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혈액투석 환자에서 대퇴신경병증으로 발현된 장골근 및 요근 농양
이준상 ( Lee Jun Sang ),강동구 ( Kang Dong Gu ),신상열 ( Sin Sang Yeol ),윤재호 ( Yun Jae Ho ),조영일 ( Jo Yeong Il ),고성은 ( Go Seong Eun ),유영범 ( Yu Yeong Beom ),전혜정 ( Jeon Hye Jeong ),진춘조 ( Jin Chun Jo ),송종오 ( Song 대한신장학회 2004 Kidney Research and Clinical Practice Vol.23 No.1
Primary iliopsoas abscess is a rare but potentially serous condition. The diagnosis is frequently delayed due to its variable and nonspecific fcatures and occult clinical course. The delayed diagnosis and treatment of iliopsoas abscess is the major poor prognostic factor. We report a rare case of primary iliopsoas abscess that presented as a femoral neuropathy in a patient on hemodialysis. A 49-year-old man with end stage renal disease was admitted due to pain in the lft inguinal area, and weakness and hypoesthesia of left lower leg. Left iliopsoas abscess was confirmed by CT and MRI. Left femoral neuropathy was diagnosed with electrodiagnostic study. Iliopsoas abscess with femoral neuropathy was completely treated with CT-guided aspiration, antibiotics and prolonged physical therapy of hip and knee joints. To our knowledge, this is the first case report of primary iliopsoas abscess presented as a femoral neuropathy in a patient on hemodialysis in Korea. (Korean J nephrol 2004;23(1):180-184)
유산균(L.lactis CBT-8)및 발효 추출물의 Helicobacter pylori 억제 능력
진춘조,박형석,이혜운,김성렬,강동구,이준상,이재동,왕준호 건국대학교 의과학연구소 2002 건국의과학학술지 Vol.12 No.-
Helicobacter pylori infection was the cause of chronic gastritis, duodenal ulcer and gastric MALT lymphoma. The eradication rates of H. pylori using antibiotics are around 80%. Lactobacilli have been demonstrated to have in vivo and in vitro inhibitory effects on H. pylori infection. We aimed to evaluate the inhibitory effect of L. lactis CBT-8 and its extract on H. pylori in human stomach. Thirty-five H. pylori-infected volunteers(30-49 yr)were randomized into two groups which were treated with L. lactis CBT-8 and its extract(Group A n=17) or milk containing L. lactis CBT-8(Group B, n=18). They underwent 13C-urea breath tests before and after treatment. The DOB30 of group A(n=14) was decreased 41.0% after treatment(26.0±4.9 before, 15.3±2.1 after treatment)(p<0.05). the DOB30 of group B(n=13) was decreased 22.3% after treatment(22.0±2.2 before, 17.1±1.7 after treatment)(p<0.05). In conclusion, L. lactis CBT-8 was effective in suppressing H. pylori infection in human stomach.
윤호상,진춘조,유광하,이상엽,이수인,정상만,김선두,이순제,이길도,전혜정 건국대학교 의과학연구소 2000 건국의과학학술지 Vol.10 No.-
Chronic eosinophilic pneumonia(CEP) is a rare disease of unknown etiology characterized by chronic infiltration of the lung with eosinophils. It presents with profound systemic symptoms comprising fever, night sweats, weight loss, dyspnea and blood eosinophilia with nonsegmental air-space consolidation confined to the outer third of the lung, the "photographic negative of pulmonary edema". Histopathologic features of chronic eosinophilic pneumonia are intraalveolar and interstitial infiltrations with eosinophils, histiocytes, giant cells, scattered lymphocytes and plasma cells. Glucocorticoid therapy cause prompt resolution of symptoms as well as disappearans of blood eosinophils, elevated serum Ig E levels and the roentgenographic lesions. Infrequent radiographic findings include nodular infiltrates, consolidations, cavitations, atelectasis and pleural effusions. Deaths from CEP although rare, have been reported, but the majorities of CEP have benign courses and do not need a therapy with ventilator. We report a case of chronic eosinophilic pneumonia, which had a sudden course associated with diffuse pneumonic consolidations on the both lung and bilateral pleural effusion.
