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ISFET Glucose and Sucrose Sensors by Using Platinum Electrode and Photo-crosslinkable Polymers
Jang, Won-Duk,Cho, Byung-Woog,Lee, Soo-Keun,Lee, Jong-Duk,Sohn, Byung-Ki 경북대학교 센서기술연구소 1994 센서技術學術大會論文集 Vol.5 No.1
The ISFET glucose and sucrose sensors containing platinum electrode and photopolymeric enzyme membrane were fabricated. The platinum working electrode was used for the electrolysis of hydrogen peroxide, which was the other product of the enzyme reaction, to improve sensing characteristics of the sensors. In order to improve response time, photo-crosslinkable polymer(PVA-SbQ) was used. The characteristics of glucose and sucrose sensors were investgated according to platinum electrode area. The response time was about 2-3 minutes and determinations of glucose and sucrose in the range of about 30-300mg/dl could be possible.
사진식각기술을 이용한 FET형 반도체 요소 및 포도당센서의 제조와 그 특성
조병욱,김창수,서화일,손병기,Cho, Byung-Woog,Kim, Chang-Soo,Seo, Hwa-Il,Sohn, Byung-Ki 한국센서학회 1992 센서학회지 Vol.29 No.3
pH-ISFETs, the semiconductor pH sensors, were combined with immobilized enzyme membranes to prepare FET type urea and glucose sensors and its operational characteristics were investigated. Photolithography techniques were applied to immobilize enzymes on the $H^{+}$ sensing membrane of the pH-ISFET with photo-sensitive polymers, PVA-SbQ. Fabricated urea and glucose sensors could determine $0.5{\sim}50{\;}mg/dl$ urea concentrations and $10{\sim}1000{\;}mg/dl$ glucose concentrations, respectively. 반도체 pH 센서인 pH-ISFET와 효소 고정화막을 기술적으로 결합한 FET형 반도체 요소 및 포도당센서를 제조하고 그 동작특성을 조사하였다. 사진식각기술을 이용하여 pH-ISFET의 수소이온 감지막 위에 urease와 glucose oxidase를 감광성 고분자 물질인 PVA(polyvinyl alcohol)-SbQ(stilbazolium group)로 고정화(immobilization)시켰다. 제조된 요소센서와 포도당센서는 각각 $0.5{\sim}50{\;}mg/dl$ 범위의 요소농도와 $10{\sim}1000{\;}mg/dl$의 포도당 농도를 정량 할 수 있었다.
Improvement of reliability of an ISFET pH-meter by employing multiple sensors
Kim, Chang Soo,Sohn, Byung Ki,Chang, Kee Seok,Cho, Byung Woog,Choi, Sang Bok 한국센서학회 1997 센서학회지 Vol.6 No.2
The ISFET(ion sensitive field effect transistor), a semiconductor ion sensor, has many advantages over conventional ion sensors. Various single-sensor type ISFET pH-meters have been developed. However, they could not be applied in fields because their performances are directly affected by the sensor condition. With only one sensor, the system could be easily damaged from environmental factors, and reliability of it is decreased. Therefore, a 4-channel pH-meter system is proposed to improve the reliability of ISFET pH-meter. It has 4 ISFETs as ion sensor, and a software which contains a new calibration and measurement algorithm appropriate to the system. The reliability of the system was proved by measuring hydrogen ion concentration in the pH standard solutions and buffer solutions.
