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비규격 스틸커튼월 부재의 적용을 위한 로봇 레이저용접 성능에 관한 연구
나상호 ( Na¸ Sangho ),이장현 ( Lee¸ Janghyun ),박영미 ( Park¸ Youngmi ),김성진 ( Kim¸ Sungjin ) 한국건축시공학회 2021 한국건축시공학회 학술발표대회 논문집 Vol.21 No.2
In irregular curtain walls, the nominal stress required for each member varies greatly depending on the shape, so it is inefficient to design members based on the maximum required stress. Then, built-up members are absolutely necessary, but built-up members manufactured by Manpower-welding cannot be constructed in an irregular curtain wall building because it' not precise. In order to address the problems, this paper presents why Robotic-laser-welding should be used in irregular curtain walls using Gwanggyo Galleria Department Store involving 3D printing as an example. Results verify the performance of Robot-Laser-Welding as an efficient solution for precise steel curtain wall members.
Dynamic Regulation of TLE3 Expression during Spermatogenesis in Mouse Testis
Sangho Lee,Sohyeon Moon,Minha Cho,Miseon Park,Boreum Song,Ok-Hee Lee,Hoon Jang,Kyung-Ah Lee,Sunghan Shim,Jung Jae Ko,Youngsok Choi 한국동물생명공학회(구 한국동물번식학회) 2017 Reproductive & Developmental Biology(Supplement) Vol.41 No.2
Spermatogenesis is the process of proliferation and differentiation of spermatogonial stem cells into adult spermatozoa within seminiferous tubules. Sperm cells undergo extensive epigenetic modifications during spermatogenesis. One of the epigenetic modifications, histone acetylation induces a loose chromatin structure and active transcription which facilitates binding of transcription factors at sperm chromosome. Therefore, histone acetylation is known to play an important role in spermatogenesis. However, factors involved in histone acetylation during spermatogenesis are not well known. We found a factor TLE3(Transducin Like Enhancer of Split 3). The transcriptional co-repressor TLE family is known to regulate histone acetylation by interacting with histone deacetylase( HDAC). We examined the expression level of TLE3 in various mouse tissues. As a result of RT-PCR, TLE3 showed significantly higher expression in testis than that in other tissues. Immunofluorescent and Immunohistochemical analysis revealed that TLE3 protein was located in sertoli cell and spermatid in seminiferous tubules of adult mouse testis. In addition, the differential regulation in TLE3 protein expression site was observed in the testis during postnatal development. We also analyzed the expression pattern of HDAC2, which is known to cooperate with TLE3. Both HDAC2 and TLE3 protein were detected in spermatogonial stem cells at one-weeks-old mouse, however, Their expression site were transferred to sertoli cell at six-weeks-old mouse. aken together, TLE3 may play a role in regulating histone acetylation via interaction with HDAC2 in the testis. Futher studies are needed to look into a relation between TLE3 and histone acetylation during spermatogenesis and postnatal development in testis.
Lee Sangho,Lee Han-Teo,Kim Young Ah,Lee Il-Hwan,Kang Seong-Jun,Sim Kyeongpyo,Park Chung-Gyu,Choi Kyungho,Youn Hong-Duk 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-
The C-terminal fragment of CABIN1 interacts with calcineurin and represses the transcriptional activity of the nuclear factor of activated T cells (NFAT). However, the specific sequences and mechanisms through which it binds to calcineurin are unclear. This study determined that decameric peptide (CABIN1 residues 2146–2155) is minimally required for binding to calcineurin. This peptide contains a unique “PPTP” C-terminal sequence and a “PxIxIT” N-terminal motif. Furthermore, p38MAPK phosphorylated the threonine residue of the “PPTP” sequence under physiological conditions, dramatically enhancing the peptide’s binding affinity to calcineurin. Therefore, the CABIN1 peptide inhibited the calcineurin-NFAT pathway and the activation of T cells more efficiently than the VIVIT peptide without affecting calcineurin’s phosphatase activity. The CABIN1 peptide could thus be a more potent calcineurin inhibitor and provide therapeutic opportunities for various diseases caused by the calcineurin-NFAT pathway.
EPON에서 효율적 대역폭 할당을 위한 최대전송윈도우 크기의 동적변화기법
이상호 ( Sangho Lee ),이태진 ( Tae-jin Lee ),정민영 ( Min Young Chung ),이유호 ( Youho Lee ),추현승 ( Hyunseung Choo ) 한국인터넷정보학회 2007 인터넷정보학회논문지 Vol.8 No.4
EPON(Ethernet Passive Optical Network)는 적은 비용으로 고품질 서비스를 제공하기 위한 차세대 기술로써, EPON을 구성하는 모든 ONU(Optical Network Unit)들은 한정된 업링크 채널을 나누어 사용한다. 대용량 LAN에 사용자들의 대역폭 요구를 충족시키기 위해서, OLT(Optical Line Terminal)는 효과적인 방법으로 업링크 채널의 시간슬롯을 각 ONU에게 분할·할당한다. 본 논문에서는 효율적인 업링크 채널의 시간슬롯 분배(대역폭 할당)를 위해 기존 연구 IPACT(Interleaved Polling with Adaptive Cycle Time)와 SLICT(Sliding Cycle Time)방식에 대해 살펴보고, 새로운 대역폭 할당 방식인 DRSM(Dynamic Right Sizing of Maximum-windows)을 제안한다. 이 방식은 과거 모든 ONU에게 할당된 대역폭 정보를 기반으로 다음 구간에서 ONU에 할당 가능한 최대 대역폭을 계산하고, 계산된 최대 전송 가능 대역폭과 ONU의 대역폭 요구량으로 각 ONU의 전송 윈도우의 크기를 결정한다. 제안한 방식은 모든 ONU의 대역폭 요구를 허용 범위 내에서 최대한 충족시키고, ONU들간 균등한 대역폭 할당을 추구한다. Ethernet passive optical network (EPON) is the next-generation technology for supporting services of high-quality at low-cost. In the EPON, all optical network units (ONUs) have to share a limited uplink channel for upstream data. In order to satisfy bandwidth demands of users on high-capacity local access networks (LANs), the optical line terminal (OLT) efficiently divides and allocates time slots of uplink channel to all ONUs. We discuss previous schemes for dynamic bandwidth allocation (DBA), such as interleaved polling with adaptive cycle time (IPACT) and sliding cycle time (SLICT). In this paper, dynamic right sizing of maximum-windows (DRSM), as a novel bandwidth allocation service, is proposed for more effective and efficient time slot allocation of the uplink channel. DRSM which is based on past information of bandwidth allocated by OLT calculates maximum available bandwidth and dynamically alters the maximum window size for the next ONU. This scheme does not only exert every effort to meet bandwidth demands of ONUs within the possible scope, it also seeks fairness of bandwidth allocation among ONUs.