세침흡인 세포학적 검사로 진단한 간모세포종

임현이(Hyunee Yim),진윤미(Yoon Mi Jin),김문규(Moon Kyu Kim),홍정(Jung Hong) 한국간담췌외과학회 1997 한국간담췌외과학회지 Vol.1 No.1

폐로 전이한 유방의 악성 엽상종양 - 세침흡인 세포학적 소견의 1례 보고 -

임현이,이광길,Yim, Hyun-Ee,Lee, Kwang-Gil 대한세포병리학회 1993 대한세포병리학회지 Vol.4 No.2

Phyllodes tumor of the breast, especially malignant, is a rare tumor which has characteristic cytologic features. We recently experienced a case of fine needle aspiration cytology of malignant phyllodes tumor of the breast metastatic to the lung. The aspirate showed cellular smear with biphasic population of epithelial and stromal cells. Many individual large cells with round hyperchromatic nuclei were found in the necrotic background and stromal cell atypia was also present. Chondrosarcomatous fragments were also seen in cytologic specimens.

경부 종괴로 나타난 수막종의 세침흡인 세포학적 소견

임현이,박영년,이광길,Yim, Hyun-Ee,Park, Young-Nyun,Lee, Kwang-Gil 대한세포병리학회 1992 대한세포병리학회지 Vol.3 No.2

Meningioma is the most common neoplasm of central nervous system which is hardly diagnosed by cytologic examination. However, preoperative cytologic diagnosis can be easily made in the case of extracranial meningioma, especially in head and neck lesion. We recently experienced a case of fine needle aspiration cytology of meningioma in sub-mandibular area of a 24 year-old male patient. The smear revealed high cellularity in the clean background. individual tumor cell of nests or syncytium had round or oval nuclei with fine chromatin and moderate amount of lightly stained cytoplasm with indistinct margin. Characteristic cellular whorls, intranuclear inclusions and scattered psammoma bodies made it easy to diagnose a meningioma.

간의 다발성 맥관근지방종 - 세침흡인 세포학적 검사로 진단한 1예 보고 -

임현이,박광화,이기범,Yim, Hyun-Ee,Park, Kwang-Wha,Lee, Kyi-Beom 대한세포병리학회 1998 대한세포병리학회지 Vol.9 No.1

Angiomyolipoma(AML) of the liver is a rare benign tumor; about 50 cases, almost solitary, have been reported. We present here a extremely rare case of multiple AML in the liver diagnosed by fine needle aspiration cytology(FNAC). Two large masses were found in a 51 year-old woman complaining of abdominal discomfort by computed tomography and several smaller masses are scattered in the liver. FNAC was performed, showing bundles of spindle shaped smooth muscle cells intermingled with mature fat cells. FNAC may be a valuable method for definitive diagnosis of hepatic AML. The diagnosis was further confirmed by histologic examination with immunohistochemical studies.

두개내 악성 생식세포종양의 압착도말 세포학적 소견

임현이,김정선,심철,Yim, Hyun-Ee,Kim, Jung-Sun,Shim, Chul 대한세포병리학회 1996 대한세포병리학회지 Vol.7 No.2

Intraoperative cytologic examination of intracranial tumors using crush preparation provides useful information in operative decision making. The diminutive nature of many biopsy specimens, particularly those obtained by stereotactic neurosurgical procedures emphasizes the importance of combining the cytologic smear method with conventional frozen section interpretation. The great advantage of the cytologic smear method resides in its suitability for the study of minute fragments of tissue, allowing retention of the majority of the specimen for optimal processing. We present the cytologic features of 3 cases of intracranial germ cell tumors(2 germinomas and 1 endodermal sinus tumor), using crush preparation during intraoperative diagnosis and compare them with histologic findings. The cytologic features of the germ cell tumors were similar to those of the respective gonadal counterparts. The cytologic differential diagnosis of both types of germ cell tumors is described.

