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허덕현,장일미,노학재,안무영,진소영 대한임상신경생리학회 2012 Annals of Clinical Neurophysiology Vol.14 No.1
Nephrogenic systemic fibrosis (NSF) is a systemic disease that affects the skin and other tissues in patients with renal insufficiency and exposure to gadolinium-containing contrast. A 55-year-old woman with end-stage renal disease on hemodialysis was consulted for progressive general weakness. After she had undergone multiple MRIs with gadolinium-containing contrast media, muscle weakness and skin lesions were developed. Her skin and muscle biopsy specimens showed CD34+ fibroblast entrapping collagen bundles. There are few reports of NSF with myopathy.
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편두통 환자에서 토피라메이트 사용 중 발생한 가역적 뇌량팽대병변
허덕현,이승근,박정호,이태경 대한신경과학회 2017 대한신경과학회지 Vol.35 No.3
Reversible lesion in the splenium of the corpus callosum in patients with epilepsy is often associated with some antiepileptic drugs. However, topiramate has never been reported as a possible inducer of the focal lesion. We report a case of reversible splenial lesion of the corpus callosum presumed to be induced by low dose topiramate in a patient with chronic migraine.
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이상우,김형석,허덕현,박정호 대한신경과학회 2018 대한신경과학회지 Vol.36 No.4
Oculogyric crisis is an acute dystonia involving ocular muscles characterized by sustained conjugate upward or lateral deviation of the eyes. Metronidazole is a commonly used antimicrobial agent in treatment of anaerobic infections. However, its long-term use can cause toxic encephalopathy particularly in patients with hepatic dysfunction. Here, we describe a case of oculogyric crisis as a presenting manifestation of metronidazole-induced encephalopathy.
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서재영,이정곤,허덕현,장일미,이경복,노학재,안무영 대한신경과학회 2013 대한신경과학회지 Vol.31 No.1
While acute anemia is regarded as a precipitating factor of ischemic stroke, there have been few reports on the evolution of infarction in the acute period of ischemic stroke by anemia. We describe a 71-year-old man with acute multiple territory infarction who had progressive neurologic deficits of paraparesis and dysarthria. This case suggests that sustained severe anemia due to intractable intestinal bleeding is an important cause of aggravation of ischemic stroke.
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이동현,김태은,허덕현,허태훈,박선아,이태경,성기범,박정호 대한신경과학회 2012 대한신경과학회지 Vol.30 No.3
Background: The purpose of this study is to identify the differences of risk factors and stroke mechanism between early and late recurrence in patients with long-term antiplatelet therapy for stroke prevention. Methods: We enrolled 114 consecutive patients with recurrent infarction who had been taking antiplatelet agents regularly since previous noncardioembolic cerebral infarction. Total 81 patients (49 men and 32 women) were met to the inclusion criteria through standardized evaluation. Subjects were classified into two groups depending on the time-to-recurrence after antiplatelet therapy: early antiplatelet failure (within 2 years, n=41, hereafter as “EAF”) and later antiplatelet failure (after 2 years, n=40, hereafter as “LAF”). We investigated the differences of clinical factors between two groups using univariate and multivariate analysis. Results: Family history of stroke (29.3% in EAF vs. 10% in LAF, p=0.029) was more frequent in EAF group. Low HDL-cholesterol and High total cholesterol/HDL-cholesterol ratio were associated with the LAF group (p=0.042, 0.005respectively). Multivariate analysis showed that family history of stroke (OR=5.283, 95%CI 1.178-23.699, p=0.030) and previous infarction classified as large artery atherosclerosis (OR=8.497, 95%CI 1.444–50.015, p=0.018) were significant predictors for EAF whereas total cholesterol/HDL-cholesterol ratio (OR=2.002, 95%CI 1.183–3.389, p=0.010) was for LAF. Conclusions: This study suggests that family history of stroke and cerebral infarction due to large artery atherosclerosis are more responsible for the early recurrence while dyslipidemic condition is more related to the late recurrence during long-term antiplatelet therapy in patients with previous cerebral infarction.
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급성 뇌경색 환자 중 흡연군과 비흡연군의 뇌혈관 질환 위험인자의 차이
김도의,김지선,허덕현,이경복,양광익,노학재,안무영,황혜원 순천향대학교 순천향의학연구소 2010 Journal of Soonchunhyang Medical Science Vol.16 No.2
Cigarette smoking is a risk factor for hypertension, diabetes and hyperlipidemia. Although cigarette smoking has established as an important risk factor for stroke, the atherosclerotic effect which was based on observational studies was controversial. We were to compare profiles of the risk factors between smokers and non-smokers, and investigate the differences in risk factor of ischemic stroke. Patients were selected from 748 consecutive patients with acute ischemic stroke. The smoking was categorized into nonsmokers (never smoked regularly or stopped regular smoking ≥5 years ago) and smokers (regular smoking within the last 5 years). We compared profiles of the risk factors between smokers and non-smokers, and investigated the differences in risk factor of ischemic stroke. Much of a differences were existed in the distribution of risk factors between 574 (72.8%) non-smokers and 215 (27.2%) smokers. The frequency of hypertension was higher in non-smokers than in smokers (73.2% vs. 62.3%, P=0.002) and that of hyperlipidemia was lower in non-smokers than in smokers (20.4% vs. 26.5%, P=0.041). Our study suggests that the frequencies of major risk factors of ischemic stroke are much different between smokers and non-smokers.
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