Polystyrene 중공 미세구에 대한 연구

윤은선,김민경,박용성,우제완,황영애 한국공업화학회 2001 한국공업화학회 연구논문 초록집 Vol.2001 No.1

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활동적 비디오 게임을 활용한 신체활동이 고지방식이 후 혈관기능에 미치는 영향

윤은선,박수현,이용희,안의수,제세영 한국운동생리학회(구 한국운동과학회) 2013 운동과학 Vol.22 No.1

본 연구의 목적은 고지방 식이 섭취 후 활동적 비디오 게임을 이용한 신체활동이 혈관기능에 미치는 영향에 대해 알아보는 데 있다. 피험자는 정상체중의 건강한 성인 16명(남자 9명, 여자 7명, 나이 24±4세, 체질량지수 22.4±2.1 ㎏/㎡)을 대상으로 하였으며 모든 피험자가 신체활동 처치와 통제 처치에 모두 참여하는 cross-over design으로 설계하였다. 고지방식이는 총 1,257 kcal의 햄버거를 섭취하였다. 신체활동은 고지방 식이 섭취 후 30분에 50분간 활동적 비디오 게임(50분)을 실시하였다. 종속변인으로 혈중지질(총 콜레스테롤, 중성지방, 저밀도 지단백 콜레스테롤, 고밀도 지단백 콜레스테롤), 혈압, 혈관기능(상완동맥 혈류 의존성 혈관 이완능, 경동맥-대퇴동맥 맥파전파속도)을 측정하였으며, 측정시기는 고지방 식이 전, 고지방 식이 후 3시간, 고지방 식이 후 5시간으로 하였다. 연구 결과, 일시적 고지방식이는 활동적 비디오 게임 처치와 통제처치 모두 혈중 중성지방 농도를 유의하게 증가시켰으나(시기 효과, p=0.001) 두 처치 간 유의한 차이는 없었다. 혈관내피세포 기능은 고지방 식이 후 3시간에 통제처치에서는 감소된 반면(사전:9.32±2.86 %, 식후 3시간:8.13±3.56 %), 활동적 비디오 게임 처치에서는 혈관내피세포 기능이 개선되는 경향을 보였으나 통계적으로 유의한 차이는 나타나지 않았다(사전:8.74±3.13 %, 식후 3시간:9.21±3.40 %). 경동맥-대퇴동맥 맥파전파속도는 고지방 식이 후 변화를 보이지 않았으며 처치 간 차이 또한 나타나지 않았다. 본 연구의 결과를 종합해 보면, 고지방 식이 후 활동적 비디오 게임의 실시는 혈중 중성지방 증가를 유의하게 감소시키지 못하였으며, 고지방식이로 인한 혈관내피세포 기능 및 동맥경직도 변화를 개선시키지 못하였다. 따라서 건강한 성인에게 활동적 비디오 게임은 고지방 식이에 따른 혈관 기능 변화에 있어 운동의 보호적 효과를 얻기에 운동강도 및 운동량이 부족한 것으로 사료된다. A high fat meal transiently decreases vascular function, while acute aerobic exercise improves vascular function. Active video games are now highly popular and play a role in promoting physical activity. Although studies suggest that acute aerobic exercise attenuates high fat meal induced vascular dysfunction, but it is not clear whether an active video game could attenuate vascular dysfunction after a high fat meal. We tested the hypothesis that an active video game would partial l y prevent the unfavorable effect of vascular function by high fat meal in young adults. Using a randomized cross over design, sixteen healthy young subjects (male 9, female 7;age 24±4 yrs, BMI 22.4±2.1 ㎏/㎡) were assigned to both an active video game(AVG:50 minutes) and a seated rest(CON) after a high fat meal. Lipid profiles, blood pressure, and vascular function measured at baseline, 3 and 5 hours after a high fat meal. Vascular function was measured by endothelial function(brachial artery flow mediated dilation;FMD) and arterial stiffness(carotid-femoral pulse wave velocity;C-F PWV). Blood triglyceride levels were significantly increased in two treatment conditions after a high fat meal and did not significantly different between two groups(AVG:74.06±43.36, 160.63±106.20, 126.81±91.41 mg/dl;CON:70.06±38.67, 168.38±85.89, 128.75±87.26 mg/dl, p=0.878). FMD was decreased in the CON (9.32±2.86 to 8.13±3.56 %), but increased in the AVG (8.74±3.13 % to 9.21±3.40 %) at 3 hr after a high fat meal. However, there was no significantly different between two groups (p=0.189). C-F PWV was similarly decreased in two treatment conditions after a high fat meal and did not significantly different between two groups (AVG:6.39±1.12, 6.08±0.94, 6.38±1.07 m/s;CON:6.34±0.85, 6.19±0.89, 6.28±1.01 m/s, p=0.483). These findings show that a high fat meal caused a temporary decrease in endothelial function, but these decreases were not significantly attenuated in the group with active video game compare to the group with seated rest. Therefore, active video game may not have a cardioprotective effect in young healthy adults exposed to acute high fat meal.

