제 1형 신경섬유종증 환자에서 발생한 절반-망막중심정맥폐쇄

이연희,김경남,신경섭,김정열,Yeon Hee Lee,MD,Kyoung Nam Kim,MD,Kyoung Sup Shin,MD,Jung Yeul Kim,MD 대한안과학회 2010 대한안과학회지 Vol.51 No.1

Purpose: We report on a case of hemi-central retinal vein occlusion (Hemi-CRVO) which occurred in a patient with Type 1 neurofibromatosis. Case summary: A 31-year-old woman presented with a chief complaint of a one-month history of decreased visual acuity in the left eye. The patient had Type 1 neurofibromatosis but had no other systemic diseases. The best corrected visual acuity (BCVA) was 0.8 in the right eye and 0.05 in the left eye. Multiple Lisch nodules were present in the irises of both eyes on slit lamp examination. Fundus examination revealed a hemi-central retinal artery occlusion in the left eye. Optical coherence tomograms showed that the central macular thickness was 192 microns in the right eye and 732 microns in the left eye. There was cystoid macular edema in the left eye. A fluorescein angiogram showed delayed filling in the superior branch retinal vein of the left eye. There was an extensive area of non-perfusion of the retinal capillary in the corresponding area, including the perifoveal area. Blood tests for hyper-coagulability, autoimmune disorders, connective tissue disorders and other tests for the brain and carotid artery and coronary artery disease showed no abnormal findings. The clinical course was monitored following an intravitreal injection of bevacizumab (AvastinⓇ). Eight months later, the BCVA had improved to 0.2. Conclusions: Although it is rare, hemi-CRVO occurring in younger patients who have no underlying diseases could be related to neurofibromatosis. J Korean Ophthalmol Soc 2010;51(1):150-154

섬모체망막동맥폐쇄가 첫 임상 증후로 나타난 안매독 환자 1예

이연희,남기엽,김정열,Yeon Hee Lee,Kiyup Nam,Jung Yeul Kim 대한안과학회 2011 대한안과학회지 Vol.52 No.10

Purpose: To report a case of a neurosyphilis patient with cilioretinal artery occlusion as the first manifestation. Case summary: A 58-year old man presented with a visual impairment which developed 5 days earlier in his right eye. During initial evaluation, the visual acuity in the right eye was 0.02. On fundus examination, a whitening adjacent to the macula was observed and fluorescein angiography showed filling delay and late leakage of the cilioretinal arteries. The patient was diagnosed with cilioretinal artery occlusion. Two weeks after his initial visit, visual acuity in the patient’s right eye improved to 0.7 and retinal whitening was decreased on fundus examination. Three months later, a visual decrease in the right eye reoccurred and the visual acuity was 0.01. Anterior chamber cell reaction with hypopyon was observed on slit lamp examination and vitreal opacity was noted during fundus examination. Among the numerous tests performed in order to determine the cause of uveitis, RPR antibody and treponemal antibody were found positive. The patient was diagnosed with neurosyphylis and 2 weeks after intravenous administration of penicillin, visual acuity improved to 0.7 and anterior chamber cell reaction as well as vitreal opacity decreased. Conclusions: The authors reported a case of cilioretinal artery occlusion suspected secondary to neurosyphilis. J Korean Ophthalmol Soc 2011;52(10):1254-1258

갑상샘눈병증에서 심한 사시각변화를 보인 1예

이연희,왕선진,황정민,Yeon-Hee Lee,Seon Jin Wang,Jeong-Min Hwang 대한안과학회 2008 대한안과학회지 Vol.49 No.8

