한약복용 후 발생한 칸타리딘 중독 1례

지호진,김현,김선휴,오성범,문중범,이강현,황성오,Ji Ho Jin,Kim Hyun,Kim Sun Hyu,Oh Sung Bum,Moon Joong Bum,Lee Kang Hyun,Hwang Sung Oh 대한임상독성학회 2005 대한임상독성학회지 Vol.3 No.1

Blister beetles produce cantharidin, which is toxic to people and animals. Cantharidin has been believed to be an aphrodisiac and an abortifacient based on its tendency to cause marked irritation to the genitourinary system leading to priapism in men and pelvic congestion in women for many years. Cantharidin was used by oriental traditional medicine for more than 2000 years. Typical signs related to cantharidin ingestion are gastrointestinal tract and urinary tract irritation, endotoxemia, shock and myocardial dysfunction. Cantharidin is a severe irritant to epithelial linings (gastrointestinal tract, urinary tract, and skin) and develop systemic inflammatory response syndrome. We report a case of corrosive esophagogastritis and acute renal failure by ingestion of cantharidin.

중증외상 환자에서 중증도와 혈청 항트롬빈 III 와의 상관관계

지호진,이강현,김선휴,오성범,차경철,김호중,김현,황성오 대한응급의학회 2004 대한응급의학회지 Vol.15 No.5

An Improved Multi-resolution image fusion framework using image enhancement technique

Hojin Jhee(지호진),Chulhee Jang(장철희),Sanghun Jin(진상훈),Yonghee Hong(홍용희) 한국컴퓨터정보학회 2017 韓國컴퓨터情報學會論文誌 Vol.22 No.12

This paper represents a novel framework for multi-scale image fusion. Multi-scale Kalman Smoothing (MKS) algorithm with quad-tree structure can provide a powerful multi-resolution image fusion scheme by employing Markov property. In general, such approach provides outstanding image fusion performance in terms of accuracy and efficiency, however, quad-tree based method is often limited to be applied in certain applications due to its stair-like covariance structure, resulting in unrealistic blocky artifacts at the fusion result where finest scale data are void or missed. To mitigate this structural artifact, in this paper, a new scheme of multi-scale fusion framework is proposed. By employing Super Resolution (SR) technique on MKS algorithm, fine resolved measurement is generated and blended through the tree structure such that missed detail information at data missing region in fine scale image is properly inferred and the blocky artifact can be successfully suppressed at fusion result. Simulation results show that the proposed method provides significantly improved fusion results in the senses of both Root Mean Square Error (RMSE) performance and visual improvement over conventional MKS algorithm.

누액 침착에 의한 4주 연속착용 소프트 콘택트렌즈의 가시광선 투과율 및 굴절력 변화

김나아,지호진,최윤정,전혜진,송수빈,박정민,최건대,한규현,구태호,최선규,송우진,최현수,이석주 대한시과학회 2017 대한시과학회지 학술대회 Vol.2017 No.11

목적: 4주 연속착용 소프트 콘택트렌즈를 착용하였을 때 누액침착에 따른 가시광선 투과율 및 굴절력의 변화를 알아보고자 하였다. 방법: -1.00D, -3.00D, -7.00D의 굴절력을 가진 A社, C社, J社의 4주 연속착용 소프트콘택트 렌즈를 인공누액에 3일, 7일, 14일, 21일, 28일 배양 후 스펙트로 포토미터(7315, JENWAY, USA)를 이용하여 가시광선 투과율을 측정하였다. 굴절력의 측정은 수동렌즈미터(LM-8, TOPCON, Japan)를 이용하여 Wet Cell 방식으로 측정하였다. 결과: 굴절력의 측정결과 A社, C社, J社 4주 착용 콘택트렌즈 모두에서 굴절력의 변화는 거의 없었으며, 28일 배양 후 측정한 굴절력은 미미한 증가를 보였으나 유의성은 없는 것으로 나타 났다. 가시광선 투과율은 A社, C社, J社 4주 착용 콘택트렌즈 모두에서 인공누액 배양 기간에 따라 가시광선 투과율이 점차적으로 감소하는 것을 확인 할 수 있었다(p<0.05). 배양 28일 경 과 후 A社의 경우, -1.00D 콘택트렌즈에서 97.31 ± 1.59%에서 93.94 ± 1.39%로 감소, -3.00D에서 97.23 ± 1.28%에서 93.62 ± 1.31%로 감소, -7.00D 렌즈에서 97.56 ± 1.69% 에서 93.3 ± 1.24%로 감소하였다. C社의 경우 -1.00D의 경우, 98.69 ± 0.92%에서 95.72 ± 0.99%로 감소, -3.00D는 98.4 ± 0.10%에서 95.62 ± 0.98%로 감소하였다. -7.00D의 경우 98.16 ± 0.88%에서 95.2 ± 0.72%로 감소하였으며 J社의 경우 –1.00D에서는 97.48 ± 1.92%에서 93.85 ± 1.72%로 감소, -3.00D에서는 97.66 ± 1.76%에서 93.74 ± 1.43%로 감소하였고 –7.00D의 경우 97.16 ± 1.89%에서 93.4 ± 1.51%로 감소하였다. 결론: 인공누액 침착에 의한 4주 연속착용 소프트 콘택트렌즈의 굴절력의 변화는 미미하게 증가하였으며, 가시광선 투과율은 감소하였다. 콘택트렌즈의 가시광선 투과율은 4주 누액 침착 이후에도 모두 90%이상으로 허용 범위 내에 있었다. 그러나 이는 착용기간이 늘어갈 수록 착용 초기에 비해 시야 흐림 등의 원인이 되어 착용자의 불편함을 야기할 수 있을 것으로 사료 된다.

