국내 개발된 $N-tox^{(R)}$ 생물검정 시스템을 이용한 시안과 3, 5-이염화페놀의 발광박테리아(Vibrio fischeri)에 대한 혼합 독성 영향 연구

이정석,이규태,김찬국,김혜진,이창훈,이종현,Lee, Jung-Suk,Lee, Kyu-Tae,Kim, Chan-Kook,Kim, Hye-Jin,Lee, Chang-Hoon,Lee, Jong-Hyeon 환경독성보건학회 2007 환경독성보건학회지 Vol.22 No.1

Cyanides and dichlorophenols were important pollutants in industrial effluents of steel, petroleum, plastics, pesticides, synthetic dye and/or fiber manufacturing. The toxic effects of cyanide and 3, 5-dichlorophenol in the unary and binary solutions to Vibrio fischeri were determined using the newly developed $N-tox^{(R)}$ bioassay system. This bioassay system relies upon the attenuation of light intensity emitted by Vibrio fischeri exposed to various pollutants including metals and organic compounds. Most of studies dealing with toxicity of pollutants concerned single chemical species, while the organisms were typically exposed to pollutant mixtures. The present study showed that the toxicity of some binary combinations of cyanide and 3, 5-dichlorophenol significantly was lower than the predicted toxicity from the addicted model. This antagonistic interaction was well explained by chemical interaction model presented in this study.

경부 2, 3번 피부절을 침범한 Ramsay-Hunt 증후군 1례

이정석,최용석,송은향,김정미,한정호,김두응,Lee, Chung Seok,Choi, Yong Seok,Song, Eun Hyang,Kim, Jeung Mee,Han, Jeong Ho,Kim, Doo Eung 대한임상신경생리학회 2002 Annals of Clinical Neurophysiology Vol.4 No.1

Ramsay-Hunt syndrome is a viral disease associated with peripheral facial nerve paralysis accompany by erythematous vesicular rashs on the ear(zoster oticus) or in the mouth. Based on clinical presentations that indicated involvement of more than one ganglion, the gasserian, geniculate, petrous, accessory, jugular and second and third dorsal root ganglia comprised a chain in which inflammation of a single ganglion could extend to nearby ganglia. A 71-year-old man presented with left. peripheral facial palsy with otalgia, vesicular eruption in $V_2$, $V_3$, C2, C3 dermatome, tinnitus, and hearing loss.

수도권 규제완화 계획과 비수도권의 대응 전략

이정석,Lee, Jeong-Seok 대전발전연구원 2008 대전발전포럼 Vol.28 No.-

사과락(絲瓜絡)이 Triton Wr 투여로 유발되는 고지혈증(高脂血證) 예방에 미치는 영향에 대한 실험적 연구

이정석,소경순,정찬길,Lee Jeong-Seok,Soh Kyung-Sun,Jeong Chan-Gil 대한예방한의학회 2002 대한예방한의학회지 Vol.6 No.2

In order to study the effect of Luffae fasciculus vascularis(絲瓜絡) on hyperlipidemia, experimental study was performed on Hyperlipidemia induced by Triton WR-1339. Also the level of Total cholesterol, Triglyceride, HDL-cholesterol, Phospholipid and LDL-cholesterol were measured. The results are summarized as follow: In the model of hyperlipidemia Rats induced by Triton WR-1339, luffae fasciculus vascularis(絲瓜絡) had significantly decreasing effects on total cholesterol, triglyceride, phospholipid, LDL-cholesterol in serum and increasing effects on HDL-cholesterol level in serum but were not significant. These results show that Luffae fasciculus vascularis(絲瓜絡) has significantly inhibitory effects on hyperlipidemia and that it could be clinically applied for hyperlipidemia.

Phenotypic Features of Cerebral Autosomal-Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy Subjects with R544C Mutation

이정석,KeunHyuk Ko,오정환,Joon Hyuk Park,Ho Kyu Lee 대한치매학회 2016 Dementia and Neurocognitive Disorders Vol.15 No.1

Background and PurposeCerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most-common single gene disorder of cerebral small vessel disease. There is no definite evidence of genotype-phenotype correlation in CADASIL. However, recent studies have shown the unique phenotypic feature of NOTCH3 R544C mutation. MethodsWe investigated the phenotypic spectrum of NOTCH3 R544C mutation in 73 CADASIL patients in Jeju between April 2012 and January 2014. ResultsOf the 73 subjects from 60 unrelated families included in this study, 40 (55%) were men. The mean age of the subjects was 62.2± 12.2 (range 34–86 years). Cerebral infarction was the most frequent manifestation (37%), followed by cognitive impairment (32%), headache (17%), psychiatric symptom (16%), intracerebral hemorrhage (12%), transient ischemic attack (7%), and seizure (1%). The mean age of the subjects with ischemic or hemorrhagic episodes was 64.9±10.9 (range 41–86 years). A diagnosis of dementia was made in 12 subjects (16%). The mean age of the subjects with dementia was 75.6±6.5 (range 62–86 years). About 3% of subjects were unable to walk without assistance at assessment. Only one subject had developed chronic headache before the 40s. ConclusionsOur data support the hypothesis that CADASIL patients with R544C mutation in Jeju have relatively late onset disease.

