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Hyun Ah Lee(이현아),Ji Eun Kim(김지은),Sung Hwa Song(송성화),Ji Eun Sung(성지은),Min Gi Jung(정민기),Dong Seob Kim(김동섭),Hong Joo Son(손홍주),Chung Yeoul Lee(이충열),Hee Seob Lee(이희섭),Dae Youn Hwang(황대연) 한국생명과학회 2016 생명과학회지 Vol.26 No.5
천문동(Asparagus cochinchinensis)은 북아시아 지역에서 열병, 감기, 신장질환, 유방암, 염증질환, 뇌질환 등의 치료에 오랫동안 사용되어온 약용식물(medicinal plant)이다. 비록, 천문동의 항염증(ani-inflammatory) 효능에 대한 일부 연구들이 수행되었지만, 신경세포에서 항염증작용과 신경성장인자(nerve growth factor, NGF)의 연관성에 대한 연구는 수행된바 없다. 따라서, 본 연구에서는 신경세포에서 신경성장인자의 분비와 작용기전에 대한 천문동 열수추출물(aqueous extract from A. cochinchinensis, AEAC)의 영향을 연구하였다. AEAC로 처리된 B35세포의 배양액에 NGF단백질의 농도는 대조물질(vehicle) 처리군에 비하여 유의적으로 증가하였으며, 특별한 독성은 관찰되지 않았다. 또한, NGF mRNA의 발현도 단백질의 농도변화와 유사한 양상을 나타내었다. 더불어, B35세포로부터 분비된 NGF의 생리활성을 확인하기 위해, AEAC-조정배지(conditioned medium)를 미분화된 PC12세포에 처리한 후 이들 세포의 신경염성 성장(neuritic outgrowth)을 관찰하였다. PC12세포의 수상돌기 길이(dendritic length)는 vehicle처리군에 비하여 AEAC-조정배지처리군에서 유의적으로 증가하였다. 또한, High affinity NGF 수용체의 하위신호전달에 포함된 p-TrkA와 p-ERK의 발현은 AEAC-조정배지처리군에서 높았지만, low affinity NGF 수용체의 하위신호전달에서는 낮은 수준으로 관찰되었다. 이러한 결과는 AEAC가 신경세포에서 NGF발현과 분비의 조절에 기여하기 때문에 신경퇴행성질환(neurodegenerative disease) 치료제로서 우수한 후보물질임을 제시하고 있다. Asparagus cochinchinensis is a medical plant that has long been used to treat fever, cough, kidney disease, breast cancer, inflammatory disease and brain disease in northeast Asian countries. Although several studies have been conducted on the anti-neuroinflammatory effects of A. cochinchinensis, the correlation between these effects and nerve growth factor (NGF) has not yet been examined. In this study, we investigated the effects of an aqueous extract of A. cochinchinensis (AEAC) on the secretion and action mechanism of NGF in neuronal cells. The concentration of the NGF protein in the supernatant collected from cultured cells increased significantly in B35 cells treated with AEAC in comparison with the vehicle-treated group without any specific cytotoxicity. Furthermore, the mRNA expression of NGF showed a very similar pattern to its protein concentration. To examine the bioactivity of NGF secreted from B35 cells, undifferentiated PC12 cells were cultured in an AEAC-conditioned medium and neuritic outgrowth was observed. The dendrite length of PC12 cells in the AEAC-treated group was significantly higher than that in the vehicle-treated group. Moreover, the level of the downstream effectors p-TrkA and p-ERK of the high-affinity NGF receptor was significantly higher in the AEAC-treated group, while the expression of the downstream effectors of the low-affinity NGF receptor was significantly lower in the same group. These results suggest that AEAC may contribute to the regulation of NGF expression and secretion in neuronal cells; it is therefore an excellent candidate for further investigation as a therapeutic drug for neurodegenerative diseases.
Rhodium N-Heterocyclic Carbene Catalyzed [4 + 2] and [5 + 2] Cycloaddition Reactions.
Lee, Sang Ick,Park, Se Yeoun,Park, Ji Hoon,Jung, Il Gu,Choi, Soo Young,Chung, Young Keun,Lee, Bun Yeoul WILEY-VCH Verlag 2006 Chem Inform Vol.37 No.21
<P>ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.</P>
Lee, Woo-Jung,Cho, Dae-Hyung,Wi, Jae-Hyung,Han, Won Seok,Kim, Boo-Kyoung,Choi, Sang Dae,Baek, Ju-Yeoul,Chung, Yong-Duck Elsevier 2018 Materials science in semiconductor processing Vol.81 No.-
<P><B>Abstract</B></P> <P>Chemical bath deposition (CBD)-ZnS is used as a buffer layer for Cu(In,Ga)Se<SUB>2</SUB> (CIGS) solar cell and then, plasma damage originated from the negative oxygen ions or neutral particles with high energy is regarded as an important issue during subsequent deposition of window layer by sputtering process. To avoid negative plasma effects, we newly designed sputtering system with dual deposition mode of low damage sputtering (LDS) process and direct sputtering (DS) process, adjusting plasma direction by dual cylindrical targets. It allows to grow bilayer AZO film by sequentially depositing thin LDS AZO film as a protect layer and thick AZO film as a transparent conducting layer to collect electrons. The physical and electrical characteristics of bilayer AZO film were investigated to verify the positive effect against plasma damage. In plasma damage test using GaAs wafer, we observed that increase of sputtering power leads to a falling-off in electrical qualities by plasma damage. For practical solar cell application, we fabricated three types of CIGS/CBD-ZnS solar cells with LDS AZO film grown at 2 kW and 5 kW (by 1500 mm cylindrical targets) and Conventional-AZO film (by 4-in. circular targets), and demonstrated that the performance of CIGS solar cell with LDS AZO is superior to that with Conventional-AZO film due to the effective protection layer to relieve plasma damage.</P>
이진열,정순주,지연태,김희경 全南大學校 農業科學技術硏究所 2001 農業科學技術硏究 Vol.36 No.-
This experiment was conducted to investigate the effect of chitosan, oligosaccharides on root and shoot growth promotion and fruit harvest of cucumber. Chitosan solution was made by hydrolysis with enzyme, and diluted in 1,000(50ppm), 3,000(16.7ppm), 5,000(10ppm) and 7,000(7ppm) times. 7,000 times diluted chitosan solution showed the best results on plant height, stem diameter, number of leave, leaf area, and leaf and petiole fresh weight, but fresh stem weight was inhibited in all concentrations of chitosan solution. Also fruit yield was increased 24.7% in 7,000 times diluted chitosan solution.
