심한 하악골 전돌증 환자의 외과적 치험례

권대근,이상한,이근호,장도근 大韓顎顔面成形再建外科學會 1994 Maxillofacial Plastic Reconstructive Surgery Vol.16 No.1

Obwegeser Ⅱ method and Rigid fixation conserving the condylar position has been performed on 5 patients with severe mandibular prognathism, and we obtained the result after the follow up study follows. 1. Obwegeser Ⅱ method is considered to move the distal segment passively when surgical correction of severe open bite correction and large amount of set back above 15mm is needed. 2. In one case that has more change of condylar position after operation, documented immediate post- operative relapse have been occurred 3. In the others that have adequate control of condylar position, passive set back and firm skeletal fixation, more functional and esthetic improvement and more post-operative stability has been achieved

Efficient Construction Process and Distribution System through Construction IT Convergence based on 4th Industrial Revolution Technology: Focused on Distribution Management of Free-form Structural External panel

Lee,Dong-Woon,Kim,Dae-Geon 한국유통과학회 2019 KODISA ICBE (International Conference on Business Vol.2019 No.-

The distribution of construction materials and the schedule management of a project are important elements in ensuring an effective construction system and reasonable construction duration and cost. Therefore, IT convergence technology of distribution to the construction industry, a BIM module is composed as a 4D model more easily, which is considered to contribute to a reduction in construction duration, an improvement in quality and a reduction in cost through efficient management of manpower and the minimization of errors arising from the site construction by reflecting information in real time through an RFID system.

상악골과 비사골동에 이환된 백악질 골화성 섬유종(cemento-ssifying fibroma)의 치험례

권대현,김신유,남정순,구명숙,이봉서,권대근,김종배 大韓顎顔面成形再建外科學會 2001 Maxillofacial Plastic Reconstructive Surgery Vol.23 No.6

The cemento-ossifying fibroma is a benign fibro-osseous tumor that may behave in an aggressive pattern. Although found predominantly in the mandible, most of these unusual tumors may arise in the maxilla and paranasal sinuses. Especially these lesion in the maxilla and sinuses behave more aggressively and are more prone to recur compared to mandibular counterparts. Therefore, more radical approach may be recommended than expectant observation or curettage in the initial management of this neoplasm. This is a case report of cemento-ossifying fibroma extended to maxillary sinus and naso-ethmoidal area treated by wide surgical excision after repeated conservative treatments.

정신분열병 및 정신분열형 장애에 대한 올란자핀의 효과와 안전성

안용민,강대엽,권준수,김창윤,김철응,반건호,신영민,이기철,이동우,이중서,조현상,채정호,김용식 大韓神經精神醫學會 2001 신경정신의학 Vol.40 No.4

