Five-Year Overall Survival and Prognostic Factors in Patients with Lung Cancer: Results from the Korean Association of Lung Cancer Registry (KALC-R) 2015

전다솜,김호철,김세희,김태정,김홍관,문미형,백경민,서양권,송창훈,안진석,이정은,임정욱,전재현,정규원,정치영,조정수,최유덕,황승식,최창민,Korean Association for Lung Cancer,Korea Central Cancer Registry 대한암학회 2023 Cancer Research and Treatment Vol.55 No.1

Purpose This study aimed to provide the clinical characteristics, prognostic factors, and 5-year relative survival rates of lung cancer diagnosed in 2015.Materials and Methods The demographic risk factors of lung cancer were calculated using the KALC-R (Korean Association of Lung Cancer Registry) cohort in 2015, with survival follow-up until December 31, 2020. The 5-year relative survival rates were estimated using Ederer II methods, and the general population data used the death rate adjusted for sex and age published by the Korea Statistical Information Service from 2015 to 2020.Results We enrolled 2,657 patients with lung cancer who were diagnosed in South Korea in 2015. Of all patients, 2,098 (79.0%) were diagnosed with non–small cell lung cancer (NSCLC) and 345 (13.0%) were diagnosed with small cell lung cancer (SCLC), respectively. Old age, poor performance status, and advanced clinical stage were independent risk factors for both NSCLC and SCLC. In addition, the 5-year relative survival rate declined with advanced stage in both NSCLC (82%, 59%, 16%, 10% as the stage progressed) and SCLC (16%, 4% as the stage progressed). In patients with stage IV adenocarcinoma, the 5-year relative survival rate was higher in the presence of epidermal growth factor receptor (<i>EGFR</i>) mutation (19% vs. 11%) or anaplastic lymphoma kinase (<i>ALK</i>) translocation (38% vs. 11%).Conclusion In this Korean nationwide survey, the 5-year relative survival rates of NSCLC were 82% at stage I, 59% at stage II, 16% at stage III, and 10% at stage IV, and the 5-year relative survival rates of SCLC were 16% in cases with limited disease, and 4% in cases with extensive disease.

인장 시편 및 원자력 배관계의 반복 변형거동에 미치는 경화 모델의 영향

전다솜,강주연,허남수,김종성,김윤재,Jeon, Da-Som,Kang, Ju-Yeon,Huh, Nam-Su,Kim, Jong-Sung,Kim, Yun-Jae 한국압력기기공학회 2017 한국압력기기공학회 논문집 Vol.13 No.2

Recently there have been many concerns on structural integrity of nuclear piping under seismic loadings. In terms of failure of nuclear piping due to seismic loadings, an important failure mechanism is low cycle fatigue with large cyclic displacements. To investigate the effects of seismic loading on low cycle fatigue behavior of nuclear piping, the cyclic behavior of materials and nuclear piping needs to be accurately estimated. In this paper, the non-linear finite element (FE) analyses have been carried out to evaluate the effects of three different cyclic hardening models on cyclic behavior of materials and nuclear piping, such as isotropic hardening, kinematic hardening and combined hardening.

A case of Smooth muscle tumor of undetermined malignant potential : late recurrence with metastases

전다솜,조의리,김정은 대한내과학회 2019 대한내과학회 추계학술대회 Vol.2019 No.1

Structure-Activity Relationship of the N-terminal Helix Analog of Papiliocin, PapN

전다솜,정민철,김진경,전기웅,고윤주,김양미 한국자기공명학회 2015 Journal of the Korean Magnetic Resonance Society Vol.19 No.2

Papiliocin, from the swallowtail butterfly, Papilio xuthus, shows high bacterial cell selectivity against Gram-negative bacteria. Recently, we designed a 22mer analog with N-terminal helix from Lys3 to Ala22, PapN. It shows outstanding antimicrobial activity against Gram-negative bacteria with low toxicity against mammalian cells. In this study, we determined the 3-D structure of PapN in 300 mM DPC micelle using NMR spectroscopy and investigated the interactions between PapN and DPC micelles. The results showed that PapN has an amphipathic α-helical structure from Lys3 to Lys21. STD-NMR and DOSY experiment showed that this helix is important in binding to the bacterial cell membrane. Furthermore, we tested antibacterial activities of PapN in the presence of salt for therapeutic application. PapN was calcium- and magnesium-resistant in a physiological condition, especially against Gram-negative bacteria, implying that it can be a potent candidate as peptide antibiotics.

