적작약 꽃 추출물의 활성산소 억제와 항염증 및 MMP-1 발현 억제능 효과에 관한 연구

이재남(Jae-Nam Lee),김영삼(Young-Sam Kim) 한국유화학회 2018 한국응용과학기술학회지 Vol.35 No.3

This study attempted to investigate the effects of Paeonia Lactiflora Pallas (P. lactiflora) on the inhibition of oxygen free radical, anti-inflammation and MMP-1 inhibitory activity and examine its possibility as a functional cosmetic material. For test methods, the inhibition of oxygen free radical after measuring reactive oxygen species (ROS) in the cell, cytotoxicity assessment and anti-inflammation were measured, and MMP-1 inhibitory effects in the HDF cell were measured. According to the test, the inhibition of ROS was confirmed in RAW 264.7 and HDF cells. In terms of cytotoxicity assessment, 90% or higher cell viability was detected at 5/10μg/mL Paeonia Lactiflora Pallas extract while it was 80% or higher at other concentration levels in both RAW 264.7 and HDF cells. In addition, NO production was inhibited in the RAW 264.7 cell while MMP-1 was significantly inhibited in the HDF cell. The above results reveal a possibility of Paeonia Lactiflora Pallas extract as a functional cosmetic material after confirming the inhibition of ROS synthesis in the cell, antioxidant and anti-inflammatory effects by inhibiting NO synthesis, low toxicity on skin cells and anti-aging effect through MMP-1 inhibition. 본 연구는 적작약 꽃 추출물의 활성산소 억제와 항염증 및 MMP-1 발현 억제능 효과에 관해 알아보고 기능성 화장품 소재로써의 가능성을 확인하고자 하였다. 본 실험 방법으로는 세포 내 ROS 측정을 통한 활성산소 억제효과와 세포 독성 평가 및 항염증 측정, HDF 세포에서의 MMP-1의 발현 억제능 효과를 측정하고자 하였다. 실험 결과, RAW 264.7 세포와 HDF 세포 내에서 ROS로 억제효과를 확인하 였고, 세포 독성평가는 적작약 꽃 추출물 5, 10 μg/mL 처리 농도에서 90% 이상의 세포 생존율, 그 외 처리 농도에서는 80% 이상의 세포 생존율을 확인하였다. 또한 RAW 264.7 세포에서의 NO 생성 억제와 HDF 세포에서 MMP-1의 발현 억제능이 유의하게 억제되는 것을 확인하였다. 이상의 결과를 종합하면, 적작약 꽃 추출물의 세포 내 ROS 생성억제와 NO 생성 억제로 항산화와 항염증 효과, 피부세포에 대한 낮은 독성, MMP-1의 발현 억제를 통한 노화 효과가 확인됨에 따라 기능성 화장품 소재로써의 활용 가능성을 확인할 수 있었다.

서지보호기의 열화 주기 파악을 위한 서지카운터 설계

이재남(Jae-Nam Lee),류장렬(Jang-Ryeol Ryu),김승환(Seung-Hwan Kim),서방원(Bangwon Seo) 한국정보통신학회 2020 한국정보통신학회 종합학술대회 논문집 Vol.24 No.1

응급 수술을 시행한 신경외상 환자들에 있어 전염성 바이러스 감염의 유병율에 대한 분석

남경협 ( Kyoung Hyup Nam ),최혁진 ( Hyuk Jin Choi ),이재일 ( Jae Il Lee ),고준경 ( Jun Kyeung Ko ),한인호 ( In Ho Han ),조원호 ( Won Ho Cho ) 대한외상학회 2015 大韓外傷學會誌 Vol.28 No.1

Purpose: The aim of this study was to estimate the seropositive prevalence of blood-borne infection in neurotrauma patients who underwent emergent surgical intervention, especially patients with hepatitis B virus (HBV), hepatitis C virus (HCV), syphilis and human immunodefIciency virus (HIV). Methods: A retrospective review identified 559 patients with traumatic brain injury and spinal trauma who underwent emergent surgery between 2007 and 2014. We reviewed the medical records and extracted data, including age, sex, location of lesion, result of serologic tests, time interval of admission and surgery after presenting to emergency room. Serologic tests for HBV, HCV, syphilis and HIV were performed and analyzed to determine whether the seropositive results were confirmed by the surgeon before surgery. Results: The majority of the patients were male (74.6%), and the mean age was 55.4±20.2 years. Most patients underwent surgery due to traumatic brain injury (90.0%). Fifty-three patients (10.0%) showed a positive result on at least one serologic test. Seropositive rates according to pathogens were 0.5% for syphilis, 5.2% for HBV and 3.9% for HCV. No positive results were noted on the serologic tests for HIV. HBV in patients with spinal cord injury and age from 40 to 49 years were associated with high serologic positive rate, and that result was statistically significant. However, no statistically significant differences were found in the other variables. Serologic results could not confirmed before surgery in the majority of the cases (62.1%), and 10.4% of these patients showed seropositive results. Conclusion: The results of this study emphasize the importance of taking precautions and conducting rapid serologic testing in preventing the occupational transmission of blood-borne viruses to health-care workers. [ J Trauma Inj 2015; 28: 9-14 ]