연구목적 : 본 다기관 공동임상연구는 국내 환자를 대상으로 새로운 항정신병약물인 올라자핀의 치료 효과와 안전성을 확인하고자 시행되었다. 방 법 : 1999년 7월부터 2000년 3월까지 국내 10개 병원에 방문한 정신분열병 및 정신분열형 장애 105명을 대상으로 비대조 개방 임상연구를 시행하였다. 중등도 이상의 정신병 증상을 지니거나, 부작용으로 약물교체가 필요한 경우 또는 기분장애 증상의 치료가 필요한 환자를 대상으로 하였다. 2∼7일간의 약물 배설기간 후에 1일 10mg의 올란자핀을 투여하였고, 이후로 3∼7일 간격으로 용량을 조절하여 총 8주간 투여하였다. 치료 효과는 PANSS(Positive and Negative Syndrome Scale), BPRS(Brief Psychiatric Rating Scale), CGI(Clinical Global Impression-Severity), MADRS(Montgomery-Asberg Depression Rating Scale), HAM-A(Hamilton Rating Scale for Anxiety)로 판정하였다. 안전성 평가는 자발적인 이상반응 보고, 활력징후와 혈액 검사 및 SAS(Simpson-Angus Scale), BARS(Barnes Akathisia Rating Scale), AIMS(Abnormal Involuntary Movement Scale)척도를 이용하였다. 결 과 : 105명중에서 85.7%인 90명이 8주간의 치료를 완료하였다. 평균 최빈 용량은 일일 16.1(±4.7)mg이었고, 종료시점에서의 BPRS전체 점수가 기저 상태에 비해 40%이상 감소된 반응군은 69.5%이었다. PANSS의 양성 증후군과 일반정신병리 뿐만 아니라 음성 증후군 소척도에서도 유의한 감소를 보였으며, 이 감소들은 치료 초기부터 나타나서 8주간 지속되었다. 43.8%의 피험자가 중등도 이상의 우울증상을 같이 지니고 있었으며, 올란자핀에 의해 MADRS와 HAM-A가 유의하게 감소하였다. 치료 기간 동안에 활력징후에는 뚜렷한 변화가 없었으나 체중은 8주간 지속적으로 증가하였다. SAS와 AIMS는 감소하였으며, 정좌불능증을 제외한 나머지 추체외로 증상의 발생비율도 낮았다. 임상적인 증상이나 징후를 동반하지 않는 ALT/SGPT의 상승을 보였지만 프로락틴을 포함하는 대부분의 혈액 검사상 뚜렷한 이상 변화는 없었다. 결 론 ; 비록 본 임상연구가 비대조 개방 임상연구로서 많은 제한점을 가지고 있지만, 올란자핀이 기존 약물에 내약성을 보이거나 기분증상을 동반하는 정신병에 치료 효과가 있었다. 그리고 기존 항정신병약물 치료시에 문제가 되었던 추체외로 증상과 고프르로락틴 혈증을 포함하는 대부분의 부작용면에서 안전성을 보여 주었다. Objective : This multicenter clinical trial was carried out to investigate the efficacy and the safety of olanzpine for the treatment of Korean patients. Mothod : 105 patients with schizophrenia and schizophreniform disorder, visited at 10 mental or university hospitals, had received an open and non-comparative treatment with olanzapine for 8 weeks. Patients had psychotic or depressive symptoms with the severity above moderate degree or intolerable side effects to previous antipsychotics. After a wash-out period of 2-7 days, 10mg olanzapine was prescribed initially to all the patients, and then the dosage could be adjusted within the range of 5-20mg/day of olanzapine by 3-7 days. Results : 90(85.7%) of 105 patients completed the 8-weeks trial and the mean modal dose of olanzapine was 16.1(±4.7%)mg/day. At the end of the trial, 73 patients(69.5%) were classified as responder, which was defined as 40% or more improvement in BPRS(Brief Psychiatric Rating Scale) score comparing to baseline. There was a significant reduction in the scores of PANSS(Positive and Negative Syndrome Scale)and subscales including negative symptom scores and CGI. Also weekly analysis showed that the reductions in scores were kept on for the whole period of the trial. 43.8% of all the patients had depressive symptoms at the baseline and total scores of MADRS(Montgomery-Asberg Depression Rating Scale) and HAM-A(Hamilton Rating Scale for Anxiety) were also reduced after the trials. Vital signs revealed no clinically significant changes but continuous weight gain was observed during the treatment with olanzapine. The scores of SAS(Simpson-Angus Scale) and AIMS(Abnormal Involuntary Movement Scale) for assessing the EPS(extrapyramidal symptoms)and tardive dyskinesia respectively were significantly decreased and only a few patients reported EPS as adverse events. Although mild and clinically non-significant of ALT/SGPT was observed, most laboratory parameters including plasma prolactin level showed to significant changes during the trial. Conclusions : Although this trial had many limitations because it was a non-comparative and open study, olanzapine showed high efficacy on the positive, negative and depressive symptoms in schizophrenia and schizophreniform disorder.In addition to that, olanzapine showed a substantially favorable safety profile, such as low incidence of EPS and hyperprolactinemia.

Cao-MgO-SiO₂-P₂O -CaF₂계 생체활성 결정화 유리의 기계적 성질에 미치는 ZrO₂및 Al₂O₃의 분산 강화 효과

박찬운,강건구,원대희,이민호,배태성 대한치과기재학회 1998 대한치과재료학회지 Vol.25 No.2

Bioactive glass-ceramics can form tight chemical bonds with bone, however, their poor mechanical properties may limit their clinical applications. Alumina ceramics show good biocompatibility and high strength but can't form chemical bonds with bone. Hydroxyapatite ceramics and bioglass form chemical bonds with bone but their strength and fracture are relatively low. Glass ceramics containing apatite and wollastonite crystals can form tight chemical bonds with bone and show relatively high strength and fracture toughness. Bioactive glass-ceramics toughened by alumina and tetragonal zirconia polycrystals show relatively high mechanical strength. Both bioactive and high strength ceramics will be widely applicable to many clinical applications. In this study, bioactive glass-ceramics toughened by alumina and zirconia polycrystals were fabricated, and crystallization behavior, biaxial flexure strength, fracture toughness, and bioactivity were measured. The results obtained were summarized as follows; 1. The major crystaline phase in the matrix glass were observed to be apatite, wollastonite, and β-TCP. 2. Biaxial flexure strength and fracture toughness values were more improved by the dispersion toughening of alumina and zirconia, and the improvement of mechanical strength was more higher in the dispersion toughening of zirconia than that of alumina. 3. The bioactivity, which was evaluted from apatite formation in the simulated body fluid, was higher in the dispersion toughening of Zr-O₂than that of Al₂O₃.

