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Electrospun uniaxially-aligned composite nanofibers as highly-efficient piezoelectric material
Lee, Caroline,Wood, David,Edmondson, Dennis,Yao, Dingyu,Erickson, Ariane E.,Tsao, Ching Ting,Revia, Richard A.,Kim, Hyungsub,Zhang, Miqin Elsevier Science B.V., Amsterdam. 2016 CERAMICS INTERNATIONAL Vol.42 No.-
Intravenous delivery of a multi-mechanistic cancer-targeted oncolytic poxvirus in humans
Breitbach, Caroline J.,Burke, James,Jonker, Derek,Stephenson, Joe,Haas, Andrew R.,Chow, Laura Q. M.,Nieva, Jorge,Hwang, Tae-Ho,Moon, Anne,Patt, Richard,Pelusio, Adina,Le Boeuf, Fabrice,Burns, Joe,Evgi Nature Publishing Group, a division of Macmillan P 2011 Nature Vol.477 No.7362
The efficacy and safety of biological molecules in cancer therapy, such as peptides and small interfering RNAs (siRNAs), could be markedly increased if high concentrations could be achieved and amplified selectively in tumour tissues versus normal tissues after intravenous administration. This has not been achievable so far in humans. We hypothesized that a poxvirus, which evolved for blood-borne systemic spread in mammals, could be engineered for cancer-selective replication and used as a vehicle for the intravenous delivery and expression of transgenes in tumours. JX-594 is an oncolytic poxvirus engineered for replication, transgene expression and amplification in cancer cells harbouring activation of the epidermal growth factor receptor (EGFR)/Ras pathway, followed by cell lysis and anticancer immunity. Here we show in a clinical trial that JX-594 selectively infects, replicates and expresses transgene products in cancer tissue after intravenous infusion, in a dose-related fashion. Normal tissues were not affected clinically. This platform technology opens up the possibility of multifunctional products that selectively express high concentrations of several complementary therapeutic and imaging molecules in metastatic solid tumours in humans.
International Organization for Standardization (ISO) 15189
Frank Schneider,Caroline Maurer,Richard C. Friedberg 대한진단검사의학회 2017 Annals of Laboratory Medicine Vol.37 No.5
The College of American Pathologists (CAP) offers a suite of laboratory accreditation programs, including one specific to accreditation to the international organization for standardization (ISO) 15189 standard for quality management specific to medical laboratories. CAP leaders offer an overview of ISO 15189 including its components, internal audits, occurrence management, document control, and risk management. The authors provide a comparison of its own ISO 15189 program, CAP 15189, to the CAP Laboratory Accreditation Program. The authors conclude with why laboratories should use ISO 15189.
김규연 ( Marc Miravitlles ),( Pawel Sliwinski ),( Richard Costello ),( Victoria Carter ),( Jessica Tan ),( Therese Laperre ),( Bernardino Alcazar ),( Caroline Gouder ),( Cristina Esquinas ),( Juan Luis G 대한결핵 및 호흡기학회 2017 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.124 No.-
Background/Aim: Chronic obstructive pulmonary disease (COPD) is a heterogeneous condition requiring therapeutic management to be tailored to the clinical characteristics and disease severity of the individual patient. Due to scarcity of studies about racial differences in COPD patients, in this study, we compared clinical characteristics between Asian and other patients of COPD. Method: This was an international, multicenter, prospective study of a cohort of patients with COPD aimed to validate the concept of clinical control in COPD. We compared two subgroups (Asian versus others) by using clinical criteria, questionnaires (COPD Assessment Test -CAT- or Clinical COPD Questionnaire -CCQ-) and recent concept of control. Results: A total of 349 patients were analysed, 110 (32%) patients were Asian and 239 (68%) patients were others. There was a significant difference at sex, smoking status and BMI between Asian and others. Among clinical characteristics, there was a significant difference at median FEV1 (mL), and percentage of patients who have emphysema between two subgroups. Also, number of exacerbation and hospital admission, median CCQ score and recent concept of Impact (Clinical approach by mMRC, rescue medication, time walked/day and sputum color) were the characteristics which show significant disparities between two subgroups. Conclusion: This study showed significant differences in various factors between Asian and other patients of COPD. These results suggest that therapeutic management of COPD should be tailored to the ethnic group of the individual patients
Intelligent Robust Base-Station Research in Harsh Outdoor Wilderness Environments for Wildsense
( Junho Ahn ),( Akshay Mysore ),( Kati Zybko ),( Caroline Krumm ),( Dohyeon Lee ),( Dahyeon Kim ),( Richard Han ),( Shivakant Mishra ),( Thompson Hobbs ) 한국인터넷정보학회 2021 KSII Transactions on Internet and Information Syst Vol.15 No.3
Wildlife ecologists and biologists recapture deer to collect tracking data from deer collars or wait for a drop-off of a deer collar construction that is automatically detached and disconnected. The research teams need to manage a base camp with medical trailers, helicopters, and airplanes to capture deer or wait for several months until the deer collar drops off of the deer’s neck. We propose an intelligent robust base-station research with a low-cost and time saving method to obtain recording sensor data from their collars to a listener node, and readings are obtained without opening the weatherproof deer collar. We successfully designed the and implemented a robust base station system for automatically collecting data of the collars and listener motes in harsh wilderness environments. Intelligent solutions were also analyzed for improved data collections and pattern predictions with drone-based detection and tracking algorithms.