온라인 쇼핑에서 신뢰의 역할 -위계적 관계 관점

이재남 ( Jae Nam Lee ),강민형 ( Min Hyung Kang ) 한국지식경영학회 2013 지식경영연구 Vol.14 No.3

Nowadays, online shopping has become popular among consumers. As such, gaining loyal online shopping customers has become a rising concern for online shopping vendors. In this study, we investigated the hierarchical relationships among Lewicki and Bunker`s three different types of trust, namely, calculus-based trust, knowledge-based trust, and identification-based trust, in the context of online shopping and their impacts on customer satisfaction and loyalty. A total of 104 responses from online shopping users were analyzed to test the proposed model and its hypotheses using Partial Least Squares (PLS). The results showed that, in the online environment, hierarchical relationships between different types of trust exist and that, among them, knowledge-based trust has the strongest impact on customer satisfaction. This finding implied that practitioners should focus on developing appropriate online strategies for building trust-based relationships with online customers.

대상포진 후 신경통 치료중 발견된 척수종양에 의한 하지마비

이재남 ( Jae Nam Yi ),신용섭 ( Yong Sup Shin ),손수창 ( Soo Chang Son ),이원형 ( Won Hyung Lee ) 대한통증학회 2004 The Korean Journal of Pain Vol.17 No.1

기업의 소셜미디어 활용방안에 대한 연구 : 트위터를 중심으로

이재남(Jae-Nam Lee),변유진(Eujean Byun),한재민(Jaemin Han) 한국IT서비스학회 2011 한국IT서비스학회지 Vol.10 No.4

As the number of smart phone users increases, many organizations begin to adopt social media rapidly to diversify communication channels with customers. Specifically, twitter, which supports instant and two-way communications between users and between organizations and users, has been adopted by many organizations as an efficient way not only to identify new customers but also to retain existing customers. However, little attention has been given to the issue on how organizations can effectively use twitter to improve customer satisfaction. To explore the issue, this study proposes two major dimensions, customer participation and organization resource utilization, which should be considered in building a utilization strategy for twitter in organizations. We then develop four different combinations along with these dimensions-follow, mention, retweet, and review types. Based on case studies of 27 organizations that use twitter, we evaluate the degrees of customer participation, resource utilization, and customer satisfaction, and examine matching or mismatching of the adoption purpose of twitter and its actual utilization. The study results reveal that organizations in the matching group show higher customer satisfaction that those in the mismatching group. This study sheds new light on twitter research by developing a new conceptual framework and using a case study approach to explore the relationship between the utilization strategy of twitter and customer satisfaction.

개질 유황콘크리트를 활주로 단면 보수용으로 활용하기 위한 기초 실험

이재남 ( Lee Jae Nam ),정호진 ( Jung Ho Jin ),최문선 ( Choi Moon Sun ),최연왕 ( Choi Yun Wang ) 한국구조물진단유지관리공학회 2015 한국구조물진단유지관리공학회 학술발표대회 논문집 Vol.19 No.2

The role of trust in online shopping: A hierarchical relationship perspective

이재남,강민형,Lee, Jae Nam,Kang, Minhyung The Knowledge Management Society of Korea 2013 지식경영연구 Vol.14 No.3

Nowadays, online shopping has become popular among consumers. As such, gaining loyal online shopping customers has become a rising concern for online shopping vendors. In this study, we investigated the hierarchical relationships among Lewicki and Bunker's three different types of trust, namely, calculus-based trust, knowledge-based trust, and identification-based trust, in the context of online shopping and their impacts on customer satisfaction and loyalty. A total of 104 responses from online shopping users were analyzed to test the proposed model and its hypotheses using Partial Least Squares (PLS). The results showed that, in the online environment, hierarchical relationships between different types of trust exist and that, among them, knowledge-based trust has the strongest impact on customer satisfaction. This finding implied that practitioners should focus on developing appropriate online strategies for building trust-based relationships with online customers.

