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Consumption of Dried Apple Peel Powder Increases Joint Function and Range of Motion
Gitte S. Jensen,Victoria L. Attridge,Kathleen F. Benson,Joni L. Beaman,Steve G. Carter,David Ager 한국식품영양과학회 2014 Journal of medicinal food Vol.17 No.11
The goal for this study was to evaluate the effects of consumption of dried apple peel powder (DAPP) on joint function and range of motion (ROM). Additional in vitro and clinical testing was performed to suggest specific mechanisms of action. An open-label clinical pilot study involved 12 healthy people with moderate loss of joint ROM and associated chronic pain. The subjects consumed 4.25 g DAPP daily for 12 weeks, with evaluations at baseline, 2, 4, 8, and 12 weeks. ROM was evaluated at each visit using dual digital inclinometry. Pain scores were collected using Visual Analogue Scales. Blood draws enabled testing of serum antioxidant protective capacity using the cellular antioxidant protection (CAP-e) bioassay. Additional in vitro testing involved testing of cyclooxygenase-2 (COX-2) and lipoxygenase inhibition, cellular antioxidant protection by the CAP-e bioassay, and formation of reactive oxygen species (ROS) by polymorphonuclear (PMN) cells by flow cytometry. Twelve weeks of consumption of DAPP was associated with improved ROM. DAPP provided antioxidants that were available to enter into and protect cells from oxidative damage in vitro, and consumption of DAPP for 12 weeks was associated with a statistically significant improvement in serum antioxidant protective status. DAPP inhibited both COX-2 and lipoxygenase enzymes, and pretreatment of inflammatory PMN cells with DAPP before inflammatory stimulus resulted in reduced ROS formation. This suggests multifaceted anti-inflammatory properties of DAPP. Consumption of DAPP was associated with improved joint function and improved serum antioxidant protection status. The observed pain reduction may be associated with the improved antioxidant status and linked to the apple polyphenols’ anti-inflammatory effects.
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김규연 ( Marc Miravitlles ),( Pawel Sliwinski ),( Richard Costello ),( Victoria Carter ),( Jessica Tan ),( Therese Laperre ),( Bernardino Alcazar ),( Caroline Gouder ),( Cristina Esquinas ),( Juan Luis G 대한결핵 및 호흡기학회 2017 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.124 No.-
Background/Aim: Chronic obstructive pulmonary disease (COPD) is a heterogeneous condition requiring therapeutic management to be tailored to the clinical characteristics and disease severity of the individual patient. Due to scarcity of studies about racial differences in COPD patients, in this study, we compared clinical characteristics between Asian and other patients of COPD. Method: This was an international, multicenter, prospective study of a cohort of patients with COPD aimed to validate the concept of clinical control in COPD. We compared two subgroups (Asian versus others) by using clinical criteria, questionnaires (COPD Assessment Test -CAT- or Clinical COPD Questionnaire -CCQ-) and recent concept of control. Results: A total of 349 patients were analysed, 110 (32%) patients were Asian and 239 (68%) patients were others. There was a significant difference at sex, smoking status and BMI between Asian and others. Among clinical characteristics, there was a significant difference at median FEV1 (mL), and percentage of patients who have emphysema between two subgroups. Also, number of exacerbation and hospital admission, median CCQ score and recent concept of Impact (Clinical approach by mMRC, rescue medication, time walked/day and sputum color) were the characteristics which show significant disparities between two subgroups. Conclusion: This study showed significant differences in various factors between Asian and other patients of COPD. These results suggest that therapeutic management of COPD should be tailored to the ethnic group of the individual patients
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