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      • Decision-making Method in Emergency Rescue Based on Cloud Model

        Dan ZHOU,An CHEN 위기관리 이론과 실천 2016 위기관리 이론과 실천 세미나발표논문집 Vol.2016 No.-

        Emergency incident makes a high request for timeliness of emergency rescue. How to make scientific and reasonable schemes and reduce the influence of subjectivity is the key to rescue in order. According to situations in disaster, three issues of environmental limits, objective attributes and subjective judgments need to consider in decision-making. A method combing cloud model and interval number was put forward. An optimal scheme was obtained by comparing the rescue scheme evaluation cloud with the standard cloud. The results showed that the cloud model decision-making method can overcome the subjectivity of decision and the conclusion was clear and easy to sort. With this method the decision scheme can be more direct and vivid.

      • KCI등재

        Impact of Cu2O doping on high dielectric properties of CuO ceramics

        Dan-Dan Wang,Feng-Zi Zhou,Jing-Xiao Cao,Li-Ben Li,Guo-Ling Li 한국물리학회 2017 Current Applied Physics Vol.17 No.5

        Single-phase CuO ceramic samples were prepared with the starting nano powders of CuO þ xCu2O (x ¼ 0, 1, 3, 7% in mole ratio) via solid state reaction method, and characterized by X-ray diffraction, Raman scattering and scanning electron microscopy. For all the samples, the temperature dependences of dielectric constants and losses were measured at the frequencies of 102, 103, 104, 105 and 106 Hz, respectively. With increasing doping content of Cu2O, a strong correlation is demonstrated at given temperature and frequency between the measured dielectric constants and the unit-cell volumes of CuO. The strong correlation is argued in terms of the change in densities of Cu]O defects (e.g. Cu/O vacancies and/or interstitial Cu impurities) due to Cu2O doping, which is supported by the formation energies of Cu]O defects and the corresponding unit-cell volume from first-principles calculations. The high dielectric constant (~103e105) of CuO ceramic is therefore attributed to the reduction in resistance due to Cu/O defects in the grain by Maxwell-Wagner mechanism.

      • KCI등재

        Sculptural Qualities in Yeats’s Later Poetry

        Zhou Dan 한국예이츠학회 2018 한국예이츠 저널 Vol.55 No.-

        본 논문은 엑프라시스에 이론에 근거하여, 예이츠가 어떻게 자신의 후기시에 그리스와 비잔티움의 조각의 미학과 다양한 형식을 녹여내는지 논의한다. 예이츠는 상반의 시학에 조각적 특징을 사용하는데, 모순을 찾고 모순을 해결하기 위한 여러 가지 생각과 방법을 제시하고, 예술과 영원성에 대한 개념을 만든다. 예술적 형식을 통해서 예이츠는 시에서 인생과 역사의 모순을 화합시킴으로써 존재의 통일을 달성한다. Based on the theories of ekphrasis, the paper discusses how Yeats melts the various forms and aesthetics of the Greek and Byzantine sculptures into his later poems. Yeats makes use of sculptural qualities in his antithetical poetics, which he uses to present the conflicts and the ways to reconcile the conflicts; and to give the ideas of arts and eternity. Through the artistic form, Yeats could achieve the Unity of Being in his poetry, by reconciling the conflicts in life and in history.

      • Decision-making Method in Emergency Rescue Based on Cloud Model

        Dan ZHOU,An CHEN 위기관리 이론과 실천 2016 위기관리 이론과 실천 학술대회 Vol.2016 No.08

        Emergency incident makes a high request for timeliness of emergency rescue. How to make scientific and reasonable schemes and reduce the influence of subjectivity is the key to rescue in order. According to situations in disaster, three issues of environmental limits, objective attributes and subjective judgments need to consider in decision-making. A method combing cloud model and interval number was put forward. An optimal scheme was obtained by comparing the rescue scheme evaluation cloud with the standard cloud. The results showed that the cloud model decision-making method can overcome the subjectivity of decision and the conclusion was clear and easy to sort. With this method the decision scheme can be more direct and vivid.

      • KCI등재

        Nondestructive Surface Threshold Definition for Remanufacturing Disassembly of Interference Fit

        Dan Zhou,Sen Lan,Xin Gao,Haihong Huang,Guang-Fu Liu 한국정밀공학회 2018 International Journal of Precision Engineering and Vol.19 No.11

        The disassembly of interference fit is a difficult process for remanufacturing engineering, which frequently causes multiple types of friction damage, such as scratches, furrow, and adhesion on the surface of parts. The form and size of surface damage directly affect the cost of remanufacturing repair. If the damage is less than a threshold, the part can be directly used for assembly without repairing. This condition represents a nondestructive disassembly, which is the goal of remanufacturing disassembly for interference fit. In this study, varying degrees of disassembly surface damage of interference fit are obtained by experiment and detected by TRIMOS-CL3 3D surface profilometer. Six surface evaluation parameters Sv, Sp, Sq, Str, Vmp, and Sa, are selected from ISO 25178 as indexes for entropy analysis to evaluate the damage comprehensively. According to the interface state, a comprehensive evaluation threshold of nondestructive disassembly is proposed. The rationality of the threshold is verified by the load-carrying capacity experiment of the interference fit.