소화성 궤양에서 삼제 병합 요법의 저용량에 의한 Helicobacter pylori 제균률과 궤양 치유효과
김예리,박봉안,이재동,이종혁,김인숙,박형석,진춘조,김상윤,박의우 건국대학교 의과학연구소 2000 건국의과학학술지 Vol.10 No.-
Helicobacter pylori is the major cause of histologic chronic gastritis and is strongly associated with peptic ulcer disease, gastric cancer and lymphoma. Several recommendations for the management of the Helicobacter pylori infection have been developed. However, there has been no clear therapeutic regimen for the optimal treatment of Helicobacter pylori infection. This study was desinged to evaluate the eradication rate and the ulcer healing rate of the triple regimen with low-dose clarithromycin(0.5g/day) in peptic ulcer patients. Forty three patients with gastric ulcer(n=15) and duodenal ulcer(n=28) were enrolled. The patients were treated either with omeprazole 20mg b.i.d. amoxicillin 0.5g b.i.d. and clarithromycin 250mg b.i.d. (low-dose regimen group, n=29) or with omeprazole 20mg b.i.d., amoxicillin 1.0g b.i.d. and clarithromycin 0.5g b.i.d.(high-dose regimen group, n= 14) for 2 weeks. After 4 weeks, the patients were evaluated for the eradication of Helicobacter pylori and the healing of ulcer. And gastritis scores according to the Sydney system were evaluated before and after 4 weeks from the end of the triple regimen. There was no significant difference in the eradication rate and the ulcer healing rate between the low-dose regimen group, group and the high-does regimen group. In the low-does regimen group, the mean initial scores of chronic inflammation and activity were decreased after the eradication of Helicobacter pylori. In conclusion, the low-dose triple regimen is as effective as the high-dose triple regimen on the eradication of Helicobacter pylori and the ulcer healing rate in peptic ulcer disease.
다발성 간종괴의 형태로 나타난 특발성 과호산구 증후군 치험1예
최승오,연규민,이승민,김순제,왕준호,박형석,이재동,진춘조,이창훈,신현준,김정은 건국대학교 의과학연구소 2004 건국의과학학술지 Vol.14 No.-
Hypereosinophilic syndrome is characterized by persistent blood eosinophilia of 1,500/ul or more in the absence of known causes and multiorgan dysfunction by eosinophil-related tissue damage. In Korea, some cases of hypereosinophilic syndrome with hepatic involvement have been described with prolonged benign clinical courses. Most of them were diffuse or multifocal lesions in imaging studies, and a few case presenting as a single mass has been described. Here we report a case of hypereosinophilic syndrome with hepatic involvement in a 65-year-old man who presented with multifocal mass lesions. By abdominal US and CT scan, multiple, ill-defined nodules were detected in throughout the liver. Liver biopsy revealed severe eosinophilic hepatitis, suggestive of hypereosinophilic syndrome. Hepatic mass lesions improved after steroid administration for several weeks.
기능성 소화불량 환자에서 Helicobacter pylori의 발현 및 균 박멸이 임상 증상에 미치는 효과
진춘조,이재동,이수인,송기호,박형석,윤호상,김석,이승철 건국대학교 의과학연구소 1999 건국의과학학술지 Vol.8 No.-
This study was designed for the assessment of the prevalence of Helicobacter pylori and the effect of its eradication on clinical symptoms in patients with functional dyspepsia. We enrolled 51 patient with dyspepsia more than 3 months. The patients, who had no organic lesion in endoscopy into 4 groups: A (Helicobacter pylori infected and eradication group), B (Helicobacter pylori infected and non-eradicated group), C (Helicobacter pylori not infected and proton-pump inhibitor and free radical scavenger administration group), and D (Helicobacter pylori not infected and free radical scavenger only group). And follow-up the patients on 10th day and 30th day, when we score the dyspeptic symptom and frequency. 24 out of 51(47.1%) were CLO positive. There were much improvements at 30th day dyspepsia score in eradicated group(A) but not in non-eradicated group. And the difference between two groups was statistically significant (p<0.001). There was no difference between group C and D. In conclusion, Helicobacter pylori has a role in functional dyspepsia and the eradication of Helicobacter pylori in patients with functional dyspepsia improve the clinical symptoms of dyspepsia.
김미진,박형석,이재동,왕준호,김순제,진춘조 건국대학교 의과학연구소 2004 건국의과학학술지 Vol.13 No.-
The seroprevalance of Helicobacter pylori (H. pylori) infection in Korea is relatively high And bacterial resistance to metronidazole and clarithromycin is high. Thus, the indications of H. pylori treatment should be strict to avoid antibiotics abuse which causes side effects and the increase of antibiotics resistant strains. Reinfections most likely occur in areas where the force of infection is high, ie, where both the prevalence of infection and the opportunities for transmission are high. In korea, the annual reinfection rate is high(4.4% ∼ 18.6%) compared with developed countries. So effective first line therapy with regular follow-up is essential in the management of H. pylori infection. compared to those in other country.
이해운,김성렬,강동구,이준상,유광하,진춘조 건국대학교 의과학연구소 2003 건국의과학학술지 Vol.13 No.-
One hundred thirty seven patients with pulmonary and extrapulmonary tuberculosis who visited Konkuk University Hospital between July 1996 and July 2002, were treated with isoniazid, rifampin, ethambutol, and pyrazinamide. Among these patients, ten patients had underlying diabetes mellitus, and three HB viral hepatitis. Their medical chart were reviewed retrospectively to evaluate the adverse effects of anti -tuberculous medication. The major side effects of patients are gastrointestinal intolerance(26.4%) and hepatotoxicity(25.3%). Minor side effects are itching sensation, fever, skin eruption, myalgia, arthlagia, and other hypersensitivity reaction. We evaluated the onset, duration, and management of side effect during TB medication according to underlying diseases