관상동맥 스텐트 내 재협착의 발생에 미치는 임상적 관동맥 조영술적 요인들

윤혁준,김기식,박형섭,이영수,현대우,한성욱,허승호,김윤년,김권배,박남희,원경숙 대한순환기학회 2003 Korean Circulation Journal Vol.33 No.12

제대혈 림프구의 면역표현형 및 증식능

양윤선,김대원 대한임상병리학회 1998 대한임상병리학회지 Vol.18 No.2

타이어의 동특성 분석을 위한 소프트웨어 개발

尹大遠,朴鍾演,張牧淳,朴贊元 江原大學校 産業技術硏究所 1993 産業技術硏究 Vol.13 No.-

To analyze dynamic characterics for a motorcar, the creating and the hammering test methods are introduced. This paper has studied the method of computing the natural frequency of the impulse wave on a tire, the decay constant which determines the absorption capability for the impulsive force. Moreover we have examined the reliability for the decay constant calculated, in this paper theoritical results are agreed with the simulated ones.

정신분열증 환자에서 대뇌 반구간 정보전달

임두원,이대희,이병윤 大韓神經精神醫學會 1988 신경정신의학 Vol.27 No.6

The author studied on the callosal function of 20 chronic schizophrenic patients who met DSM-Ⅲ criteria and compared the results with those of age, sex matched 20 controls. In this study Cross Retrieval of Small Test Objects, Cross Replication of Hand Postures and Cross Localization of Fingertips, which are known as test that can evaluate interhemispheric transfer of information, were used. The results were as follows: 1) Correct answers in normal control group were 633 out of 640 total questions with 98.9% of correctness, which approximates almost 100%. 2) Number of mean errors in patient group(2.8000±2.262) was higher than that of control group (0.400±0.503) and the difference between the 2 groups was significant (p<0.001). 3) Number of delayed responses in the patient group(3.100±2.789) was also higher than of control group (0.5500±0.887)and the difference between the 2 groups was significant too (p<0.001). 4)Subtype (paranoid vs undifferentiated), family history of mental and/or neurological disease and sex in the patient group made no difference. With the above results the author suggest that chronic schizophrenics suffer from callosal dysfunction and schizophrenic patients (in the case of paranoid and undifferentiated type)are homogeneous in terms of callosal function as far as family history and sex are concerned.

AE 신호의 주파수분석에 의한 Chatter진동의 감시

조대현,이상태,원종식,정윤교 韓國工作機械學會 2000 한국생산제조학회지 Vol.9 No.5

A machine tool generally has some serious stability problems in the form of tool chatter during the cutting process. Chat-ter vibration deteriorates the surface finish, reduce tool and machine life, accelerates machine tool system component wear, and may lead to an unacceptable noise sound in the working environment. In this study, the behavior of spectral density of AE signal and principal cutting force signal in order to monitor the chatter vibration in the cutting process has been investi-gated. From the results, the reliability of proposed monitoring method has been confirmed.

스위치드 릴럭턴스 전동기를 위한 구동시스템의 역률개선과 고효율에 관한 연구

한대희,최준혁,윤용호,정동효,김도군,원충연 성균관대학교 2003 학술회의지원논문목록집 Vol.2003 No.-

Switched Reluctance Motor (SRM) offers the advantages of simple and robust motor construction, high speeds and high efficiencies over a wide operating range of torque and speed, excellent controllability. However, SRM has the disadvantages of high current harmonics, and low power factor because of a capacitor filter is inserted in the power converter and inductance of SRM is high, it has pulse waveform of current. This paper deals with an energy efficient converter fed SRM system with the reduced harmonics and improved power factor and with higher efficiency. The validity of the proposed scheme is verified via experiment. We are implemented the proposed control system using 8OC196KC micro-controller.

