중이염 환자에서의 측두골 CT 이용

함소희 대한영상의학회 1987 대한영상의학회지 Vol.23 No.5

High resolution CT is well known excellent modality for evaluation of fine eqr structures and its changes, but is not usual method for detection of inflammatory disease of ear. Forty cases of OMPC were reviewed and advantages & limitations were also evaluated. RESULTS : 1. On CT findings of OMPC, abnormalities were external auditory canal in 14 cases, tympanic membrane in 31 cases, soft tissue mass in middle ear cavity and/or mastoid antrum in 34 cases, middle ear effusion in 9 cases, and bony labyrinth in 5 cases. 2. Partial erosion and missing of ossicles were long process and lenticular process of incus, body of incus, head of malleus, and stapes in order. 3. Advantage of temporal bone CT were early detection of soft tissue mass, evaluation of extent of disease, destruction of bony structure and ossicular destructioin. 4. Differentiation of cholesteatoma and granulation was difficult and examination of superstructures such as stapes and facial nerve canal were limited.

위에서 발생한 평활근 아세포종 - 1예 보고 - 고려병원 방사선과

함소희 대한영상의학회 1987 대한영상의학회지 Vol.23 No.2

Leiomyoblastomas are radiologically and grossly indistinguishable from the leiomyoma or leiomyosarcoma. Tey tend to occur later in life, but attain the same size and shape and have the same sex attribution as the other smooth muscle tumors. The major difference is their histologic appearance. Leiomyoblastomas are composed primarily of rounded or polygonal cells with a clear space surrounding the nucleus instead of spindle cell mainly found in leiomyoma or leiomyosarcoma. Leiomyoblastomas are felt to have considerably more malignant potential than leiomyoma, but this has rarely been demonstrated. Exophytically growing tendency limits conventional barium studies. So recently CT is useful in depicting the origin, extend of these masses, and detection of distant metastasis. CT is an ideal imaging modality for study of this unusual neoplasm. We report a case of exophytic growing leiomyoblastoma from posterior wall of the stomach in 43 year old woman. We discussed with CT finding an reviewed the literature.

대전자와 좌골 결핵성 병변의 단순 방사선학적 소견

함소희 대한영상의학회 1996 대한영상의학회지 Vol.35 No.5

Purpose : To evaluate, if possible, the radiographic features of tuberculous osteitis in the greatertrochanter and ischium, and to determine the cause of the lesions. Materials and Methods : We retrospectivelyreviewed the plain radiographic findings of 14 ptients with histologically proven tuberculous osteitis involvingthe greater trochanter and ischium. In each case, the following were analyzed : morphology of bone destruction,including cortical erosion; periosteal reaction ; presence or abscence of calcific shadows in adjacent softtissue. On the basis of an analysis of radiographic features and correlation of the anatomy with adjacentstructures we attempted to determine causes. Results : Of the 14 cases evaluated, 12 showed varrious degrees ofextrinsic erosion on the outer cortical bone of the greater trochanter and ischium ; in two cases, bonedestruction was so severe that the radiographic features of advanced perforated osteomyelitis were simulated. Inaddition to findings of bone destruction, in these twelve cases, the presence of sequestrum or calcific shadowswas seen in adjacent soft tissue. Conclusion : Tuberculous osteitis in the greater trochanter and ischium showedthe characteristic findings of chronic extrinsic erosion. On the basis of these findings we can suggest that theselesions result from an extrinsic pathophysiologic cause such as adjacent bursitis.

자폐성 정신지체 아동의 개별치료 효과에 대한 사례연구 : Case Study

함소희,한현민 대진대학교 교육대학원 교육연구소 1999 교육연구 Vol.1 No.1

AbstractThis present study ws designed to determine the effect of individual therapy with a 11-3 boy with autistic mental retardation. The client was chraterized to exhibit excessive perseveration and difficulties in interpersonal relations. The intervention was composed of making comfortable learning environment and setting reliable relationships with therapist, and persisted over 54 sessions. As a result, the client demonstrated the satisfactory affectional attachment and less anxious behaviors The present study was designed to determine the effect of individual therapy with a 11-3 boy with autistic mental retardation. The client was characterized to exhibit excessive perseveration and difficulties in interpersonal relations. The intervention was composed of making comfortable learning environment and setting reliable relationships with therapist, and persisted over 54 sessions. As a result, the client demonstrated the satisfactory affectional attachment and less anxious behaviors.

