정형외과 수술후 창상 감염에 대한 Cefirad^(�)(cefpiramide sodium)의 임상효과

정영주,신동민,하상호 최신의학사 1989 最新醫學 Vol.32 No.5

버밍엄의 '도시 르네상스' -그 영욕과 브루미들-

정영주 한국서양사학회 2017 西洋史論 Vol.0 No.135

부산국제보트쇼의 경험가치와 만족도가 참관 후 행동에 미치는 영향

정영주 한국자료분석학회 2016 Journal of the Korean Data Analysis Society Vol.18 No.2

부산국제보트쇼의 경험가치와 만족도가 참관 후 행동에 미치는 영향을 분석하여 부산지역 보트쇼 활성화를 위한 기초 자료를 제공하는데 목적이 있으며, 2014년~ 2016년에 부산국제보트쇼를 찾은 참관객 772명을 대상으로 설문조사를 실시하여 다음과 같은 결론을 얻었다. 첫째, 부산국제보트쇼 참관객의 경험가치, 만족도가 참관 후 행동에서 모두 유의한 차이가 있는 것으로 나타났다. 둘째, 경험가치가 만족도에 대한 영향에서는 2014년과 2016년은 경험가치의 모든 하위요인, 2015년에는 경제적 가치와 서비스 가치가 영향을 미치는 것으로 나타났다. 셋째, 참관객의 경험가치가 참관 후 행동에 대한 영향에서 2014년의 재방문의도에서는 유희적 가치 및 서비스 가치, 구전의도에서는 경험가치의 모든 하위요인이 영향을 주며 2015년의 재방문의도에서는 서비스 가치, 구전의도에서는 경제적 가치와 서비스가치에서 영향을 미치는 것으로 나타났다. 그리고 2016년 재방문의도에서는 경제적 가치와 서비스 가치, 구전의도에서는 경험가치의 모든 하위요인에서 영향을 미치는 것으로 나타났다. 넷째, 참관객의 만족도가 참관 후 행동에 대한 영향은 재방문의도와 구전의도에서 만족도가 모두 영향을 미치는 것으로 나타났다. This study aims to provide the basic data for the revitalization of a boat show in Busan by analyzing effects of the experience value and satisfaction on behaviors by participating in Busan international boat show. To achieve this aims, it is conducted the survey of 772 attendees of Busan international boat show from 2014 to 2016. It results as follows. First, experience value and satisfaction of boat show attendees show significant differences on behavior by participating. Second, in the influence on satisfaction by attendees’ experience value, experience value is effected every sub-factor in 2014 and 2016, also, economic and service value have an effect on experience value in 2015. Third, in the influence on behavior by participating in experience value, the revisit intention has impact on amusement and service value in 2014, only service value in 2015, both economic and service value in 2016. Also, the word-of-mouth intention has effect on every sub-factor of experience value in 2014 and 2016, economic and service value in 2015. Lastly, regarding to effect of attendees’ satisfaction on behavior by participating, satisfaction has an impact on the revisit and word-of-mouth intention in all.

Ethanol Upregulates PTEN via Nuclear Factor-kappa B (NF-κB) Signaling Pathways in HL-60 Cells

정영주,김종석 대한암예방학회 2010 Journal of cancer prevention Vol.15 No.1

The phosphatase tensin homolog deleted on chromosome 10 (PTEN) has various cellular functions including cell growth, proliferation, migration and cell survival. PTEN also plays an important role in ethanol-induced cytotoxicity. The present study was performed to determine the role of ethanol in PTEN expression of HL-60 cells. Here we show that ethanol up-regulates PTEN via activation of nuclear factor-kappa-light-chain-enhancer of activated B (NF-κB) in HL-60 cells. Western blot and RT-PCR results revealed that ethanol increased PTEN expression at HL-60 cells in a dose-dependent manner. In addition, we found that ethanol activated the NF-κB pathways, evidenced by NF-κB DNA binding activity in ethanol-treated cells. However, ethanol-induced PTEN expression was completely blocked by disruption of NF-κB with pyrrolidine dithiocarbamate (PDTC). We conclude that ethanol induces up-regulation of PTEN expression through NF-κB activation in HL-60 cells. (Cancer Prev Res 15, 34-38,2010)

