인체 상피세포에서 ras-종양유전자의 발암화가 신호 전달 기작에 미치는 영향

장도근 慶北大學校 齒科大學 1999 慶北齒大論文集 Vol.16 No.1

Controlling the spectrum of high-power terahertz radiation from a laser-driven plasma wave

장도근,김진주,남인혁,허민섭,석희용 한국물리학회 2012 Current Applied Physics Vol.12 No.5

Generation of strong THz waves is a very important and difficult research issue. We performed particlein-cell (PIC) simulation studies to investigate the possibility of powerful THz generation and spectrum controllability by using a laser-driven plasma wave. Our results show that it is possible to produce spectrum-controllable high-power (>1 MV/cm) THz waves by manipulating the plasma density profiles. This method may provide a good way for coherent high-power THz radiation sources, of which the spectrum ranges from a narrow bandwidth to a wide bandwidth. Generation of strong THz waves is a very important and difficult research issue. We performed particlein-cell (PIC) simulation studies to investigate the possibility of powerful THz generation and spectrum controllability by using a laser-driven plasma wave. Our results show that it is possible to produce spectrum-controllable high-power (>1 MV/cm) THz waves by manipulating the plasma density profiles. This method may provide a good way for coherent high-power THz radiation sources, of which the spectrum ranges from a narrow bandwidth to a wide bandwidth.

가토 하악골 결손부의 골재생에 있어서 n-PTFE의 효과

장도근 慶北大學校 齒科大學 1996 慶北齒大論文集 Vol.13 No.-

n-PTFE를 가토하악골의 결손부에 적용하여 그 성질과 조직에 대한 반응과 골의 재생성도를 평가해 보고 n-PTFE가 초기에 미치는 영향과 그것을 지속적 효과에 대해 실험적 증명을 꾀하고자 하였다. 실험의 결과를 요약하면 아래와 같다. 1. 초기1주 실험군의 골결손부는 대조군의 결손부위가 혈병이 상실되고 근육과 섬유조직으로 채워진 것과 달리 소성 결체조직으로 채워지며 골형성 활성이 보다 뚜렷하였다. 2. 실험군은 3주 이후 막의 경계를 따라 내부에 현저한 골형성이 이루어졌으며 혈관이 풍부한 소성 골수조직이 신생골주 사이 사이를 채웠고 시간이 경과되면서 골주의 수는 감소되나, 성숙된 피질골의 두께는 보다 증가되었으며 조혈성 골수의 형성이 뚜렸하였다. 3. 삽입된 차단막은 실험 전 기간을 통해 특기 할 염증소견이나 이물반응을 야기하지 않았다. 4. 차단막을 제거한 이후에는 파골세포들의 활성에 의해 형성골이 재형성되면서 골량의 감소가 현저하였으며 제거 4주후 소견은 대조군 10주 소견과 유사하였다. 5. 대조군은 실험군에 비해 골성 회복이 현저히 미약하였다. 이상의 소견으로 n-PTFE 막은 생체적합성, 굽힙성과 견고성을 가져 가토의 하악골 결손부에 적용시 빠른 골의 재생을 보이나, 이차적인 제거시 흡수로 인하여 골량의 소실이 야기된다. 따라서 제거 시기가 골량의 확보에 중요한 요소가 될 것으로 사료된다. We observed the effect of application of n-PTFE on mandibular bone defects in the rabbit. GTR is based on the hypothesis that during wound healing, non-osteogenic cells are mechanically blocked from entering a bone defect. This allows the slower-migrating mesenchymal cells from the surrounding bone and marrow, having osteogenic potential, to move the defect site Bilateral through & through defects, 8mm * 4mm in size involving the inferior border of mandible, were created in the mandible angle of 15 rats. The experimental side was applied with high-density n-PTFE membrane, with the opposite side serving as a control. In the first week fo the early experimental period, the bone defects of experimental groups were filled with highly vascularized fibrous connective tissue showing prominent osteoblastic activity with osteoid formation, whereas the defects of control were replaced by dense fibro-muscular tissure without osteoblastic activity. After 3 weeks, the experimental group revealed well formed bone trabeculae and fibro-vascular marrow within surrounding membrane. membrane With time the amount of new bone was decreased with increase of hemato-poietic marrow, and the cortical plate composed of dense mature bone was more thicker. In the whole experimental periods, the inflammation and foreign body reaction were not found around the inserted n-PTFE membrane. In the whole experimental periods, the inflammation and foreign body reaction were not found around the inserted n-PTFE membrance. After remoival of membrane there was marked remodeling of newly formed bone by active osteoclasts in periosteal soft tissue, which decreased the bone volume apparantly. These findings suggest that n-PTFE has biocompatibility, flexibility, and rigidity and offer rapid bone regeneration within limited area by the membrane. On the other hand, the early removal of membrane caused reduction of bone volume by the osteoclastic resorption. Thus, the time of removal may be more important factor for maintenance of regenerated bone volume.

