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증례 : 소화기 ; 원발성 간암의 신생물딸림증후군으로 표현된 다발성근염과 횡문근융해
서윤종 ( Yoon Jong Seo ),장재희 ( Jae Hee Jang ),박자비 ( Ja Be Park ),주정철 ( Jung Chul Joo ),정재일 ( Jei Il Jung ),조혜제 ( Hye Jae Jo ),곽재규 ( Jae Gyu Kwak ) 대한내과학회 2012 대한내과학회지 Vol.82 No.2
다발성근염은 사지 근위부의 골격근을 대칭적으로 침범하는 원인불명의 자가면역 질환으로, 악성종양과 동반된 사례가 보고되고 있으나 피부 근염에 비해 드물다. 이에 혼합간세포-담관상피암종으로 추정되는 원발성 간암의 신생물딸림증후군에 의한 횡문근융해와 다발성근염 1예를 경험하여 보고하는 바이다. Polymyositis is characterized by symmetrical proximal muscle weakness, nonsuppurative inflammation of skeletal muscle, elevation of muscle enzyme levels, and abnormality of electromyographical change. Its pathogenesis is unclear. Paraneoplastic syndromes are caused by malignant tumors, although not through direct effects of the primary tumor or its metastases. Several paraneoplastic syndromes, including erythrocytosis, hypoglycemia, and hypercholesterolemia, have been reported in patients with hepatocellular carcinoma. A few cases of polymyositis associated with hepatocellular carcinoma and one case of combined hepatocellular-cholangiocarcinoma associated with polymyositis and chronic hepatitis B virus infection have been reported. Skeletal muscle injuries without trauma, including metabolic myopathy, effects of certain drugs and toxins, infection, electrolyte imbalances, and endocrine disorders, may cause rhabdomyolysis. We present here a case of primary liver cancer associated with polymyositis and rhabdomyolysis. (Korean J Med 2012;82:212-216)
증례 : 혈액종양 ; 동시성으로 발생한 폐 편평세포암종과 비강의 비호지킨 림프종 1예
박현근 ( Hyun Keun Park ),서윤종 ( Yoon Jong Seo ),김종상 ( Jong Sang Kim ),곽재욱 ( Jae Wook Kwak ),김효헌 ( Hyo Hun Kim ),조혜제 ( Hye Jae Jo ),유문빈 ( Mun Bin You ) 대한내과학회 2009 대한내과학회지 Vol.77 No.5S
저자들은 지금까지 보고된 바 없는 안구돌출 및 통증을 주소로 내원한 폐편평세포암종 환자에서 병발한 비강의 비호지킨림프종 1예를 경험하여 문헌고찰과 함께 보고하는 바이다. Nasal cavity lymphomas constitute 5% of head and neck lymphomas and are rarer than lymphomas that involve Waldeyer`s ring. To our knowledge, no case of synchronous double cancers of the nasal cavity lymphoma and primary lung cancer has previously been reported. We report a case of synchronous double primary cancer of nasal non-Hodgkin lymphoma and squamous cell carcinoma of the lung in a 57-year-old man who presented with blindness and orbital pain. (Korean J Med 77:S1285-S1288, 2009)
간으로 전이된 후 인슐린종으로 발현한 소마토스타틴종 1예
김상욱,박중열,고경수,방성조,조혜제,공경엽,김기수,이병두,이재환,정윤이,이기업 대한내분비학회 1998 Endocrinology and metabolism Vol.13 No.4
We report a case of somatostatinoma, which manifested as insulinoma after liver metastasis. A 74-year-old man suffered from diabetes mellitus and jaundice. The abdominal CT scan of this patient showed a mass in the pancreas head, which obstructed biliary duct. He underwent Whipples procedure. Immunohistochemical staining of postoperative specimen disclosed that this tumor was strongly positive for somatostatin. After 4 months, follow up CT scan showed multiple metastatic lesions in the liver. We performed transarterial chemoinfusion two times, but the response was disappointing. After 2 months, he suffered from altered mentality, which was relieved by intake of sugar. Biochemical laboratory findings and immunohistochemical staining of liver biopsy disclosed that the metastatic lesion in this patient was insulinoma. We performed embolization of hepatic artery with gelform. The biochemical response was dramatic, but he died of septic shock, which was caused by gas forming liver abscess. In summary, we report a case of somatostatinoma which manifested as insulinoma after metastasis to the liver (J Kor Soc Endocrinol 13:670-676, 1998).