Acetazolamide의 뇌척수액 생성에 미치는 영향

박연묵,변승열,김승래 慶北大學校 醫科大學 1975 慶北醫大誌 Vol.16 No.2

To study, in seven men and women volunteers, the effect of acetazolamide on CSF producation, we measured the concentration and disappearance of the indigocarmine injected already into the spinal subarachnoid space by the spectrophotometer and then compaired it of control group whom acetazolamide was not given with diamox group whom acetazolamide was given intravenously in the same man. The 2㎖. CSF perfused with indigocarmine was taken at first and fifth hour after injection of indigocarmine and in diamox group, acetazolamide 5㎎./㎏. to be reported as maximum action of Maren's renal carbonic anhydrase inhibition was given intravenously 30 minutes before injection of indigocarmine into to spinal subarachnoid space. The results showed that in the man the production of CSF by acetazolamide was diminished by 8.3% and also the carbonic anhydrase system affected markedly the formation of the human CSF.

非結核性 脊髓硬膜外膿瘍의 臨床的 考察

朴淵默,鄭基煥,邊承烈,宋豊鎬,金乘來 慶北大學校 醫科大學 1975 慶北醫大誌 Vol.16 No.2

Nontubercolous spinal epidural abscess is a relatively uncommon disease that usually occurs in patients who harbour a focus of chronic infection somewhere outside the spinal epidural abscess, and that demands early diagnosis and operation to prevent paralysis. The etiological, pathological, clinical, therapeutic and prognostic aspects of nontuberculous spinal epidural abscess are studied in the light of experience gathered in definite treatment of 34 consecutive cases on the neurosurgical service of Kyungpook Nation University Hospital between the years 1965 and 1975.

흰쥐에 있어서 膽汁鬱滯時 Alpha-Amino Isobutyric Acid-^14C의 肝細胞內 移行에 關하여

朴淵默,柳虎烈 慶北大學校 醫科大學 1975 慶北醫大誌 Vol.16 No.1

This study is to observe the change in cellular transport of amino acid in liver tissue after total and partial ligation of blie duct in rats. When common bile duct was ligated, cellular transport of alph-amino isobutyric acid-^14C in liver tissue was significantly increased after 3~5 days, whereas serum bilirubin showed a rapid increase after the ligation. After partial ligation, ligation of bile ducts of median and left laleral lobes, serum bilirubin remained with in normal, but the cellular transport of labelled amino acid showed an increase in bile duct ligated lobes compared to unligated right lateral lobe.