흰쥐 소뇌 연접후치밀질내 phosphotryrosine 함유 단백질에 대한 연구

전일수,함소희,고복현 한국생명과학회 1997 생명과학회지 Vol.7 No.3

tyrosine 인산화효소계를 통한 신호전달은 신경의 발생과 연접환성조절에 중요한 역할을 한다. 흰쥐 소뇌의 연접후치밀질에 존재하는 tyrosine 함유 당백질들을 조사하기 위하여 immunoblot 분석을 한 결과, 소뇌 연접후치밀질의 전반적인 단백질조성은 전뇌와 비슷하였다. phosphotyrosine 특이성 항체로, immunobolot 한 결과 소뇌의 주된 tyrosine 인산화 단백질은 50 kD 크기의 새로운 단백질이었다. PSD-50로 명명한 이 단백질은 SDS-PAGE에서 $\alpha$CaMKII와 같은 위치에 이동하였다. 그러나 소뇌에는 전뇌에 비하여 적은량의 $\alpha$CaMKII가 존재함에도 불구하고 전뇌보다 더 강한 phosphotyrosine immunoblot signal을 보이는 것으로 보아 PSD-50는 아마도 $\alpha$CaMKII와는 다른 단백질로 추정된다. The signal transduction through tyrosine kinases play important roles in neuronal development and synaptic regulation. We carried out immunoblot analyses to study tyrosine=phosphorylated proteins in the rat cerebellar postsynaptic density (PSD), a protein-rich cytoskeletal specialization underlying beneath the postsynaptic membrane. The overall protein composition of cerebellar PSD fractions was similar to that of the forebrain’s and only a few bands were different in Coomassie stain. Immunoblot analyses with phosphtyrosine-specific antiboy (4G10) showed that there are many more tyrosine-phosphorylated proteins in the cerebellar PSD than in the forebrain PSD. Interestiingly, a major phosphotyrosine signals in cerebellar PSD fractions was associated with a 50 kD molecular size, named as PSD-50. Migration of PSD-50 coincided with that of $\alpha$CaMKII and remained in the pellet fraction after N-octylglucoside extraction. These results indicate that tyrosine phosphorylation is important in cerebellar synaptic regulation and that the PSD-50 may be same as $\alpha$CaMKIIor a new protein which is a major substrate of tyrosine kinase.

저산소증에서 NMDA 수용체 2B의 증가에 따른 흰쥐 해마형성체 신경세포의 손상기전

정용욱,함소희,문일수,고복현 대한해부학회 1997 Anatomy & Cell Biology Vol.30 No.4

정신지체아동의 정수준과 사회적 행동과의 관계

조용태,함소희,Cho, Yong-Tae 대진대학교 2002 大眞論叢 Vol.10 No.-

This study is correlation between Cheong levels and social behaviors(social skills and antisocial behavior) in the mentally retarded children. Cheong it is one of the most commonly felt psychological aspect of Koreans in their everyday life. Social behavior is usually importance children with mental retardation. This study's focus is on investigation about Cheong's level and social behavior and the correlation between Cheong's level and social behaviors according to handicaps and sex. The subjects are 125 normal children and 76 mental retardation enrolled at special schools and primary schools in Seoul and Keong Gi-Do. Cheong Level Scale was made on third process for this study and the School Social Behavior Scales(SSBS) redesigned by Song(1999) was used. Data analysis methods used in this study are that one is t-test and the other is pearson's correlation analysis. The results of this study were first, normal children are found to be high level in Cheong than mentally retarded children. Female is found to be high level in Cheong than male. Children with mental retardation or not disability are female is found to be high level in Cheong then male. Second, normal children are found to be high level in social skills but not found to be difference in antisocial behavior. As against sex, Female is found to be high level in social skills than male. Female is found to be low level in antisocial behavior. Also female with mental retardation is found to be high level in social skills than male. Normal female children are found to be low level in antisocial behavior than male. Finally, if normal children's Cheong level is higher then social skills increase, in order to Cheong level is higher and antisocial behavior decrease. Also mentally retarded children's Cheong level is higher then social skills increase. but whether Cheong level is higher or lower then antisocial behavior not change.

혐오자극과 모델링 및 언어적 지시가 발달지체 아동의 상동행동에 미치는 효과 : 사례연구

한현민,함소희,김윤선,지지영,홍희영 대진대학교 교육연구소 2000 교육연구 Vol.2 No.1

The experiment was undertaken to determine the combined effects of aversive, modeling, and verbal instruction on the self-stimulatory stereotyped benavior exhibited by a three-year two-month old with developmental delay, The behavioral interventions were consisted of lemon juice(aversive), behavioral rehearsal(moleling), verbal instruction(prompting), and defferential reinforcement of incompatible behavior (DRI), and continued over 73 sessions. The data gathered across multitreatments design (A-BCD-A-BD-DE) were visually analyzed. The results revealed that all the treatments reduced the occurrences of stereotyped behavior, the significant differences among any interventions were not found, and more importantly, the behavior effects were maintained.

건조 혈액표본으로 부터의 DNA추출

홍해숙,조희중,함소희,김은희,박매자,주강 慶北大學校 醫科大學 1990 慶北醫大誌 Vol.31 No.1

건조된 혈액에서 직접 추출한 DNA양은 7∼9㎎/㎖로써 혈액에서 직접 추출한 DNA양(22㎍/㎖)에 비해 1/3의 양이었다. 건조된 혈액에서 추출한 DNA는 DNA분석을 위해 충분한 양으로 pERT 87-8 probe/Taq 1로써 hybridize한 결과 3.6kb, 0.9kb에 band가 나타났다. Microextraction of DNA from dried blood specimens would ease specimen transport to centralized laboratory facilities for recombinant DNA diagnosis in the same manner as use of dried blood spots allowed the broad application of screening tests to newborn population. These dried blood samples have been used for various tests including those bases on screening for red blood cell proteins, as in galactosemia or the hemoglobinopathies, for hormone metabolite accumulations, as in phenylketonuria, homocystin uria, or maple syrup urine disease. We have been interested in appling molecular genetics techniques to newborn screening. Thus, the purpose of this study was to detrmine whether DNA was present in dried blood spots on filter paper blotters in a form that could be extracted and isolated and in sufficient quantities for use in DNA analyses. The suitable obtained results were as follows: The extracted volume of DNA was 7-9ug per one blotted blood paper. There was no differentiation of extracted DNA volume among dry period. This DNA volume was about 1/3 of direct ordinary extracts of 1 ㎖ whole blood. This microextraction procedure will allow immediate application of molecular genetic technology to direct newborn screening follow up of disorders amenable to DNA diagnosis.