심한 하악골 전돌증 환자의 외과적 치험례

권대근,이상한,이근호,장도근 大韓顎顔面成形再建外科學會 1994 Maxillofacial Plastic Reconstructive Surgery Vol.16 No.1

Obwegeser Ⅱ method and Rigid fixation conserving the condylar position has been performed on 5 patients with severe mandibular prognathism, and we obtained the result after the follow up study follows. 1. Obwegeser Ⅱ method is considered to move the distal segment passively when surgical correction of severe open bite correction and large amount of set back above 15mm is needed. 2. In one case that has more change of condylar position after operation, documented immediate post- operative relapse have been occurred 3. In the others that have adequate control of condylar position, passive set back and firm skeletal fixation, more functional and esthetic improvement and more post-operative stability has been achieved

인체 상피세포에서 ras-종양유전자의 발암화가 신호 전달 기작에 미치는 영향

장도근(Do Geun Jang),변기정(Ki Jeong Byeon),김진수(Chin Soo Kim) 대한구강악안면외과학회 2000 대한구강악안면외과학회지 Vol.26 No.3

The present study has attempted to look into the mechanism of ras-induced carcinogenesis in a human epithelial cell system. Human epithelial cells immortalized with Ad12-SV40 hybrid virus were used to assess carcinogenic potential of the ras-oncogene. Cells transfected with pSV2-ras showed characteristics of cellular transformation. The transformation parameters such as cell density, soft-agar colony formation, and cell aggregation were significantly increased in the cells expressing ras oncoprotein. In addition, the duration required for the appearance of foci was shortened in the ras-transfected cells. Consistent with other reports, our results demonstrated an evidence that the ras-oncogene induced the cellular transformation of human epithelial cell system. When a high concentration of glucocorticoid was added into the media, transformation process was accelerated. It is speculated that glucocorticoid may provide an advantageous environment for the proliferation of the transformed cells. The induction of the intracellular free calcium concentrations following agonist treatment was significantly lower in the transformed cells than in the control cells. These effects were more manifested in the presence of extracellular cacium, indicating that the transformation process may alter the influx pathway of extracellular calcium. The induction of IP₃ following agonist treatment was also lower in the transformed cells than in the control cells. Thus, it is suggested that phospholipase C-coupled pathway was down-regulated in the process of the ras-induced transformation. While the levels of TGF-β1 and PAI-2 mRNAs were decreased, the level of fibronectin mRNA was increased. The results indicate that mechanism of the ras-induced transformation may be associated with the altered expressions of growth regulatory factors. The present study demonstrates an evidence that the ras-induced cellular transformation may be associated with alteration of signal transduction and growth regulatory factors. The study will contribute to improve the understanding of molecular mechanism of epithelium-derived cancers including oral cancer.

우측 상악동 및 측두하간극에 걸쳐 발생한 선낭포성암의 치험례

장도근(Do Geun Jang),이용규(Yong Gyoo Lee),김사엽(Sa Yub Kim),김준연(Joon Yeun Kim),김진수(Chin Soo Kim) 대한구강악안면외과학회 1993 대한구강악안면외과학회지 Vol.19 No.4

This is a case report of adenoid cystic carcinoma on the right maxillary antrum and infratemporal space. The treatment of adenoid cystic carcinoma is chiefly surgical, although in some case surgery has been successfully coupled with radiation. The patient, aged 52 female, developed a pain involving the right side of face was diagnosed adenoid cystic carcinoma and treated with right tootal maxillectomy, preserving the inferior orbital rim of the right orbit, radical neck dissection performed and postoperative radiation therapy. No recurrence has been observed for 3.9 years. We will examine. Periodically the patient because of its poor prognosis and high recurrence during long term.

The management of mandibular arteriovenous malformation using the surgical therary with preoperative embolization

장도근(Do Geun Jang),최강영(Kang Young Choi),김진수(Chin Soo Kim) 대한구강악안면외과학회 1995 대한구강악안면외과학회지 Vol.21 No.4

구강악안면영역의 혈관질환은 매우 위험한 질환으로 술자에게 주의를 요한다. 여기에는 혈관종과 혈관기형이 있으며 정확한 기왕력과 적절한 임상검사로 감별진단이 가능하지만 진단적인 혈관조영술이 요구되기도 한다. 치료에는 경화술, 냉동술, 방사선치료, 결찰술, 혈관색전술, 레이저치료 및 외과적 접근법이 있다. 특히 동정맥기형에서의 외과적 접근법에는 많은 논란이 있는데, 병소의 경계를 포함한 완전한 제거가 요구된다는 의견과 단순한 소파술만으로 치료가 가능하다는 상반된 경우가 있다. 본 증례는 Gelfoam을 이용하여 술전 혈관색전술 시행한 후 건전한 협측 피질골을 거상, 내부 종물의 소파술을 시행한 후 거상한 피질골을 재위치시킴으로서 악골의 외형을 잘 보존한 경우로 술후 기능적 및 심미적으로 양호한 결과를 얻었기에 보고합니다. Vascular lesions of the oral and maxillofacial region are as challenging to clinicians as they are devastating to patients. Two basic entities of hemangioma and vascular malformations exist as vascular lesions. The differential diagnosis bfetween these two lesions can be done through the history and the phyisical findings. Some lesions may be difficult to evaluate; therefore, a diagnostic angiography may be employed. Management of maxillofacial vascular malformations consists of sclerotherapy, cryotherapy, radiotherapy, intralesional ligation, embolotherapy, laser therapy, and surgical treatment. The surgical management of vascular malformations, particularly the arteriovenous malformation, remains as controversial an issue as any in contemporary oral and maxillofacial surgery. On one hand, there is a surgically aggressive school of thought that advocates major segmental or en bloc resecton of the arteriovenous malformation. The opposite point of view is clearly reflected by the numerous case reports that appear in the literature of arteriovenous malformations managed by simple curettage. We experienced a large mandibular arteriovenous malformation with an intact buccal cortex that was treated with curettage with the lateral decortication and reposition of the decorticated buccal bone plate after preoperative embolization using Gelfoam and without arbitrary sacrifice of the uninvolved cortical margin that could provide stability of the mandibular arch. The postoperative result was good aesthetically and functionally.