한.양약 복용이 간기능에 미치는 영향-피부과치료 한약복용 환자를 중심으로-

이정석,이선동,Lee Jung-Seok,Lee Sun-Dong 대한예방한의학회 2004 대한예방한의학회지 Vol.8 No.1

We have conducted questionnaire and measured serum liver function tests on 153 patients whom have received a treatment at a local Oriental medicine clinic in Seoul from Sept. 1, 2002 to Dec. 31, 2002. Patients were categorized into the groups of control(10), decoction group(41), herbal group(5), western medicine group(45), and the group taking both herbal and western medicines(55) concurrently or separately. This study was conducted to investigate how these treatment methods can affect the liver functions. Following results were obtained : 1) Most of the research subjects were male(l03 individuals) living in large urban area, with drinking habit, highly educated, and with normal marriage. For the treatment history, 45 individuals received western medicine treatment(28.85%), 46 with Oriental medicine (29.49%), and 55 patients(35.26%) experienced both forms of treatment. 2) Measuring SD of serum liver functions for all the research subjects, T-protein was 6.95(0.73)g/dl, 4.07(0.51)g/dl for albumin, 0.44(0.19)mg/dl for T-bilirubin, 23.18(18.68)U/L for ALT, 27.42(27.43)U/L for AST, and 22l.27(64.58)mg/dl for LDH. 3) Among the research subjects with the liver functions outside of normal range were 0.64% for T-protein, 3.21% for T-bilirubin and ALT, 36.62% for AST, 0.64% for LDH, and none for Albumin. 4) Confusion variables which may affect the liver functions such as age, smoking, drinking, occupation, and residence were eliminated in calculation and no significant differences were witnessed between the control and experiment groups. 5) In measuring affects of treatment duration on the liver functions, no statistical significances were shown in multiple regression's ,${\beta}$(SE) values. 6) The values of odd ratio in the experiment groups compared to the control were in the range of $0.26(0.22){\sim}0.62(1.23)$. but T-bilirubin of the group receiving both Oriental and western medicine was 1.47(1.90) which showed statistical increase(p<0.001). 7) Factors affecting the liver functions are drinking volume per round duration of alcohol intake, western medicine treatment, gender, and age difference caused significant influences. 8) 57 individuals with serum liver functions out of normal range were mostly male, living in large urban area, median age of 38.89, with normal marriage, highly educated drinking less than once a week with less than 2 bottles per round, and with prior treatment in either western or Oriental medicine. Summarizing above results, we can carefully deduce that taking herbal medicine (both decoction and pills) or western medicine doesn't cause much affect in the liver functions. But taking two forms of medication simultaneously or altering dosage affect significant increase in the T-bilirubin level, thus one needs to take precaution when taking both. Further research is needed in this field to verify this evidence.

TOFD UT 기법을 활용한 원자로 상부헤드관통부 J-groove 용접부 결함 검출 가능성 평가

이정석,이태훈,김용식,Lee, Jeong Seok,Lee, Tae Hun,Kim, Yong Sik 한국압력기기공학회 2015 한국압력기기공학회 논문집 Vol.11 No.2

A failure or degradation of reactor upper head penetration is a troublesome problem at Nuclear Power Plants. A flaw in the reactor upper head penetration can result in unplanned plant shutdown for repair, and cause serious economic losses on the plants. Consequently, a detection of flaws is a matter of more importance. Until now, only the base metal, not including J-groove weld, in reactor upper head penetration has been inspected in accordance with 10 CFR 50.55a and ASME code case N-729-1 requirements. Accordingly, it is rather difficult to detect manufacturing defects and repair defects in J-groove weld. This paper presents a case study on the application of Time of Flight Diffraction UT technique to examine the J-groove weld in reactor head penetration using reactor head penetration mockup with artificial flaws. We expect that this study result will offer a way to understand the non-destructive examination technology for J-groove weld in reactor upper head penetration.