기능성 Catechol-O-Methyltransferase 유전자 다형성과 한국인 정신분열병의 관련성

박태원,홍영준,박임순,김형섭,최인미,배수영,윤경식,강대희 大韓神經精神醫學會 2001 신경정신의학 Vol.40 No.4

연구목적 : Catechol-O-Methyltransferase(COMT)는 카테콜아민 신경전달물질의 불활성화를 담당하는 효소로서, 정신분열병과 관련된 후보 유전자로서 알려져 왔다. 최근, 기능성 COMT유전자 다형성과 정신분열병의 관련성이 제기되었는데, 한국인 정신분열병에서도 이러한 관련성이 있는지를 살피기 위해 본 연구를 시행하였다. 방 법 : 정신분열병으로 진단된 환자군 103명과 성별 및 연령별로 1:1 짝짓기 대조군 사이에 유전자형과 대립유전자의 분포를 비교하였다. 또한, 환자군은 공격적 행동, 가족력, 아동기 발병 여부에 따라 두 군으로 나누어 비교하였다. DNA의 다형성 부의를 중합효소연쇄반응에 의해 증폭한 후 ,NlaⅢ제한효소법과 전기영동을 실시하여 유전자형을 판별하였다. 결 과 : 환자군 전체와 대조군 사이에 유전자형과 대립유전자 빈도의 차이가 없었다. 가족력이 있는 환자군을 대조군과 비교하였을 때는, 대립유전자 L을 포함하는 유전자형과 그렇지 않은 유전자형의 분포에 있어 유의한 차이를 보였다(p=0.02, OR=3.9, 95% Cl=1.1∼14.3). 결 론 : 한국인 정신분열병과 기능성 COMT 유전자 다형성 사이에 유의한 관련성이 없었다. 따라서, 기능성 COMT 유전자 다형성이 한국인 정신분열병의 발병에 영향을 주지 못한다. 그러나, 정신분열병 가족력과 기능성 COMT유전자 다형성의 관련성이 시시돠어, 향후 본 연구에서 나타난 방법론적인 문제점을 보완하고 추가 대상자를 확보한 연구가 필요하다. Objectives : Catechol-O-methyltransferase(COMT) is involved in the degradation of catecholamine meurotransmitters and has been investigated as a candidate gene in schizophrenia. Recently, possible relationship between functional COMT gene polymorphism and schizophrenia has been suggested. To address the possible role of functional COMT gene polymorphism in the predisposition to schizophrenia, we carried out an association study in Korean schizophrenic patients and controls. Methods : One hundred and three Korean inpatients diagnosed as schizophrenia and 103 age and sex matched controls were selected as study subjects. Patients were subgrouped into two groups on the basis of history of aggressive behavior, family history of schizophrenia and related disorders, and age at onset. We determined COMT genotypes using PCR of the relevant region followed by digestion with NlaⅢ and electrophoresis. Results : No significant differences of allele and genotype frequencies were noted between patients and controls. However, when patients were categorized by the presence of family history of schizophrenia and related disorders, patients with family history showed almost 4 fold higher frequency of having COMT L allele containing genotype compared to controls(p=0.02, OR=3.9, 9.5% CI=1.10-14.33). Conclusion : Although our results do not support an association between functional polymorphism of COMT gene and schizophrenia overall, the findings suggest an association between functional COMT gene polymorphism and familial schizophrenia. Further studies with large samples are needed to confirm this association.

