocyanato-1-methylbenzene and 1,1' -methylenebis(4-isocyanatobenzene) with 5,5'-carbonylbis(l,3-isobenzofurandione)) co-polyimide fibers were prepared by wet-spinning. The basic spinning conditions were found from the studies of dope viscosity, ternary phase diagrams, coagulation value, and precipitation value. The effect of the coagulation bath composition on the morphology of as-spun fibers was investigated and a theoretical approach was used to understand the coagulation phenomena. Scanning electron microscopy (SEM) showed that the cross-sectional shape of the fiber deviated more from an ellipse shape with the increasement of N-methyl-2-pyrrdidinone (NMP) content. The surface and cross section morphology of the as-spun fibers was also analyzed by the rate of diffusion and phase separation. The as-spun fibers were treated in heating tubes without drawing at different temperatures. The gravimetric analysis spectra showed that the BTDA-TDI/MDI co-polyimide fibers, which had been heat treated at 350 and 400 ℃, possessed better thermal properties than the as-spun fibers, a large weight loss was observed only above 550 ℃. Heat treatment of the fibers resulted in relatively high tensile strength and modulus. The fibers spun in Bath C (70/30, NMP/water, wt/wt)and Bath D (80/20, NMP/water, wt/wt) showed better thermal properties and higher tensile strength.