Circadian Polymorphisms in Night Owls, in Bipolars, and in Non-24-Hour Sleep Cycles
Daniel F Kripke,Walter T. Klimecki,Caroline M. Nievergelt,Katharine M Rex,Sarah S. Murray,Tatyana Shekhtman,Gregory J. Tranah,Richard T. Loving,이헌정,이민규,Farhad F. Shadan,J. Steven Poceta,Shazia M. Jami 대한신경정신의학회 2014 PSYCHIATRY INVESTIGATION Vol.11 No.4
People called night owls habitually have late bedtimes and late times of arising, sometimes suffering a heritable circadian disturbance called delayed sleep phase syndrome (DSPS). Those with DSPS, those with more severe progressively-late non-24-hour sleep-wake cycles, and those with bipolar disorder may share genetic tendencies for slowed or delayed circadian cycles. We searched for polymorphisms associated with DSPS in a case-control study of DSPS research participants and a separate study of Sleep Center patients undergoing polysomnography. In 45 participants, we resequenced portions of 15 circadian genes to identify unknown polymorphisms that might be associated with DSPS, non-24-hour rhythms, or bipolar comorbidities. We then genotyped single nucleotide polymorphisms (SNPs) in both larger samples, using Illumina Golden Gate assays. Associations of SNPs with the DSPS phenotype and with the morningness-eveningness parametric phenotype were computed for both samples, then combined for meta-analyses. Delayed sleep and “eveningness” were inversely associated with loci in circadian genes NFIL3 (rs2482705) and RORC (rs3828057). A group of haplotypes overlapping BHLHE40 was associated with non-24-hour sleep-wake cycles, and less robustly, with delayed sleep and bipolar disorder (e.g., rs34883305, rs34870629, rs74439275, and rs3750275 were associated with n=37, p=4.58E-09, Bonferroni p=2.95E-06). Bright light and melatonin can palliate circadian disorders, and genetics may clarify the underlying circadian photoperiodic mechanisms. After further replication and identification of the causal polymorphisms, these findings may point to future treatments for DSPS, non-24-hour rhythms, and possibly bipolar disorder or depression.
Issa Tariq Z.,Lee Yunsoo,Berthiaume Emily,Lambrechts Mark J.,Zaworski Caroline,Qadiri Qudratallah S.,Spracklen Henley,Padovano Richard,Weber Jackson,Mangan John J.,Canseco Jose A.,Woods Barrett I.,Kay 대한척추외과학회 2023 Asian Spine Journal Vol.17 No.4
Study Design: Retrospective cohort study.Purpose: Our goal was to determine which radiographic images are most essential for degenerative spondylolisthesis (DS) classification and instability detection.Overview of Literature: The heterogeneity in DS requires multiple imaging views to evaluate vertebral translation, disc space, slip angle, and instability. However, there are several restrictions on frequently used imaging perspectives such as flexion-extension and upright radiography.Methods: We assessed baseline neutral upright, standing flexion, seated lateral radiographs, and magnetic resonance imaging (MRI) for patients identified with spondylolisthesis from January 2021 to May 2022 by a single spine surgeon. DS was classified by Meyerding and Clinical and Radiographic Degenerative Spondylolisthesis classifications. A difference of >10° or >8% between views, respectively, was used to characterize angular and translational instability. Analysis of variance and paired chi-square tests were utilized to compare modalities.Results: A total of 136 patients were included. Seated lateral and standing flexion radiographs showed the greatest slip percentage (16.0% and 16.7%), while MRI revealed the lowest (12.2%, <i>p</i> <0.001). Standing flexion and lateral radiographs when seated produced more kyphosis (4.66° and 4.97°, respectively) than neutral upright and MRI (7.19° and 7.20°, <i>p</i> <0.001). Seated lateral performed similarly to standing flexion in detecting all measurement parameters and categorizing DS (all <i>p</i> >0.05). Translational instability was shown to be more prevalent when associated with seated lateral or standing flexion than when combined with neutral upright (31.5% vs. 20.2%, <i>p</i> =0.041; and 28.1% vs. 14.6%, <i>p</i> =0.014, respectively). There were no differences between seated lateral or standing flexion in the detection of instability (all <i>p</i> >0.20).Conclusions: Seated lateral radiographs are appropriate alternatives for standing flexion radiographs. Films taken when standing up straight do not offer any more information for DS detection. Rather than standing flexion-extension radiographs, instability can be detected using an MRI, which is often performed preoperatively, paired with a single seated lateral radiograph.
