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In situ screening of 3-arylcoumarin derivatives reveals new inhibitors of mast cell degranulation
Marcela de Souza Santos,Maria Perpe´tua Freire de Morais Del Lama,Laila Aparecida Deliberto,Fla´vio da Silva Emery,Moˆnica Tallarico Pupo,Rose Mary Zumstein Georgetto Naal 대한약학회 2013 Archives of Pharmacal Research Vol.36 No.6
Due to the severity and high prevalence ofallergic diseases, there is growing interest in the developmentof inhibitors of such conditions. 3-Arylcoumarinderivatives emerge as promising compounds for thetreatment of allergic disorders, in particular due to theirclose structural similarity to flavonoids, whose anti-allergicactivity has been extensively reported. The aim of this workwas to perform a screening of a set of 3-arylcoumarins aspotential inhibitors of mast cell degranulation, a key eventfor the development of allergic reactions. For that purpose, itwas utilized a biosensor model based on mast cells, whosein vitro assay allows for such screening, in a high throughputfashion, and also permits bringing to attention some coumarinstructural features that are important for their biologicalactivity. The mast cell-based biosensor was shown todiscriminate, with high sensitivity and reproducibility,between coumarins that did not affect or caused differentdegrees of inhibition of degranulation. Among activecoumarins, some substituents could be accounted for theirinhibitory activity, such as the hydroxylation of positions 6and 20 of 3-phenylcoumarins, in addition to catechol, aminoand thiophene moieties. In summary, 3-arylcoumarins couldbe suggested as potential candidates for the developmentof new anti-allergic drugs.
Dynamic Simulation and Aircraft Level Assessment of CMC Implementation on GTF Engine
Da Mo,Ioannis Roumeliotis,Yixiong Liu,Christos Mourouzidis,Sajal Kissoon 한국항공우주학회 2023 International Journal of Aeronautical and Space Sc Vol.24 No.3
This paper dynamically simulated the geared turbofan engine with CMC turbine components, including impacts of fuel schedule, shaft inertia, volume packing, BOV schedule. Deliberated comparisons were performed between CMC engine and Inconel engine on aircraft level performance and transient behaviour. Heat load examination is included in flight mission analysis, which lays the basis on the gearbox efficiency map related to torque and rotational speed. Results indicate that IPC surge margin of the CMC case slightly fall 0.15% but maintain steady. The mitigated T4 overshooting phenomenon has offered a 30 K drop and thus extended turbine life. More importantly, Fan shaft inertia dominantly affects engine operability, whereas the blow-off air fraction severely impacts the low power setting operation. Further investigation of heat load reveals that power loss at take-off segment accounts for 1.1% of IP shaft input power, which is 3.98% higher than Inconel case. The thermal management system needs to be redesigned to absorb extra heat. On assessment of aircraft level performance, CMC engine provides superior profits in maximizing airline revenue. The predicted annual fuel cost saving is about 0.08 million dollars coming from block fuel reduction. NOx, noise and CO2 demonstrate obvious decline, approaching 5.9%, 1.0% and 4.9%, respectively.
( Da Lei Yao ),( Chang Hao Zhang ),( Jie Luo ),( Mei Jin ),( Ming Shan Zheng ),( Jiong Mo Cui ),( Jong Keun Son ),( Gao Li ) 영남대학교 약품개발연구소 2015 영남대학교 약품개발연구소 연구업적집 Vol.25 No.-
Two new (1 and 3) two known diarylhep-tanoids (2 and 4), along with two tetralones (5 and 6), one naphthoquinone (7), four phenylpropanoids (8-11), and phenol (12) were isolated from the leaves of Juglans mandshurica. Their structures were elucidated on the basis of spectral and chemical data. Compounds 2 and 10 are firstly isolated from this plant and 8 and 12 were isolated from the Juglans genus for the first time. Among these compounds, only 7 cxhibitcd moderate cytotoxicities against cultured Mgc-803, A549, K562, and Hela tumor cell lines with IC50 values of 25.90, 28.60, 39.06, 44.90 LLM, respectively.
