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경구 프레드니솔론 투여에 즉각적인 호전을 보인 CAPD 환자의 호산구성 복막염
조영일 ( Jo Yeong Il ),이정연 ( Lee Jeong Yeon ),안해련 ( An Hae Lyeon ),이해운 ( Lee Hae Un ),김성열 ( Kim Seong Yeol ),강남규 ( Kang Nam Gyu ),신석균 ( Sin Seog Gyun ),송종오 ( Song Jong O ) 대한신장학회 2001 Kidney Research and Clinical Practice Vol.20 No.6
Eosinophilic peritonitis is not uncommonly observed in patients on peritoneal dialysis. It typically occurs within the first 3 months after the initiation of peritoneal dialysis. Eosinophilic peritonitis is usually a benign and self-limiting process with the exception of fungal eosinophilic peritonitis. The use of oral or intraperitoneal steroids has been suggested only for patients with abdominal pain or with markedly turbid peritoneal effluent. We report a case of eosinophilic peritonitis with severe abdominal pain, which successfully resolved on treatment with single dose of oral prednisolone.
흰쥐에서 허혈성 재관류 손상에 대한 Amphetamine 전처치의 신보호 효과가 Heat Shock Protein에 의한 것인가?
조영일 ( Jo Yeong Il ),나흥식 ( Na Heung Sig ),백승근 ( Baeg Seung Geun ),조승제 ( Jo Seung Je ),김교순 ( Kim Gyo Sun ),최영숙 ( Choe Yeong Sug ),송종오 ( Song Jong O ) 대한신장학회 2004 Kidney Research and Clinical Practice Vol.23 No.1
목 적 : In vivo에서 heat shock protein (HSP)이 허혈성 재관류 손상 (I/R injury)에 대한 신보호 효과를 가지는지에 대해서는 상반된 연구 결과들이 보고되고 있다. 저자들은 발열작용을 하는 암페타민과 HSP의 발현을 억제하는 작용이 있는 quercetin을 이용하여 in vivo에서 열전처치가 신장의 I/R injury에 대해 어떤 효과를 나타내는지, 그리고 신보호 효과가 있다면 그것이 HSP의 발현에 의한 것인지를 규명하고자 하였다. 방 법 : Sprague-Dawley rat를 대상으로 암페타민 혹은 quercetin으로 전처치 후에 양측 신동맥을 30분 혹은 60분 동안 결찰하고 24시간 동안 재관류시킨 다음 희생시켜 BUN/Cr, histopathologic score 및 HSP70의 발현을 조사하기 위한 immunohistochemistry 검사를 시행하였다. 결 과 : 신동맥을 결찰하기 전에 암페타민 전처치를 시행한 군에서는 재관류 후의 BUN, Cr, histopathologic score가 대조군에 비해 유의하게 낮았다. 반면에, 암페타민 전처치 전에 quercetin을 투여한 군이나 quercetin만을 단독으로 투여한 군에서는 대조군과 유의한 차이를 나타내지 않았다. HSP70은 암페타민 전처치를 시행한 군에서 발현이 증가하였으나, 나머지 군에서는 HSP70이 발현되지 않거나 미미하였다. 결 론 : 흰쥐에서 암페타민 전처치는 신장의 I/R injury에 대해 신보호 효과를 나타내었고, 이러한 효과는 암페타민 전처치로 생성된 HSP70과 관련이 있었다. Background : Heat shock proteins (HSOs) induced by variable kinds of stress produce tolerance to a variety of adverse conditions. However, the protective effect of HSP on ischemia/reperfusion injury (I/R injury) of kidney in vivo remains unclear. The present study was designed to evaluate whether HSP70 induced by hyperthermic preconditioning had renoprotective effect on I/R injury of the kidney in vivo. Methods : 82 Sprague-Dawley male rats were esed. Animals in control group (n=24) were subjected to bilateral occlusion of renal pedicles for 30 or 60 minutes followed by 24-hour reperfusion. In amphetamine (Amp, n=18) and quercetin (Q, n=16) group, amphetamine sulfate, a sympathomimetic drug which can elevate the body temperature as a result of enhanced endogenous lipolysis, and quercetin, a biflavonoid which inhibit the expression of HSP, were injected 4 hours prior to renal ischemia, respectively. In quercetin-amphetamine (QAmp, n=7) group, quercetin was injected 1 hour before administration of amphetamine. AA (n=8) or QQ (n=9) group was identical to Amp or Q group except that sham operation was performed instead of ischemic insult. In all groups, animals were sacrificed prior to or 24 hours after I/R injury. HSP70 induction was confirmed by immunohistochemistry. To assess the I/R injury of kidney, BUN, Cr, histopathologic change of tubular cell and HSP70 expression were evaluated. Results : In Amp group, an increase of BUN and Cr were significantly lower than other groups and less severe renal tubular injury was also observed. In addition, HSP70 was strongly expressed in Amp group, whereas HSP70 was weakly expressed in control group and not expressed in QAmp and Q group. There were no differences in the functional and histologic injuries of kidney after I/R injury between AA, QQ and control group. Conclusion : These data demonstrate that the renoprotective effect by amphetamine preconditioning to I/R injury is linked with the expression of HSP70. (Korean J Nephrol 2004;23(1):12-21)