최후통첩게임 상황에서의 부정정서 조절에 관한 연구: 한국 노인과 청년 비교

전다솜,김혜리,허아정,박선우,김문걸 한국노년학회 2019 한국노년학 Vol.39 No.4

According to the social selectivity theory (SST), despite the disadvantages of life conditions, older adults experience less negative emotions because they regulate their emotions by avoiding negative stimuli or situations. Based on the SST, this study attempted to find out whether older adults are better able to regulate negative emotions than young adults in the Ultimatum Game (UG). In an UG, if the proposer proposes to distribute a portion of the money to the responder, the responder must decide whether to accept or reject it. If the responder accepts the offer, the proposer and the responder can each have their own share as proposed, but if s/he reject the offer, both get nothing. Thus, if the responder considers own economic benefits, it is a more reasonable decision to accept the unfair offer no matter how low, than to reject it. To accept an unfair offer, the responder must regulate the anger felt at the proposer. If older adults could regulate anger better than young adults, they would be less likely to reject the unfair offer than young adults. Fifty-seven olders and 60 university students participated in this study. Both the older and young adults accepted most of the fair offers. In contrast, older adults accepted unfair offers at a significantly higher rate than young adults. In addition, compared to young adults, older adults reported anger less frequently at the unfair offers. Accepting unfair offers was negatively correlated with anger report, but positively correlated with the emotion regulation measured by ERQ. The ERQ score was negatively correlated with anger report. Emotion regulation partially mediated the relationship between the age groups and acceptance of unfair offers. The present results showed that older adults accepted the unfair offers at a higher rate than young adults because they could regulate the negative emotions felt at the unfair offer better than young adults. This study provided new evidence for the claim that improving emotional regulation is a major developmental change in adulthood. 노화와 함께 심리사회적 여건이 불리해지는 데도 불구하고 노인이 청년보다 부정적 정서를 덜 경험하는 것을 사회정서적 선택이론은 노인이 부정 정서가 경험될 수 있는 상황을 선택하지 않거나 부정 정서를 유발하는 자극으로부터 주의를 돌려서 사전에 정서조절하기 때문이라 고 설명한다. 이에 본 연구에서는 부정적 정서가 경험되는 상황에서도 노인이 청년보다 부정적 정서를 더 잘 조절하는지 알아보고자 하였으며 이를 위해 최후통첩게임을 사용하였다. 최후통첩게임에서 제안자가 한정된 자원의 일부를 응답자에게 분배하겠다고 제안했을 때, 응답자가 이를 수락하면 둘 다 각자의 몫을 가질 수 있으나 거절하면 둘 다 아무것도 가질 수 없다. 따라서 자신의 경제적 이득을 고려한다면 제안자의 불공평한 제안에 대해 화가 나더라도 이를 조절하고 제안을 받아들여야 한다. 노인이 청년보다 정서조절을 더 잘 한다면 불공평한 제안을 받았을 때 분노를 덜 경험할 것이므로 청년보다 더 많이 수락할 것이다. 57명의 노인과 60명의 대학생이 연구에 참가하였다. 연구결과 노인과 청년 모두 공평한 제안은 80% 이상으로 수락하였으나, 불공평한 제안 수락률은 노인이 청년보다 더 높았다. 불공평한 제안에 대해 분노를 보고한 비율은 노인이 더 낮았다. 불공평한 제안 수락률은 분노 보고율과 부적 상관이, 정서조절 점수와는 정적 상관이 있었으며, 정서조절과 분노 보고 간에는 부적 상관이 있었다. 연령집단과 불공평한 제안 수락률 간의 관계를 정서조절이 부분적으로 매개하는 것으로 나타났다. 이는 노인이 청년보다 불공평한 제안을 더 많이 수락하는 것은 노인이 분노를 더 잘 조절하는 것으로 일부 설명될 수 있음을 보여준다. 본 연구 결과는 정서조절의 향상이 성인기의 주요한 발달적 변화라는 주장에 대한 새로운 증거가 됨을 논의하였다.

