Influences of Structure Defects on the Performances of Solution-Processed OFET

Chien-Lung Wang,Yi-Fan Huang,Kuan-Yi Wu,Chou-Ting Hsieh 한국고분자학회 2020 한국고분자학회 학술대회 연구논문 초록집 Vol.45 No.2

Interactive Computation of Type-Threshold Functions in Collocated Gaussian Networks

Chien-Yi Wang,Sang-Woon Jeon,Gastpar, Michael IEEE 2015 IEEE transactions on information theory Vol.61 No.9

<P>In wireless sensor networks, various applications involve learning one or multiple functions of the measurements observed by sensors, rather than the measurements themselves. This paper focuses on the class of type-threshold functions, e.g., the maximum and the indicator functions. A simple network model capturing both the broadcast and superposition properties of wireless channels is considered: the collocated Gaussian network. A general multiround coding scheme exploiting superposition and interaction (through broadcast) is developed. Through careful scheduling of concurrent transmissions to reduce redundancy, it is shown that given any independent measurement distribution, all type-threshold functions can be computed reliably with a nonvanishing rate in the collocated Gaussian network, even if the number of sensors tends to infinity.</P>

Persuasion effect of e-WOM : The Impact of Involvement and Ambiguity Tolerance

Chih-Chien Wang,Yi-Ting Wang 한국마케팅과학회 2010 마케팅과학연구 Vol.20 No.4

Prior to purchasing a new product, consumers search external information about the product to make a well-informed purchase decision and decrease the potential risk involved in buying products. Due to the popularity of Internet, e-WOM has already become an important information source for many consumers. The current study proposed the idea that the distribution and quantity of electronic word-of-mouth would be related to consumers' purchase intentions. In addition, consumers' personality trait of tolerance of ambiguity and involvement would also be related to purchase intention. Tolerance of ambiguity and personal involvement were as mediators for the influence of e-WOM on purchase intentions. This article conducted three studies in order to investigate the persuasion effects of e-WOM. A restaurant was selected as the target of e-WOM in all the three studies. Authors created a simulated online community for a gourmet restaurant in order to manipulate the experimental variables for the three studies. Study 1 examined the impact of consumers' characteristics of tolerance of ambiguity and involvement on the persuasion effects of e-WOM. This article recruited 122 voluntary participants in an online community. After deleting redundant responses and responses with missing data, a remaining 83 completed responses were accepted for data analysis. Study 1 adopted Partial Least Squares (PLS) to test the influence of involvement and ambiguity tolerance on purchase intention. The explanatory power of the construct was 19.4% for purchase intention and the path linkages from consumers' tolerance of ambiguity and involvement to purchase intention were all significant. This study results displayed that a positive relationship between involvement and purchase intention and a negative relationship between ambiguity tolerance and purchase intention. Study 2 utilized a three factorial design to test the relationship between the quantity of e-WOM and purchase intention. Three web pages containing one, five, or fifteen customer reviews were created as experimental scenarios. Study 2 re-cruited 150 participants in total. After deleting redundant responses and responses with missing data, the remaining 98 completed responses were accepted for data analysis. An ANOVA analysis revealed significant differences in consumers' purchase intention among three groups of e-WOM quantity (F(2,95)=3.55, p