항진균성 항생물질을 생산하는 Streptoverticillium sp. NA-4083의 분리 및 동정

임대석,윤상균,이명섭,윤원호,김창한 한국미생물생명공학회 ( 구 한국산업미생물학회 ) 1996 한국미생물·생명공학회지 Vol.24 No.6

전국 각지의 토양에서 441균주의 방선균을 분리한 결과 Trichophyton mentagrophytes, Trichophyton rubrum, Nanniza otae 및 Pyricularia oryzae 등의 진균에 광범위한 항진균활성을 나타내는 방선균 NA-4803을 선발하여 그 균주의 동정을 실시하였다. 분리균주 NA-4803은 Gram 양성세균 4균주, Gram 음성세균 2균주, 효모 2균주, 곰팡이 5균주, 조류 1균주에 대해 약한 항균활성을 보이는 반면, 곰팡이 Trichophyton mentagrophytes, Trichophyton rubrum, Nanniza otae 및 Pyricularia oryzae에 대해서는 비교적 강한 항진균활성을 나타내었다. 분리균주 NA-4803은 생리적 특성, 항균활성, lectithinase 및 lipolytic 활성, 각종 유기물의 분해력, 항생물질에 대한 저항성, 온도, pH 및 화학저해제의 첨가에 따른 생육, 질소원의 이용성 및 탄소원의 이용성 등에 있어서 cluster group F에 속하며 Cluster No. 58에 해당하는 Streptoverticillium blastmyceticum과 가장 유사하게 비교·동정되었으나 nitrate 환원성의 양성반응, L-tyrosine 분해력의 음성반응 및 cephaloridine에 대한 저항성에 음성반응을 보였고, 탄소원 중 L-rhamnose와 inulin을 이용하는 것으로 보아 Streptoverticillium blastmyceticum과 다른 특성을 나타내었다. 따라서 분리균주 NA-4803은 Streptoverticillium sp. NA-4803으로 동정되었다. The aim of the present research program was to develop a strain of actinomycetes producing antifungal substance. Soil samples were collected from various sites in Korea and a number of actinomycetes were isolated from the soil samples by applying selective agar for actinomycetes. Among over 440 isolates, a strain (NA-4803) producing antifungal substance against Trichophyton spp. Nannizzia otae and Pyricularia oryzae was selected. The strain NA-4803 was identified as strain similar to Streptoverticillium blastmyceticum with respect to morphological and physiological characteristics, lecithinase and lipolytic activity, degradation of organic compounds, resistance to antibiotics and utilization of carbon and nitrogen sources. But it showed some differences such as positive reaction of nitrate reduction, negative reaction of L-tyrosine degradation, resistance to cephaloridine, and utilization of I rhamnose and inulin. The strain NA-4803 was named as Streptoverticillium sp. NA-4803.

일산화탄소 중독의 지연성 후유증에 관한 임상적 연구

김원,이대희,서광윤 大韓神經精神醫學會 1987 신경정신의학 Vol.26 No.4

A total of 34 patients admitted to Korea University Medical Center with the diagnosis of delayed sequeale of carbon monoxide intoxication were studied and evaluated in terms of various clinical aspects and compared with 57 control patients randomly selected from a total of 128 patients who had admitted to the Medical Center with the diagnosis of acute carbon monoxide intoxication. The results were as follows: 1) The proportion of the 34 cases of dealyed sequelae to the 128 admitted cases with acute CO intoxication was 26.6% during the same period. 2) In the cases of delayed sequelae, the age of onset ranged from 23 to 79 years (mean age=34.6 years) and the age groups with the highest incidence were in the 50s(35.3%) and the 60s(29.4%). The age of onset of the delayed sequelae group was significantly old than the control(P<0.0005). 3) Compared with the control, the patients with the delayed sequelae showed a much longer duration of impairment of consciousness (P<0.05), were fewer in number who had been administered oxygen therapy (P<0.01), and had more concomitant physical illness (P<0.01) at the time of their acute intoxication. 4) The lucid interval ranged from 3 to 43 days (mean = 16.8 days) and the lucid interval with the highest incidence was in the 2nd week*38.2%) and the 3rd week (32.5%). A possible factor influencing the lucid interval seems to have been the severity of the impairment of consciousness. 5) The characteristic symptoms manifested in patients with the delayed sequelae were mental confusion, impairment of orientation, memory, calculation and judgement, apathy or dullness, and incontinence. 6) The proportion of an abnormal EEG finding in the delayed sequelae cases was 87.5%. Diffuse irregular slow waves of 1.5-6㎐ were prominent on both hemispheres, particulaly predominent on both frontal areas. 7) The proportion of an abonormal brain CT findings in the delayed sequelae cases was 46.7% and the characteristic findings included an enlarged ventricle, low density of cerebral white matter and infarction of basal ganglia. 8) Among the cases of delayed sequelae, 70.6% were discharged in an improved state. As compared with the not improved patients, the improved patients were significantly younger (P<0.05) and had much longer length of stay in the hospital (P<0.005). In addition, the improved patients tended to show evidence of improvement on subsequent EEG follow-up and no observable lesion of basal ganglia on brain CT scan.

Behcet 환자에 합병된 우측 쇄골하동맥 가성동맥류에서의 경피적 Stent-Graft 삽입술 1례 : 증례보고

김대경,윤영섭,최승혁,이동일,이도연,장병철,심원흠 대한순환기학회 1999 Korean Circulation Journal Vol.29 No.11