Determination of Building Model Key Points Using Multidirectional Shaded Relief Images Generated from Airborne LiDAR Data

Lee, Dong-Cheon,Lee, David H.,Lee, Dae Geon Hindawi Limited 2019 Journal of sensors Vol.2019 No.-

<P>Light detection and ranging (LiDAR) data collected from airborne laser scanner system is one of the major sources to reconstruct Earth’s surface features. This paper presents a method for detecting model key points (MKPs) of the buildings using LiDAR point clouds. The proposed approach utilizes shaded relief images (SRIs) derived from the LiDAR data. The SRIs based on the concept of the shape from shading could provide unique information about individual surface patches of the building roofs. The main advantage of the proposed approach is to detect directly MKPs, which are primitives for 3D building modeling, without segmenting point clouds. Depending on the location of the light source, the SRIs are created differently. Therefore, integration of the multidirectional SRIs created from different locations of the light source could provide more reliable results. In addition, the vertical exaggeration (i.e., scaling<I> Z</I>-coordinates) is also beneficial because constituent surface patches of the roofs in the SRIs created with vertically exaggerated LiDAR data are more distinguishable. To determine the MKPs of the roofs, building data was separated from other objects using modified marker-controlled watershed algorithm in accordance with criteria to specify buildings such as area, height, and standard deviation. This process could remove the unnecessary objects such as trees, vegetation, and cars. The curvature scale space (CSS) corner detector was used to determine MKP since this method is robust to geometric changes such as rotation, translation, and scale. The proposed method was applied to simulated and real LiDAR datasets with various roof types. The experimental results show that the proposed method is effective in determining MKPs of various roof types with high level of detail (LoD).</P>

Manufacture and characterization of functional foods by using Pholiota adiposa

Dae-Hyung Lee,Jeong-Sik Park,Geon-Sik Seo,Soo-Muk Cho,Jong-Soo Lee 한국버섯학회 2007 한국버섯학회지 Vol.5 No.3·4

3The goal of this study was to develop high value mushroom foods possessing functionality. The effect of the Pholiota adiposa on the alcohol fermentation and its antihypertensive angiotensin I-converting(ACE) inhibitory activity of Korean traditional rice wine, Yakju was investigated. The ACE inhibitory activity of traditional rice wine was increased about 8% by the addition of 0.1% of the edible mushroom Pholiota adiposa ASI 24012 fruiting bodies into the mash containing 1% Lycii fructus, cooked rice, koji and antihypertensive S. cerevisiae and its Pholiota adiposa PAD-022 which showed anticholesteromia HMGCoA reductase inhibitory activity. Its quality characteristics and stability were investigated during the storage of room temperature and 40℃ for 3 months. It showed very high acceptability and also was very stable at 40℃ for 3 months[This study was supported by a grant from ARPC, 2005-2007].

Improvement Scheme of Airborne LiDAR Strip Adjustment

Lee, Dae Geon,Lee, Dong-Cheon 한국측량학회 2018 한국측량학회지 Vol.36 No.5

Strip Adjustment of Airborne Laser Scanner Data Using Area-based Surface Matching

Lee, Dae Geon,Yoo, Eun Jin,Yom, Jae-Hong,Lee, Dong-Cheon 한국측량학회 2014 한국측량학회지 Vol.32 No.6

Hydrogen Trapping Characteristics and Mechanical Degradation in a Duplex Stainless Steel

Dae Geon Lee,Ji Hoon Kim,Seong Hoon Kim,Heon Young Ha,Tae Ho Lee,Joonoh Moon,Dong‑Woo Suh 대한금속·재료학회 2023 METALS AND MATERIALS International Vol.29 No.1

We investigated the hydrogen behaviors and corresponding mechanical degradation in the duplex stainless steel under theex-situ and in-situ cathodic charging condition. In the ex-situ condition, where the hydrogen charging was conducted priorto the slow strain tensile test, the hydrogen uptake linearly increased with the charging time. The absorbed hydrogen wasthought to be trapped at dislocation and grain boundary in ferrite at early stage of cathodic charging, but the ferrite-austeniteinterface gradually involved in the hydrogen trapping at the prolonged charging time, leading to the increase of trap activationenergy as the charging time elapsed. When the cathodic charging was conducted during the slow strain tensile test, i.e. in-situcondition, the hydrogen uptake was remarkably accelerated and the hydrogen penetrated more deeply into the steel interior. It is believed to be attributed to the transport of hydrogen atoms from the surface by gliding dislocations. The elongation lossin the duplex stainless steel became less sensitive to the hydrogen content as the charging time increased and more than 60%of ductility was preserved even with diffusible hydrogen content around 50 ppm, which represented a remarkable resistanceto the hydrogen embrittlement compared to those in the conventional high strength steels.