한국 성인의 사회 심리적 스트레스와 운동 미참여의 관련성 : 한국인 유전체 역학 조사사업 자료를 기반으로

윤은선,박수현,박세정 한국운동생리학회 2019 운동과학 Vol.28 No.4

PURPOSE: Psychological factors have been identified as an important factor underlying physical activity behavior in adults. However, the extent to which these psychological factors impact physical activity behavior remains poorly understood. The aim of the study was to examine the association between psychological stress and physical inactivity in subsets of data from the Korean Genome and Epidemiology Study (KoGES). METHODS: 69,219 participants (24,025 men) aged 40-69 were drawn from urban and rural community based cohort studies, which are subprojects of KoGES. We analyzed the association between psychological stress and physical inactivity using logistic regression. Cox’s proportional hazard regression analysis was used to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs) of exercise behavior changes according to psychological stress level changes. RESULTS: Compared to the healthy stress group, the likelihood of physical inactivity was increased in high-risk stress group (men OR=1.88, 95% CI 1.63-2.17, p<0.001, women OR=2.24 95% CI, 2.04-2.47, p<0.001). During the mean follow-up period of 4.6 years, compared to the sustained healthy stress, the group with increased stress level was at a higher risk of remaining physical inactive (men HR=2.16, 95% CI 1.24-3.69, p<0.001, women HR=1.54, 95% CI 1.12-4.06, p<0.001), and the risk becoming physical inactive (men HR=2.33, 95% CI 1.33-4.09, p=0.003, women HR=2.13, 95% CI 1.12-4.06, p=0.021). CONCLUSIONS: These results suggest that the psychological stress could be barrier of exercise participation. Management of psychological stress should be considered in the strategy for promoting exercise participation in the community.