      • KCI등재

        GPR78 promotes lung cancer cell migration and metastasis by activation of Gαq-Rho GTPase pathway

        ( Dan-dan Dong ),( Hui Zhou ),( Gao Li ) 생화학분자생물학회(구 한국생화학분자생물학회) 2016 BMB Reports Vol.49 No.11

        GPR78 is an orphan G-protein coupled receptor (GPCR) that is predominantly expressed in human brain tissues. Currently, the function of GPR78 is unknown. This study revealed that GPR78 was expressed in lung cancer cells and functioned as a novel regulator of lung cancer cell migration and metastasis. We found that knockdown of GPR78 in lung cancer cells suppressed cell migration. Moreover, GPR78 modulated the formation of actin stress fibers in A549 cells, in a RhoA- and Rac1-dependent manner. At the molecular level, GPR78 regulated cell motility through the activation of Gαq-RhoA/ Rac1 pathway. We further demonstrated that in vivo, the knockdown of GPR78 inhibited lung cancer cell metastasis. These findings suggest that GPR78 is a novel regulator for lung cancer metastasis and may serve as a potential drug target against metastatic human lung cancer. [BMB Reports 2016; 49(11): 623-628]

      • KCI등재

        Preparation and Characterization of a Novel pH-Sensitive Coated Microsphere for Duodenum-Specific Drug Delivery

        Dan Zhou,Yuan Huang,Xi Zhu,Yang Wang,Yun Jin,Xuefan Xu,Tingting Fan,Yan Liu,Zhirong Zhang 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.5

        The aim of this study is to develop a duodenum-specific drug delivery system on the basis of a pH-sensitive coating and a mucoadhesive inner core for eradication of Helicobacter pylori (H. pylori) in the ulcer duodenum. Hydroxypropyl methylcellulose acetate maleate (HPMCAM) was used as the pH-sensitive material, which dissolves around pH 3.0. The mucoadhesive microspheres loaded with furazolidone (FZD-ad-MS) were prepared by the emulsification-solvent evaporation method using Carbopol 971NP as the mucoadhesive polymer. The prepared pH-sensitive coated mucoadhesive microspheres (AM-coated-MS) were characterized in regards to particle size, drug loading efficiency, morphological change, drug stability, drug release and in vitro anti-H. pylori activity. The particle size was 160.97 ± 47.24 μm and 336.44 ± 129.34 μm, and the drug content was 42.33 ± 3.43% and 10.96 ± 1.29% for FZD-ad-MS and AM-coated-MS, respectively. The morphological changes in different pH media were characterized by scanning electron microscopy (SEM). HPMCAM coating improved the stability of the FZD-ad-MS and these particles were expected to remain intact until their arrival in the duodenum. The drug release was extremely suppressed at pH 1.2 for AM-coated-MS, but increased at pH 4.0 after regeneration of FZD-ad-MS. In addition, FZD-ad-MS exhibited excellent anti-H. pylori activity in vitro. Thus, the HPMCAM-coated microspheres developed in this study hold great promise for use as a duodenum-specific drug delivery system for H. pylori clearance.

      • Homicidal Poisoning of Heroin and Estazolam : Autopsy and Pathological Findings, Toxicological Analysis

        Dan Liu,Shangxun Li,Xiangtao Ma,Jinxue Gao,Liang Xu,Jun He,Yuhong Li,Dan Yan,Yiwu Zhou,Qingming Wu 보안공학연구지원센터 2016 International Journal of Multimedia and Ubiquitous Vol.11 No.4

        We reported an unusual homicidal case in which a 40-year-old woman was deceived into drinking a cup of milk that had 72 tablets of estazolam (2mg/tablet) dissolved in, and then being injected heroin aqueous solution on the right deltoid region by the criminal. At autopsy, pinpoint pupils and a new injection site on the right deltoid region were found. The pathologic pictures showed multiple patchy hemorrhages and considerable amounts of foreign amorphous substance with yellow appearance at the injection site. Some double refracting crystals with the forms of Maltese cross, acicular, rhomb or irregular were found by polarizing microscope, which may result from the diluent in heroin such as starch. Toxicological qualitative analysis by gas chromatography mass spectrometry (GC-MS) demonstrated the presence of benzodiazepine and morphine in blood and urine, and heroin in the injector left at scene. Quantitative analysis was also performed by liquid chromatography-tandem mass spectrometry (LC-MS/MS), providing the data on distribution of 6-monoacetylmorphine, morphine and estazolam in the woman’s body. And the cause of death was determined to polydrug heroin-related deaths due to the combined poisoning of heroin and estazolam. It taught a lesson that the determination of other drugs, particularly central nervous system depressants in heroin poisoning were quite important in forensic expertise.

      • SCIEKCI등재

        Flavonoid Glycosides and Potential Antivirus Activity of Isolated Compounds from the Leaves of Eucalyptus citriodora

        Zhou, Zhong-Liu,Yin, Wen-Qing,Zou, Xiao-Peng,Huang, Dan-Ying,Zhou, Cui-Liu,Li, Lian-Mei,Chen, Ke-Cheng,Guo, Zi-Ying,Lin, San-Qing 한국응용생명화학회 2014 Applied Biological Chemistry (Appl Biol Chem) Vol.57 No.6

        The extraction and solvent partition of the leaves of Eucalyptus citriodora, and repeated column chromatography for n-BuOH fraction yielded a new flavonoid glycoside, citrioside C (1), along with three known flavonoid glycosides (2-4). The latter were identified with kaempferol-3-O-${\beta}$-$\small{D}$-glucopyranosyl (12)-${\alpha}$-$\small{L}$-rhamnoside (2), kaempferol-3-O-${\alpha}$-$\small{L}$-rhamnoside (3), and quercetin-3-O-${\alpha}$-$\small{L}$-rhamnoside (4). Their chemical structures were identified on the basis of spectroscopic data analyses including NMR, MS, UV, and IR. All constitutents were isolated for the first time from the leaves of Eucalyptus citriodora. The potential antivirus activity of all the isolated compounds was evaluated. Compound 4 showed potent antiviral activity against respiratory syncytial virus with 50% inhibition concentration ($IC_{50}$) value of $1.9{\mu}g/mL$ and selective index value of 9.8.

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