Effect of Added Block Copolymer on the Phase separation of Poly ( α- methylstyrene ) / Polystyrene Blends

김진환,지호진,이두성 한국고분자학회 1993 한국고분자학회 학술대회 연구논문 초록집 Vol.1993 No.4

스키 또는 스노우보드 손상 환자에서 응급의료 정보센터를 이용한 전원의 효과

김선휴,이강현,지호진,오성범,김현,황성오,김성훈,이영희 대한스포츠의학회 2004 대한스포츠의학회지 Vol.22 No.1

The purpose of this study is to analyze the effects of transportation via Emergency Medical Service Information Center in a ski or snowboard injured patients. We evaluated 233 patients with ski or snowboard injuries who transported to emergency department from Nov. 2002 to Feb. 2003 via Emergency Medical Service Information Center or not. Among the patients, 66 patients were transported via Emergency Medical Service Information Center(group 1) and 167 patients were transported without using the information center(group 2). Transportation time and time for treatment of group 1 were shorter than that of group 2. Transportation time after injury were 119±92 minutes in group 1, 128±82 minutes in group 2. Treatment time after arrival of emergency department were 116±54 minutes in group 1, 126±75 minutes in group 2. Our results show that transportation after winter sports injury via Emergency Medical Service Information Center is effective for transportation and treatment.

Polystyrene/Polyisoprene 블렌드의 상평형도

김진환,이승욱,지호진,이두성 成均館大學校 科學技術硏究所 1993 論文集 Vol.44 No.1

저분자량의 Polystyrene(PS)과 Polyisoprene(PI)로 이루워진 블렌드의 여러 조성에서의 cloud point를 본 실험실에서 제작한 광산란장치를 사용하여 실험적으로 측정하여 PS/PPI 블렌드의 상평형도를 구하였다. 실험에 사용한 PS의 중량평균분자량(Mw)은 2514이었고 PI의 Mw은 각각 2700과 5800이었다. Flory-Huggins 격자이론에 바탕을 둔 interaction energy density(IED)를 온도와 조성 의존성이 포함된 식으로 정의하고, 그에 따른 상평형방정식들을 유도하고, 유도한 binodal 곡선과 실험치를 비교하여 비선형회귀법에 의하여 IED를 결정하고, 이를 사용하여 이론적인 binodal과 spinodal 곡선을 구하였다. 또한, 본 연구에서 구한 IED와 문헌에 보고된 값을 비교검토하여 정확한 IED의 결정이 중요함과 IED의 온도, 조성 및 분자량 의존성을 논의하였다. The phase diagram of the Polystyrene (PS)/Polyisoprene(PI) blend was constructed experimentally by measuring the cloud points using the light scattering apparatus. For this purpose, one PS and two PIs were employed whose molecular weights were low enough to make the experimental determinations possible. The weight-average molecular weight(Mw) of PS was 2514, and Ms of two PIs were 2700 and 5800. Interaction energy density(IED) of the Flory-Huggins lattice theory was defined as a function of temperature and composition, and the consequent equations for the binodal, spinodal, and critical points were derived. By fitting the experimental binodal points to the derived binodal curve with a nonlinear regression method, the expression for the IED was determined. And the expression for the IED obtained from this study was compared with those reported in the literatures. Also were discussed the importance of accuracy in the expression the IED, and the IED's dependency on the temperature, composition and molecular weights.