非結核性 脊髓硬膜外膿瘍의 臨床的 考察

朴淵默,鄭基煥,邊承烈,宋豊鎬,金乘來 慶北大學校 醫科大學 1975 慶北醫大雜誌 Vol.16 No.2

흰쥐에 있어서 胚汁鬱滯時 Alpha-Amino Isobutyric Acid-^(14)C의 肝細胞內 移行에 關하여

朴淵默,柳虎烈 慶北大學校 醫科大學 1975 慶北醫大雜誌 Vol.16 No.1

高脂肪食餌및 人蔘投與가 肝質大謝에 미치는 影響

朴淵默,曺準承 慶北大學校 醫科大學 1982 慶北醫大誌 Vol.23 No.1

高脂肪食餌의 種類 및 人蔘投與가 肝 및 脂肪組織에 있어서 脂質代謝에 어떠한 影響을 미치는가르 硏究하기 위하여 平均 體重이 95g 되는 흰쥐 수컷을 使用하여 5群으로 나누어 各各의 實驗食餌와 人蔘을 投與하여 40日間 飼育하고 體重, 肝, 部丸 및 間膜의 脂肪組織量을 測定하고 肝의 脂質像과 肝 및 脂肪組織의 脂質에의 放射性 醋酸의 編入率등을 調査하였다. 5實驗群으로서 A群에는 正常食餌群으로 總熱量의 12%에 該當되는 脂肪을, B 및 C 群에는 總熱量의 45%에 該當되는 옥수수기름을, D 및 E 群에는 總熱量의 45%에 該當되는 버터脂肪을 各各 投與하였다. 飼料는 自由攝取토록 하였으며, 人蔘은 me-thanol 抽出 成分을 精製하여 體重 100g 當 5㎎ m이 生理的 食鹽水溶液을 C 및 E 群의 쥐 腹腔內로 1日 1回씩 마지막 10日間 投與하였다. 다른 B 및 D 群에는 같은 量의 生理的 食鹽水만 注入하였다. 마지막 날에는 9時에 飼料를 除去하여 11時에 人蔘抽出物 또는 生理的 食鹽水를 投與하고 12時에 放射性 醋酸을 體重 100當 4μc를 腹腔으로 注入해서 3時間뒤에 쥐를 잡아서 各種 測定을 實驗하였다. 正常食餌群에 比하여 高脂肪食餌群의 體重增加는 若干 떨어지는 傾向이었으나 反對로 體重에 대한 肝 무게의 比率은 높았다. 이러한 傾向은 옥수수 기름 投與群보다 보다 버터攝取群에서 더욱 뚜렷하였으며, 人蔘의 投與로써 이러한 肝무게 比率의 增加를 낮추는 효과를 보였다. 高脂肪食餌의 攝取로써 肝의 總脂肪, 中性脂肪 및 colesterol 의 濃度가 뚜렷하게 增加되었으며, 燐脂質에는 變化가 없었다. 이러한 現象은 버터攝取群에서 더욱 뚜렷하였으며, 人蔘의 投與는 chole-sterol 의 增加를 抑制하는 효과를 보였다. 脂肪組織量의 增加는 副丸보다 間膜에서, 옥수수 기름投與群보다 버터投與群에서 더욱 顯著하였다. 人蔘은 脂肪組織의 量的增加에는 影響을 미치지 않았다. 放射性 醋酸의 脂肪質에의 編入率은 高脂肪食餌 特히 버터의 攝取로써 顯著히 低下되었으며, 人蔘의 投與는 이 低下를 多少 抑制하는 효과를 나타내었다. 脂肪組織에 있어서 放射性 醋酸의 脂質에의 編入率은 高脂肪食餌 特히 옥수수 기름攝取群에는 더욱 減少되없으며, 여기에 人蔘을 투여하면 옥수수 기름攝取群에는 別다른 影響이 없었으나 버터 攝取群에서의 編入率은 2.5倍로 顯著하게 上昇하였다. 以上의 結果로서 植物性보다 動物性脂肪의 多量攝取는 體內에 脂肪蓄積을 잘 일으키고 肝이나 脂肪組織에서의 脂質合成을 低下케 하며, 人蔘의 投與는 肝에서의 脂肪蓄積과 cholesterol 의 合成등을 低下케하고 脂肪組織에서는 脂質合成을 促進시키는 등 高脂肪食餌때에 過多하게 攝取되는 脂肪을 個體에 有利하게 處理하는 것으로 示唆된다. The effect of a high level type of dietary fat with and without ginseng on lipid metabolism in the liver and adipose tissue of rats was investigated. The animals were divided into five groups; group A was fed the control diet consisting by calorie of 12% fat, groups B and C were fed a 45% corn oil-diet and groups D and E were fed a 45% butter fat-diet. The diets for all groups were isoenergetic (4.4 ㎉/g) but the diet for group A had a slightly lower density of energy (0.5 ㎉/g) than those for other groups. All animals were fed ad libitum for forty days. For the last ten days of the period ginseng extract prepared by methanol extraction of dried ginseng roots was given intraperitoneally to groups C and E at a dose of 5㎎ per 100g body weight, and the same volume of the saline solution to groups B and D. The body weight gain was not different statistically between high fat-diet groups and the control diet group, but was substantially less in ginseng-treated groups C and E compared with groups B (corn oil) and D (butter fat). However, the liver mass and fat pad of adipose tissue with the ratios of liver and fat pad weight to body weight were more higher in high fat-diet groups B and D than in the control diet group A, especially remarkable in group D (butter fat). And liver weight with the ratio of liver weight but non fat pad of adipose tissue were lower in ginseng treated groups C and E than in high fat-diet groups B and D. Liver total lipid, triacylglycerol and cholesterol, but not phospholipid, were markedly increased in high fat-diet groups B and D compared with the control group A. Among these, total lipid and triacylglycerol of group D (butter fat) were higher than that of group B (corn oil). The increase in liver cholesterol of high fat-diet groups was declined remarkably by administration of ginseng, but a minor changes were noted about on total liver lipid and triacylglycerol in high fat-groups by ginseng treatment. In other hand, the incorporation rates of acetate-^14C into lipid of liver and adipose tissue were significantly lower in high fat-diet groups B and D than in the control group A. The incorporation into liver lipid was lower in group D (butter fat) than in group B (corn oil), while the incorporation into adipose tissue lipid was higher in groupD (butter fat) compared with group B (corn oil). By administration of ginseng the incorporation into liver lipid in high fat-diet groups was incseased slightly. However, the incorporation into adipose tissue lipid in high butter-fat-diet groups but high corn oil-diet groups, showed dramatic rise in ginseng treated group E compared with group D. These results have generally indicated that long-feeding of hight fat-diet might induce fat accumulation in the body and causes it to be decrased in the liver and adipose tissue. For this result, butter fat-diet is more effective corn oil, and ginseng might act to reduce fat accumulation and cholesterol synthesis in the liver and stimulate lipogensis in the adipose tissue.