Persuasion effect of e-WOM: The Impact of Involvement and Ambiguity Tolerance

Chih-Chien Wang,Yi-Ting Wang 한국마케팅과학회 2010 마케팅과학연구 Vol.20 No.4

Prior to purchasing a new product, consumers search external information about the product to make a well-informed purchase decision and decrease the potential risk involved in buying products. Due to the popularity of Internet, e-WOM has already become an important information source for many consumers. The current study proposed the idea that the distribution and quantity of electronic word-of-mouth would be related to consumers’ purchase intentions. In addition, consumers’ personality trait of tolerance of ambiguity and involvement would also be related to purchase intention. Tolerance of ambiguity and personal involvement were as mediators for the influence of e-WOM on purchase intentions. This article conducted three studies in order to investigate the persuasion effects of e-WOM. A restaurant was selected as the target of e-WOM in all the three studies. Authors created a simulated online community for a gourmet restaurant in order to manipulate the experimental variables for the three studies. Study 1 examined the impact of consumers’ characteristics of tolerance of ambiguity and involvement on the persuasion effects of e-WOM. This article recruited 122 voluntary participants in an online community. After deleting redundant responses and responses with missing data, a remaining 83 completed responses were accepted for data analysis. Study 1 adopted Partial Least Squares (PLS) to test the influence of involvement and ambiguity tolerance on purchase intention. The explanatory power of the construct was 19.4% for purchase intention and the path linkages from consumers’ tolerance of ambiguity and involvement to purchase intention were all significant. This study results displayed that a positive relationship between involvement and purchase intention and a negative relationship between ambiguity tolerance and purchase intention. Study 2 utilized a three factorial design to test the relationship between the quantity of e-WOM and purchase intention. Three web pages containing one, five, or fifteen customer reviews were created as experimental scenarios. Study 2 recruited 150 participants in total. After deleting redundant responses and responses with missing data, the remaining 98 completed responses were accepted for data analysis. An ANOVA analysis revealed significant differences in consumers’ purchase intention among three groups of e-WOM quantity (F(2,95)=3.55, p<.05). The e-WOMs with five and 15 customer reviews influenced respondents to visit the restaurant, while the e-WOM with one customer review did not. Study 2 also used a t-test analysis to examine the differences in purchase intention between groups of one and 15 customer reviews. The results revealed that high involvement consumers reported higher purchase intentions in the 15 customer review group than in the one customer review (t=2.35, p<.05). Study 3 utilized a three factorial design to test the influence of distribution of e-WOMs on purchase intention. It included three e-WOM rating score distributions: J-shape, U-shape, and inverted U-shape (normal distribution). Study 3 recruited a total of 329 participants. After deleting redundant responses and responses with missing data, the remaining 215 completed responses were accepted for data analysis. ANOVA analysis showed a significant difference in purchase intentions among groups with different e-WOM rating score distributions (F(2, 212)=3.59, p<.05). Participants reported higher intention to dine at the restaurant when the rating score distribution was J-shape. The ANOVA results also found that the impact of e-WOM distribution on persuasion effect existed only in the high involvement group. For high involvement consumers, J-shape e-WOMs increase consumers purchase intention compared to other distributions. Base on the analyses of the three empirical studies, this article revealed that e-WOMs were more persuasive for individuals with high involvement and low ambiguity tolerance. Low ambiguity tol...

Dysregulated Free Fatty Acid Receptor 2 Exacerbates Colonic Adenoma Formation in ApcMin/+ Mice: Relation to Metabolism and Gut Microbiota Composition

Yi-Wen Huang,Chien-Wei Lin,Pan Pan,Carla Elena Echeveste,Athena Dong,Kiyoko Oshima,Martha Yearsley,Jianhua Yu,Li-Shu Wang 대한암예방학회 2021 Journal of cancer prevention Vol.26 No.1

Free fatty acid receptor 2 (FFAR2) has been reported as a tumor suppressor in colon cancer development. The current study investigated the effects of FFAR2 signaling on energy metabolism and gut microbiota profiling in a colorectal cancer mouse model (ApcMin/+). Ffar2 deficiency promoted colonic polyp development and enhanced fatty acid oxidation and bile acid metabolism. Gut microbiome sequencing analysis showed distinct clustering among wild-type, ApcMin/+, and ApcMin/+-Ffar2-/- mice. The relative abundance of Flavobacteriaceae and Verrucomicrobiaceae was significantly increased in the ApcMin/+-Ffar2-/- mice compared to the ApcMin/+ mice. In addition, knocking-down FFAR2 in the human colon cancer cell lines (SW480 and HT29) resulted in increased expression of several key enzymes in fatty acid oxidation, such as carnitine palmitoyltransferase 2, acyl-CoA dehydrogenase, longchain acyl-CoA dehydrogenase, C-2 to C-3 short chain, and hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase, alpha subunit. Collectively, these results demonstrated that Ffar2 deficiency significantly altered profiles of fatty acid metabolites and gut microbiome, which might promote colorectal cancer development.