Expression of Leptin, Leptin Receptor, Adiponectin, and Adiponectin Receptor in Ductal Carcinoma In Situ and Invasive Breast Cancer

정영주,Jin-Gu Bong,박성환,최정혜,오훈규 한국유방암학회 2011 Journal of breast cancer Vol.14 No.2

Purpose: Adipocytokines, such as leptin, resistin, and adiponectin, are associated with obesity and breast cancer. Several studies have indicated that adipocytokines may influence tumor growth or differentiation. The aims of this study were to determine the expression of leptin, leptin receptor (ObR), adiponectin and adiponectin receptor (AdipoR) in human breast cancer, to evaluate their prognostic significance in the breast cancer. Methods: Specimens from 198 patients with primary breast cancer were enrolled, and representative paraffin tumor blocks were selected for constructing tissue microarrarys (TMA). Immunohistochemical staining for leptin, ObR, adiponectin, and AdipoR was performed using TMA, and the clinicopathologic characteristics were evaluated from the patient’s medical records. Results: Stage 0 breast cancer accounted for 41 cases, and 157 cases were invasive cancer. Positive rates of leptin and ObR expression in the ductal carcinoma in situ (DCIS) group were significantly higher than those of the invasive cancer group (97.4% vs. 34.0%, p<0.001; 74.4% vs. 29.8%, p<0.001). However, positive rates of adiponectin and AdipoR expression in the invasive cancer group were significantly higher than those in the DCIS group (53.7% vs. 33.3%, p=0.024; 59.9% vs. 26.3%, p<0.001). High leptin expression was significantly associated with high Ki-67 expression (p=0.016). High adiponectin expression was significantly correlated with smaller tumor size (p=0.001). Conclusion: We suggest that losses of leptin and ObR expression could be associated with invasive cancer, whereas high adiponectin and AdipoR expression may be associated with breast cancer invasiveness.

Undifferentiated Pleomorphic Sarcoma of the Male Breast Causing Diagnostic Challenges

정영주,오훈규,Jin-Gu Bong 한국유방암학회 2011 Journal of breast cancer Vol.14 No.3

Undifferentiated pleomorphic sarcoma of the breast are uncommon and often present diagnostic challenges. Herein, we report a case of the undifferentiated pleomorphic sarcoma occurring in the male breast. A 76-year-old man presented with a palpable bean-sized mass in his left breast for two months. Core needle biopsy revealed the presence of atypical cells in a fibrous proliferative lesion, which was removed by wide excision. Based on examination of the excised tumor, the initial pathologic diagnosis was atypical spindle cell lesion with uncertain malignant potential. One year later, the patient returned with a recurrent mass at the previous surgical site. The mass was again surgically removed using wide excision. Based on histological findings with immunomarkers, the final diagnosis was undifferentiated pleomorphic sarcoma. Undifferentiated pleomorphic sarcoma of the breast can cause genuine diagnostic difficulty and appropriate immunohistochemistry is mandatory for differential diagnosis.

외국어로서의 우크라이나어 교육의 관점에서 본 수르지크

정영주 한국러시아문학회 2015 러시아어문학 연구논집 Vol.50 No.-

Surzhyk is a mixed language of Ukrainian and Russian, and the number of Surzhyk speakers exceeds a million, even in the most conservative terms. The majority of people in all regions of Ukraine use Surzhyk, both in daily life and public life. Accordingly, learners of Ukrainian language are forced to encounter Surzhyk through various means. Unlike native Ukrainians who do not feel inconvenient about communication as they grow up and live in bilingual environment using Ukrainian and Russian at the same time, learners cannot properly understand Surzhyk. Most of learners do not have a chance to hear or learn Surzhyk, and they are not aware of where they can go to seek help. Despite this, teachers of Ukrainian as a foreign language still do not have awareness and consensus about the need to consider Surzhyk as a practical speech. This paper proposes the relevant problem and argues the necessity of informing learners of Ukrainian about Surzhyk. The aim is to seek for an appropriate education method.