Purpose: We report a patient with strabismus associated with thyroid ophthalmopathy whose condition changed remarkably for 6 years of a natural course. Case summary: A 69-year-old woman with Graves' disease presented with diplopia in April 1999. On examination, she showed left hypotropia of 50 prism diopters (Δ) accompanied by supraduction limitation and lid lag in the left eye. She was diagnosed with strabismus associated with thyroid ophthalmopathy and was observed without any intervention. In October 2000, her left hypotropia decreased to 16Δ, and esotropia of 14Δ developed. Both eyes showed limitation of supraduction, and the left eye showed limitation of abduction. In December 2003, the esotropia increased to 35Δ, and the direction of vertical strabismus changed to 40Δ of right hypotropia. Supraduction limitation of the right eye and abduction restriction of both eyes increased, and infraduction limitation of the left eye developed. In April 2005, esotropia increased to 75Δ, and the amount of right hypotropia was 35Δ. The abduction limitation of both eyes increased. Conclusion: The natural course of strabismus associated with thyroid ophthalmopathy can show continuous and remarkable changes. J Korean Ophthalmol Soc 49(8):1350-1355, 2008

갑상샘눈병증과 관련된 사시의 자연경과

이연희,황정민,오세열,Yeon Hee Lee,M,D,Jeong Min Hwang,M,D,Sei Yeul Oh,M,D 대한안과학회 2006 대한안과학회지 Vol.47 No.12

Purpose: This study investigated the natural course of strabismus associated with thyroid ophthalmopathy. Methods: A retrospective review was performed on the medical records of 31 patients with strabismus associated with thyroid ophthalmopathy who had been followed up for more than 6 months and had not received surgery. For the purpose of this study, a significant change of deviation angle was defined as more than 10 prism diopters in the primary position. Results: Forty-two percent of patients showed a significant change in deviation angle during the observation period of 23.8±17.7 months. The direction of the change was vertical in 32%, horizontal in 3%, and vertical and horizontal in 6% of patients. A significant change of deviation angle developed in 30% of patients within 6 months from the initial ophthalmologic examination, in 24% between 6 and 12 months, and in 13% of patients between 12 and 18 months from the initial examination. Conclusions: Although the deviation angle of strabismus associated with thyroid ophthalmopathy tended to stabilize with time, it nonetheless was susceptible to change even 12 months after the initial ophthalmologic examination. In addition, a vertical change in the deviation angle was more frequent than a horizontal change

특발성 비대경수막염에 동반된 급성 양안 시력 소실

이연희,김정열,남기엽,Yeon-Hee Lee,MD,Jung Yeul Kim,MD,Ki Yup Nam,MD 대한안과학회 2011 대한안과학회지 Vol.52 No.7

Purpose: To report a case of bilateral optic neuropathy related with idiopathic hypertropic pachymeningitis. Case summary: A 66-year old woman presented with acute visual loss that developed 6 days previously in the right eye and 3 days prior in the left eye. During the initial evaluation, her visual acuity was light perception in the right eye and counting fingers at 30 cm in the left eye. A relative afferent papillary defect (RAPD) was noted in the patient’s right eye. On brain MRI, the duramater was thickened and enhanced by contrast. The erythrocyte Sedimentation Rate (ESR) and C-reactive protein (CRP) level were increased and myeloperoxidase-antineutrophil cytoplasmic antibody (MPO-ANCA) as positive. Other neurological and medical abnormalities were not found. Under the suspicion of bilateral optic neuropathy due to idiopathic hypertrophic pachymeningitis, the patient was treated with methylprednisolone pulse therapy. Two days after the treatment, the visual acuity was hand movements at 20 cm in the right eye and 0.6 in the left eye. Three months after the treatment, the visual acuity was counting fingers at 20 cm in the right eye, and 0.7 in the left eye. The right eye showed optic disc pallor and diffuse retinal nerve fiber layer (RNFL) defect. The left eye showed a suspicious RNFL defect, and was otherwise normal. Conclusions: The authors report a rare case of optic neuropathy related with idiopathic hypertrophic pachymeningitis. Idiopathic hypertrophic pachymeningitis should be considered as one of the various causes of optic neuropathy. J Korean Ophthalmol Soc 2011;52(7):893-896

양방 항암치료와 병행하여 산삼약침과 봉약침 치료를 받은 전립선암 환자들의 PSA 수치 변화 관찰 보고

이연희,김채원,이광호,Lee, Yeon-Hee,Kim, Chae-Won,Lee, Kwang-Ho 대한약침학회 2011 Journal of pharmacopuncture Vol.14 No.4