( In Hee Lee ),( Byung Woog Kang ),( Jong Gwang Kim ),( Woo Kyun Bae ),( Myung Seo Ki ),( Inkeun Park ),( Jae-cheol Jo ),( Jin Young Kim ),( Sung Ae Koh ),( Kyung Hee Lee ),( Yoon Young Cho ),( Hun Mo 대한내과학회 2020 The Korean Journal of Internal Medicine Vol.35 No.1
Background/Aims: For metastatic renal cell carcinoma (RCC), various prognostic scoring systems have been developed. However, owing to the low prevalence of non-clear cell RCC, the three most commonly used tools were mainly developed based on patients with clear cell histology. Accordingly, this study applied three prognostic models to Korean non-clear cell RCC patients treated with first-line temsirolimus. Methods: This study analyzed data for 74 patients with non-clear cell RCC who were treated with temsirolimus as the first-line therapy at eight medical centers between 2011 and 2016. The receiver-operating characteristic (ROC) curves for the different prognostic models were analyzed. Results: Twenty-seven (36.5%), 24 (32.4%), and 44 patients (59.5%) were assigned to the poor prognosis groups of the Memorial Sloan-Kettering Cancer Center (MSKCC), International Metastatic RCC Database Consortium (IMDC), and Advanced Renal Cell Carcinoma (ARCC) risk stratification models, respectively. All three prognostic models reliably discriminated the risk groups to predict progression-free survival and overall survival (p < 0.001). The area under the ROC curve (AUC) for progression and survival was highest for the ARCC model (0.777; 0.734), followed by the IMDC (0.756; 0.724) and the MSKCC (0.742; 0.712) models. Furthermore, the sensitivity and specificity for predicting progression were highest with the ARCC model (sensitivity 63.6%, specificity 85.7%), followed by the MSKCC (sensitivity 58.2%, specificity 86.5%) and the IMDC models (sensitivity 56.4%, specificity 85.7%). Conclusions: All three prognostic models accurately predicted the survival of the non-clear cell RCC patients treated with temsirolimus as the first-line therapy. Furthermore, the ARCC risk model performed better than the other risk models in predicting survival.
Lee, Soo Jung,Kang, Byung Woog,Moon, Joon Ho,Chae, Yee Soo,Kim, Jong Gwang,Jung, Joo Seop,Cho, Goon-Jae,Jo, Deog-Yeon,Kim, Yeo Kyeoung,Kim, Hyeoung Joon,Ryoo, Hun-Mo,Eom, Hyeon Seok,Le, Sang Min,Joo, S. Karger AG 2012 Acta haematologica Vol.127 No.2
<P>Abstract</P><P>This study compared the results of allogeneic peripheral blood stem cell transplantation (PBSCT) from unrelated and related donors in 142 consecutive patients with acute myeloid leukemia (AML). The cumulative incidence of acute graft-versus-host disease (GVHD) was 37.6% in the related PBSCT group and 53.7% in the unrelated PBSCT group. The cumulative incidence of extensive chronic GVHD was also higher in the unrelated PBSCT group (19.5%) than in the related PBSCT group (8.9%). The overall survival rate at 4 years was 62.4 ± 5.4 and 53.8 ± 1.2% (p = 0.535) in the related and unrelated PBSCT group, respectively. In a multivariate analysis, unrelated PBSCT was identified as a risk factor for the development of extensive chronic GVHD (hazard ratio = 3.019, p = 0.027). Unfavorable cytogenetics and the disease status at the time of transplantation were found to be related to overall survival. In the case of high-risk AML, the survival rate and relapse incidence were significantly better in the matched unrelated PBSCT group (p = 0.047 and 0.039, respectively). In conclusion, the allogeneic PBSCT outcomes for AML were comparable in the matched related and matched unrelated groups. Nonetheless, for high-risk AML patients, matched unrelated PBSCT was found to be preferable to matched related PBSCT.</P><P>Copyright © 2011 S. Karger AG, Basel</P>
사진식각기술을 이용한 FET 형 반도체 요소 및 포도당센서의 제조와 그 특성
조병욱,김창수,서화일,손병기 ( Byung Woog Cho,Chang Soo Kim,Hwa Il Seo,Byung Ki Sohn ) 한국센서학회 1992 센서학회지 Vol.1 No.1
pH-ISFETs, the semiconductor pH sensors, were combined with immobilized enzyme membranes to prepare FET type urea and glucose sensors and its operational characteristics were investigated. Photolithography techniques wore applied to immobilize enzymes on the H^+ sensing membrane of the pH-ISFET with photo-sensitive polymers, PVA-SbQ. Fabricated urea and glucose sensors could determine 0.5∼50 mg/dl urea concentrations and 10∼1000 mg/dl glitdbse concentrations, respectively.