Cilostazol ameliorates diabetic nephropathy by inhibiting highglucose-induced apoptosis

Chien-Wen Chian,Yung-Shu Lee,Yi-Ju Lee,Ya-Hui Chen,Chi-Ping Wang,Wen-Chin Lee,Huei-Jane Lee 대한생리학회-대한약리학회 2020 The Korean Journal of Physiology & Pharmacology Vol.24 No.5

Diabetic nephropathy (DN) is a hyperglycemia-induced progressive development of renal insufficiency. Excessive glucose can increase mitochondrial reactive oxygen species (ROS) and induce cell damage, causing mitochondrial dysfunction. Our previous study indicated that cilostazol (CTZ) can reduce ROS levels and decelerate DN progression in streptozotocin (STZ)-induced type 1 diabetes. This study investigated the potential mechanisms of CTZ in rats with DN and in high glucose-treated mesangial cells. Male Sprague-Dawley rats were fed 5 mg/kg/day of CTZ after developing STZ-induced diabetes mellitus. Electron microscopy revealed that CTZ reduced the thickness of the glomerular basement membrane and improved mitochondrial morphology in mesangial cells of diabetic kidney. CTZ treatment reduced excessive kidney mitochondrial DNA copy numbers induced by hyperglycemia and interacted with the intrinsic pathway for regulating cell apoptosis as an antiapoptotic mechanism. In high-glucose-treated mesangial cells, CTZ reduced ROS production, altered the apoptotic status, and down-regulated transforming growth factor beta (TGF-β) and nuclear factor kappa light chain enhancer of activated B cells (NF-κB). Base on the results of our previous and current studies, CTZ deceleration of hyperglycemia-induced DN is attributable to ROS reduction and thereby maintenance of the mitochondrial function and reduction in TGF-β and NF-κB levels.

Transarterial Chemoembolization Using Gelatin Sponges or Microspheres Plus Lipiodol-Doxorubicin versus Doxorubicin-Loaded Beads for the Treatment of Hepatocellular Carcinoma

Yi-Sheng Liu,Ming-Ching Ou,Yi-Shan Tsai,Xi-Zhang Lin,Chien-Kuo Wang,Hong-Ming Tsai,Ming-Tsung Chuang 대한영상의학회 2015 Korean Journal of Radiology Vol.16 No.1

To retrospectively compare treatment of hepatocellular carcinoma (HCC) with transarterial chemoembolization (TACE) using gelatin sponges or microspheres plus lipiodol-doxorubicin vs. doxorubicin-loaded drug-eluting beads (DEB). A total of 158 patients with HCC received TACE from November 2010 to November 2011 were enrolled in this study, including 64 (40.5%) received TACE with lipiodol-doxorubicin and gelatin sponges (group A), 41 (25.9%) received TACE with lipiodol-doxorubicin and microspheres (group B), and 53 (33.5%) received TACE with doxorubicin-loaded DEB (group C). Tumor response and adverse events (AEs) were evaluated. No significant difference was found at baseline among the three groups. The doxorubicin dosage in group C wassignificantly (p < 0.001) higher compared to the dose used in groups A or B (median, 50 mg vs. 31 mg or 25 mg). Significantly (p < 0.001) more patients in group C achieved complete response compared to those in groups A or B (32.1% vs. 6.3% or 2.4%). Significantly (p < 0.001) less patients in group C had progressive disease compared to those in groups A or B (34.0% vs. 57.8% or 68.3%). Minor AEs were more common in groups A and B compared to group C, with rates of 54.7%, 34.1%, and 5.7%, respectively. In patients with HCC, TACE with DEB offers better safety and efficacy profiles compared to either TACE with gelatin sponges or TACE with microspheres.