방사광 위상차 현미경을 이용한 여성 유방 조직의 미세 구조 영상

정영주,봉진구,김홍태,김종기,전상훈,윤화식,박성환 한국유방암학회 2008 Journal of breast cancer Vol.11 No.1

Purpose: X-ray microscopy with synchrotron radiation might be a useful tool for novel x-ray imaging in the clinical and laboratory settings. This technique provides detailed images of internal structures non-invasively. It also has the potential to resolve some of the limitations of conventional breast imaging. We evaluated high resolution synchrotron imaging of breast tissues from normal breasts and breasts with fibroadenomas and cancer. Methods: A new x-ray microscope was installed on the 1B2 beamline of a Pohang Light Source, at a third generation synchrotron radiation facility in Pohang, Korea. The phase contrast x-ray energy was set at 6.95 keV and the x-ray beam was monochromatized by a W/B4C monochromator. Formalin-fixed or unfixed female breast tissue from normal breast as well as breasts with fibroadenomas and carcinoma were attached onto the Kapton film. The sample was positioned 25 m away from the beam source. The x-ray image of the sample was converted into a visual image on the CsI(TI) scintillation crystal, and magnified 20 times by the microscopic objective lens. After an additional 10 fold digital magnification, this visual image was captured by a full frame CCD camera. Results: The monochromated x-ray microscopic images of female breast tissue from normal breast, fibroadenoma and carcinoma cases were evaluated. The total magnifying power of the microscope was 200 x. This synchrotron radiation imaging enabled us to observe detailed structures of breast tissue without sample preparation such as staining or fixation. Conclusions: Using monochromated synchrotron radiation, the x-ray microscopic images of the normal breast and breasts with fibroadenomas and cancer were obtained. From the images obtained, the x-ray microscopic imaging of breast tissue with synchrotron radiation appears to have great potential for clinical and research purposes such as oncology studies, early detection of cancer and as an aide to the pathological diagnosis in the future.

Clinical Validation of a Protein Biomarker Panel for Non-Small Cell Lung Cancer

정영주,오인재,김윤동,정종하,석민경,이우창,박철규,임정환,김영철,김우성,최창민 대한의학회 2018 Journal of Korean medical science Vol.33 No.53

We validated the diagnostic performance of a previously developed blood-based 7-protein biomarker panel, AptoDetect™-Lung (Aptamer Sciences Inc., Pohang, Korea) using modified aptamer-based proteomic technology for lung cancer detection. Non-small cell lung cancer (NSCLC), 200 patients and benign nodule controls, 200 participants were enrolled. In a high-risk population corresponding to ≥ 55 years of age and ≥ 30 pack-years, the diagnostic performance was improved, showing 73.3% sensitivity and 90.5% specificity with an area under the curve of 0.88. AptoDetect™-Lung (Aptamer Sciences Inc.) offers the best validated performance to discriminate NSCLC from benign nodule controls in a high-risk population and could play a complementary role in lung cancer screening.

러시아의 학습사전 연구의 특징

정영주 이중언어학회 2012 이중언어학 Vol.50 No.-

This paper examines characteristics of studies of learner’s dictionary in the Soviet Union and independent Russia. The term uchebnyj slovar’ was first used in bilingual dictionary. It is widely accepted that uchebnyj slovar’s are designed for beginners, not for advanced learners. As a result, learner’s dictionary and uchebnyj slovar’ differ in size,expected user, goals and so on. The author also tries to define the origin of the terms active dictionary and passive dictionary from the works of Lev Shcherba and the trend in studying of uchebnyj slovar’ after Shcherba.