이영철,손병기,조병욱,김영진,김현수 한국센서학회 1999 센서학회지 Vol.8 No.4
A small cartridge, with a nozzle system for washing off the dirt from the surfaces of sensing gates, was fabricated. The proposed nozzle structure was designed for cartridge by using the simulation tool of fluid (CFD-ACE). Whole size of the fabricated cartridge by using micromachining techniques is about 2.6 cm X 1.5 cm, the size of the washing nozzle is 0.2 mm X 0.6 mm and its dead volume is only about 20 ㎕. A micro-reference electrode was achieved by employing a differential system with ISFETs/QRE (quasi-reference electrode)/REFET (reference field-effect transistor). Metal electrodes was deposited at both ends of blowing channel were used to check the presence of bubble in the microchannel. The pH-ISFET was inserted into the fabricated cartridge and the washing effect of the nozzle system in cartridge was invested.
14 비트 분해능을 갖는 2차 Sigma-Delta 변조기 설계 및 검증
조병욱,최평,손병기,Cho, Byung-Woog,Choi, Pyung,Sohn, Byung-Ki 대한전자공학회 1999 電子工學會論文誌, S Vol.s36 No.5
저주파의 아날로그 신호를 디지털 신호로 변환하기 위해 sigma-delta 아날로그-디지털 변환기의 이용이 용이하다. 이 변환기는 변조기와 디지털 필터로 구성되는데 본 논문에서는 변조기에 대해서만 언급한다. 모델링을 통해 14비트 분해능을 갖는 2차 sigma-delta 변조기를 설계하기 위한 변조기의 구성요소 즉 연산 증폭기, 적분기, 내부 ADC 및 DAC의 최대 허용 에러 범위를 규정하였으며, 이를 토대로 연산증폭기, 2비트 ADC 및 DAC 등을 설계·검증하고, 이들을 서로 연결하여 2차 sigma-delta 변조기를 구성하였다. 3비트 ADC의 기준전압을 조절하여 변조기 성능 향상을 도모하였으며, 내부 DAC를 축전기 및 간단한 제어회로로 구성하여 비선형성 에러를 최소화하였다. 설계된 각각의 구성요소들은 모델링에서 정의된 에러 범위를 모두 만족하였으며, 전체 변조기는87㏈의 입력범위와 87㏈의 최대 신호 대 잡음 비를 가졌다.
14 비트 분해능을 갖는 2차 Sigma-Delta 변조기 설계를 위한 구성요소의 최대에러 허용 범위 조사
조병욱,최평,손병기,Cho, Byung-Woog,Choi, Pyung,Sohn, Byung-Ki 한국통신학회 1998 韓國通信學會論文誌 Vol.23 No.5
저주파의 아날로그 신호를 디지털 신호로 변환하기 위해 sigma-delta 아날로그-디지털 변환기의 이용이 용이하다. 이 변환기는 변조기와 디지털 필터로 구성되는데 여기에서는 변조기에 대해 언급한다. 14비트 분해능을 갖는 2차 sigma-delta 변조기를 설계하기 위한 변조기의 구성요소 즉 연산 증폭기, 적분기, 내부 ADC 및 DAC의 최대 허용 에러 범위를 규정하였다. 이를 위하여 먼저 이상적인 변조기를 모델링하고 다음으로 변조기의 성능을 저하시키는 여러 가지 에러 요인 즉 연산증폭기의 최대 출력 제한, DC 이득, slew rate, 축전기의 불일치에 의한 적분기 이득 에러와 내부 ADC 및 DAC의 에러 등을 이상적인 모델에 적용하여 성능을 검증하였다. 이러한 에러 허용 범위에 대한 조사를 바탕으로 sigma-delta 변조기 설계 시 요구되는 구성 요소의 사양을 결정 할 수 있으며, 제조과정에서 나타나는 에러 성분에 대한 한계를 규정하여 최종 제작될 변조기의 성능을 확신 할 수 있다. Sigma-delta converter is frequently used for conyerting low-frequency anglog to digital signal. The converter consists of a modulator and a digital filer, but our work is concentrated on the modulator. In this works, to design second-order sigma-dalta modulator with 14bit resolution, we define maximumerror limits of each components (operational smplifier, integrator, internal ADC, and DAC) of modulator. It is first performed modeling of an ideal second-order sigma-delta modulator. This is then modified by adding the non-ideal factors such as limit of op-amp output swing, the finit DC gain of op-amp slew rate, the integrator gian error by the capacitor mismatch, the ADC error by the cmparator offset and the mismatch of resistor string, and the non-linear of DAC. From this modeling, as it is determined the specification of each devices requeired in design and the fabrication error limits, we can see the final performance of modulator.