Takagi-Sugeno 퍼지 시스템에 대한 최적 제어기 설계 및 우주 비행체의 자세 제어 응용

박연묵(Yonmook Park),탁민제(Min-Jea Tahk) 제어로봇시스템학회 2001 제어·로봇·시스템학회 논문지 Vol.7 No.7

GEVP를 이용한 GBSB 연상 메모리의 설계

박연묵(Yonmook Park),박주영(Jooyoung Park) 대한전기학회 1999 대한전기학회 학술대회 논문집 Vol.1999 No.7

Takagi-Sugeno 퍼지 모델로 표현된 비선형 시스템의 최적 퍼지 제어

박연묵(Yonmook Park),박주영(Jooyoung Park) 대한전기학회 1999 대한전기학회 학술대회 논문집 Vol.1999 No.7

연상 메모리 기능을 수행하는 셀룰라 신경망의 설계 방법론

박연묵(Yonmook Park),김혜연(Hye-Yeon Kim),박주영(Jooyoung Park),이성환(Seong-Whan Lee) 한국정보과학회 2000 정보과학회논문지 : 소프트웨어 및 응용 Vol.27 No.5

본 논문에서는 연상 메모리 기능을 수행하는 셀룰라 신경망(Cellular Neural Network)의 설계를 위한 새로운 방법론을 제안한다. 먼저, 셀룰라 신경망 모델의 기본적 특성들을 소개한 후, 최적 성능을 가지고 이진 원형 패턴들을 저장할 수 있는 셀룰라 신경망 모델의 설계 방법을 제약 조건이 가해진 최적화 문제로 공식화한다. 다음으로 이 문제의 제약 조건을 선형 행렬 부등식(Linear Matrix Inequalities) 을 포함하는 부등식의 형태로 변환시킬 수 있음을 관찰한다. 마지막으로 셀룰라 신경망 최적 설계 문제를 내부점 방법(interior point method)에 의해 효율적으로 풀릴 수 있는 일반화된 고유값 문제(Genaralized EigenValue Problem)로 변환한다. 본 논문에서 제시하는 셀룰라 신경망 설계 방법론은 공간 변형 형판 셀룰라 신경망과 공간 불변 형판 셀룰라 신경망 설계에 모두 적용될 수 있다. 설계 예제를 통해 제안된 방법의 유효성을 검증한다. In this paper, we consider the problem of realizing associative memories via cellular neural network(CNN). After introducing qualitative properties of the CNN model, we formulate the synthesis of CNN that can store given binary vectors with optimal performance as a constrained optimization problem. Next, we observe that this problem's constraints can be transformed into simple inequalities involving linear matrix inequalities(LMIs). Finally, we reformulate the synthesis problem as a generalized eigenvalue problem(GEVP), which can be efficiently solved by recently developed interior point methods. Proposed method can be applied to both space varying template CNNs and space-invariant template CNNs. The validity of the proposed approach is illustrated by design examples.