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Lidocaine에 의한 경련이 뇌조직에서 c-fos 발현에 미치는 영향
조성범,채한정,강장숙,김형룡 원광대학교 생체재료·매식연구소 1998 원광생체재료·매식 Vol.7 No.1
Recently, a variety of stimuli including convulsion, ischemia and noxious stimuli have been shown to induce the expression of c-fos mRNA in central nervous system (CNS). In this study, c-fos expression in both mRNA and protein (Fos) levels is examined up to 72 hr in brain regions, including hippocampus, piriform cortex, neostriatum, amygdala, dentate gyrus, cerebral cortex, and thalamus during lidocaine-inducced convulsion. Intraperitoneal administration of lidocaine (120 mg/kg) induces generalized convulsion of rats within 10 min and subsequent increase of c-fos expression in both mRNA and Fos protein levels in dentate gyrus, piriform cortex, amygdala, neostriatum, cerebral cortex, hippocampus, and thalamus. A prominent induction of c-fos mRNA and Fos protein in dentate gyrus suggests that dentate gyrus plays an important role in the process of lidocaine-induced convulsion. These results suggest that c-fos may participate in plastic changes of central nervous system associated with stimuli such as seizure activity.
임플랜트와 경부골이 이루는 각도가 치경부 응력 발생에 미치는 영향
조성범,이규복,조광헌,Cho, Sung-Bum,Lee, Kyu-Bok,Jo, Kwang-Hun 대한치과보철학회 2007 대한치과보철학회지 Vol.45 No.2
Statement of problem: Main consideration was given to the stresses at the site of implant entry into the cortical bone at the alveolar crest. As a suspectible factor affecting the occurrence of stress concentrations, the contact angle between the implant and the alveolar crest bone was addressed. Purpose: The purpose of this study is to evaluate angles between the alveolar crest bone and the implant effect on the implant crestal area induced stresses using a finite element method. Material and methods: Cylindrically shaped, standard size ITI implants entering into alveolar crest with four different contact angles of 0, 15, 30, and 45 deg. with the long axis of the implant were axisymmetrically modelled. Alterations of stresses around the implants were computed and compared at the cervical cortical bone. Results and conclusion: The results demonstrated that regardless of the difference of the implant/alveolar crest bone contact angles, stress concentration occurred at the cervical bone and the angle differences led to insignificant variations in stress level.