정밀 유도무기용 적외선 영상탐색기의 운용환경에 따른 성능대비 개발비용 최적화 연구

김호용,강석중,지호진 한국정보통신학회 2019 한국정보통신학회논문지 Vol.23 No.4

An Image Infra-Red(IIR) seeker is widely used for precision guided munitions to provide intelligent and precise target detection in terms of high kill probability. However, there have been issues in determining the performance versus cost trade-offs due to high cost of seeker comparing to other units of the munitions. In this paper, performance/cost evaluations have been carried out to find the most cost-effective solution for developing the IIR seekers. The relationships between the critical parameters and cost are investigated to determine the optimal point which represents the low cost with high performance. It is expected that the presented approach will be able to be used for guidelines to select the appropriate IIR seeker for the given operating conditions and can be useful to estimate the cost effectiveness of the precision guided munitions at early design stage. 본 논문은 정밀 유도무기에 장착되어 목표물 명중 확률을 좌우하고, 비용적인 측면에서 유도무기의 가장 큰 부분을 차지하는 적외선 영상탐색기에 대한 성능 대비 개발비용 최적화에 대한 연구이다. 탐색기 개발 비용의 주요항목인 해상도와 그에 따른 탐지성능에 영향을 미치는 인자들을 분석함으로써, 설계 단계에서 해상도 별 탐지성능과 개발 비용과의 상관관계를 분석하는 연구를 수행하였다. 다양한 신호 대 클러터 비 조건에서 해상도 별 표적탐지 확률을 설계 시 중요인자로 정의하고, 개발비용 선정의 기준이 되는 해상도 별 탐지성능 분석을 수행하였으며, 탐지성능 확보를 위한 최적의 해상도와 그에 따른 투입비용에 대한 관계를 도출하였다. 다양한 클러터 환경에 따른 사례연구를 통하여 제안한 분석 방식이 탐지성능 만족을 위하여 요구되는 개발비용 예측에 효과적임을 검증하였으며, 유도무기 운용 환경에서 성능대비 최적화된 개발비용을 설계단계에서 미리 도출할 수 있는 연구 자료로 활용하고자 한다.

Effect of Block Copolymer Addition on the Phase Separation Behaviors of Polystyrene / Polyisoprene Mixtures

김진환,이승욱,지호진,이두성 한국고분자학회 1992 한국고분자학회 학술대회 연구논문 초록집 Vol.1992 No.10

The Frequency of Reexpansion Pulmonary Edema after Trocar and Hemostat Assisted Thoracostomy in Patients with Spontaneous Pneumothorax

차경철,김현,지호진,권우철,신형진,차용성,이강현,황성오,Christopher C. Lee,Adam J. Singer 연세대학교의과대학 2013 Yonsei medical journal Vol.54 No.1

Purpose: Several risk factors for development of reexpansion pulmonary edema (REPE) after drainage of pneumothoraces have been reported, but the association between the method of thoracostomy and the development of REPE is unknown. The aim of this study was to compare the frequency of REPE after treatment of spontaneous pneumothorax with trocar or hemostat assisted closed thoracostomy. Materials and Methods: We performed a prospective, observational study including 173 patients with spontaneous pneumothorax who visited the emergency department from January 2007 to December 2008. In 2007, patients were treated with hemostat-assisted drainage, whereas patients in 2008 were treated with trocar-assisted drainage. The main outcome was the development of REPE, determined by computed tomography of the chest 8 hours after closed thoracostomy. Outcomes in both groups were compared using univariate and multivariate analyses. Results: Ninety-two patients were included, 48 (42 males) of which underwent hemostat-assisted drainage and 44 (41 males) underwent trocar-assisted drainage. The groups were similar in mean age (24±10 vs. 26±14 respectively). The frequencies of REPE after hemostat- and trocar-assisted drainage were 63% (30 patients) and 86% (38 patients) respectively (p=0.009). In multivariate analysis, trocar-assisted drainage was the major contributing factor for developing REPE (odds ratio=5.7, 95% confidence interval, 1.5-21). Age, gender, size of pneumothorax, symptom duration and laboratory results were similar between the groups. Conclusion: Closed thoracostomy using a trocar is associated with an increased risk of REPE compared with hemostat-assisted drainage in patients with spontaneous pneumothorax.