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조대철,권성현 한국산학기술학회 2003 한국산학기술학회논문지 Vol.4 No.3
산업체 발생 VOC를 효과적으로 처리하는 Biofilter 시스템을 고안하였다. 재질과 다공성이 다른 3기의 시스템으로부터 황화수소, 벤젠, 톨루엔, 크실렌의 단일성분과 복합성분계의 성능을 고찰하였다. 저 pH Biofilter(pH 2-3)의 장기운전이 가능하였고 벤젠의 경우 경쟁적 저해를 나타내었으나 일정기간의 순응 이후 혼합처리시 양호한 처리능력을 보여주었다.
조대철,황정현,성주경,황성규,함인석,박연묵,변승열,김승래,Jo, Dae-Chuol,Hwang, Jeong-Hyun,Sung, Joo-Kyung,Hwang, Sung-Kyu,Hamm, In-Suk,Park, Yeun-Mook,Byun, Seung-Yul,Kim, Seung-Lae 대한신경외과학회 2001 Journal of Korean neurosurgical society Vol.30 No.12
Objectives : Gliomatosis cerebri is an uncommon primary brain tumor characterized by diffuse neoplastic proliferation of glial cells, with the preservation of the underlying cytoarchitecture. The aim of this study is to evaluate clinical features, outcome of surgical treatment and adjuvant therapy of gliomatosis cerebri. Methods : Between Jan. 1990 and Dec. 2000, 12 patients were diagnosed with gliomatosis cerebri based on characteristic radiological and histological findings. The patients' age ranged from 18 to 77(mean 44) years and the male to female ratio was 7 : 5. Nine patients underwent decompressive surgery and three, biopsy only. Postoperative radiation therapy was given in all cases except three. In addition to radiation therapy, four patients received chemotherapy. The mean duration of follow-up period was 18.8 months. Results : The most common presenting symptom were seizure and motor weakness. The mean duration of symptom was 5.9 months. There was 5 bilateral lesions and tumor involved corpus callosum in 5, basal ganglia-thalamus in 4, and brain stem in 2. There was no operative mortality but four patients died during the follow-up. The mean survival period for 11 patients was 20.5 months from the time of diagnosis. In univariate analysis, the lesion involving corpus callosum, basal ganglia-thalamus and brain stem correlated significantly with the short length of survival(p<0.05). Also, postoperative radiation as a adjuvant therapy prolonged the patient's survival(p<0.05). Conclusions : In the management of gliomatosis cerebri patients, early detection by MR imaging, active management of increased intracranial pressure, decompressive surgical removal and postoperative adjuvant therapy such as radiation is thought to be a good treatment modality.
조대철 순천향대학교 부설 산업기술연구소 2004 순천향 산업기술연구소논문집 Vol.10 No.2
단백질 칩은 DNA칩에 이어 산업계와 환경 분야에서 보다 편리하고 신뢰도가 큰 분석 도구로 각광받고 있다. 특히 약학, 진단, 생화학 및 생물 산업에서 주요 현안이 되고 있는 항원-항체 반응, 단백질-단백질 작용, 단백질-소분자 작용의 분석기법에 혁신을 가져왔다. 또한 단백질 칩은 칩 개발과 연관된 표면화학 및 분자 검출 전략에 치중하고 있다. 본 고는 과거와 현재의 단백질 칩 연구를 개괄하고 향후 상용화 될 칩의 미래를 진단하고자 한다.
A solid control strategy for preparation of silver nanoparticles in aqueous medium
조대철,권성현 한국화학공학회 2015 Korean Journal of Chemical Engineering Vol.32 No.12
Uniformly distributed, spherically shaped, mild concentrated silver nanoparticles with single-digit to hundreds nm size have been prepared by reducing silver nitrate with popular reducers like sodium borohydride or hydrazine in the presence of ordinary stabilizers such as SDS, PVP, Polysorbates and ultrasonication. Uv-visble spectroscopic analysis, particle size analysis, and particle-imaging through transmission electron microscopy (TEM) were used for nanoparticle characterization. Higher temperature accelerated the reduction rates, which follows the typical autocatalytic kinetics. Particularly, ultrasonication helped to facilitate the crucial stage of reduction phase to result in excellent quality of nanosolution, such as narrow distribution of particles and size uniformity. We found that initial location or arrangement of silver ions in clouds of stabilizers and ‘effectve mixing’ in the stage of reduction were vital for successful preparation of silver nanosolution. Also, reagent/stabilizer ratio, reducer input, solution environment such as pH, temperature, and stabilizer properties were optimized and discussed in detail. Proper selection of stabilizer and molar ratio to reagent and effective ‘mixing’ for preventing grain growth needs to be investigated more in the future work.
담체 변화에 따른 Labscale 바이오 필터의 성능 실험
조대철,권성현 한국산학기술학회 2003 한국산학기술학회 학술대회 Vol.- No.-
The low-pH biofiltration system in laboratory experiments demonstrate defectiveperformance for treating H<sub>2</sub>S. When leachate pH was in the range of 1.5 tO₄. the biofilters in three different media removed H<sub>2</sub>S with efficiencies greater than 99% while it was treated as a single contaminant. The posibility of using a single-stage low pH biofilter depends on its performance in treating VOCs. During Phase 2. a single-stage biofilter was effective for treating mixtures of H<sub>2</sub>S and toluene with toluene concentrations below 20ppm and leachate pH between 2 and 3.5. Biofiltration of xylene was ineffective when pH was lower than 1.5. The treatment sysytem acclimated most slowly to benzene, and treatment of benzene was apparently subject to some competive inhibition from xylene and toluene. However, co-treatment was possible after some acclimation time. Xylene was not easily treated, with higher elimination capacities and no sign of competitive inhibition.
조대철,류경수,김경태,성주경 대한척추신경외과학회 2017 Neurospine Vol.14 No.2
Objective: The purpose of this study was to evaluate the therapeutic effects of combination therapy with curcumin and alendronate on spine fusion surgery in ovariectomized rats. Methods: Thirty-two female Sprague-Dawley rats (12 weeks old) underwent bilateral ovariectomy (OVX). Eight weeks after surgery, animals underwent intertransverse spine fusion at L4-5. The rats were randomly distributed amongst 4 groups; untreated OVX group, curcumin administered group, alendronate administered group, and the combination therapy group. At 8 weeks after fusion surgery, the animals were sacrificed and the fusion mass was assessed by manual palpation, radiographic scan, and micro-computed tomographic scan. In addition, mechanical strength was determined by a 3-point bending test. Results: Based on the results of manual palpation testing and three-dimensional microcomputed tomography scanning, solid bone fusion rate was 50% (4 of 8) in the OVX group, 75% (6 of 8) in the alendronate-only and curcumin-only group, and 87.5% (7 of 8) in the combination therapy group, respectively. The combination therapy group had a higher fusion rate compared with the other treatment groups, though not statistically significantly (p>0.05). And the combination therapy group had a significant increase in fusion volume at 8 weeks after spine fusion surgery compared with curcumin-only group (p=0.039). The 3-point bending test showed that combination therapy group had a significantly greater maximal load value compared to that of curcumin-only group (p=0.024). Conclusion: The present study demonstrated that additional treatment of curcumin and alendronate after spine fusion surgery in rat can promote higher fusion volume, and improve bone mechanical strength.