토지구획정리사업지구에서의 블록유형별 노후건축물 분포를 고려한 주거지 정비방안

이재남(Lee, Jae-Nam),이희정(Lee, Hee-Chung) 한국도시설계학회 2013 도시설계 : 한국도시설계학회지 Vol.14 No.2

본 연구는 토지구획정리사업으로 조성된 격자형 저층주거지정비에 있어 기존의 대규모 단지식 개발에서 벗어나 부분적이고 점진적인 소규모 개발의 정비방향을 제시하는 것을 목적으로 한다. 이에 문헌연구를 통해 토지구획정리사업의 배경과 조성된 주거지의 특성을 고찰하였고, 조성시기별로 블록 형태와 가로체계가 상이하며 다른 주거환경이 나타나고 있음을 확인하였다. 구체적인 사례연구를 위해 이수지구, 영동2지구, 개포지구를 사례대상지로 선정하고 노후주택의 밀집 정도와 블록의 형태를 통해 총 6개의 유형으로 구분하였다. 각 유형별로 필지별 개발 가능성을 고려하여 블록단위개발, 소규모 합필개발, 필지단위개발, 유지관리의 4가지 정비방향을 제시하였다. 이러한 정비방식을 규제?유도하기 위해 지구단위계획이 활용될 필요가 있고 저층주거지에 적합한 인센티브 방안이 적극적으로 개발될 필요가 있으며 현재 개정 중인 도정법의 각 사업들과 연계된 구체적인 시행방안이 마련되었을 때 효과적으로 저층주거지를 관리할 수 있음을 제시하였다. This study focuses on Land-readjustment-project Areas in Seoul to provide schemes for improving the current redevelopment tool, which is a Small-scale Renewal program for residential areas. The main issues of this paper can be summarized as follows. First, the residential environment includes different types of blocks and the streetsystems depending on when they were developed. Second, the 6 types of the residential environments were categorized in terms of the block-type and the aging building distribution patterns through three case studies in Seoul(Isu district, Youngdong-2 district and Gaepo district). Third, it proposes 4 types of Small-scale Renewal plan considering the development possibility. In addition, it proposes that low-rise residential areas developed by the Land-readjustment-project should be more effectually managed according to a concrete action plan, t like the District-Unit-Plan or another type of intentive plan under the Urban and Residential Environment Improvement Act, which is now being renewed.

증례 : 소화기 ; 다운증후군 환자에서 발생한 결합조직형성 소원형세포종양 1예

이재남 ( Jae Nam Lee ),이상용 ( Sang Yong Lee ),유현석 ( Hyun Seuk Yu ),장수민 ( Su Min Jang ),이동건 ( Dong Gun Lee ),최정문 ( Jung Mun Choi ),박성후 ( Sueong Hu Park ) 대한내과학회 2009 대한내과학회지 Vol.76 No.4

결합조직형성 소원형세포종양은 비교적 최근에 독립된 질환으로 분류되었으며 젊은 나이의 남자에게서 복막에서 기원한 것으로 보이는 종괴가 복강에 다발성으로 있으나 복부 장기에서의 기원이 불명확하며, 여러 장기를 침범하고, 공격적인 성향을 보이는 경우에 복강 내 결합조직형성 소원형세포종양의 가능성을 고려해 봐야 될 것이다. 본 저자들은 다운증후군 환자에서 발생한 결합조직형성 소원형세포종양 1예를 경험하였기에 보고하는 바이다. A desmoplastic small round cell tumor (DSRCT) is a rare, aggressive neoplasm that occurs predominantly in children and young men. It presents as a large mass inside the abdomen, particularly within the pelvis, and may be accompanied by extensive tumor implants throughout the peritoneum. Microscopically, it typically appears as nests of small undifferentiated cells within a desmoplastic stroma. A DSRCT shows a special immunohistochemical staining pattern, expressing epithelial, neural, and muscle markers. A DSRCT is associated with a specific chromosomal translocation, t(11;22) (p13;q12), resulting in a chimeric EWS/WT1 transcript that is helpful for diagnosing this tumor. We experienced a case of DSRCT in a 19-year-old man who had been diagnosed with Down`s syndrome. (Korean J Med 76:471-475, 2009)