산업안전보건 종사자들의 4차 산업혁명 인식과 준비도, 직무스트레스, 조직유효성의 구조적 관계 연구

전다솜,김현수 한국지역사회복지학회 2022 한국지역사회복지학 Vol.- No.82

The purpose of this study was to examine the relationships among 4Th Industrial Revolution awareness and readiness, Job stress, and organizational effectiveness of Industrial Safety and Health workers. A survey was conducted for employees working at the Industrial Safety and Health agency, and 286 data were included in the final analysis. A structural equation model was developed to examine the relationships among the variables used in this study. The model-fit and mediating effects of the research model were examined using SPSS and AMOS. The result showed that job stress negatively associated with 4th Industrial Revolution awareness, and positively associated with readiness. In addition, job stress and job satisfaction were fully mediated between 4th Industrial Revolution awareness and readiness and organizational effectiveness. Based on these results, the future implications of 4th Industrial Revolution awareness and readiness strategies were discussed in order for Industrial Safety and Health workers to decrease job stress and increase organizational effectiveness. 직업군과 업무영역에 따라 4차 산업혁명에 대한 인식과 준비정도가 다르겠지만, 신기술이 이끄는 산업현장의 변화는 다양한 관련 업계 종사자들에게 업무관련 스트레스로다가올 수밖에 없다. 이러한 스트레스는 조직유효성(직무만족, 조직몰입)과도 관련이 있는 만큼 산업현장에서는 이에 대해 관심을 가질 필요가 있다. 본 연구는, 4차 산업혁명현장에서 산업재해와 근로자들의 안전·보건에 막중한 역할을 하며 선제적으로 4차 산업혁명에 대비하고 있는 산업안전보건 종사자 286명을 대상으로 4차 산업혁명에 대한 인식과 준비도 직무스트레스, 그리고 직무만족, 조직몰입 변수 간 구조적 관계를 살펴보았다. 분석결과 4차 산업혁명에 대한 인식수준이 높을수록 직무스트레스가 낮고, 준비도가높을수록 직무스트레스는 높으며 직무만족도 높았다. 4차 산업혁명 인식수준과 준비도모두 조직몰입에 직접적인 영향을 미치지는 않았지만, 직무스트레스와 직무만족을 매개로 조직몰입에 유의미한 영향을 미치고 있었다. 이러한 결과를 바탕으로 4차 산업혁명에대응하는 산업안전보건 종사자들의 직무스트레스를 줄이고 직무만족과 조직몰입을 높일수 있는 방안에 대해 논의하였다.