제사부(第四部): 포스터발표(發表) 연제(演題) : 6. GC-FPD방법을 이용한 우유의 잔류유기인계농약 분석에 관한 연구

윤은선,황래홍,김현정,김연주,김동언,한인규,이병동 한국가축위생학회 2001 학술대회논문집 Vol.2001 No.-

여름철 안전운동 가이드

윤은선 한국스포츠정책과학원(구 한국스포츠개발원) 2020 스포츠과학 Vol.151 No.-

한국 성인에서 상대악력과 제2형 당뇨병 발생률과의 연관성: 한국인 유전체 역학 조사사업 자료를 기반으로

윤은선,박수현 한국운동생리학회 2020 운동과학 Vol.29 No.4

PURPOSE: We investigated whether relative handgrip strength (RHS) and change in handgrip strength predicted Type 2 DM incidence in middle-aged and older adults. METHODS: Total of 29,098 participants (8,609 men and 20,489 women) aged 40-69 who were free of diabetes at the baseline examination drawn from the Korean Genome and Epidemiology Study-Urban Health Examinees cohort (KoGES-HEXA), a large prospective population-based study. RHS was assessed with a dynamometer and divided by body mass index. Diabetes was defined as selfreported physician-diagnosed diabetes, use of anti-diabetic medications or measured fasting glucose ≥126 mg/dl, or glycated hemoglobin (HbA1C) ≥6.5%. Cox proportional hazard regression analysis was used to estimate the hazard ratio (HRs) and 95% confidence intervals (CIs) of Diabetes incidences according to baseline RHS levels and RHS changes. RESULTS: During a mean follow-up period of 4 years (49.8±13.3 month), 1,167 (4.0%) participants developed diabetes. Compared with the high RHS group, higher risk of diabetes incidence was observed in low RHS group (men HR=1.28, 95% CI 1.06-1.55, women HR=1.32, 95% CI 1.12-1.54) after adjusted for age, triglyceride, cigarette smoking, alcohol consumption, marriage, income, education hypertension, family history of diabetes, fasting glucose, regular exercise. In addition, compared with the sustained high RHS group, sustained low RHS group showed an increased risk of diabetes incidence (men HR=1.60, 95% CI 1.28-2.00, women HR=1.85, 95% CI 1.52-2.24) after adjustment. However, the risk was not statistically significant in increased RHS group (men HR=0.98, 95% CI 0.73-1.31, women HR=1.11, 95% CI 0.85-1.43). CONCLUSIONS: The present findings indicate that RHS is independently associated with the risk of incident diabetes in middle and older adults. RHS measurement may be useful to identify individuals at increased risk for diabetes incidence. Maintaining a high level of RHS is important strategies for diabetes prevention among adults.

Effects of Acute Resistance Exercise on Arterial Stiffness in Young Men

윤은선,정수진,천성근,오유성,김설향,제세영 대한심장학회 2010 Korean Circulation Journal Vol.40 No.1

Background and Objectives: Increased central arterial stiffness is an emerging risk factor for cardiovascular disease. Acute aerobic exercise reduces arterial stiffness, while acute resistance exercise may increase arterial stiffness, but this is not a universal finding. We tested whether an acute resistance exercise program was associated with an increase in arterial stiffness in healthy young men. Subjects and Methods: Thirteen healthy subjects were studied under parallel experimental conditions on 2 separate days. The order of experiments was randomized between resistance exercise (8 resistance exercises at 60% of 1 repeated maximal) and sham control (seated rest in the exercise room). Carotid-femoral pulse wave velocity (PWV) and aortic augmentation index as indices of aortic stiffness were measured using applanation tonometry. Measurements were made at baseline before treatments, 20 minutes, and 40 minutes after treatments (resistance exercise and sham control). Results: There was no difference in resting heart rate or in arterial stiffness between the two experimental conditions at baseline. At 20 minutes after resistance exercise, heart rate, carotid-femoral PWV and augmentation index@75(%) were significantly increased in the resistance exercise group compared with the sham control (p<0.05). Brachial blood pressure, central blood pressure and pulse pressure were not significantly increased after resistance exercise. Conclusion: An acute resistance exercise program can increase arterial stiffness in young healthy men. Further studies are needed to clarify the effects of long-term resistance training on arterial stiffness.