Bimol C. Roy,Patience Coleman,Meghan Markowsky,Kun Wang,Yongbo She,Caroline Richard,Spencer D. Proctor,Heather L. Bruce 한국축산식품학회 2024 한국축산식품학회지 Vol.44 No.1
This study investigated how birth weight differences in piglets affected carcass and muscle fiber properties as well as meat quality at slaughter. Within litters, piglets were grouped according to their birth weight as either normal (NBW; 1.62–1.73 kg) or low (LBW; 1.18–1.29 kg). At 5 weeks of age, NBW piglets were randomly transitioned to control (C) or isocaloric high fat diets derived from non-dairy (HF), while LBW piglets were randomly transitioned to high fat diets derived from non-dairy (HF) or dairy sources (HFHD). Piglets were reared in individual pens under standardized housing and feeding conditions. Live weight was recorded weekly, and pigs were slaughtered at 12 weeks of age. Hot carcass weights, dressing percentages, lean meat yield, and primal cut proportions were determined. The m. longissimus thoracis was collected from the right side of the carcass for measurement of physical and chemical properties of meat and muscle fiber characteristics. Results indicated that LBW pigs compensated for their live weight compared to NBW pigs at 6 weeks of age. The mean muscle fiber diameter of LBW-HFHD group is significantly higher than NBW-C and NBW-HF group, and the type I muscle fiber diameter is significantly higher than NBW-C group. Dairy fat inclusion in LBW pig diet reduced carcass back fat thickness. This increased the calculated lean meat yield to be comparable to that of NBW pigs fed a commercial diet. Incorporating dairy-sourced high-fat into LBW pigs’ diets appears to be an effective strategy for producing carcasses equivalent to NBW pigs.
Choi, Jean,Hyun, Youbong,Kang, Min-Jeong,In Yun, Hye,Yun, Jae-Young,Lister, Clare,Dean, Caroline,Amasino, Richard M.,Noh, Bosl,Noh, Yoo-Sun,Choi, Yeonhee Blackwell Publishing Ltd 2009 The Plant journal Vol.57 No.5
<P>Summary</P><P>The epigenetic regulation of the floral repressor <I>FLOWERING LOCUS C</I> (<I>FLC</I>) is one of the critical factors that determine flowering time in <I>Arabidopsis thaliana</I>. Although many <I>FLC</I> regulators, and their effects on <I>FLC</I> chromatin, have been extensively studied, the epigenetic resetting of <I>FLC</I> has not yet been thoroughly characterized. Here, we investigate the <I>FLC</I> expression during gametogenesis and embryogenesis using <I>FLC::GUS</I> transgenic plants and RNA analysis. Regardless of the epigenetic state in adult plants, <I>FLC</I> expression disappeared in gametophytes. Subsequently, <I>FLC</I> expression was reactivated after fertilization in embryos, but not in the endosperm. Both parental alleles contributed equally to the expression of <I>FLC</I> in embryos. Surprisingly, the reactivation of <I>FLC</I> in early embryos was independent of FRIGIDA (FRI) and SUPPRESSOR OF FRIGIDA 4 (SUF4) activities. Instead, <I>FRI</I>, <I>SUF4</I> and autonomous-pathway genes determined the level of <I>FLC</I> expression only in late embryogenesis. Many <I>FLC</I> regulators exhibited expression patterns similar to that of <I>FLC</I>, indicating potential roles in <I>FLC</I> reprogramming. An <I>FVE</I> mutation caused ectopic expression of <I>FLC</I> in the endosperm. A mutation in <I>PHOTOPERIOD-INDEPENDENT EARLY FLOWERING 1</I> caused defects in <I>FLC</I> reactivation in early embryogenesis, and maintenance of full <I>FLC</I> expression in late embryogenesis. We also show that the polycomb group complex components, Fertilization-Independent endosperm and MEDEA, which mediate epigenetic regulation in seeds, are not relevant for <I>FLC</I> reprogramming. Based on our results, we propose that <I>FLC</I> reprogramming is composed of three phases: (i) repression in gametogenesis, (ii) reactivation in early embryogenesis and (iii) maintenance in late embryogenesis.</P>