Thyroid fine-needle aspiration cytology in Taiwan: a nationwide survey and literature update

Chien-Chin Chen,Jen-Fan Hang,Chih-Yi Liu,Yeh-Han Wang,Chiung-Ru Lai 대한병리학회 2020 Journal of Pathology and Translational Medicine Vol.54 No.5

In Taiwan, thyroid fine-needle aspiration cytology is easily accessible and reliable for evaluating thyroid nodules. The sonographic pattern plays a major role and is the deciding factor for aspiration. We conducted a nationwide survey in 2017 and it revealed that 31% of laboratories had adopted The Bethesda System for Reporting Thyroid Cytopathology. There was a relatively high unsatisfactory rate (24.04%) and low rates of indeterminate diagnoses, including atypia of undetermined significance/follicular lesions of undetermined significance: 4.87%, and follicular neoplasm/suspicious for a follicular neoplasm: 0.35%. Moreover, the risks of malignancy in benign, atypia of undetermined significance, and suspicious for a follicular neoplasm were relatively high. These may reflect strict diagnostic criteria for indeterminate categories and better patient selection for surgery. Improvements in specimen sampling and continuing education programs are crucial. Newly-developed thyroid cytology technologies, such as immunocytochemistry, molecular testing, and computerized cytomorphometry, may further facilitate cytology diagnoses.

The EGF/hnRNP Q1 axis is involved in tumorigenesis via the regulation of cell cycle-related genes

Yu-Chu Wang,Kung-Chao Chang,Bo-Wen Lin,Jenq-Chang Lee,Chien-Hsien Lai,Li-Jyuan Lin,Yun Yen,Chang-Shen Lin,Shiang-Jie Yang,Peng-Chan Lin,Chung-Ta Lee,Liang-Yi Hung 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-

Heterogeneous nuclear ribonucleoprotein (hnRNP) Q1, an RNA-binding protein, has been implicated in many posttranscriptional processes, including RNA metabolism and mRNA splicing and translation. However, the role of hnRNP Q1 in tumorigenesis remains unclear. We previously performed RNA immunoprecipitation (RIP)-seq analysis to identify hnRNP Q1-interacting mRNAs and found that hnRNP Q1 targets a group of genes that are involved in mitotic regulation, including Aurora-A. Here, we demonstrate that altering the hnRNP Q1 level influences the expression of the Aurora-A protein, but not its mRNA. Stimulation with epidermal growth factor (EGF) enhances both binding between hnRNP Q1 and Aurora-A mRNA as well as the efficacy of the hnRNP Q1-induced translation of Aurora-A mRNA. The EGF/hnRNP Q1-induced translation of Aurora-A mRNA is mediated by the mTOR and ERK pathways. In addition, we show that hnRNP Q1 up-regulates the translation of a group of spindle assembly checkpoint (SAC) genes. hnRNP Q1 overexpression is positively correlated with the levels of Aurora-A and the SAC genes in human colorectal cancer tissues. In summary, our data suggest that hnRNP Q1 plays an important role in regulating the expression of a group of cell cycle-related genes. Therefore, it may contribute to tumorigenesis by up-regulating the translation of these genes in colorectal cancer.

Human-Oriented Recognition for Intelligent Interactive Office Robot

Chia-Ming Wang,Shin-Huan Tseng,Pei-Wen Wu,Yuan-Han Xu,Chien-Ke Liao,Yu-Chi Lin,Yi-Shiu Chiang,Chung-Dial Lim,Ting-Sheng Chu,Li-Chen Fu 제어로봇시스템학회 2013 제어로봇시스템학회 국제학술대회 논문집 Vol.2013 No.10

This paper presents our new intelligent interactive robot, which is constructed to eagerly provide multi-functional services in an office environment. In order to endow a full interactive capability of our robots for realizing so-called human-robot interaction (HRI), we propose sensor fusion based human detection and tracking system and human pose estimation to deal with a number of situations which may take place in the office environment. Not only by these perceptions, human interact with the robot also by some natural way, such as touching the interface screen and talking with the robot through microphone. Finally, the effectiveness of the proposed work is tested and validated by some of experiments.