세침흡인 세포학적 검사로 진단한 폐의 Nocardiosis - 1예 보고 -

임현이,박광화,Yim, Hyun-Ee,Park, Kwang-Hwa 대한세포병리학회 1995 대한세포병리학회지 Vol.6 No.2

Nocardia, aerobic members of the order of Actinomycetaceae, produces infections in human lung. Nocardial infection is associated with underlying diseases of immuno-suppression or treatment with corticosteroid. It is difficult to detect Nocardia by sputum examination or histologic sections and it has rarely been diagnosed by fine needle aspiration of the lung. We describe a case of pulmonary nocardiosis in a 72 year-old man, diagnosed by fine needle aspiration, which was confirmed by culture of aspirates. The aspirates showed neutrophil-predominant inflammatory cells with microorganisms demonstrated by Gomori methenamine silver and Gram stain. The organisms had characteristic long blanching filamentous structures. The lesions on chest X-ray were in resolution with antimicrobial therapy.

류마티스관절염 환자에서 Bucillamine에 의한 신병증

김현아 ( Hyoun Ah Kim ),임현이 ( Hyun Ee Yim ),성준모 ( Jun Mo Sung ),이진우 ( Jin Woo Lee ),서창희 ( Chang Hee Suh ) 대한류마티스학회 2009 대한류마티스학회지 Vol.16 No.3

Objective: Bucillamine is a disease-modifying antirheumatic drug that`s widely used in Korea and Japan, and it is reported to be a cause of proteinuria. However, the clinical course of the nephropathy associated with the use of bucillamine in rheumatoid arthritis patients has not been described in detail in Korea. Methods: We examined clinical records of 835 patients who were treated with bucillamine for rheumatoid arthritis at least 2 months at Ajou University Hospital from 2003 to 2008, and we found 23 patients (2.75%) with proteinuria. Each patient was followed up until the proteinuria had resolved. Results: At the time the proteinuria developed, the mean age of patients was 53.8±11.0 years. Only one patient had marked hypoalbuminemia (<3.0g/dL). The mean value of the random urine protein-creatinine ratio was 3.44±2.99. The proteinuria appeared 4∼18 months after the initiation of the treatment with bucillamine. Among the patients, renal biopsy was carried out in 18 patients, and pathological findings were 17 cases of membranous glomerulopathy and 1 case of focal segmental glomerulosclerosis. On the follow-up of the 18 patients, the proteinuria in all the patients had resolved completely without deterioration of renal function. But the time to resolution of the proteinuria was positively correlated with the length of bucillamine treatment after the onset of proteinuria (p<0.001, r=0.744). Conclusion: Prevalence of proteinuria in patients receiving bucillamine was 2.75%, and bucillamine-induced nephropathy showed a good prognosis in Korea. The most important thing for resolving the bucillamine-induced proteinuria is to discontinue the bucillamine.

신증후군에서 의료방임으로 발생한 복부농양 1례

신윤혜,허준,이강균,임현이,배기수,Shin Yun-Hye,Hur Joon,Lee Kang-Gyoon,Yim Hyun-Ee,Pai Ki-Soo 대한소아신장학회 2005 Childhood kidney diseases Vol.9 No.1

세균성 복막염은 신증후군 환아의 생명을 위협하는 중요한 감염성 합병증으로 초기에 광범위한 항생제 병용치료가 이루어져야한다. 저자들은 신증후군 진단 후 치료가 지연된 환아에서 발생한 복막염 및 복부농양 증례를 경험하였기에 보고하는 바이다. Nephrotic syndrome is a common chronic disease in childhood. Patients with nephrotic syndrome are at an increased risk of bacterial Infections due to immunological changes secondary to proteinuria. Primary bacterial peritonitis is one of the most serious and common infectious complications. The rate of peritonitis is, 2-6% and overwhelming infection still carries a mortality rate of 1.5%. We experienced a rare case of nephrotic syndrome complicated with severe peritonitis and Peritoneal empyema in a 10-year old girl after 2 months of medical neglect by parents. Here we emphasize thf: importance of early detection and treatment of peritoneal infection in nephrotic syndrome.

Clinicopathologic Changes in Children with Immunoglobulin A Nephritis and Henoch-Sch$\ddot{o}$nlein Purpura Nephritis after Cyclosporine A and Angiotensin-converting Enzyme Inhibitor Treatment

이정주,김용진,신재일,임현이,박세진,Lee, Jeong Ju,Kim, Yong-Jin,Shin, Jae Il,Yim, Hyunee,Park, Se Jin Korean Society of Pediatric Nephrology 2013 Childhood kidney diseases Vol.17 No.2