하구의 생물다양성확보를 위한 어도설치 방안에 관한 연구
( Lee Kang Yeoul ),( Chung In Young ),( Park Kwang Su ),( Cho Young Kweon ),( Kim Meyong Won ) 한국농공학회 2006 한국농공학회 학술대회초록집 Vol.2006 No.-
As constructing new type fishway, they will provide aid for the preservation of ecological environments and biodiversity but also improving the quality of water in Korean estuaries. When new type fishway and incidental facilities sublimate into a natural park, it will be a help that people increasingly consider estuaries and as, an environment which should be well maintained along with the human beings as well as subjects of irrigation and flood control.
생쥐 대장 평활근 세포에서 내향 정류성 칼륨 전류의 특성 연구
이은주,김명,정명섭,조향훈,김기훈,하현철,김준수,최석,전제열 朝鮮大學校 附設 醫學硏究所 2006 The Medical Journal of Chosun University Vol.31 No.2
Objectives: K^(+) channels play an important role in regulating cellular excitability. The aim of this study was to know whether or not inward rectifier K^(+) channel exists in colonic smooth muscle cells. Methods: Mouse colonic smooth muscle cells were isolated using collagenase, and then we recorded their membrane currents using a whole-cell patch clamp technique. Results: With 90 mM K^(+) in bath, hyperpolarization-induced inward currents from -120 mV to 20 mV with 400 ms duration at a holding potential of -10 mV showed rapid activation, inactivation and inward rectification. The inactivation showed single exponential time course. Reduction of external K^(+) to 60 mM decreased the amplitudes of the currents in whole test voltage range and shifted the reversal potential to more negative potential. The inactivation process and peak currents of hyperpolarization-induced inward currents were not affected by removing external Na^(+). External Ba^(+) blocked hyperpolarization-induced inward currents by dose-dependent manner and pure Ba^(+)-sensitive currents showed strong inward rectification. Cs^(+) also suppressed hyper- polarization-induced inward currents. Ba^(+) and Cs^(+)-induced inhibitiOn of hyperpolarization-induced inward currents was voltage-dependent, and the extent of inhibition increasing with membrane hyperpolarization. Conclusions: These results suggest that inward rectifier KU channels may exist in proximal colonic smooth muscle and may play an important role in regulating membrane potential.
Double-Phase Polling Algorithm Based on Partitioned ONU Subgroups for High Utilization in EPONs
Sam Yeoul Choi,Sangho Lee,Tae-Jin Lee,Min Young Chung,Hyunseung Choo IEEE 2009 Journal of optical communications and networking Vol.1 No.5
<P>The Ethernet passive optical network (EPON) is an emerging technology for the next-generation broadband access networks and is considered an up-to-date candidate network for future fiber to the home. A crucial issue in EPONs is the sharing of uplink bandwidth among optical network units (ONUs). To manage resources efficiently, research on polling schemes based on multipoint control protocol has been conducted. We propose a novel polling algorithm to increase resource utilization by partitioning ONUs into two subgroups with some overlap. In the proposed scheme, after receiving frames from ONUs in one subgroup, the OLT performs dynamic bandwidth allocation for ONUs in the other. Hence, the OLT continuously receives frames from ONUs without significant interruptions. Comprehensive computer simulation results show that the proposed algorithm both defers saturation points of queues in ONUs and provides outstanding network throughput compared with previous work. It has up to 45% lower average packet delay and maximum performance improvement of 17% with respect to network throughput.</P>
A Temperature-Controllable Microelectrode and Its Application to Protein Immobilization
Dae-Sik Lee,Hyoung Gil Choi,Kwang Hyo Chung,Bun Yeoul Lee,Hyeon-Bong Pyo,Hyun C. Yoon 한국전자통신연구원 2007 ETRI Journal Vol.29 No.5
This letter presents a smart integrated microfluidic device which can be applied to actively immobilize proteins on demand. The active component in the device is a temperature-controllable microelectrode array with a smart polymer film, poly(N-isopropylacrylamide) (PNIPAAm) which can be thermally switched between hydrophilic and hydrophobic states. It is integrated into a micro hot diaphragm having an integrated micro heater and temperature sensors on a 2-micrometer-thick silicon oxide/silicon nitride/silicon oxide (O/N/O) template. Only 36 mW is required to heat the large template area of 2 mm×16 mm to 40℃ within 1 second. To relay the stimulus-response activity to the microelectrode surface, the interface is modified with a smart polymer. For a model biomolecular affinity test, an anti-6-(2, 4-dinitrophenyl) aminohexanoic acid (DNP) antibody protein immobilization on the microelectrodes is demonstrated by fluorescence patterns.