Chemical constituents from the leaves of Juglans mandshurica
Da Lei Yao,Chang Hao Zhang,Jie Luo,Mei Jin,Ming Shan Zheng,Jiong Mo Cui,손종근,Gao Li 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.4
Two new (1 and 3) and two known diarylheptanoids(2 and 4), along with two tetralones (5 and 6), onenaphthoquinone (7), four phenylpropanoids (8–11), andone phenol (12) were isolated from the leaves of Juglansmandshurica. Their structures were elucidated on the basisof spectral and chemical data. Compounds 2 and 10 arefirstly isolated from this plant and 8 and 12 were isolatedfrom the Juglans genus for the first time. Among thesecompounds, only 7 exhibited moderate cytotoxicitiesagainst cultured MGC-803, A549, K562, and HeLa tumorcell lines with IC50 values of 25.90, 28.60, 39.06,44.90 lM, respectively.
Da-Som Kim,Han-Mo Oh 강원대학교 경영경제연구소 2017 Asia-Pacific Journal of Business Vol.8 No.1
The present study aims to examine the role of market orientation as an international partnership property. This property, labeled export-venture market orientation, is at the inter-firm level and is related to the new market development (NMD) activities of export-ventures. Specifically, this article is to define the export-venture market orientation; to argue that it is a major factor in NMD export-venture success; and to argue that the resource-advantage (R-A) theory of competition can provide a theoretical foundation for this concept and explain its contribution to export-ventures’ international expansion success. This manuscript is conceptual in approach. In their efforts to strengthen relationships, export-ventures may tend to focus so much time on the partnership factors that they miss market opportunities. As a spanning process, NMD should be informed by both external and internal activities. In an export-venture, market orientation helps guide NMD activities from outside to inside and vice versa. As a dynamic and disequilibrium provoking process, the R-A theory can theoretically ground the concept of export-venture market orientation and explain its role in NMD export-venture success. The current study contributes to business marketing theory in three ways: it extends the concept of intra-organizational market orientation to an inter-organizational context; contributes to understanding the role of idiosyncratic resources in export-ventures; and theoretically explains the concept of export-venture market orientation. The present study is the first to extend the concept of market orientation into inter-organizational NMD framework and to examine the role of export-venture market orientation in NMD export-venture success.
( Da Hyun Jung ),( Jie-hyun Kim ),( Su Jin Jeong ),( Soon Young Park ),( Il-mo Kang ),( Kyoung Hwa Lee ),( Young Goo Song ) 대한소화기학회 2018 Gut and Liver Vol.12 No.6
Background/Aims: Helicobacter pylori eradication rates are decreasing because of increases in clarithromycin resistance. Thus, finding an easy and accurate method of detecting clarithromycin resistance is important. Methods: We evaluated 70 H. pylori isolates from Korean patients. Duallabeled peptide nucleic acid (PNA) probes were designed to detect resistance associated with point mutations in 23S ribosomal ribonucleic acid gene domain V (A2142G, A2143G, and T2182C). Data were analyzed by probe-based fluorescence melting curve analysis based on probe-target dissociation temperatures and compared with Sanger sequencing. Results: Among 70 H. pylori isolates, 0, 16, and 58 isolates contained A2142G, A2143G, and T2182C mutations, respectively. PNA probe-based analysis exhibited 100.0% positive predictive values for A2142G and A2143G and a 98.3% positive predictive value for T2182C. PNA probe-based analysis results correlated with 98.6% of Sanger sequencing results (κ-value=0.990; standard error, 0.010). Conclusions: H. pylori clarithromycin resistance can be easily and accurately assessed by dual-labeled PNA probe-based melting curve analysis if probes are used based on the appropriate resistance-related mutations. This method is fast, simple, accurate, and adaptable for clinical samples. It may help clinicians choose a precise eradication regimen. (Gut Liver 2018;12:641-647)