Objectives: The purpose of this report is to find out how Mountain Ginseng Pharmacopuncture(MGP) and Sweet Bee Venom(SBV) treatments are effective on prostate cancer patients by monitoring Prostate specific antigen(PSA) values. Methods: We treated two prostate cancer patients with MGP and SBV from October 2008 to April 2011. One patient had localized prostate cancer, the other was in the terminal stage of prostate cancer with lung and bone metastasis and both had been receiving western anticancer therapy. We had monitored the changes of PSA value. Results: In case 1, MGP and SBV treatments seemed to be helpful in preventing the recurrence of localized prostate cancer. In case 2, PSA value was decreased by MGP treatment. Conclusions: It is conceivable that MGP and SBV are effective treatments for patients with prostate cancer.

개방성 안구손상 환자의 시력 예후 인자와 안외상점수의 예측도

이연희,곽주영,이성복,Yeon Hee Lee,MD,Joo Young Kwag,MD,Sung Bok Lee,MD,PhD 대한안과학회 2012 대한안과학회지 Vol.53 No.6

Purpose: To determine the prognostic factors of visual outcome in open globe injury and to assess the possibility of an ocular trauma score (OTS) model of predictive value in open globe injuries in Koreans. Methods: The medical records of 242 patients with open globe injury from 2000 to 2010 were retrospectively reviewed. Prognostic factors of visual outcome, positive predictive rate, and negative predictive rate were surveyed. Results: In the multivariate analysis, old age, relative afferent pupillary defect, impaired initial visual acuity and retinal detachment were the worst predictive factors of vision survival. In OTS categories 1 and 2, worse final visual acuity was acquired, and positive predictive rate and negative predictive rate for assessment of final visual acuity less than 0.02 were 70.1% and 89.8%, respectively. Conclusions: The prognostic factors of open globe injury associated with impaired final visual acuity were old age, relative afferent pupillary defect, worse initial visual acuity, retinal detachment and OTS categories 1 and 2. The OTS may have prognostic value in open globe injuries in Korean patients. However, identified prognostic factors of the present study did not entirely coincide with those of other Koreans or previous studies. Therefore, additional studies on the modified open globe injury as a prognostic model in Korean patients are needed. J Korean Ophthalmol Soc 2012;53(6):825-832

Ciprofloxacin , HK - 3140 , Norfloxacin , Ofloxacin 에 대한 Escherichia coli 저항균주의 특성

이연희,김경순,편희은,박원봉,박명환,김완주 ( Yeon Hee Lee,Kyung Soon Kim,Hee En Pyun,Woon Boong Park,Myung Hwan Park,Wan Joo Kim ) 생화학분자생물학회 1992 BMB Reports Vol.25 No.2

Resistant strains of Escherichia coli were obtained against ciprofloxacin, ofloxacin, norfloxacin and HK-3140. Each resistant strain showed cross-resistance to other quinolones and peniciline-G. To find out the resistant mechanism, lipid and outer membrane proteins of the cells were separated and analyzed with gas chromatography and SDS denaturing gel electrophoresis. Lipid profiles from sensitive and resistant cells showed no big differences while outer membrane protein profiles showed a large variation. Sensitive cells showed better uptake of quinolone than resistant cells suggesting that the resistance against quinolone was resulted from the change in permeability through the outer membrane proteins.

