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Huan-Ping Chao,Chung-Cheng Chang,Aileen Nieva 한국공업화학회 2014 Journal of Industrial and Engineering Chemistry Vol.20 No.5
This study used three types of agricultural waste, Citrus maxima peel, passion fruit shell, and sugarcane bagasse, to produce biosorbents for copper(II), cadmium(II), nickel(II), and lead(II) metal ion removal in a fixed-bed column. The biosorbent properties were characterized using scanning electron microscopy, zeta potential analysis, Fourier transform infrared spectroscopy, and cation exchange capacity. The adsorption capacities were determined using the Thomas model for various pH values and flow rates. The results indicated that biosorbents possess carboxylic acid groups, which function as exchangeable cation and complexation sites for removing heavy metals. The biosorbents exhibited great adsorption capacity.
Role of Intertube Interactions in Double- and Triple-Walled Carbon Nanotubes
Hirschmann, Thomas Ch.,Araujo, Paulo T.,Muramatsu, Hiroyuki,Rodriguez-Nieva, Joaquin F.,Seifert, Max,Nielsch, Kornelius,Kim, Yoong Ahm,Dresselhaus, Mildred S. American Chemical Society 2014 ACS NANO Vol.8 No.2
<P>Resonant Raman spectroscopy studies are performed to access information about the intertube interactions and wall-to-wall distances in double- and triple-walled carbon nanotubes. Here, we explain how the surroundings of the nanotubes in a multiwalled system influence their radial breathing modes. Of particular interest, the innermost tubes in double- and triple-walled carbon nanotube systems are shown to be significantly shielded from environmental interactions, except for those coming from the intertube interaction with their own respective host tubes. From a comparison of the Raman results for bundled as well as individual fullerene-peapod-derived double- and triple-walled carbon nanotubes, we observe that metallic innermost tubes, when compared to their semiconducting counterparts, clearly show weaker intertube interactions. Additionally, we discuss a correlation between the wall-to-wall distances and the frequency upshifts of the radial breathing modes observed for the innermost tubes in individual double- and triple-walled carbon nanotubes. All results allow us to contemplate fundamental properties related to DWNTs and TWNTs, as for example diameter- and chirality-dependent intertube interactions. We also discuss differences in fullerene-peapod-derived and chemical vapor deposition grown double- and triple-walled systems with the focus on mechanical coupling and interference effects.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancac3/2014/ancac3.2014.8.issue-2/nn500420s/production/images/medium/nn-2014-00420s_0008.eps'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nn500420s'>ACS Electronic Supporting Info</A></P>
Intravenous delivery of a multi-mechanistic cancer-targeted oncolytic poxvirus in humans
Breitbach, Caroline J.,Burke, James,Jonker, Derek,Stephenson, Joe,Haas, Andrew R.,Chow, Laura Q. M.,Nieva, Jorge,Hwang, Tae-Ho,Moon, Anne,Patt, Richard,Pelusio, Adina,Le Boeuf, Fabrice,Burns, Joe,Evgi Nature Publishing Group, a division of Macmillan P 2011 Nature Vol.477 No.7362
The efficacy and safety of biological molecules in cancer therapy, such as peptides and small interfering RNAs (siRNAs), could be markedly increased if high concentrations could be achieved and amplified selectively in tumour tissues versus normal tissues after intravenous administration. This has not been achievable so far in humans. We hypothesized that a poxvirus, which evolved for blood-borne systemic spread in mammals, could be engineered for cancer-selective replication and used as a vehicle for the intravenous delivery and expression of transgenes in tumours. JX-594 is an oncolytic poxvirus engineered for replication, transgene expression and amplification in cancer cells harbouring activation of the epidermal growth factor receptor (EGFR)/Ras pathway, followed by cell lysis and anticancer immunity. Here we show in a clinical trial that JX-594 selectively infects, replicates and expresses transgene products in cancer tissue after intravenous infusion, in a dose-related fashion. Normal tissues were not affected clinically. This platform technology opens up the possibility of multifunctional products that selectively express high concentrations of several complementary therapeutic and imaging molecules in metastatic solid tumours in humans.
María I. Isla,Iris C. Zampini,Roxana M. Ordóñez,Soledad Cuello,Belén Carrasco Juárez,Jorge Esteban Sayago,María I. Nieva Moreno,María Rosa Alberto,Nancy R. Vera,Enrique Bedascarrasbure,Alejandro Alvar 한국식품영양과학회 2009 Journal of medicinal food Vol.12 No.6
Propolis was included in the Argentine Food Code as a functional food. The chemical parameters and antioxidant properties of propolis samples from the same colonies of Apis mellifera in San Juan (Cuyo region, Western Argentine) were compared every month for 1 year using two collection methods. Chemical parameters were analyzed by the spectrophotometric method and fingerprinting using high-performance liquid chromatography with ultraviolet detection. The antioxidant activities of propolis samples were measured using model systems including the analysis of the scavenging activities for 2,2′-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals and the β-carotene bleaching assay. The results showed that propolis had a higher free radical scavenging and lipid peroxidation inhibitory capacity than butylated hydroxytoluene and quercetin, antioxidants used in the pharmaceutical and food industries. The concentration required to scavenge 50% of free radicals (SC50) values differed depending on the sample collection month. Samples collected in November had the highest antioxidant capacity. In all cases, SC50 values of propolis samples obtained by scraping were similar to those collected from a wire mesh (5μg/mL for ABTS and 20–30μg/mL for DPPH radicals). A significant positive correlation was found between the antioxidant capacity and flavonoid content of each analyzed extract. The chemical profiles were very similar. Galangin (3,5,7-trihydroxyflavone), an antioxidant compound, was detected in all samples as a major compound. The chromatographic profile suggests that of Baccharis sp., which would be one of the botanical sources of propolis from western Argentina, and the content of galangin can be used as a parameter for evaluating propolis quality. Our results suggest that Argentine propolis from Cuyo is a promising source of bioactive compounds as ingredients for developing functional foods with a beneficial impact on oxidative stress.