폐교(초·중·고)기록물 이관현황과 개선방안에 관한 연구: 공공기록물법 제정 이후

전다솜,이지수 한국기록관리학회 2023 한국기록관리학회지 Vol.23 No.4

This study explores the transfer of defunct school records (by preservation period, type, and place of transfer) in South Korea since the Public Records Management Act was enacted in 1999 and suggests improvements. Metropolitan and provincial offices of education, totaling 17, were asked to disclose information about the status of defunct school records. Since 1999, 1,411 schools nationwide have closed permanently, predominantly elementary schools, followed by high then middle schools. By preservation period, there were more records in the 1 to 10-year category than in the 30-year to permanent category. By record type, most were electronic records, followed by paper records, archival objects, and audiovisual records. By place of transfer, most nonelectronic records were transferred to integrated schools, and most electronic records were transferred to the Records Management System. In-depth interviews with 10 record managers from local education offices found that the management of defunct school records varies widely by region and institution because of the lack of specified manuals. Participants also reported difficulties in transferring web-based records, archival objects, and audiovisual records, as well as insufficient archival space and computer systems. This study also provides suggestions to improve the management of defunct school records, such as establishing specified manuals, creating a dedicated government department for managing defunct school records, deploying workforces, and improving computer systems. 이 연구는 공공기록물 관리에 관한 법률이 제정된 1999년 이후 전국의 폐교(초·중·고)기록물 이관현황(보존기간, 유형별, 이관장소)을 분석하여 문제점을 파악하고 개선방안을 제안한 연구이다. 17개 시·도 교육청을 대상으로 한 정보공개 청구 결과, 1999년 이후 전국의 폐지학교는 총 1,411개로, 초등학교, 고등학교, 중학교 순으로 집계되었고, 보존기간별로는 1년-10년 기간의 기록물이 30년-영구 기간의 기록물보다 수량이 많았다. 유형별로는 전자기록물, 종이기록물, 행정박물, 시청각기록물 순으로 집계되었고 비전자기록물 대부분은 통합학교로 이관되고 전자기록물은 표준기록관리시스템(RMS)으로 이관되었음을 확인하였다. 지역 교육(지원)청 소속의 기록연구사 총 10명을 대상으로 반구조화된 심층면담을 실시한 결과, 폐교기록물 관리 지침 부재로 인해 체계적인 이관과 관리가 이루어지지 않으며 지역별 기관별 편차가 크다는 점, 웹기록물, 행정박물, 시청각기록물 이관의 어려움이 크고, 물리적 시스템적 이관 장소의 문제가 존재함을 확인하였다. 이상을 종합하여 폐교기록물 관리 지침의 제정, 전담부서 신설 및 인력 배치, 전산시스템 개선을 향후 폐교기록물 이관 및 관리 개선방안으로 제시하였다.

Short Antimicrobial Peptides Exhibiting Antibacterial and Anti-Inflammatory Activities Derived from the N-Terminal Helix of Papiliocin

전다솜,Binu Jacob,곽철희,김양미 대한화학회 2017 Bulletin of the Korean Chemical Society Vol.38 No.11

Papiliocin is a 37-residue antimicrobial peptide, with Trp2 and Phe5 previously reported as key residues necessary for its antibacterial activity. This study determined the essential length of the N-terminal fragment of papiliocin necessary to retain its biological activity. We designed and synthesized an array of seven peptides from the N-terminal helix (PapN), with longest peptide with 22 residues and the shortest peptide consisting of the first 10 residues. The minimum inhibitory concentration (MIC) values and cytotoxicity measurement revealed that a PapN-12mer containing a three-turn, amphipathic helix was the shortest peptide exhibiting antibacterial activity without cytotoxicity. Additionally, PapN-20mer peptide containing two isoleucines at the C-terminus represented the shortest peptide exhibiting potent anti-inflammatory activities by inhibiting nitric oxide production and inflammatory cytokine production in lipopolysaccharide-stimulated mouse macrophage RAW264.7 cells. These results provided valuable insights into the design of short, potent peptide analogs of papiliocin.

아동복지시설의 미용서비스 현황 및 만족도 연구

전다솜,도주연 국제보건미용학회 2017 국제보건미용학회지 Vol.11 No.1

Currently, There are 1,849 children living in 22 Child welfare facilities in Busan. However, considering the number of children, there are insufficient beauty service providers and volunteers for them, and the government does not have enough budget to support the children living in welfare facilities. For that reason, in study, Survey will be conducted to find out current status and satisfaction about beauty service given to them. After analyzing the status, relevant problems will be examined and practical ways will be researched by the government to improve beauty service for the children. Based on the research, infrastructure and collaboration system for beauty volunteer service for the children at welfare facilities will be establish.

토양 효소 활성도를 이용한 간척지 토양의 건전성 검증

전다솜(Dasom Jeon),김계훈(Kye-Hoon Kim) 한국토양비료학회 2016 한국토양비료학회 학술발표회 초록집 Vol.2016 No.10