목적: IgA 신병증, HSP 신병증은 사구체의 메산지움에 IgA가 침착되는 대표적인 질환이다. 본 연구는 소아에서, 이 두 가지 질환에 대한 Cyclosporin A 의 임상적 및 병리학적 효과를 평가하기 위하여 시행되었다. 방법: 총 54명의 환자(IgA 신병증: Henoch-Sch$\ddot{o}$nlein purpura 신병증=36:18)를 대상으로 후향적으로 연구를 진행하였다. CsA는 5mg/kg/day 으로 투여하였으며, 투여 전, 후로 단백뇨의 양을 측정, 병리학적 변화를 조사하기 위해 신생검을 시행하였다. HSP 신병증 및 IgA 신병증의 신생검은 병리학적으로 각각 ISKDC 분류법, Oxford 분류체계(2009)로 구분하였다. 결과: 혈청 단백/크레아티닌 비는 치료 전후로 $3.7{\pm}1.5$에서 $0.6{\pm}0.4$으로 호전되었고(P<0.001), 총 54명 중 32명의 환자(59.2%)에서 CsA 치료 1년 후 단백뇨의 관해를 보였다. 신생검의 병리학적 소견은 호전되거나, 또는 치료 전후로 유지되는 양상을 보였으며, CsA로 인한 합병증은 없었다. 결론: CsA 는 IgA의 사구체 침착을 특징으로 하는 IgA 신병증, HSP 신병증 환자에서 단백뇨 감소효과 및 말기신부전으로의 진행을 예방하는 데에 효과적인 것으로 사료된다. Purpose: To investigate the clinicopathologic effects of cyclosporine A (CsA) in children with diseases characterized by mesangial immunoglobulin A deposits such as immunoglobulin A nephropathy (IgAN) and Henoch-Sch$\ddot{o}$nlein purpura nephritis (HSPN). Methods: We retrospectively reviewed the clinicopathologic outcomes of 54 children (IgAN, 36; HSPN, 18) treated with CsA. The starting dose of CsA was 5 mg/kg per day, and it was administered in 2 divided doses. The degree of proteinuria and pathologic changes in renal biopsies were evaluated before and after CsA treatment. Results: The mean protein to creatinine ratio decreased from $3.7{\pm}1.5$ to $0.6{\pm}0.4$(P <0.001), and 32 (59.2%) children achieved complete remission of proteinuria after 1-year CsA treatment. Among the 54 children, 24 maintained normal renal function and 25 exhibited microscopic hematuria or proteinuria at the end of CsA treatment. In the HSPN group, 3 children whose initial biopsies indicated class IIIb disease showed class II disease on follow-up, and the follow-up biopsies of 2 children who had class II disease indicated the same class II disease. In the IgAN group, cortical tubular atrophy occurred in 1 child, and no child with IgAN had cortical interstitial fibrosis or tubular atrophy after 1-year CsA treatment. No significant complications were found in the children treated with CsA. Conclusion: Our findings indicate that CsA treatment is effective and beneficial in reducing massive proteinuria and preventing progression to end-stage renal failure in children with glomerular diseases characterized by IgA deposits, such as IgAN and HSPN, within 1 year of treatment.

다발내분비샘종양1형 환자에서 동반된 미세변화신증

고윤정 ( Yunjung Ko ),안미선 ( Mi Sun Ahn ),임현이 ( Hyun Ee Yim ),이민정 ( Min-jeong Lee ),신규태 ( Gyu-tae Shin ),김흥수 ( Heungsoo Kim ),박인휘 ( Inwhee Park ) 대한내과학회 2020 대한내과학회지 Vol.95 No.5

고형암에서 발생하는 신증후군의 원인은 막성 사구체신염인 경우가 많으나 본 증례와 같이 미세변화신증이 동반될 수 있으므로 치료 방향 결정을 위해서는 조직 검사를 통한 최종 확인이 필요하겠다. 다발내분비샘종양1형에서 미세변화신증이 동반된 경우는 국내에서 처음으로 경험하여 보고 하는 바이다. Multiple endocrine neoplasia type 1 (MEN 1) is an autosomal dominant disorder characterized by two or more tumors of the parathyroid gland, duodenum-pancreas, and anterior pituitary. Membranous nephropathy is the most common manifestation of paraneoplastic glomerulopathy. However, minimal change disease in patients with MEN 1 has yet to be reported. Here, we report a case of minimal change disease in a 59-year-old man with MEN 1, along with a review of the relevant literature. (Korean J Med 2020;95: 340-343)