노인 고혈압 환자에서 등척성 악력운동과 유산소 운동의 동맥경직도 및 혈관이완능 개선에 미치는 효과 비교

윤은선,추진아,김장영,제세영 대한스포츠의학회 2019 대한스포츠의학회지 Vol.37 No.4

Purpose: Isometric handgrip exercise (IHE) is an easy and accessible form of exercise that has beneficial effects on blood pressure (BP). However, it remains unclear whether IHE is similar benefits on arterial stiffness and endothelial function compared with aerobic exercise (AE) in elderly hypertensive patients. The aim of this study was to compare the effects of IHE versus AE on arterial stiffness and endothelial function in elderly hypertensive patients. Methods: We conducted a randomized controlled trial with a three-arm design. Fifty-four elderly hypertensive patients (15 men; mean age, 69±6 years; systolic blood pressure, 131.2±14.7; diastolic blood pressure, 80.2±7.9 mm Hg) were randomized to IHE training (n=18), AE training (n=21), or non-exercise control group (n=21) for 12 weeks. Bilateral IHE training was performed four times of 2 minutes at 30% of maximal voluntary contraction with three times per week. AE training was performed brisk walking for 30 minutes at moderate intensity with three times per week. Carotid-femoral pulse wave velocity (PWV), augmentation index heart rate corrected (AIx@75 bpm) and brachial artery flow-mediated vasodilation (FMD) as indices of arterial stiffness and endothelial function were measured at baseline and after the intervention. Results: Following 12-week intervention, resting BP was significantly decreased in both IHE (p=0.001) and AE groups (p=0.002). AIx@75 bpm and FMD were unchanged in the all groups. However, PWV was significantly decreased in both IHE and AE groups (IHE, 10.9±2.3 to 9.9±2.1 m/s [p<0.001]; AE, 10.5±2.0 to 9.4±1.6 m/s [p=0.001]), without any change in the control group. Conclusion: These findings suggest that both IHE and AE trainings were comparable effect in improving arterial stiffness in elderly hypertensive patients.

젊은 성인에서 허혈성 전처치가 최대운동수행능력에 미치는 영향

윤은선,제세영 대한스포츠의학회 2018 대한스포츠의학회지 Vol.36 No.2

Purpose: Remote ischemic preconditioning (RIPC), induced by repeated bouts of ischemia followed by reperfusion of the arm or leg is a noninvasive strategy to protect a target organ against oxidative stress and injury caused by ischemia and reperfusion. Interestingly, recent evidence suggests that RIPC may also improve exercise performance by increasing maximal oxygen consumption, but such finding remain equivocal. As such, the purpose of the study was to examine the effect of RIPC on exercise performance in healthy individuals. Methods: In a randomized cross-over design, 17 healthy male participants (age, 23±3 years) were exposed to either a sham control (six cycles of 5 minutes bilateral thigh cuff occlusion at 20 mm Hg) or RIPC (six cycles of 5 minutes bilateral thigh cuff occlusion at 180 mm Hg) an hour before a maximal exercise test. We measured maximal oxygen consumption, power output, heat rate, blood pressure, and blood lactate as exercise performance parameters during a maximal exercise test performed on an upright bicycle. Results: Compared with the sham control, RIPC improved maximal oxygen consumption (7.4%, p=0.025) and maximal power output (11.5%, p=0.010), whereas other exercise performance parameters remained unchanged with RIPC (p>0.05). Conclusion: Taken together, the improvements in maximal oxygen consumption and maximal power output induced by RIPC may suggest that RIPC should be considered as a method for improving exercise performance.

동물원(動物園)의 야생동물(野生動物) 분변(糞便)에서 분리(分離)한 살모넬라균의 생물형(生物型), 혈청형(血淸型) 및 약제내성(藥劑耐性)

윤은선,박석기,오영희,김태종,Youn, En-sun,Park, Seog-gee,Oh, Young-hee,Kim, Tae-jong 대한수의학회 1994 大韓獸醫學會誌 Vol.34 No.2

Feces samples, obtained from zoo animals around Seoul, were examined for the isolation of Salmonella species, bioserotype and drug resistance for the prevention and treatment of salmonellosis, Salmonella spp were isolated 19(4.7%) from 408 samples of zoo animals. The subspecies in 19 Salmonella were all subspecies 1. The serological identification of Salmonella isolated were 31.6% in Sal typhimurium, 26.3% in Sal hadar, 21.1% in Sal muenchen, 15.8% in Sal enteritidis and 5.3% in Sal ayinde. The antibiotic resistance of Salmonella isolated were 13(68.4%) strains. The multiple resistant patterns of antibiotics in Salmonella were 2 drugs- and 3 drugs-resistance 30.8% respectively. The transferred rate of resistance to recipients(E coli ML 1410 $NA^r$) in Salmonella was 38.5%.