북한 토목 인프라의 안전성 및 기술수준 고찰

이정석,Lee, Jeong-Seok 한국건설관리학회 2016 한국건설관리학회 논문집 Vol.17 No.2

삼나무(杉), 편백나무 산출묘(山出苗)의 활착(活着) 영향인자(影響因子(I) -건조(乾燥)(실내(室內), 실외(室外), OED green) 및 침지(浸漬)-

이정석,오광인,Lee, Jyung Seuk,Oh, Kwang In 한국산림과학회 1979 한국산림과학회지 Vol.44 No.1

삼나무 및 편백나무의 산지조림시(山地造林時) 활착율(活着率)아 낮은 경우(境遇)가 왕왕(往往) 있으므로 이들 요인(要因)을 구명(究明)코저 1979년(年) 2월(月)부터 9월(月)까지 삼나무, 편백나무, 1-1실생묘(實生苗)와 삼나무 2-1삽목묘(揷木苗)를 공시목(共試木)으로 실내(室內) 및 주간노지(晝間露地) 건조조건(乾燥條件)과 OED green 및 수침적(水浸積) 조건처리(條件處理)를 하여 활착률(活着率)을 시험(試驗)하였던 바 다음과 같은 결과(結果)를 얻었다. 1. 수분함량(水分含量)은 11시(時)부터 15시(時)까지 급격(急激)히 떨어졌으며 실내(室內)에서 17시(時)가지의 감량(減量)은 실외(室外)에서 1사간(時間) 동안의 감량(減量)과 같다. 2. OED green 처리(處理)와 무처리간(無處理間)에는 함수량(含水量) 변도(變動)에 큰 차이(差異)가 없었다. 3. 삼나무, 편백나무, 실생묘(實生苗)의 실(室) 및 주간건조(晝間乾燥) 조건(條件)에 있어서의 활착률(活着率)은 OEDgreen 처리(處理)나 무처리(無處理)가 각각(各各) 고도(高度)의 유의성(有意性)이 있었고 침적효과(浸積效果)도 미약(微弱)했다. 4. 편백나무묘(苗)의 활착률(活着率)은 삼나무 실생묘(實生苗)와 거의 일치(一致)하였으나 건조(乾燥)에 대(對)한 저항력(抵抗力)은 낮은 편(便)이다. 5. 삼나무 삽목묘(揷木苗)고 실생묘(實生苗)에 비(比)하여 활착률(活着率)이 높았으며 2시간(時間) 동안 건조(乾燥)한 경우(境遇)도 전(全)혀 활착률(活着率)에 영향(影響)이 없었다. 또한 건조시간(乾燥時間)과 침적시간(浸積時間)과의 상호작용(相互作用)에 고도(高度)의 유의성(有意性)이 있었다. 6.삼나무, 편백나무, 실생묘(實生苗)는 실내(室內)에서 4일간(日間) 건조(乾燥)하였을 때 2시경(時頃)부터 활착률(活着率)이 현저(顯著)히 떨어졌으며 건조일수간(乾燥日數間)에 고도(高度)의 유의성(有意性)이 있었다. Factors affecting the survival of out planted Cryptomena and Japaneses Cypress seedlings. (I) - Especially on the drying and water soaking duration ­ There are often the cases of poor survival percentage for the economic forest establishments of Cryplomeria japonica D. Don. and Chamaecyparis obtusa End. This study was carried out to investigate the survival factors of both 1-1 seedlings and Cryptomena cutting Seedlings by room drying conditions, day drying conditions, OED green water soaking treatment and drying duration at the forest nursery of Chonnam National University from February to September. 1979. The results are as follows: 1. From 11 a.m. to 3 p.m. fluctuation in then moisture contents(MC) rapidly decreased and M.C. fluctuation in indoor until 5 p.m. showed the same results with the amount of an hour fluctuation in outdoor. 2. M.C. fluctuations between OED green and non-treatment of these seedlings were silghtly different. 3. The survival percentage of OED green and non-treatment of seedlings were highly significant in the room drying conditions and the day drying conditions respectively The effects of water soaking treatment on rooting was negligible. The survival percentage of seedlings of OED green was higher than that of non-treatment. 4. Although survival percentage of Japanese Cypress was almost in accord with Cryptomena, the power of resistance to drying was lower m Japanese Cypress than m Cryptomeria. 5. Compared with Cryptomena seedlings the survival percentage of Cryptomeria cutting seedlings was higher and not influenced at all in case of being drying for two hours; but it was highly significant in interactions between the drying time and the water soaking time. 6. When Cryptomena and Japanese Cypress seedling become drying in indoor for four days, the survival percentage remarkably reduced after two days and also was highly significant among numbers of drying days.