장애자녀를 둔 어머니의 공감피로, 공감만족에 양육유능감이 미치는 매개효과 분석

이연희 ( Lee Yeon-hee ),황순영 ( Hwang Soon-young ) 한국특수아동학회 2016 특수아동교육연구 Vol.18 No.3

연구목적: 본 연구는 장애자녀를 둔 어머니의 공감피로, 공감만족에 양육유능감이 미치는 매개효과를 분석하는데 그 목적이 있다. 연구방법: 장애자녀를 둔 어머니 336명을 대상으로 공감피로, 공감만족과 양육유능감을 조사하였고, 상관관계 분석과 3단계 매개회귀분석을 통해 분석되었다. 연구결과: 첫째, 장애자녀를 둔 어머니의 공감피로, 공감만족과 양육유능감 수준은 중간수준으로 나타났으며, 공감피로와 공감만족, 공감피로와 양육유능감 간에 부적 상관관계와 공감만족과 양육유능감 간에는 정적 상관관계를 나타냈다. 둘째, 장애자녀를 둔 어머니의 공감피로, 공감만족 간에 양육유능감이 매개변수로 영향을 주었다. 결론: 연구결과를 토대로 장애자녀를 둔어머니의 공감피로를 줄여 공감만족을 높일 수 있는 방법으로 양육유능감을 간접적으로 강화하는 방법을 시사점으로 제안하였다. Purpose: The purpose of this study was to analyze the mediation effect influencing the parenting sense of competence on the compassion fatigue and compassion satisfaction of mother of children with disabilities. Method: To this end, 336 mother of children with disabilities were asked to completed the questionnaires investigating the compassion fatigue, compassion satisfaction and parenting sense of competence. The collected data were analyzed by using the correlation analysis and the three step mediation regression analysis. Results: The results were as follows. First, the level of the compassion fatigue, compassion satisfaction and parenting sense of competence of mother of children with disabilities were on the average. And there was a statistically negative correlation between the compassion fatigue and compassion satisfaction, and so was between the compassion of fatigue and parenting sense of competence. As well, there was positive correlation between the compassion of satisfaction and parenting sense of competence. Second, the mediation effect of parenting sense of competence was on the compassion fatigue and compassion satisfaction. Based on these results, It could be presented that to reduce compassion fatigue in the relation of between compassion fatigue and compassion satisfaction of mother of children with disabilities. Conclusion: For this, for the parenting sense of competence improve, it is necessary to provide an opportunity through various support of personal and social aspect.

자녀의 장애진단 시기에 따른 장애아동 어머니의 공감피로와 공감만족 수준 분석

이연희 ( Yeon Hee Lee ),황순영 ( Hwang Soon Young ) 한국특수아동학회 2014 특수아동교육연구 Vol.16 No.3

본 연구의 목적은 자녀의 장애진단 시기에 따른 장애아동 어머니의 공감피로와 공감만족 수준에 대해 알아보고자 하는 것이다. 이를 위해 장애 자녀를 둔 장애아동 어머니 117명을 대상으로 하여 공감피로와 공감만족에 대한 설문조사를 실시하였다. 수집된 공감피로와 공감만족에 관한 자료는 ANOVA 분석하였다. 연구결과는 전체 장애아동 어머니의 공감피로와 공감만족은 중간 수준으로 나타났으며, 자녀의 장애진단 시기에 따른 장애아동 어머니의 공감피로와 공감만족 수준은 자녀 진단시기가 3년 이상인 집단에서 공감만족에 통계적으로 유의한 차이를 보였다. 따라서 장애아동 어머니를 지원함에 있어서 장애자녀가 진단을 받은 후 조기에 적절한 지원이 제공되어야 할 것이며, 이후에도 공감피로를 감소시키고 공감만족을 증가시켜 나갈 수 있는 다양한 지원으로 발전시켜야 할 것이다. 또한 장애아동 어머니가 장애 자녀를 양육하면서 경험할 수 있는 심리·정서적인 특성과 변화를 잘 이해하고 이를 긍정적으로 이끌어 줄 수 있는 체계적인 지원과 함께 지속적인 사회적 차원의 관심과 노력이 필요할 것이다. The purpose of this study was to investigate the level of compassion fatigue and compassion satisfaction of mothers of children with disabilities according to the moment of diagnosis of disability. 117 mothers of children with disabilities were asked to complete the questionnaires on compassion fatigue and satisfaction. The collected data were analyzed by using ANOVA. The results were as follows. The overall level of compassion fatigue and compassion satisfaction was showed on average level. For the level of compassion fatigue and compassion satisfaction of mothers of children with disability according to the moment of diagnosis of disability, compassion satisfaction was statistically significant difference in the group that consisted of mothers with children diagnosed with disabilities 3 years ago or more. Based on these findings, it can be concluded that the development of early and systematic support systems for mothers of children with disabilities is crucial to increase their compassion satisfaction and decrease the compassion fatigue.