가토 하악골 결손부의 골재생에 있어서 n-PTFE의 효과

장도근(Do Geun Jang),송재철(Jae Chul Song),이용규(Yong Gyoo Lee),김진수(Chin Soo Kim) 대한구강악안면외과학회 1997 대한구강악안면외과학회지 Vol.23 No.3

We observed the effect of application of n-PTFE on mandibular bone defects in the rabbit. GTR is based on the hypothesis that during wound healing, non-osteogenic cells are mechanically blocked from entering a bone defect. This allows the slower-migrating mesenchymal cells from the surrounding bone and marrow, having osteogenic potential, to move the defect site Bilateral through & through defects, 8mm * 4mm in size involving the inferior border of mandible, were created in the mandible angle of 15 rats. The experimental side was applied with high-density n-PTFE membrane, with the opposite side serving as a control. In the first week fo the early experimental period, the bone defects of experimental groups were filled with highly vascularized fibrous connective tissue showing prominent osteoblastic activity with osteoid formation, whereas the defects of control were replaced by dense fibro-muscular tissure without osteoblastic activity. After 3 weeks, the experimental group revealed well formed bone trabeculae and fibro-vascular marrow within surrounding membrane. membrane With time the amount of new bone was decreased with increase of hemato-poietic marrow, and the cortical plate composed of dense mature bone was more thicker. In the whole experimental periods, the inflammation and foreign body reaction were not found around the inserted n-PTFE membrane. In the whole experimental periods, the inflammation and foreign body reaction were not found around the inserted n-PTFE membrance. After remoival of membrane there was marked remodeling of newly formed bone by active osteoclasts in periosteal soft tissue, which decreased the bone volume apparantly. These findings suggest that n-PTFE has biocompatibility, flexibility, and rigidity and offer rapid bone regeneration within limited area by the membrane. On the other hand, the early removal of membrane caused reduction of bone volume by the osteoclastic resorption. Thus, the time of removal may be more important factor for maintenance of regenerated bone volume.

Spatial and Temporal Measurements of Plasma/Gas Densities in a Capillary Gas-Cell for Laser-Plasma Accelerators

남인혁,김민석,이승우,장도근,석희용 한국물리학회 2016 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.69 No.6

The measurement of the plasma density is of crucial importance in laser-plasma accelerators. We measured the spatial and the temporal plasma/gas densities in a capillary gas-cell by using the interferometric and the Raman scattering methods. By using transverse interferometry, we were able to measure directly the spatial distribution of the electron density between the entrance and the location of gas injection in the capillary, and we compared the result with that from a computational fluid dynamics (CFD) simulation. By using longitudinal interferometry along the capillary’s axis, we were able to obtain the temporal evolution of the density of hydrogen gas. Furthermore, we used the stimulated Raman forward scattering method with a terawatt-level high-power laser beam for real-time measurement of the localized electron density inside the capillary. We found that the interferometry and the Raman scattering methods gave consistent results for the plasma density.

하악 구치부 치주인대에서 발생한 변연성 백악질 섬유종의 치험례 : 증례보고

노충(Chung Noh),최문식(Mun Sik Choi),장도근(Do Geun Jang),김준연(Joon Yeun Kim) 대한구강악안면외과학회 1997 대한구강악안면외과학회지 Vol.23 No.1

Peripheral cementifying fibroma is histomorphologically similar to the central cementifying fibroma, but this lesion is unique to the gingival mucosa and is only rarely seen in edentulous area. In most instances, it arise from interdental papilla, with 80% occurring anterior to molar region. This lesion appears to involve the maxilla and mandible equally, demonstrates the highest occurrence rate during the second decade of life, and affects female more frequently than male, with 4.3:1 to 3:2. Peripheral cementifying fibroma presents as firm, pedunculated or sessile mass with an intact or ulcerated surface depending on the presence of trauma. Microscopically, it reveals a highly cellular mass of connective tissue containing numerous plump, proliferating fibrolasts and several forms of calcification. Effective treatment requires deep excision, which includes the ligament and periosteum, followed by a thorough root scaling of the adjacent teeth. A reveiw of the literature and a report of a case of peripheral cementifying fibroma are presented.