저온삼투압탈수법(低溫渗透壓脫水法)에 의한 고품질(高品質)의 반염건(半鹽乾)고등어 제조(製造)

이정석,주동식,김진수,조순영,이응호,Lee, Jung-Suck,Joo, Dong-Sik,Kim, Jin-Soo,Cho, Soon-Yeong,Lee, Eung-Ho 한국식품과학회 1993 한국식품과학회지 Vol.25 No.5

가공적성이 좋지 못한 적색육어류를 수산가공품의 효율적인 원료로 활용할 수 있는 새로운 가공법의 개발에 관한 연구로서 적색육어류의 하나인 고등어를 이용하여 고분자 수분흡수성 수지가 내재된 탈수시트로 저온에서 단시간 건조함으로써 건조공정 중 고도불포화지방산의 산화 및 단백질변성을 가능한 억제하여 안전성이 높은 반염건고등어의 제조를 시도하였고, 아울러 천일건조, 열풍건조 및 냉풍건조법으로 제조한 반염건고등어의 품질과 비교하였다. 반염건고등어의 제조를 위한 건조시간은 저온삼투압탈수법을 이용한 경우 $90{\sim}160$분으로 천일건조, 열풍건조 및 냉풍건조 등의 재래식 건조법을 이용하는 경우의 $180{\sim}510$분 보다 상당히 단축되었으며, 탈수시트의 종류에 따라서도 약간의 차이는 있어 sodium polyacrylate로 만든 탈수시트로 건조시킨 것이 가장 빨랐다. 반염건고등어의 수분함량은 $59.4{\sim}62.4%$의 범위이었고, 단백질함량 및 조지방함량은 각각 $26.3{\sim}28.1%$ 및 $7.2{\sim}9.7%$의 범위였다. 반염건고등어의 histamine함량은 $2.5{\sim}3.6mg/100g$의 범위로 건조방법에 관계없이 식중독은 문제되지 않았다. 반염건고등어의 과산화물값, 혼합지방산조성, 갈변도, 염용성질소의 용해도 및 근원섬유 Ca-ATPase 활성은 저온삼투압탈수법으로 제조한 것이 재래식 건조방법으로 제조한 것보다 변화가 적어 가공 중 지질산패 및 단백질변성이 억제되었다는 것을 알 수 있었다. 텍스튜어 및 관능검사 결과, 저온삼투압 탈수법으로 제조한 반염건고등어가 재래식 건조방법으로 제조한 반염건고등어보다 산패취가 적으면서 조직감이 우수하였다. 한편 탈수시트의 종류를 달리하여 저온삼투압탈수법으로 제조한 반염건고등어간에는 과산화물값, 혼합지방산조성, 염용성질소의 용해도 및 근원섬유 Ca-ATPase 활성에는 큰 차이가 없었다. 이상의 결과들로 미루어 볼 때 가공적성이 좋지 못하여 재래식 건조조건으로는 가공하기에 곤란하였던 적색육어류도 고분자 수분흡수제가 내재된 탈수시트로 탈수한다면 가공 중 지질산패, 단백질변성 및 바람직하지 못한 성분상호간의 반응을 최대한 억제할 수 있어 적색육어류의 식용화 뿐만 아니라 건조를 필요로 하는 수산식품가공에 광범위하게 이용 가능하리라는 결론을 얻었다. A dehydrating sheet comprises polymeric water absorber. which are packed in a semipermeable cellophane film bag allowing selective permeation of water. This sheet dehydration is quite different from conventional drying method such as sun drying, hot-air blast drying and cold air blast drying in a sense that samples are dried without heat treatment. As a part of the studies to develope a new processing method for effective utilization of dark muscle fishes, the preparation of a good quality salted and semi-dried mackerel by the dehydrating sheet was attempted. The dehydration time for preparation of a salted and semi-dried mackerels containing approximately equal moisture content were revealed $180{\sim}510min$ in conventional drying method and $90{\sim}160min$ in this sheet dehydration, respectively. The moisture and histamine contents of those salted and semi-dried mackerels were $59.4{\sim}62.4%$ and $2.5{\sim}3.6 mg/100g$, respectively. The changes in peroxide value, fatty acid composition, brown pigment formation, myofibrillar protein solubility and Ca-ATPase activity during processing of the salted and semi-dried mackerel prepared by the sheet dehydration were more lower than those of products prepared by conventional drying methods. Therefore, these result showed that the quality of a salted and semi-dried mackerel prepared by the sheet dehydration was imperial to that of those products by conventional drying method.